Molecular basis for primary and secondary tyrosine kinase inhibitor resistance in gastrointestinal stromal tumor

Phase II study of oral masitinib mesilate in imatinib-naïve patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST)

(2010) Axel Le Cesne et al.   EUROPEAN JOURNAL OF CANCER

Pharmacological management of gastrointestinal stromal tumours: an update on the role of sunitinib

(2009) J.-Y. Blay   ANNALS OF ONCOLOGY

Targeting HSP90 for cancer therapy

(2009) D Mahalingam et al.   BRITISH JOURNAL OF CANCER

Proapoptotic Activity of Bortezomib in Gastrointestinal Stromal Tumor Cells

(2009) S. Bauer et al.   CANCER RESEARCH

Inhibitors of Deacetylases Suppress Oncogenic KIT Signaling, Acetylate HSP90, and Induce Apoptosis in Gastrointestinal Stromal Tumors

(2009) T. Muhlenberg et al.   CANCER RESEARCH

Resistance to Tyrosine Kinase Inhibitors in Gastrointestinal Stromal Tumors

(2009) A. W. Gramza et al.   CLINICAL CANCER RESEARCH

Phase I Dose-Escalation and Pharmacokinetic Study of Dasatinib in Patients with Advanced Solid Tumors

(2009) G. D. Demetri et al.   CLINICAL CANCER RESEARCH

High Efficacy of Panobinostat Towards Human Gastrointestinal Stromal Tumors in a Xenograft Mouse Model

(2009) G. Floris et al.   CLINICAL CANCER RESEARCH

Phase 1 dose-escalation study of oral tyrosine kinase inhibitor masitinib in advanced and/or metastatic solid cancers

(2009) J.C. Soria et al.   EUROPEAN JOURNAL OF CANCER

Insulin-like growth factor 1 receptor expression in wild-type GISTs: A potential novel therapeutic target

(2009) Maria A. Pantaleo et al.   INTERNATIONAL JOURNAL OF CANCER

Imatinib Plasma Levels Are Correlated With Clinical Benefit in Patients With Unresectable/Metastatic Gastrointestinal Stromal Tumors

(2009) George D. Demetri et al.   JOURNAL OF CLINICAL ONCOLOGY

Histone Deacetylase Inhibitors in Cancer Therapy

(2009) Andrew A. Lane et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II Study of Sorafenib in Patients With Metastatic or Recurrent Sarcomas

(2009) Robert G. Maki et al.   JOURNAL OF CLINICAL ONCOLOGY

Expression of insulin-like growth factor 2 in mesenchymal neoplasms

(2009) Sonja E Steigen et al.   MODERN PATHOLOGY

Activate and resist: L576P-KIT in GIST

(2009) E. Conca et al.   MOLECULAR CANCER THERAPEUTICS

Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT

(2009) Patrice Dubreuil et al.   PLoS One

Insulin-like growth factor (IGF) 1 and 2 help to predict disease outcome in GIST patients

(2008) C. Braconi et al.   ANNALS OF ONCOLOGY

Heat Shock Protein 90 Overexpression Independently Predicts Inferior Disease-Free Survival with Differential Expression of the   and   Isoforms in Gastrointestinal Stromal Tumors

(2008) C.-F. Li et al.   CLINICAL CANCER RESEARCH

Distribution and prognostic value of histopathologic data and immunohistochemical markers in gastrointestinal stromal tumours (GISTs): An analysis of the EORTC phase III trial of treatment of metastatic GISTs with imatinib mesylate

(2008) Raf Sciot et al.   EUROPEAN JOURNAL OF CANCER

Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors

(2008) Narasimhan P. Agaram et al.   GENES CHROMOSOMES & CANCER

Maternal Transmission of Symptomatic Disease withSDHDMutation: Fact or Fiction?

(2008) Hartmut P.H. Neumann et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Long-Term Results From a Randomized Phase II Trial of Standard- Versus Higher-Dose Imatinib Mesylate for Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors Expressing KIT

(2008) Charles D. Blanke et al.   JOURNAL OF CLINICAL ONCOLOGY

Primary and Secondary Kinase Genotypes Correlate With the Biological and Clinical Activity of Sunitinib in Imatinib-Resistant Gastrointestinal Stromal Tumor

(2008) Michael C. Heinrich et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase III Randomized, Intergroup Trial Assessing Imatinib Mesylate At Two Dose Levels in Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors Expressing the Kit Receptor Tyrosine Kinase: S0033

(2008) Charles D. Blanke et al.   JOURNAL OF CLINICAL ONCOLOGY

Heterogeneity of kinase inhibitor resistance mechanisms in GIST

(2008) B Liegl et al.   JOURNAL OF PATHOLOGY