Article
Cell Biology
Baoshi Yuan, Kexin Shi, Juanmin Zha, Yujia Cai, Yue Gu, Kai Huang, Wenchang Yue, Qiaocheng Zhai, Ning Ding, Wenyan Ren, Weiqi He, Ying Xu, Tao Wang
Summary: Osteosarcoma is the most common primary malignant bone tumor in children and adolescents, but chemoresistance limits the efficacy of conventional therapy. This study identified nuclear receptor modulators that inhibit osteosarcoma growth by regulating the PI3K/AKT/mTOR and ERK/mTOR pathways, suggesting a potential therapeutic strategy.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Francesco Rugolo, Nicolas G. Bazan, Jorgelina Calandria, Bokkyoo Jun, Giuseppe Raschella, Gerry Melino, Massimiliano Agostini
Summary: The study demonstrates that MYCN represses ELOVL4 expression and lipid metabolism, contributing to the progression of neuroblastoma, while high expression of ELOVL4 is associated with a better prognosis in subsets of patients.
Review
Health Care Sciences & Services
Nadiya Bayeva, Erin Coll, Olga Piskareva
Summary: Neuroblastoma is a common pediatric tumor with challenges in treatment, but vitamin A derivative retinoic acid shows potential efficacy, prompting research on enhancing its anti-NB action and exploring synergy with other drugs.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
Chenzhao Feng, Ting Li, Jun Xiao, Jing Wang, Xinyao Meng, Huizhong Niu, Bin Jiang, Lei Huang, Xiaogeng Deng, Xueqiang Yan, Dianming Wu, Yifan Fang, Yu Lin, Feng Chen, Xiaojuan Wu, Xiang Zhao, Jiexiong Feng
Summary: This study analyzed the tumor microenvironment (TME) of neuroblastoma (NB) patients using a self-curated gene list, identifying three prognostic TME subgroups and constructing a genetic signature and three gene subgroups. The study also found that the worst prognostic subgroup lacked immune cell infiltration and may benefit from anti-GD2 therapy. Additionally, a 48-gene signature (TMEscore) was determined, which could predict prognosis and response to immunotherapies. After incorporating clinical features, the nomogram-based score system (TMEIndex) showed better predictive accuracy for survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Hao Li, Alessia Perino, Qingyao Huang, Giacomo V. G. Von Alvensleben, Amir Banaei-Esfahani, Laura A. Velazquez-Villegas, Karim Gariani, Melanie Korbelius, Maroun Bou Sleiman, Jeromine Imbach, Yu Sun, Xiaoxu Li, Alexis Bachmann, Ludger J. E. Goeminne, Hector Gallart-Ayala, Evan G. Williams, Julijana Ivanisevic, Johan Auwerx, Kristina Schoonjans
Summary: This study comprehensively investigates the role of bile acids in metabolic traits using a mouse model, revealing regulators of bile acid homeostasis and the association between CES1C and plasma TUDCA, a bile acid species with disease-preventing actions.
Review
Biochemistry & Molecular Biology
Marie Berenguer, Gregg Duester
Summary: The role of retinoic acid (RA) and Meis1/2 in limb development is complex, with RA activating Meis1/2 in the proximal limb bud mesoderm while FGF8 represses Meis1/2 in the distal limb to generate proximodistal patterning.
Article
Multidisciplinary Sciences
Cecilie Abildgaard, Salvatore Rizza, Helle Christiansen, Steffen Schmidt, Christina Dahl, Ahmad Abdul-Al, Annette Christensen, Giuseppe Filomeni, Per Guldberg
Summary: Metabolic modulation can be a potential therapeutic approach for melanoma, with two compounds enhancing the effect of the BRAF inhibitor. The combinations of these metabolic modulators led to increased production of reactive oxygen species, suggesting a role of oxidative stress in the cellular response. This study supports the use of such combination therapies in cancer treatment for metastatic melanoma patients.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Joachim T. Siaw, Jonatan L. Gabre, Ezgi Uckun, Marc Vigny, Wancun Zhang, Jimmy Van den Eynden, Bengt Hallberg, Ruth H. Palmer, Jikui Guan
Summary: The research reveals that ALK and RET play crucial roles in regulating cell signaling and phenotype transition in neuroblastoma. ALK is able to modulate the phosphorylation and transcription levels of RET signaling, while RET knockout results in a striking epithelial-to-mesenchymal transition phenotype in the cells.
Article
Medicine, Research & Experimental
Thale Kristin Olsen, Cecilia Dyberg, Bethel Tesfai Embaie, Adele Alchahin, Jelena Milosevic, Jane Ding, Jorg Otte, Conny Tummler, Ida Hed Myrberg, Ellen M. Westerhout, Jan Koster, Rogier Versteeg, Han-Fei Ding, Per Kogner, John Inge Johnsen, David B. Sykes, Ninib Baryawno
Summary: By applying a multiomic system approach, researchers identified DHODH as a potential treatment target for high-risk neuroblastoma. Inhibiting DHODH could significantly reduce tumor growth and improve survival rates. Combining the DHODH inhibitor brequinar with temozolomide showed promising therapeutic potential in neuroblastoma.
Article
Multidisciplinary Sciences
Yeon-Woo Cho, Seohyeon Jee, Intan Rosalina Suhito, Jeong-Hyeon Lee, Chun Gwon Park, Kyung Min Choi, Tae-Hyung Kim
Summary: This study reports a new platform called SMENA, which enables efficient generation of neuronal cells using single metal-organic framework nanoparticles embedded in nanopit arrays. The platform allows for long-term storage and release of retinoic acid, leading to enhanced mRNA expressions of neurogenesis-related activities in neural stem cells.
Article
Cell Biology
Mengzhen Li, Chengtao Sun, Xiaoyun Bu, Yi Que, Lian Zhang, Yu Zhang, Li Zhang, Suying Lu, Junting Huang, Jia Zhu, Juan Wang, Feifei Sun, Yizhuo Zhang
Summary: The study identified ISL1 as an oncogene in neuroblastoma, with high expression associated with poor patient outcomes. ISL1 promotes cell proliferation and EMT transformation in NB through the PI3K/AKT signaling pathway by upregulating AURKA. Knockdown of ISL1 inhibits proliferation and induces apoptosis, while overexpression has the opposite effects.
CELL DEATH & DISEASE
(2021)
Review
Physiology
Anqun Chen, Yu Liu, Yu Lu, Kyung Lee, John Cijiang He
Summary: Retinoic acid (RA) has dual effects in kidney disease, providing renal protection while also potentially inducing podocyte injury and apoptosis, highlighting the need to target specific RA-mediated pathways for effective therapeutic treatments.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Cell Biology
Roshna Lawrence Gomez, Laura M. Woods, Revathy Ramachandran, Ahmad N. Abou N. Tayoun, Anna Philpott, Fahad R. Ali
Summary: This study identifies the differential super-enhancer landscape between different cell types in neuroblastoma, which may contribute to the diverse response to retinoic acid. The study also identifies key super-enhancers responsible for maintaining differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Biomedical
Beatrice Labat, Nimrod Buchbinder, Sandrine Morin-Grognet, Guy Ladam, Hassan Atmani, Jean-Pierre Vannier
Summary: By developing a biomimetic culture system using LbL films, we were able to control neuritogenesis of neuroblastoma cells and enhance the effect of pharmacologic drugs. Our results emphasize the crucial role of mechanical cues in the microenvironment of neuroblastoma, which can significantly modulate the efficacy of drug treatments.
ACTA BIOMATERIALIA
(2021)
Article
Hematology
Rui Vilar, Samuel W. Lukowski, Marco Garieri, Corinne Di Sanza, Marguerite Neerman-Arbez, Richard J. Fish
Summary: The study identified anthralin and all-trans retinoic acid as chemical entities capable of altering fibrinogen production, leading to effects on experimental venous thrombosis. Anthralin may lower fibrinogen levels by affecting the protein secretion pathway.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Multidisciplinary Sciences
Maja Milanovic, Dorothy N. Y. Fan, Dimitri Belenki, J. Henry M. Dabritz, Zhen Zhao, Yong Yu, Jan R. Doerr, Lora Dimitrova, Dido Lenze, Ines A. Monteiro Barbosa, Marco A. Mendoza-Parra, Tamara Kanashova, Marlen Metzner, Katharina Pardon, Maurice Reimann, Andreas Trumpp, Bernd Doerken, Johannes Zuber, Hinrich Gronemeyer, Michael Hummel, Gunnar Dittmar, Soyoung Lee, Clemens A. Schmitt
Article
Chemistry, Medicinal
Shinya Fujii, Shuichi Mori, Hiroyuki Kagechika, Marco Antonio Mendoza Parra, Hinrich Gronemeyer
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2018)
Editorial Material
Oncology
Hinrich Gronemeyer
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Melanie Kahl, Annamaria Brioli, Martin Bens, Florian Perner, Anne Kresinsky, Ulf Schnetzke, Anna Hinze, Yordan Sbirkov, Sven Stengel, Giorgia Simonetti, Giovanni Martinelli, Kevin Petrie, Arthur Zelent, Frank-Dietmar Boehmer, Marco Groth, Thomas Ernst, Florian H. Heidel, Sebastian Scholl, Andreas Hochhaus, Tino Schenk
Correction
Oncology
Melanie Kahl, Annamaria Brioli, Martin Bens, Florian Perner, Anne Kresinsky, Ulf Schnetzke, Anna Hinze, Yordan Sbirkov, Sven Stengel, Giorgia Simonetti, Giovanni Martinelli, Kevin Petrie, Arthur Zelent, Frank-Dietmar Bohmer, Marco Groth, Thomas Ernst, Florian H. Heidel, Sebastian Scholl, Andreas Hochhaus, Tino Schenk
Editorial Material
Oncology
Hinrich Gronemeyer
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Multidisciplinary Sciences
Maha Siouda, Audrey D. Dujardin, Laetitia Barbollat-Boutrand, Marco A. Mendoza-Parra, Benjamin Gibert, Maria Ouzounova, Jebrane Bouaoud, Laurie Tonon, Marie Robert, Jean-Philippe Foy, Vincent Lavergne, Serge N. Manie, Alain Viari, Alain Puisieux, Gabriel Ichim, Hinrich Gronemeyer, Pierre Saintigny, Peter Mulligan
Article
Oncology
Mina M. Tayari, Helena G. Dos Santos, Deukwoo Kwon, Terrence J. Bradley, Amber Thomassen, Charles Chen, Yvonne Dinh, Aymee Perez, Arthur Zelent, Lluis Morey, Luisa Cimmino, Ramin Shiekhattar, Ronan T. Swords, Justin M. Watts
Summary: Clinical trial of ATRA plus TCP in patients with relapsed/refractory AML and MDS showed acceptable safety and improved efficacy in subsets of patients. Gene expression analysis revealed that responders had a more quiescent phenotype while nonresponders exhibited a more proliferative one.
CLINICAL CANCER RESEARCH
(2021)
Correction
Biochemistry & Molecular Biology
Angela Nebbioso, Fabio Manzo, Marco Miceli, Mariarosaria Conte, Lucrezia Manente, Alfonso Baldi, Antonio De Luca, Dante Rotili, Sergio Valente, Antonello Mai, Alessandro Usiello, Hinrich Gronemeyer, Lucia Altucci
Editorial Material
Oncology
Hinrich Gronemeyer, Nicole Y. Souren
INTERNATIONAL JOURNAL OF CANCER
(2021)
Editorial Material
Oncology
Hinrich Gronemeyer
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Yasenya Kasikci, Hinrich Gronemeyer
Summary: Cancer genetics and genomics have provided insights into tumor development and heterogeneity. However, current cancer research may overlook complexity and individual diversity. A systems approach that reconstructs altered information networks and identifies key regulators is suggested. Individualized strategies are favored, as interindividual variability within patient cohorts is too high to extract common polygenic network information. A multinational and multidisciplinary effort is needed to develop dynamic regulatory networks and propose targeted therapies based on altered information transfer in individual cancers.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Cell Biology
A. Huyghe, G. Furlan, J. Schroeder, E. Cascales, A. Trajkova, M. Ruel, F. Studer, M. Larcombe, Y. Bo Yang Sun, F. Mugnier, L. De Matteo, A. Baygin, J. Wang, Y. Yu, N. Rama, B. Gibert, J. Kielbassa, L. Tonon, P. Wajda, N. Gadot, M. Brevet, M. Siouda, P. Mulligan, R. Dante, P. Liu, H. Gronemeyer, M. Mendoza-Parra, J. M. Polo, F. Lavial
Summary: Coordinated changes of cellular plasticity and identity are critical for pluripotent reprogramming and oncogenic transformation. This study provides insights into the partitioned control of cellular plasticity and identity for both regenerative and cancer biology.
NATURE CELL BIOLOGY
(2022)
Article
Oncology
Akinchan Kumar, Yasenya Kasikci, Alaa Badredine, Karim Azzag, Marie L. Quintyn Ranty, Falek Zaidi, Nathalie Aragou, Catherine Mazerolles, Bernard Malavaud, Marco A. Mendoza-Parra, Laurence Vandel, Hinrich Gronemeyer
Summary: Prostate cancer shows diverse patient-specific network alterations, with different signaling pathways affected by mutations and altered gene expression. In individual cases, deregulated pathways share common factors and have synergistic effects on cancer progression, providing a paradigm for identifying druggable key deregulated factors within regulatory networks for personalized therapies.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biology
Matthias Blum, Pierre-Etienne Cholley, Valeriya Malysheva, Samuel Nicaise, Julien Moehlin, Hinrich Gronemeyer, Marco Antonio Mendoza-Parra
LIFE SCIENCE ALLIANCE
(2020)
