Journal
CANCER CELL
Volume 16, Issue 6, Pages 452-454Publisher
CELL PRESS
DOI: 10.1016/j.ccr.2009.11.008
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Eph receptors are important but controversial regulators of cancer development. A recent study reported in Cell reveals that in the intestinal epithelium, EphB2 enhances proliferation through a kinase-dependent pathway and inhibits migration independent of its kinase activity. These separate pathways simultaneously promote proliferation but suppress invasive growth of intestinal adenomas.
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