4.8 Editorial Material

Sirt4: The Glutamine Gatekeeper

Journal

CANCER CELL
Volume 23, Issue 4, Pages 427-428

Publisher

CELL PRESS
DOI: 10.1016/j.ccr.2013.04.003

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Funding

  1. European Research Council [233270] Funding Source: Medline
  2. European Research Council (ERC) [233270] Funding Source: European Research Council (ERC)

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Little is known about how DNA damage and metabolism are interconnected. In this issue of Cancer Cell, Jeong and colleagues report that an important component of the DNA damage response is the SIRT4-mediated blockade of glutamine catabolism. Failure to shut down glutamine consumption results in unscheduled proliferation, genomic instability, and cancer.

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