Clinical pharmacokinetics of Icotinib, an anti-cancer drug: evaluation of dose proportionality, food effect, and tolerability in healthy subjects

Meeting Report: Metabolites in Safety Testing (MIST) Symposium—Safety Assessment of Human Metabolites: What’s REALLY Necessary to Ascertain Exposure Coverage in Safety Tests?

(2013) Hongying Gao et al.   AAPS Journal

Icotinib, a potent and specific EGFR tyrosine kinase inhibitor, inhibits growth of squamous cell carcinoma cell line A431 through negatively regulating AKT signaling

(2013) Zhenzhen Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

Integrating Clinical Pharmacology Concepts in Individualized Therapy With Tyrosine Kinase Inhibitors

(2013) C D Drenberg et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Icotinib: kick-starting the Chinese anticancer drug industry

(2013) D Ross Camidge   LANCET ONCOLOGY

Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial

(2013) Yuankai Shi et al.   LANCET ONCOLOGY

Effect of the CYP2C19 genotype on the pharmacokinetics of icotinib in healthy male volunteers

(2012) Can-Jun Ruan et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Bioequivalence of Oral Products and the Biopharmaceutics Classification System: Science, Regulation, and Public Policy

(2011) K S Amidon et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Icotinib (BPI-2009H), a novel EGFR tyrosine kinase inhibitor, displays potent efficacy in preclinical studies

(2011) Fenlai Tan et al.   LUNG CANCER

Metabolite characterization of a novel anti-cancer agent, icotinib, in humans through liquid chromatography/quadrupole time-of-flight tandem mass spectrometry

(2011) Dongyang Liu et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Phase I study of icotinib hydrochloride (BPI-2009H), an oral EGFR tyrosine kinase inhibitor, in patients with advanced NSCLC and other solid tumors

(2010) Qiong Zhao et al.   LUNG CANCER

Quantitative determination of icotinib in human plasma and urine using liquid chromatography coupled to tandem mass spectrometry

(2009) Dongyang Liu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Current Methods for Predicting Human Food Effect

(2008) Kimberley A. Lentz   AAPS Journal

Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption

(2007) Joseph M. Custodio et al.   ADVANCED DRUG DELIVERY REVIEWS