No Association between Common Chemokine and Chemokine Receptor Gene Variants and Prostate Cancer Risk

There is growing evidence that inflammation and infection play important roles in the etiology of prostate cancer. As the chemokine network is directly involved in inflammation and infectious diseases, we tested for an association between six common putative functional variants and prostate cancer risk using an Australian case-control study. We measured CCL5 -4036 > A, CXCL12 +8016 > A, CCR2 V641 (G > A), CCR5 Delta 32, CX3CRIV2491 (G > A), and CX3CR1T280M (C > T) for 815 cases and 738 controls. Of these, only CXCL12 +801G > A has previously been tested and found to be associated with prostate cancer risk. We found no significant associations with prostate cancer risk (all P > 0.4). All per allele odds ratios ranged from 0.96 (95% confidence intervals, 0.80-7.16) to 1.06 (95% confidence intervals, 0.90-1.23). This suggests that these common chemokine and chemokine receptor variants do not play a major, if any, role in susceptibility to prostate cancer. (Cancer Epidemiol Biomarkers Prev 2008;1.7(12):3615-17)