Article
Oncology
Chunling Hu, Anil Belur Nagaraj, Hermela Shimelis, Gemma Montalban, Kun Y. Lee, Huaizhi Huang, Carolyn A. Lumby, Jie Na, Lisa R. Susswein, Maegan E. Roberts, Megan L. Marshall, Susan Hiraki, Holly LaDuca, Elizabeth Chao, Amal Yussuf, Tina Pesaran, Susan L. Neuhausen, Christopher A. Haiman, Peter Kraft, Sara Lindstrom, Julie R. Palmer, Lauren R. Teras, Celine M. Vachon, Song Yao, Irene Ong, Katherine L. Nathanson, Jeffrey N. Weitzel, Nicholas Boddicker, Rohan Gnanaolivu, Eric C. Polley, Georges Mer, Gaofeng Cui, Rachid Karam, Marcy E. Richardson, Susan M. Domchek, Siddhartha Yadav, Kathleen S. Hruska, Jill Dolinsky, S. John Weroha, Steven N. Hart, Jacques Simard, Jean Yves Masson, Yuan-Ping Pang, Fergus J. Couch
Summary: Pathogenic protein-truncating variants of RAD51C increase the risk of breast and ovarian cancer. The effects of RAD51C missense variants on its function and cancer predisposition are still unknown. Functional analysis showed that these missense variants disrupt RAD51C activity and are associated with increased breast and ovarian cancer risks. These findings have significant implications for the clinical management of RAD51C variant carriers.
Article
Oncology
Yu Xin Xu, Ying Huang, Xiao Jie Wang, Dao Xiong Ye, Pan Chi
Summary: The study suggests that lymph node metastasis in station 206 is not an independent prognostic factor for transverse colon cancer, but it can serve as a predictive factor for disease-free survival (DFS). Only patients with T1-3, N+ and high risk should consider dissecting the lymph nodes in station 206.
Review
Multidisciplinary Sciences
Jong Hyuk Yoon, Youngsuk Seo, Yeon Suk Jo, Seulah Lee, Eunji Cho, Amaury Cazenave-Gassiot, Yong-Seung Shin, Myeong Hee Moon, Hyun Joo An, Markus R. Wenk, Pann-Ghill Suh
Summary: This review highlights the importance of lipidomics in diagnosing and treating brain diseases, and explores lipid alterations associated with brain diseases, the functions of brain lipids, and the latest analytical techniques and potential applications.
Article
Oncology
Shutaro Sumiyoshi, Atsushi Shiozaki, Toshiyuki Kosuga, Hiroki Simizu, Michihiro Kudo, Jun Kiuchi, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Yoshiaki Kuriu, Takeshi Kubota, Hitoshi Fujiwara, Yukiko Morinaga, Eiichi Konishi, Eigo Otsuji
Summary: Na(+)/K+-ATPase & alpha;1 subunit (ATP1A1) exhibits aberrant expression in various types of cancer and its levels in specific tissues are associated with the development of cancer. However, the mechanism and signaling pathways underlying the effects of ATP1A1 in colon cancer (CC) have not been elucidated, and its prognostic impact remains unknown.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Po-Shuan Huang, Chia-Jung Liao, Ya-Hui Huang, Chau-Ting Yeh, Cheng-Yi Chen, Hui-Chi Tang, Cheng-Chih Chang, Kwang-Huei Lin
Summary: Liver cancer, with its high mortality rate globally, lacks early diagnostic tools and effective treatment methods. MicroRNAs play important roles in liver cancer treatment, but there are challenges in improving diagnostic technologies and addressing the side effects of microRNA-based drugs.
Article
Biotechnology & Applied Microbiology
Tengfei He, Xiaohui Cheng, Chungen Xing
Summary: 16SrDNA sequencing revealed a more diverse microbial community in the feces of colon cancer patients, with a decrease in beneficial bacteria and an increase in harmful bacteria. These findings provide microbial strategies for the treatment of colon cancer.
Article
Oncology
Elena Fountzilas, Alexia Eliades, Georgia-Angeliki Koliou, Achilleas Achilleos, Charalambos Loizides, Kyriakos Tsangaras, Dimitrios Pectasides, Joseph Sgouros, Pavlos Papakostas, Grigorios Rallis, Amanda Psyrri, Christos Papadimitriou, Georgios Oikonomopoulos, Konstantinos Ferentinos, Anna Koumarianou, George Zarkavelis, Christos Dervenis, Gerasimos Aravantinos, Dimitrios Bafaloukos, Paris Kosmidis, George Papaxoinis, Maria Theochari, Ioannis Varthalitis, Nikolaos Kentepozidis, Georgios Rigakos, Zacharenia Saridaki, Adamantia Nikolaidi, Athina Christopoulou, Florentia Fostira, Epaminontas Samantas, Elena Kypri, Marios Ioannides, George Koumbaris, George Fountzilas, Philippos C. Patsalis
Summary: Limited data exists on the prognostic and predictive value of germline cancer predisposing pathogenic/likely pathogenic variants (P/LPVs) in patients with pancreatic ductal adenocarcinoma. This study examined germline testing of 62 cancer susceptibility genes in 549 unselected patients with pancreatic cancer, revealing a significant proportion of patients carrying P/LPVs in clinically relevant genes. While the presence of any P/LPVs was associated with improved overall survival, its independent prognostic significance was not retained in multivariate analysis, and P/LPVs in homologous recombination repair genes did not predict benefit from platinum-based treatment. The results suggest the need for further validation through universal genetic testing and consideration of newer treatments for patients with pancreatic cancer.
Review
Biochemistry & Molecular Biology
Thomas Cadoux-Hudson, Christopher J. Schofield, James S. O. McCullagh
Summary: This review provides a current overview of cancer-linked IDH mutations, focusing on their distribution in different cancer types, the effects of substitution mutations on enzyme activity, the mode of action of recently developed inhibitors, and their relationship with emerging resistance-mediating double mutations.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Oncology
Shijie Wu, Lina Qi, Huihui Chen, Kun Zhang, Jiapan He, Xianan Guo, Lu Shen, Yunxiang Zhou, Xi Zhong, Shu Zheng, Jiaojiao Zhou, Yiding Chen
Summary: This study evaluated the functional impacts of ten potentially pathogenic PALB2 variants of uncertain significance (VUSs) in 2279 Chinese patients with breast cancer. It was found that two variants, p.L24F and p.L35F, compromised PALB2 function and increased cancer risk. These variants exhibited significant sensitivity to olaparib and cisplatin, suggesting their potential predictive value for targeted therapy response.
Article
Oncology
Laetitia Marisa, Yuna Blum, Julien Taieb, Mira Ayadi, Camilla Pilati, Karine Le Malicot, Come Lepage, Ramon Salazar, Daniela Aust, Alex Duval, Helene Blons, Valerie Taly, David Gentien, Audrey Rapinat, Janick Selves, Sophie Mouillet-Richard, Valerie Boige, Jean-Francois Emile, Aurelien de Reynies, Pierre Laurent-Puig
Summary: The study demonstrates that intratumor heterogeneity (ITH) in colon cancer, decoded based on consensus molecular subtypes (CMS), is common and impacts prognosis. Combinations of different CMSs are associated with poorer outcomes, with ITH being a significant factor in disease-free survival variance. Additionally, cellular analysis suggests that ITH could reflect distinct functional statuses of colon cancer cells, implying potential plasticity between different cell populations related to CMS. Further evaluation of transcriptomic ITH is warranted in the context of personalized medicine.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Emilia M. Pinto, Kara N. Maxwell, Hadeel Halalsheh, Aaron Phillips, Jacquelyn Powers, Suzanne MacFarland, Michael F. Walsh, Kelsey Breen, Maria N. Formiga, Richard Kriwacki, Kim E. Nichols, Roya Mostafavi, Jinling Wang, Michael R. Clay, Carlos Rodriguez-Galindo, Raul C. Ribeiro, Gerard P. Zambetti
Summary: Germline TP53 variants at exon 4-intron 4 junctions are frequent in pediatric adrenocortical tumors (ACT) and rare in other pediatric tumors. These variants result in improper expression and loss of function, and are associated with a high incidence of pediatric ACTs not consistent with classic Li-Fraumeni syndrome.
MOLECULAR CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hager Tarek H. Ismail, Manar AbdelMageed, Gudrun Lindmark, Marie-Louise Hammarstrom, Sten Hammarstrom, Basel Sitohy
Summary: This study investigated the prognostic value of GPR55 in colon cancer. Combining GPR55 with CEA, CXCL16, or CXCL17 improved the discrimination between high and low expression groups. The GPR55/CEA ratio showed the best result, with a significant increase in mean survival time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Li Gao, Ying Lu, Hai-Ning Chen, Zhigui Li, Meng Hu, Rou Zhang, Xiuxuan Wang, Zhiqiang Xu, Yanqiu Gong, Rui Wang, Dan Du, Shan Hai, Shuangqing Li, Dan Su, Yuan Li, Heng Xu, Zong-Guang Zhou, Lunzhi Dai
Summary: This study found that the expression of GSK3 alpha, but not GSK30, was significantly correlated with the overall survival of colon cancer patients. Through analysis of its phosphorylation substrates and protein interactions, specific functions of GSK3 alpha in colon cancer were revealed, suggesting it as a potential therapeutic target.
MOLECULAR & CELLULAR PROTEOMICS
(2023)
Review
Biochemistry & Molecular Biology
Jane H. Frederiksen, Sara B. Jensen, Zeynep Tumer, Thomas V. O. Hansen
Summary: Lynch syndrome is a common hereditary cancer predisposition syndrome caused by pathogenic variants in DNA mismatch repair genes, emphasizing the importance of clear genetic diagnosis for clinical management. Functional assays can provide insights into difficult-to-predict variants. Future perspectives include high-throughput functional analyses of MMR genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Trisha Dwight, Edward Kim, Karine Bastard, Diana E. Benn, Graeme Eisenhofer, Susan Richter, Massimo Mannelli, Elena Rapizzi, Aleksander Prejbisz, Mariola Peczkowska, Karel Pacak, Roderick Clifton-Bligh
Summary: Somatic mutations in EPAS1 are associated with various phenotypes, while the pathogenic potential of germline variants remains unclear. Functional studies showed that three germline variants of EPAS1 have similarities to somatic activating mutations in PPGL, suggesting they may act as modifiers in the expression of PPGL.
ENDOCRINE-RELATED CANCER
(2021)
Article
Hematology
Susan L. Slager, Mark C. Lanasa, Gerald E. Marti, Sara J. Achenbach, Nicola J. Camp, Fatima Abbasi, Neil E. Kay, Celine M. Vachon, James R. Cerhan, James B. Johnston, Timothy G. Call, Kari G. Rabe, Geffen Kleinstern, Nicholas J. Boddicker, Aaron D. Norman, Sameer A. Parikh, Jose F. Leis, Versha Banerji, Danielle M. Brander, Martha Glenn, Alessandra Ferrajoli, Karen Curtin, Esteban Braggio, Tait D. Shanafelt, Mary L. McMaster, J. Brice Weinberg, Curtis A. Hanson, Neil E. Caporaso
Summary: The study investigated the incidence and natural history of MBL in relatives from CLL families, finding that low-count MBL may precede progression to CLL with a higher transformation rate in these families. Furthermore, the study estimated an annual progression rate from low-count MBL to CLL that exceeds that in the general population.
Article
Oncology
Alessia Castellino, Aung M. Tun, Yucai Wang, Thomas M. Habermann, Rebecca L. King, Kay M. Ristow, James R. Cerhan, David J. Inwards, Jonas Paludo, Stephen M. Ansell, Thomas E. Witzig, Grzegorz S. Nowakowski
Summary: Primary GI MCL is rare but has similar outcomes as secondary GI MCL. Less aggressive frontline treatment is reasonable for primary GI MCL, with the impact of GI involvement on treatment selection but not on outcome. It remains uncertain whether more aggressive treatment can lead to improved outcomes.
BLOOD CANCER JOURNAL
(2021)
Article
Oncology
Mark Liebow, Melissa C. Larson, Carrie A. Thompson, Grzegorz S. Nowakowski, Timothy G. Call, William R. Macon, Neil E. Kay, Thomas M. Habermann, Susan L. Slager, James R. Cerhan
Summary: The study found that regular use of low-dose aspirin may reduce the risk of non-Hodgkin lymphoma, while other NSAIDs and statins showed no association with NHL risk.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Joshua C. Pritchett, Zhi-Zhang Yang, Hyo Jin Kim, Jose C. Villasboas, Xinyi Tang, Shahrzad Jalali, James R. Cerhan, Andrew L. Feldman, Stephen M. Ansell
Summary: AITL is an aggressive lymphoid malignancy with a unique tumor microenvironment characterized by a minority population of malignant TFH cells and a diverse infiltrate of immune cells. Non-malignant populations within the TME, such as B cells and CD8+ T cells, are increasingly recognized for their potential role in AITL biology. These non-malignant populations exhibit specific expression patterns that may contribute to the understanding of AITL pathogenesis.
Editorial Material
Hematology
James R. Cerhan
Summary: In this article, Williams et al. provide a clearer perspective on the additional burden of neurocognitive, psychosocial, and quality of life impairments faced by long-term survivors of childhood Hodgkin lymphoma. The authors also identify potentially modifiable factors that could help prevent or reduce adverse outcomes.
Article
Oncology
Sophia S. Wang, Claire M. Vajdic, Martha S. Linet, Susan L. Slager, Jenna Voutsinas, Alexandra Nieters, Delphine Casabonne, James R. Cerhan, Wendy Cozen, Graciela Alarcon, Otoniel Martinez-Maza, Elizabeth E. Brown, Paige M. Bracci, Jennifer Turner, Henrik Hjalgrim, Parveen Bhatti, Yawei Zhang, Brenda M. Birmann, Christopher R. Flowers, Ora Palliel, Elizabeth A. Holly, Eleanor Kane, Dennis Weisenburger, Marc Maynadie, Pierluigi Cocco, Lenka Foretova, Elizabeth Crabb Breen, Qing Lan, Angela Brooks-Wilson, Anneclaire J. De Roos, Martyn T. Smith, Eve Roman, Paoloa Boffetta, Anne Kricker, Tongzhang Zheng, Christine F. Skibola, Jacqueline Clavel, Alain Monnereau, Stephen J. Chanock, Nathaniel Rothman, Yolanda Benavente, Patricia Hartge, Karin E. Smedby
Summary: This study suggests that polygenic risk scores (PRS) constructed from currently known subtype-specific loci may not capture biological pathways shared with autoimmune conditions. Targeted genetic screening (PRS) among populations with autoimmune conditions may help identify individuals at highest risk for DLBCL and enable early detection.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Sanjal H. Desai, Levi D. Pederson, Betsy Laplant, Raphael Mwangi, Matthew J. Maurer, Jason R. Young, William R. Macon, Rebecca L. King, Yucai Wang, James R. Cerhan, Andrew L. Feldman, David J. Inwards, Ivana N. Micallef, Patrick B. Johnston, Luis F. Porrata, Stephen M. Ansell, Thomas M. Habermann, Thomas E. Witzig, Grzegorz S. Nowakowski
Summary: This study found that PET2 after two cycles of chemotherapy can predict the risk of disease progression and death in patients with diffuse large B cell lymphoma. PET2-guided risk-adapted strategies may improve outcomes for these patients.
BLOOD CANCER JOURNAL
(2022)
Article
Oncology
Surbhi Sidana, Cristine Allmer, Melissa C. Larson, Amylou Dueck, Kathleen Yost, Rahma Warsame, Gita Thanarajasingam, James R. Cerhan, Jonas Paludo, S. Vincent Rajkumar, Thomas M. Habermann, Grzegorz S. Nowakowski, Yi Lin, Morie A. Gertz, Thomas Witzig, Angela Dispenzieri, Wilson Gonsalves, Stephen M. Ansell, Carrie A. Thompson, Shaji K. Kumar
Summary: Patients treated on CTs reported similar QoL and quality of care compared to the non-CT group, but both groups experienced increasing financial burden over time.
JCO ONCOLOGY PRACTICE
(2022)
Review
Hematology
Grzegorz Nowakowski, Matthew J. Maurer, James R. Cerhan, Debarshi Dey, Laurie H. Sehn
Summary: Comparative effectiveness studies using real-world data can provide complementary evidence on treatment effectiveness. By balancing baseline covariates using propensity score methods, closely matched patient-level cohorts can be generated for robust comparative analyses.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Hematology
Juan Pablo Alderuccio, Isildinha M. Reis, Thomas M. Habermann, Brian K. Link, Catherine Thieblemont, Annarita Conconi, Melissa C. Larson, Luciano Cascione, Wei Zhao, James R. Cerhan, Emanuele Zucca, Izidore S. Lossos
Summary: The study developed and validated a new prognostic index, the Revised mucosa-associated lymphoid tissue International Prognostic Index (Revised MALT-IPI), which is centered on disease characteristics and provides robust risk stratification, identifying a group of patients characterized by earlier progression of EMZL.
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Article
Oncology
Terry Boyle, Geffen Kleinstern, Paige M. Bracci, James R. Cerhan, Yolanda Benavente, Delphine Casabonne, Brian C-H Chiu, Thomas M. Habermann, Elizabeth A. Holly, Mark Liebow, Aaron Norman, Ora Paltiel, Dennis Robinson, Nathaniel Rothman, Rania Abu Seir, Susan L. Slager, Paul J. Villeneuve, Sophia S. Wang, Dennis D. Weisenburger, John J. Spinelli
Summary: This study, which pooled data from nine case-control studies, found that moderate-to-vigorous intensity physical activity can reduce the risk of non-Hodgkin lymphoma.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Hematology
Sanjal H. Desai, Raphael Mwangi, Wern Lynn Ng, Rebecca L. King, Matthew J. Maurer, James R. Cerhan, Andrew L. Feldman, Umar Farooq, Eric Mou, Thomas M. Habermann, Carrie A. Thompson, Yucai Wang, Thomas E. Witzig, Grzegorz S. Nowakowski
Summary: This observational study found that patients with DLBCL who underwent CNB had poor-risk features, worse outcomes, and inadequate tissue for molecular analyses compared to those who underwent EB. The increasing tissue requirements of biomarker-driven clinical trials may result in the exclusion of high-risk DLBCL patients who need novel agents.
Letter
Oncology
Sameer A. Parikh, Sara J. Achenbach, Kari G. Rabe, Aaron D. Norman, Nicholas J. Boddicker, Janet E. Olson, Timothy G. Call, James R. Cerhan, Celine M. Vachon, Neil E. Kay, Esteban Braggio, Curtis A. Hanson, Susan L. Slager, Tait D. Shanafelt
BLOOD CANCER JOURNAL
(2022)
Article
Oncology
Cristina Correia, Matthew J. J. Maurer, Samantha J. J. McDonough, Paula A. A. Schneider, Paige E. E. Ross, Anne J. J. Novak, Andrew L. L. Feldman, James R. R. Cerhan, Susan L. L. Slager, Thomas E. E. Witzig, Bruce W. W. Eckloff, Hu Li, Grzegorz S. S. Nowakowski, Scott H. H. Kaufmann
Summary: The identification of follicular lymphoma (FL) patients with low disease burden but high risk for early progression is unclear. In a study on newly diagnosed FLs, BCL2 mutations with high variant allele frequency (VAF) were found to be associated with increased transformation risk and shorter event-free survival. However, other sequenced genes did not contribute significantly to the prognostic value of the panel. Nonsynonymous BCL2 mutations with VAF = 20% were consistently associated with decreased event-free survival and overall survival.
BLOOD CANCER JOURNAL
(2023)
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: Many studies have found associations between neighborhood deprivation and disease, emphasizing the importance of social determinants of health. However, when studying diseases with long latency periods such as cancers, considering the timing of exposures for deprivation becomes more important.
ENVIRONMENTAL RESEARCH
(2023)