Article
Oncology
Lina Marie Hoffmeister, Julia Suttorp, Christiane Walter, Evangelia Antoniou, Yvonne Lisa Behrens, Gudrun Goehring, Amani Awada, Nils von Neuhoff, Dirk Reinhardt, Markus Schneider
Summary: RNA-FS reliably detects risk-relevant fusion genes in pediatric AML, improves the detection of cryptic fusion genes, and allows for the design of new MRD assays.
Review
Biochemistry & Molecular Biology
Fabiana Cacace, Rossella Iula, Danilo De Novellis, Valeria Caprioli, Maria Rosaria D'Amico, Giuseppina De Simone, Rosanna Cuccurullo, William G. Wierda, Kris Michael Mahadeo, Giuseppe Menna, Francesco Paolo Tambaro
Summary: Pediatric acute myeloid leukemia is a clonal disorder characterized by malignant transformation of the hematopoietic stem cell. Treatment includes chemotherapy and stem cell transplantation. Although prognosis has improved, it remains inferior to pediatric acute lymphoblastic leukemia.
Review
Medicine, General & Internal
Dirk Reinhardt, Evangelia Antoniou, Katharina Waack
Summary: This review discusses the key developments in pediatric acute myeloid leukemia (AML) in terms of diagnosis, treatment, risk groups, and outcomes. It also provides a brief overview of current and future approaches.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Meriem Ben Khoud, Tiziano Ingegnere, Bruno Quesnel, Suman Mitra, Carine Brinster
Summary: Acute myeloid leukemia (AML) is a cancer characterized by impaired differentiation and excessive expansion of blood progenitor cells leading to their accumulation in the bone marrow and circulation. The disease alters the bone marrow microenvironment, inhibits proper hematopoiesis, and causes sustained cytopenia and immunodeficiency. AML influences the immune system, particularly T lymphocytes, and therapeutic strategies aim to improve the anti-leukemic immune response and patient outcomes.
Article
Genetics & Heredity
Olga Krali, Josefine Palle, Christofer L. Backlin, Jonas Abrahamsson, Ulrika Noren-Nystrom, Henrik Hasle, Kirsi Jahnukainen, Olafur Gisli Jonsson, Randi Hovland, Birgitte Lausen, Rolf Larsson, Lars Palmqvist, Anna Staffas, Bernward Zeller, Jessica Nordlund
Summary: This study explored the use of DNA methylation signatures to predict molecular subtypes and prognosis in pediatric acute myeloid leukemia (AML). Genome-wide DNA methylation analysis was conducted on diagnostic and relapse AML samples, leading to the development of DNA methylation-based classifiers with an overall test accuracy of 91%. Methylation signatures associated with specific cytogenetic subtypes were identified, highlighting the potential clinical value of DNA methylation analysis in AML.
Review
Biochemistry & Molecular Biology
Piotr Obszanski, Anna Kozlowska, Jakub Wancowiat, Julia Twardowska, Monika Lejman, Joanna Zawitkowska
Summary: Acute myeloid leukemia (AML) comprises 15-20% of childhood leukemia cases, with a survival rate of not exceeding 82% and 5-year event-free survival rates ranging from 46% to 69%. The disease is influenced by multiple mutations and epigenetic changes, affecting treatment susceptibility and relapse rate. Molecular-targeted therapies have been developed and studied in clinical trials to address these challenges, originally introduced in adult AML and now gradually changing the therapeutic approach to pediatric AML. Research involving larger pediatric populations is needed to further improve outcomes.
Editorial Material
Cell & Tissue Engineering
Malini Gupta, Britta Will
Summary: Adaptive aberrant gene regulation is a hallmark of malignant growth and therapy resistance in acute myeloid leukemia (AML). In this study, Eagle et al. identified oncogenic enhancer-driven overexpression of selenophosphate synthetase 2 (SEPHS2) as a targeted opportunity for mitigating malignant cell growth in AML.
Review
Pharmacology & Pharmacy
Natasa Tosic, Irena Marjanovic, Jelena Lazic
Summary: Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy that accounts for 20% of pediatric leukemia cases. While overall survival rates have improved, AML remains a leading cause of mortality in pediatric cancers. Targeted therapy approaches and advances in genomic techniques have identified novel therapeutic targets and provided potential for significant clinical benefits in pediatric AML.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Hematology
Genki Yamato, Tomoko Kawai, Norio Shiba, Junji Ikeda, Yusuke Hara, Kentaro Ohki, Shin-Ichi Tsujimoto, Taeko Kaburagi, Kenichi Yoshida, Yuichi Shiraishi, Satoru Miyano, Nobutaka Kiyokawa, Daisuke Tomizawa, Akira Shimada, Manabu Sotomatsu, Hirokazu Arakawa, Souichi Adachi, Takashi Taga, Keizo Horibe, Seishi Ogawa, Kenichiro Hata, Yasuhide Hayashi
Summary: The study found that DNA methylation patterns were associated with genetic alterations in pediatric patients with acute myeloid leukemia (AML). Specific CpG sites were useful in categorizing patients into different clusters based on methylation levels, which were related to gene expression patterns and prognosis.
Article
Multidisciplinary Sciences
Ting Liu, Jianan Rao, Wenting Hu, Bowen Cui, Jiaoyang Cai, Yuhan Liu, Huiying Sun, Xiaoxiao Chen, Yanjing Tang, Jing Chen, Xiang Wang, Han Wang, Wubin Qian, Binchen Mao, Sheng Guo, Ronghua Wang, Yu Liu, Shuhong Shen
Summary: This study identifies potential driver alterations in Chinese pediatric AML, which differ from Western populations, and proposes a prognostic risk classification model.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Sonali P. Barwe, Fei Huang, Edward Anders Kolb, Anilkumar Gopalakrishnapillai
Summary: Imetelstat has been shown to specifically kill leukemia stem cells (LSCs) in pediatric AML cells and mouse models, and it can extend animal survival when used as a single agent or in combination with chemotherapy or azacitidine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Jolien Vanhooren, Laurens Van Camp, Barbara Depreter, Martijn de Jong, Anne Uyttebroeck, An Van Damme, Laurence Dedeken, Marie-Francoise Dresse, Jutte van der Werff ten Bosch, Mattias Hofmans, Jan Philippe, Barbara De Moerloose, Tim Lammens
Summary: Survival rates for children with acute myeloid leukemia have significantly improved, but a considerable proportion of patients still face the risk of treatment failure or relapse. This study investigates the expression of non-coding RNA in pediatric AML, providing a foundation for further translational research.
Article
Biochemistry & Molecular Biology
Maddalena Benetton, Pietro Merli, Christiane Walter, Maria Hansen, Ambra Da Ros, Katia Polato, Claudia Tregnago, Jonas Abrahamsson, Luisa Strocchio, Edwin Sonneveld, Linda Fogelstrand, Nils Von Neuhoff, Dirk Reinhardt, Henrik Hasle, Martina Pigazzi, Franco Locatelli
Summary: This study investigates qPCR-MRD as a predictor of relapse in pretransplant bone marrow samples of AML patients. The study identifies a cutoff value and finds that patients with lower qPCR-MRD values have increased overall survival and relapse-free survival, independent of genetic markers, conditioning regimen, donor, and stem cell source. These findings suggest the clinical relevance of the PCR-based approach in AML transplant management.
Review
Oncology
Daisuke Tomizawa, Shin-Ichi Tsujimoto
Summary: Acute Myeloid Leukemia (AML) is the second most common type of leukemia in children. Recent advances in high-resolution genomic profiling techniques have uncovered the mutational landscape of pediatric AML as distinct from adult AML. Overall survival rates of children with AML have dramatically improved in the past 40 years, currently reaching 70% to 80% in developed countries. This was accomplished by the intensification of conventional chemotherapy, improvement in risk stratification using leukemia-specific cytogenetics/molecular genetics and measurable residual disease, appropriate use of allogeneic hematopoietic stem cell transplantation, and improvement in supportive care. However, the principle therapeutic approach for pediatric AML has not changed substantially for decades and improvement in event-free survival is rather modest. Further refinements in risk stratification and the introduction of emerging novel therapies to contemporary therapy, through international collaboration, would be key solutions for further improvements in outcomes.
Article
Cell Biology
Xiancong Yang, Yaoyao Wang, Simin Rong, Jiayue An, Xiaoxu Lan, Baohui Yin, Yunxiao Sun, Pingyu Wang, Boyu Tan, Ye Xuan, Shuyang Xie, Zhenguo Su, Youjie Li
Summary: This study investigates the role of SH3BGRL3 gene and its product circRNA_0010984 in acute myeloid leukemia. The results demonstrate that circSH3BGRL3 promotes leukemia cell proliferation and cell cycle arrest by regulating miR-375 through molecular sponge action, and activates the Hippo signaling pathway involved in malignant tumor proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Physics, Particles & Fields
Arash Arabi Ardehali, Jiaqi Jiang, Wenli Zhao
Summary: We discuss N = (2, 2) AdS(3)/CFT2 dualities proposed in the large central charge limit and propose the associated D1-D5 systems to be orbifolds of the standard N = (4, 4) systems. This elevates the dualities to the finite-c level on the boundary and quantum level in the bulk. We demonstrate that our brane systems produce low-energy sigma models with subleading central charges that match earlier predictions from bulk one-loop supergravity computations.
JOURNAL OF HIGH ENERGY PHYSICS
(2022)
Article
Multidisciplinary Sciences
Zhan Su, Yao Liu, Wenli Zhao, Yuanyan Bai, Nan Jiang, Songsong Zhu
Summary: This study examined the effects of a systematic digital training system on the learning efficiency of first-year orthognathic surgery residents. The results showed that the experimental group, which used the digital training system, had higher scores in theoretical tests, practical operations, and teacher evaluations compared to the control group. Additionally, the experimental group reported higher levels of study interest, self-confidence, satisfaction, and academic performance.
Article
Multidisciplinary Sciences
Minmin Lu, Wenli Zhao, Shuo Han, Xiaowen Lin, Tingyu Xu, Qiuxiang Tan, Mu Wang, Cuiying Yi, Xiaojing Chu, Weibo Yang, Ya Zhu, Beili Wu, Qiang Zhao
Summary: CX3CR1, as the receptor of CX3CL1, has potential therapeutic significance in diseases, but drug development is hindered by lack of structural information. Studies reveal that CX3CR1 shows minimal conformational changes upon activation, possibly linked with the role of cholesterol molecules.
Article
Fisheries
Xiangsheng Zhang, Chaokai Huang, Yuhang Yang, Xiangkai Li, Chen Guo, Zheng Yang, Shichao Xie, Jiaxiang Luo, Tingting Zhu, Wenli Zhao, Min Jin, Qicun Zhou
Summary: This study aimed to investigate the effects of dietary corn starch levels on glucose metabolic responses in Portunus trituberculatus. The results showed that the glucose concentration in hemolymph was affected by corn starch levels and sampling time. Enzyme activities and gene expressions related to glucose metabolism were also influenced.
AQUACULTURE NUTRITION
(2022)
Article
Oncology
Guoyang He, Wei Li, Wenli Zhao, Hui Men, Qingqing Chen, Jinlong Hu, Jingyu Zhang, Huifang Zhu, Wenxin Wang, Meijing Deng, Zishan Xu, Gaoxiang Wang, Lin Zhou, Xinlai Qian, Li Liang
Summary: Increasing evidence suggests that FMNL2 promotes angiogenesis and metastasis in colorectal cancer (CRC) by interacting with EGFL6 and activating the ERK/MMP pathway. Thus, targeting the EGFL6/CKAP4/ERK axis could be a potential therapeutic strategy for CRC treatment.
Article
Engineering, Multidisciplinary
Wenli Zhao, Kechen Song, Yanyan Wang, Shubo Liang, Yunhui Yan
Summary: This paper proposes a feature-aware network (FaNet) for few shot defect classification, which can effectively distinguish new classes with a small number of labeled samples. In FaNet, ResNet12 is used as the baseline, and the feature-attention convolution module (FAC) is applied to extract comprehensive feature information from the base classes. An online feature-enhance integration module (FEI) is adopted during the test phase to average the noise from defect images, further enhancing image features among different tasks. In addition, a large-scale strip steel surface defects few shot classification dataset (FSC-20) with 20 different types is constructed. Experimental results show that the proposed method achieves the best performance compared to state-of-the-art methods for 5-way 1-shot and 5-way 5-shot tasks. The dataset and code are available at: https://github.com/VDT-2048/FSC-20.
Article
Medicine, General & Internal
Lianghui Zhu, Huijuan Shi, Huiting Wei, Chengjiang Wang, Shanshan Shi, Fenfen Zhang, Renao Yan, Yiqing Liu, Tingting He, Liyuan Wang, Junru Cheng, Hufei Duan, Hong Du, Fengjiao Meng, Wenli Zhao, Xia Gu, Linlang Guo, Yingpeng Ni, Yonghong He, Tian Guan, Anjia Han
Summary: Using histology slides and a regional multiple-instance learning algorithm, the origin of bone metastatic cancer (OBMC) can be accurately predicted. The model demonstrated high accuracy and consistency in both internal and external validation. Assisting pathologists in determining the OBMC, the model holds significant importance in clinical therapeutics.
Article
Chemistry, Applied
Xiaopo Niu, Jiuyi Sun, Wenli Zhao, Xinyue Yang, Xiangwen Zhang, Qingfa Wang
Summary: Selective deep hydrosaturation of polyaromatics can enhance the utilization of heavy resources and reduce harmful particulate emissions. Pt catalysts supported on various oxide supports were prepared using strong electrostatic adsorption tactics. Pt/TiO2 and Pt/CeO2 exhibited strong metal-support interactions, leading to the dispersion of electron-deficient Pt delta+ species and enhanced hydrogen spillover capacity. The Pt delta+ species displayed improved H-2 dissociation ability and boosted adsorption energy for aromatics, resulting in better activity and selectivity in the hydrogenation of phenanthrene. DFT calculations further confirmed the enhanced adsorption of aromatics on Pt delta+ species.
FUEL PROCESSING TECHNOLOGY
(2023)
Article
Engineering, Chemical
Zheng Hao, Libin Yang, Songtao Xiao, Xiechun Liu, Wenli Zhao
Summary: The flow condition and mass transfer behavior in a two-stage countercurrent extractor are studied using experimental and numerical methods. The impact of operating parameters, such as impeller speed, residence time, and organic-aqueous ratio, on the volume fraction and droplet size of the dispersed phase and volumetric mass transfer coefficient is analyzed through CFD-PBE simulation. It is found that the allocation of the dispersed phase between stages is determined by the impeller speed, while the allocation between mixers and settlers is governed by residence time and organic-aqueous ratio. Turbulence intensity, volume fraction, and droplet size distribution are identified as dominating parameters affecting the spatial nonuniform distribution of the volumetric mass transfer coefficient. Increasing impeller speed in two stages improves the mass transfer rate, but higher residence time and organic-aqueous ratio have opposite effects on the mass transfer rate in stage-1 and stage-2.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Chemistry, Physical
Fenghua Xu, Wenli Zhao, Xiaodong Hu, Baicheng Weng
Summary: Photocatalysis has attracted attention as a promising solution for energy shortage and environmental contamination. However, low light absorption and charge separation/transport efficiency limit the solar conversion efficiency. This study shows that the introduction of oxygen vacancies hinders charge separation/transfer in Ba2Bi1.4Ta0.6O6, while incorporating S extends the light absorption edge and improves charge separation/transport. As a result, S/Ov-Ba2Bi1.4Ta0.6O6 nanowires exhibit significantly higher photocatalytic activity for tetracycline hydrochloride degradation and hydrogen production.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Xinyue Yang, Wenli Zhao, Linlin Liu, Xiaopo Niu, Qingfa Wang
Summary: Developing highly selective and efficient bifunctional catalysts for the hydroisomerization of long-chain n-alkanes is crucial. In this study, a bifunctional Pt/hierarchical SSZ-32 catalyst was prepared to enhance the selective hydroisomerization of n-hexadecane. The pore structure and acid sites of SSZ-32 zeolite were tailored through a sequential desilication-dealumination treatment. The resulting catalyst exhibited high activity and selectivity towards monobranched isomers formation.
Article
Fisheries
Yangguang Bao, Yuedong Shen, Zhaoxun Wu, Shunshun Tao, Bingqian Yang, Tingting Zhu, Wenli Zhao, Yingying Zhang, Xiaoyi Zhao, Lefei Jiao, Ziyi Wang, Qicun Zhou, Min Jin
Summary: In this study, an eight-week feeding trial was conducted to evaluate the regulatory effects of dietary Arachidonic acid (ARA) and its metabolites on inflammation, oxidative stress, and apoptosis in Acanthopagrus schlegelii. Results showed that high levels of dietary ARA induced inflammation by activating the gene expression levels of nuclear factor kappa B (nf-kappa b) and oxidative stress by reducing antioxidant parameters. Additionally, excess ARA levels promoted cell apoptosis by up-regulating pro-apoptotic gene expression levels.
AQUACULTURE REPORTS
(2023)
Article
Chemistry, Physical
Wenli Zhao, Zhen Cao, Zahra Bayhan, Hanfeng Liang, Yongjiu Lei, Long Chen, Mushtaq A. Dar, Zeyad Almutairi, Luigi Cavallo, Gang Huang, Husam N. Alshareef
Summary: This research presents a dendrite-free and highly stable Na metal anode by transferring a cation-deficient Ti0.87O2 nanosheet layer onto the Na surface. The Ti0.87O2 layer seamlessly connects to the Na surface and prevents layer fracture. It also has strong Na thorn adsorption ability, high ionic conductivity, and restricts Na plating, leading to improved performance of batteries.
MATERIALS TODAY ENERGY
(2023)
Article
Fisheries
Shichao Xie, Xiangkai Li, Yuhang Yang, Chen Guo, Xiangsheng Zhang, Tingting Zhu, Jiaxiang Luo, Zheng Yang, Wenli Zhao, Yuhui Cui, Lefei Jiao, Qicun Zhou, Douglas R. Tocher, Min Jin
Summary: This study evaluated the effects of dietary isoleucine level on growth, myofiber histology, and gene expression in swimming crab. The results showed that increasing dietary isoleucine level from 0.69% to 1.78% significantly increased final weight, percent weight gain, and specific growth rate. However, further increase in dietary isoleucine level decreased these parameters. The expression levels of genes related to amino acid, glucose, and lipid metabolism were also affected by dietary isoleucine level.
Article
Chemistry, Multidisciplinary
Wenli Zhao, Wenhao Wang, Fancang Meng, Yang Du, Qingmin Ji, Heng-Dao Quan
Summary: Mesoporous silica hollow spheres with homogenous and high content distribution of Fe and Co were synthesized by a facile one-pot hydrothermal process. The sub-nanometer bimetallic components inside the silica framework facilitate stable fixation and open accessibility to active sites. The Co-doped Fe/Co spheres showed excellent peroxidase-like activity and higher catalytic performance compared to their monometallic-supported spheres.
CHINESE CHEMICAL LETTERS
(2023)
