Journal
CANCER CELL
Volume 19, Issue 1, Pages 6-8Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2011.01.003
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In this issue of Cancer Cell, Sonoshita et al. report that Aes/Grg5 prevents metastasis of colorectal cancer cells by sequestering and inactivating Notch transcriptional effectors in distinct nuclear foci. Loss of Aes/Grg5 in invasive cancer cells where Notch is activated by stroma-expressed ligands promotes invasion, transendothelial migration, intravasation, and metastasis.
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