Article
Biochemistry & Molecular Biology
Konstantina Amoiradaki, Kate R. Bunting, Katherine M. Paine, Josephine E. Ayre, Karen Hogg, Kamilla M. E. Laidlaw, Chris MacDonald
Summary: The study shows that multiple subunits of the Rpd3 lysine deacetylase complex play a crucial role in the recycling of surface proteins, with potential downstream target genes identified through validation and bioinformatics analysis. This suggests that recycling is controlled by Rpd3 at the transcriptional level through multiple downstream target genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Robert Jenke, Nina Ressing, Finn K. Hansen, Achim Aigner, Thomas Buch
Summary: Epigenetic changes can drive cancer malignancy, while histone deacetylase inhibitors (HDACis) hold promise as anticancer drugs due to their ability to target multiple pathways relevant to the disease.
Article
Agronomy
Ting-hui Chen, Wei Wei, Wei Shan, Jian-fei Kuang, Jian-ye Chen, Wang-jin Lu, Ying-ying Yang
Summary: Fruit ripening and softening is a complex process regulated by a wide range of genes, and histone modification plays a critical role in precise gene expression. This study identified a NAC transcription factor MaNAC154 as a negative regulator of banana fruit ripening and found its interaction with a histone deacetylase MaHDA6 to enhance transcriptional repression capacity, revealing a coordinated mechanism involving histone deacetylation and transcription factor-mediated gene repression for banana fruit ripening.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Kristin C. Hicks, Paul L. Chariou, Yohei Ozawa, Christine M. Minnar, Karin M. Knudson, Thomas J. Meyer, Jing Bian, Margaret Cam, Jeffrey Schlom, Sofia R. Gameiro
Summary: Combining the histone deacetylase inhibitor, Entinostat, with the recombinant murine immune-cytokine NHS-rmIL12 can reprogram the tumor microenvironment and lead to tumor eradication. This combination therapy promotes the action of functional CD8(+) T cells and activated neutrophils, driving macrophage polarization and benefiting overall survival in multiple human tumor types.
NATURE COMMUNICATIONS
(2021)
Letter
Plant Sciences
Xiaojing Liu, Weijia Cheng, Peng Yao, Kexin Ren, Yu Wang, Yingnan Sun, Xin Hou, Li Lu, Xiangsong Chen
Summary: Conserved serine phosphorylation regulates histone deacetylase activity in Arabidopsis and humans.
Article
Multidisciplinary Sciences
Frederik Oger, Maeva Moreno, Mehdi Derhourhi, Bryan Thiroux, Lionel Berberian, Cyril Bourouh, Emmanuelle Durand, Souhila Amanzougarene, Alaa Badreddine, Etienne Blanc, Olivier Molendi-Coste, Laurent Pineau, Gianni Pasquetti, Laure Rolland, Charlene Carney, Florine Bornaque, Emilie Courty, Celine Gheeraert, Jerome Eeckhoute, David Dombrowicz, Julie Kerr-Conte, Francois Pattou, Bart Staels, Philippe Froguel, Amelie Bonneford, Jean-Sebastien Annicotte
Summary: Histone deacetylase enzymes (HDACs) regulate gene expression by deacetylating specific histone and non-histone proteins. In this study, the researchers investigated the role of HDACs in maintaining the identity and function of insulin-producing beta cells in the pancreas. They found that HDAC inhibition altered the transcriptional program of beta cells and could lead to loss of their identity.
Article
Immunology
Jie Wang, Ke-yong Tian, Ying Fang, Hui-min Chang, Ya-nan Han, Fu-quan Chen
Summary: The study demonstrated that SFN can protect rats from cisplatin-induced hearing loss by reducing outer hair cell loss and restoring auditory brainstem response threshold shifts. In vitro experiments also showed that SFN can reverse cisplatin-induced ciliary morphology changes and alterations in HDAC protein expression.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daniel J. Garcia-Dominguez, Nabil Hajji, Sara Sanchez-Molina, Elisabet Figuerola-Bou, Rocio M. de Pablos, Ana M. Espinosa-Oliva, Eduardo Andres-Leon, Laura Carmen Terron-Camero, Rocio Flores-Campos, Guillem Pascual-Pasto, Maria Jose Robles, Angel M. Carcaboso, Jaume Mora, Enrique de Alava, Lourdes Hontecillas-Prieto, Isidro Machado, Antonio Llombart-Bosch, Giovanna Magagnoli, Katia Scotlandi
Summary: The study reveals that HDAC6 plays a regulatory role in EWS, and selective inhibition of HDAC6 can reduce the oncogenic functions of EWSR1-FLI1. High expression of HDAC6 is associated with poor prognosis in EWS patients, and a combination treatment of HDAC6 and doxorubicin significantly inhibits tumor growth in EWS models.
Article
Oncology
Weiyu Dai, Side Liu, Jieming Zhang, Miaomiao Pei, Yizhi Xiao, Jiaying Li, Linjie Hong, Jianjiao Lin, Jing Wang, Xiaosheng Wu, Guangnan Liu, Yaying Chen, Yusi Wang, Zhizhao Lin, Qiong Yang, Fachao Zhi, Guoxin Li, Weimei Tang, Aimin Li, Li Xiang, Jide Wang
Summary: miR-769-5p/miR-769-3p acts as a tumor suppressor in gastric cancer by targeting IGF1R and through the STAT3-IGF1R-HDAC3 complex. Treatment with the HDAC inhibitor SAHA triggers the expression of miR-769-5p/miR-769-3p, leading to inhibition of proliferation and induction of apoptosis in gastric cancer cells.
Article
Chemistry, Medicinal
Chen Chen, Xue Li, Huajun Zhao, Meng Liu, Jintong Du, Jian Zhang, Xinying Yang, Xuben Hou, Hao Fang
Summary: The combined use of a DNA minor groove binder and a histone deacetylase (HDAC) inhibitor has shown a synergistic antiproliferation effect. A new series of benzimidazole-hydroxamate hybrids were designed and synthesized to target both DNA minor groove and HDAC. The most active compounds 9k and 9l not only exhibited improved HDAC inhibitory activities but also showed potent antiproliferation activities against tumor cells. Importantly, these compounds demonstrated good in vivo antitumor efficacies and reshaped the tumor immune microenvironment by promoting antigen presentation, activating T cells, and polarizing tumor-infiltrating macrophages with antitumor activity.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Marta Halasa, Kamila Adamczuk, Grzegorz Adamczuk, Syeda Afshan, Andrzej Stepulak, Marek Cybulski, Anna Wawruszak
Summary: N-ε-lysine acetylation/deacetylation is a common post-translational modification regulated by histone acetyltransferases and histone deacetylases, influencing the properties and functions of histones and non-histone proteins, including transcription factors that alter cell signaling pathways and impact cancer progression. HDACs play a significant role in deacetylating targets, leading to the regulation of proteins involved in cell cycle and apoptosis, ultimately affecting tumor growth, invasion, and drug resistance. This review highlights the clinical importance of epigenetic modifications as a potential therapeutic target in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Zhonghai Shen, Kang Ji, Zhenhai Cai, Chenglong Huang, Xiaojun He, Hongwei Xu, Gang Chen
Summary: The study showed that using the selective inhibitor Tubastatin A to inhibit HDAC6 has a significant effect on TBHP-treated chondrocytes and a mouse OA model, reducing oxidative stress and ECM degradation, maintaining chondrocyte survival, and activating autophagy. The results suggest that HDAC6 inhibition may prevent OA development and serve as a potential therapeutic target for OA management.
Article
Cell Biology
Liutian Chu, Chao Yang, Feng Zhuang, Yingmiao Gao, Ming Luo
Summary: HDA9 and HY5 repress the expression of PIF4 and COL5 through H3K9 and H3K27 deacetylation, thereby controlling flowering time in plants.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cell Biology
Jiangyi Zeng, Yun Huang, Lijun Zhou, Xiaoju Liang, Chao Yang, Hongxia Wang, Ling Yuan, Ying Wang, Yongqing Li
Summary: A histone deacetylase inhibitor was found to enhance the accumulation of LCA and total flavonoids in Glycyrrhiza inflata seedlings, suggesting a negative regulatory role of the targeted HDAC. Further analysis revealed an up-regulated O-methyltransferase gene that is important for LCA accumulation.
Article
Developmental Biology
Min Tang, Isabel Regadas, Sergey Belikov, Olga Shilkova, Lei Xu, Erik Wernersson, Xuewen Liu, Hongmei Wu, Magda Bienko, Mattias Mannervik
Summary: In this study, the crucial functions of HDAC3 in embryo development were investigated in Drosophila. The findings demonstrate that HDAC3 is involved in both gene activation and repression, and that lysine substitution in the N terminus disrupts its catalytic activity and activator function, while a combination of substitutions enhances its repressor activity.