Journal
CANCER EPIDEMIOLOGY
Volume 37, Issue 5, Pages 625-628Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.canep.2013.06.004
Keywords
UGT2B17; Lung cancer; Copy number variation; Polymorphisms in carcinogen metabolism; Cancer risk; Cancer susceptibility genes
Funding
- Initiative Krebsforschung of the Medical University of Vienna
- Austrian Federal Ministry of Science and Research through the Gen-AU-Child project [GZ 200.136/1 - VI/1/2005]
- TRHT fellowship of the European Hematology Association
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Background: The enzyme uridine diphospho glucuronosyltansferase 2B17 (UGT2B17) glucuronidates several endogenous and exogenous compounds, including carcinogens from tobacco smoke like 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanl (NNAL). UGT2B17 shows a remarkable copy number variation (CNV) and an association between deletion genotype and increased risk of lung adenocarcinoma in women has been previously reported. Methods: We investigated the UGT2B17 CNV by PCR in 453 Austrian lung cancer patients and in 449 healthy donors and analyzed the impact on lung cancer susceptibility and outcome. Results: Copy numbers of UGT2B17 were 44.4% (+/+), 42.2% (+/-) and 13.5% (-/-) in lung cancer patients and 43.0% (+/+), 46.3% (+/-) and 10.7% (-/-) among healthy donors. The null genotype was not significantly more frequent among women with adenocarcinoma compared to healthy women (p = 0.59). There was no association with overall survival (p = 0.622) and no significant sex-associated (p = 0.423) or histology-related impact on development of lung cancer. Conclusion: UGT2B17 deletion genotype was not associated with a significant risk for lung cancer development or outcome in our Central European patient cohort. Our study indicates that UGT2B17 is not a crucial factor in lung carcinogenesis among Caucasians and shows the importance of investigating such markers in large cohorts from different populations. (C) 2013 Elsevier Ltd. All rights reserved.
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