Article
Endocrinology & Metabolism
Wen-Yu Chen, Yan-Peng Fu, Wen Zhong, Min Zhou
Summary: Our study found that E-DII was positively associated with androgens and estrogens in postmenopausal women, with some indicators showing non-linear associations, particularly among women who experienced natural menopause. Further research is needed to explore the underlying mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Layla Damen, Melitza S. M. Elizabeth, Stephany H. Donze, Sjoerd A. A. van den Berg, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega
Summary: In children with Prader-Willi syndrome receiving GH treatment, high immunoreactive IGF-I levels are often observed, while free IGF-I levels are low, indicating a significant discrepancy between the two.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Sandra Diaz del Moral, Maha Benaouicha, Ramon Munoz-Chapuli, Rita Carmona
Summary: The translation introduces the importance of insulin and insulin-like growth factors during embryonic development and their role in cardiac development and cardiomyocyte proliferation. The study also discusses the clinical potential of utilizing the IGF signaling pathway for adult cardiac repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Jon Jarlov Rasmussen, Jakob Albrethsen, Mikkel Nicklas Frandsen, Niels Jorgensen, Anders Juul, Caroline Kistorp
Summary: The study found that serum INSL3 concentrations were lower in AAS users compared to non-users, even years after cessation. This suggests a persistent impairment of Leydig cell function due to AAS, independent of testosterone levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
Liping Zhao, Boping Zhang, Shubing Huang, Zhilan Zhou, Xuebing Jia, Chenmeng Qiao, Fang Wang, Mengfei Sun, Yun Shi, Li Yao, Chun Cui, Yanqin Shen
Summary: The study revealed that IGF-1 enhances motoneuron survival and inhibits neuroinflammation in zebrafish spinal transection model, suggesting its potential involvement in motor function recovery.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Environmental Sciences
Chiara Talia, Lisa Connolly, Paul A. Fowler
Summary: This review discusses the effects of endocrine disruptors on the IGF system, focusing on different categories of EDs and their potential molecular mechanisms. While there is a lack of studies linking ED exposure to changes in IGF levels for some ED classes, this remains an area of concern that requires further research to improve reproducibility and determine the degree of risk EDs pose to the IGF system.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Medical Laboratory Technology
Jason K. Y. Lee, Kendall Cradic, Ravinder J. Singh, JoAnna Jones, Jieli Li
Summary: This study compared the measurement of IGF-1 on four different platforms and found significant variations between them. These variations should be considered when managing patients with pituitary disorders.
CLINICA CHIMICA ACTA
(2023)
Review
Biochemistry & Molecular Biology
Shiva Nasr, Athar Nakisa, Setareh Jandaghian, Monireh Kouhi, Erfan Sadeghi, Jaleh Varshosaz
Summary: This systematic review found that flavonoid supplements do not have a significant effect on IGF-1 and IGFBP-3. However, a high soy diet has beneficial effects on components of the IGF system, which may be useful in breast cancer.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Bhavesh Premdjee, Asser S. Andersen, Mark Larance, Kilian W. Conde-Frieboes, Richard J. Payne
Summary: The text discusses the successful assembly of a 31.5 kDa phosphorylated IGFBP-2 protein using two ligation manifolds, incorporating phosphoserine post-translational modification and nine disulfide bonds.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Endocrinology & Metabolism
Andrea M. Hanson, Jeffrey D. Kittilson, Mark A. Sheridan
Summary: This study investigates the direct effects of selected environmental estrogens on the sensitivity of rainbow trout to insulin-like growth factor. The results show that these estrogens reduce the sensitivity of target tissues to insulin-like growth factor by reducing the expression and functional activity of insulin-like growth factor receptors. Furthermore, the estrogens also inhibit the activation of certain cell signaling pathways and enhance the expression of suppressor of cytokine signaling 2. These findings suggest that environmental estrogens can affect the growth of rainbow trout by directly affecting the insulin-like growth factor system.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2023)
Article
Cell Biology
Charmaine J. Green, Miriam Span, Monique H. Rayhanna, Marisa Perera, Margot L. Day
Summary: The viability of embryos cultured in vitro is poor compared to those that develop in vivo. This study investigated the role of autocrine and exogenous IGFBP3 in mouse preimplantation embryos. Addition of exogenous IGFBP3 to embryo culture media increased the rate of development, and the effect was mediated by IGF1 and EGF receptors. Acute exposure to IGFBP3 activated the PI3-kinase/Akt pathway to promote cell proliferation and survival. Therefore, addition of IGFBP3 to IVF culture media should be considered.
Article
Biochemistry & Molecular Biology
Carlos Fernandez-Pereira, Maria Aranzazu Penedo, Tania Rivera-Baltanas, Rafael Fernandez-Martinez, Saida Ortolano, Jose Manuel Olivares, Roberto Carlos Agis-Balboa
Summary: This study aimed to evaluate whether the alterations in insulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) in schizophrenia patients are related to the psychiatric disorder itself or are a result of antipsychotic treatment. The results showed that drug-naive first episode patients had lower levels of IGF-2 compared to controls, but no significant change in IGFBP-7 levels. However, both IGF-2 and IGFBP-7 significantly increased after atypical antipsychotic treatment in these patients. Chronic patients, on the other hand, had higher levels of both proteins compared to controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)