Editorial Material
Biochemistry & Molecular Biology
Mikel Garcia-Marcos
Summary: This article found that GPCRs selectively bind to specific G-protein subtypes to ensure accurate signal transduction. However, the study also discovered that GPCRs can promiscuously recognize empty-like G-protein mutants, suggesting that receptors prefer to interact with cognate G proteins prior to nucleotide release.
NATURE CHEMICAL BIOLOGY
(2023)
Editorial Material
Biology
Kuldeep Singh, Rajeev Malhotra
Summary: The accumulation of iron as one grows older may hinder the positive effects of hormone replacement therapy on cardiovascular disease in women during late postmenopause.
Editorial Material
Microbiology
Feng Li, Jacob O. Brunkard, Barbara Baker
Summary: In this study, the researchers discovered that a long non-coding RNA, lncSABC1, promotes plant growth in uninfected plants and activates defense mechanisms in response to pathogen attacks by regulating salicylic acid biosynthesis.
CELL HOST & MICROBE
(2022)
Editorial Material
Multidisciplinary Sciences
Nana K. Minkah, Stefan H. I. Kappe
Summary: Clinical evidence suggests that utilizing live parasites growing in the liver for vaccination can generate high levels of immune protection against malaria infection, highlighting the urgent need for effective malaria vaccines.
Editorial Material
Immunology
Justin L. McCarville, Janelle S. Ayres
Summary: This study reveals that Pseudomonas aeruginosa drives immune deviation through induction of type 2 immune responses, resulting in allergic responses to innocuous antigens.
Editorial Material
Biotechnology & Applied Microbiology
Giorgio Tortarolo, Suliana Manley
Summary: Super-resolution microscopy with angstrom precision could enable optical structural biology studies in cells.
NATURE BIOTECHNOLOGY
(2023)
Editorial Material
Physics, Multidisciplinary
Hendrik Weimer
Summary: The simulation of open quantum many-body systems is one of the most challenging tasks in computational physics. Quantum computers are now approaching the ability to answer crucial questions for such systems that classical computers cannot reach.
Editorial Material
Biochemistry & Molecular Biology
Stuart J. D. Neil
Summary: Trafficking of live mammals is a serious risk for zoonotic virus emergence. This study found a MERS-related coronavirus in trafficked pangolins, which has a wide range of potential mammalian hosts and an acquired furin cleavage site in its Spike protein.
Article
Ergonomics
Tristan Casey, Nick Turner, Xiaowen Hu, Kym Bancroft
Summary: This research aims to develop a theoretical framework that integrates factors contributing to safety training engagement and transfer. The results propose that training engagement is a combination of pre-training factors interacting with design and delivery factors. Organizations should prioritize pre-training readiness modules to optimize engagement and transfer.
JOURNAL OF SAFETY RESEARCH
(2021)
Editorial Material
Biochemistry & Molecular Biology
Benita S. Katzenellenbogen
Summary: ER alpha, a nuclear hormone receptor, is not only a well-known transcription factor in many breast cancers but also an RNA-binding protein, which plays a crucial role in promoting cancer cell fitness and survival through its post-transcriptional activity.
Editorial Material
Biochemistry & Molecular Biology
Iliyan D. Iliev, Woan-Yu Lin, Sarah L. Gaffen
Summary: Microbiota-induced IL-17 production plays a role in CNS processes and animal behavior, but its role in the PNS is not well understood. Enamorado et al. show that commensal-specific Th17 cells are activated after tissue injury to promote local nerve regeneration, which is regulated by IL-17 signaling on peripheral neurons.
Article
Engineering, Environmental
Hina Habib, Michelle Wagner, Cornelis Peter Balde, Lucia Herreras Martinez, Jaco Huisman, Jo Dewulf
Summary: This study develops a quantitative model to describe the flows of Waste Electrical and Electronic Equipment (WEEE) in European Union (EU) Member States, Great Britain, Norway, and Switzerland in 2018. The results show that a significant amount of WEEE was not properly collected and recycled, highlighting the need for improved waste management targets.
RESOURCES CONSERVATION AND RECYCLING
(2022)
Article
Biochemistry & Molecular Biology
Thomas Carzaniga, Giuliano Zanchetta, Elisa Frezza, Luca Casiraghi, Luka Vanjur, Giovanni Nava, Giovanni Tagliabue, Giorgio Dieci, Marco Buscaglia, Tommaso Bellini
Summary: Transcription factors regulate gene activity by binding specific regions of genomic DNA through a complex interplay of specific and nonspecific interactions. The study utilized a label-free biosensor, Reflective Phantom Interface (RPI), to investigate Gal4's binding to DNA fragments and found that binding to its cognate site is stronger but slower than nonspecific binding. Analysis of binding curves and molecular dynamics simulations revealed a small free energy gap between specific and nonspecific binding, with a compensation of enthalpy and entropy in Gal4-DNA interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Nanette Santoro
Summary: The field of embryo and gamete cryopreservation is facing potential challenges and liabilities due to increased utilization and changing legal landscape. Clinics should pay attention to the current state of the science, potential legal ramifications, and long-term ethical implications.
FERTILITY AND STERILITY
(2022)
News Item
Multidisciplinary Sciences
Natasha Gilbert
Summary: Urgent progress is required to achieve the global deal for environmental conservation.
