Article
Oncology
Florian Richter, Christian Roeder, Thorben Moeller, Jan-Hendrik Egberts, Thomas Becker, Susanne Sebens
Summary: This study investigated the expression of CK20 and DEFA5 in blood and bone marrow of esophageal cancer patients and correlated positivity rates with clinical data. The study found that both markers were detected in patients and the control group, but their positivity rates did not correlate with overall survival. However, CK20 positivity in bone marrow and DEFA5 negativity in blood were associated with reduced overall survival in patients without neoadjuvant therapy. In patients with neoadjuvant therapy, DEFA5 positivity in bone marrow was associated with improved overall survival. These results suggest that DEFA5 may be a potential prognostic biomarker in liquid biopsies of esophageal cancer patients, but further validation is needed.
Article
Biophysics
Xiawei Xu, Jie Lin, Yanhong Guo, Xiaoxia Wu, Yanping Xu, Dinghu Zhang, Xiangzhi Zhang, Xie Yujiao, Jing Wang, Chengyang Yao, Junlie Yao, Jie Xing, Yi Cao, Yanying Li, Wenzhi Ren, Tianxiang Chen, Yong Ren, Aiguo Wu
Summary: This study presents a novel method for in situ isolating and directly detecting circulating tumor cells (CTCs) from peripheral blood using black TiO2-based Surface-Enhanced Raman Scattering (SERS) bio-probe. The strategy showed high efficiency, reliability, and specificity in distinguishing CTCs from peripheral blood cells. It significantly reduced the detection time and improved the detection sensitivity, making it a potential tool for liquid biopsy.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Oncology
Thomas L. Sutton, Ranish K. Patel, Ashley N. Anderson, Stephen G. Bowden, Riley Whalen, Nicole R. Giske, Melissa H. Wong
Summary: In cancer, circulating tumor cells (CTCs) have historically been the focus of study, but recently discovered tumor-immune hybrid cells offer a more accessible and potentially effective biomarker option. These hybrid cells have shown promise in early detection and assessing treatment response, indicating their importance in cancer research and patient care.
Article
Oncology
Atsuko Furukawa, Tomoko Mori, Osamu Shimomura, Kazuhisa Araki, Tatsuya Oda, Satoshi Matsusaka
Summary: This study aimed to establish a new approach to capture and cultivate circulating tumor cells (CTCs) using a microfilter device. Whole blood samples were collected from patients with pancreatic cancer, and CTCs were isolated and cultured on the microfilter. The study found that CTCs and/or CTC clusters could be observed during long-term culture.
Review
Oncology
Zuxi Li, Meijuan Song, Shangjun Han, Chuanwei Jin, Jing Yang
Summary: Circulating tumor cells (CTC) are associated with the prognosis of patients with gastric cancer. Gastric cancer patients with positive CTC may have a poorer prognosis compared to those with CTC-negative tumors. CTC-positive patients have more advanced TNM staging, poorer tumor differentiation, and earlier distant metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Alejandro Rodriguez-Pena, Estibaliz Armendariz, Alvaro Oyarbide, Xabier Morales, Sergio Ortiz-Espinosa, Borja Ruiz-Fernandez de Cordoba, Denis Cochonneau, Inaki Cornago, Dominique Heymann, Josepmaria Argemi, Delia D'Avola, Bruno Sangro, Fernando Lecanda, Ruben Pio, Ivan Cortes-Dominguez, Carlos Ortiz-de-Solorzano
Summary: This paper presents a double spiral microfluidic device based on inertial separation for efficient enrichment and isolation of circulating tumor cells (CTCs). The device has a fine-tunable cut-off value and better separation results than existing technologies.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Pai-Chi Teng, Vatche G. Agopian, Ting-Yi Lin, Sungyong You, Yazhen Zhu, Hsian-Rong Tseng, Ju Dong Yang
Summary: Serum alpha-fetoprotein and radiologic imaging are commonly used tests for early diagnosis and treatment monitoring of hepatocellular carcinoma (HCC), but their accuracy is limited. Developing novel HCC biomarkers reflecting tumor biology is an unmet need. Circulating tumor cells (CTCs) have potential as a noninvasive biomarker for HCC, offering molecular and functional data that can reflect the underlying tumor.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Oncology
Mahmoud Labib, Shana O. Kelley
Summary: Analysis of circulating tumor cells provides valuable insights in precision oncology, revealing associations between CTCs molecular profiles and tumor response to therapy. However, current limitations hinder the widespread clinical implementation of CTCs, suggesting the need for further research and advanced technologies.
MOLECULAR ONCOLOGY
(2021)
Review
Oncology
Dmitry Enikeev, Andrey Morozov, Diana Babaevskaya, Andrey Bazarkin, Bernard Malavaud
Summary: Liquid biopsy, which combines cell-dependent and cell-independent information from the blood stream, has the potential to revolutionize cancer management. However, the science behind liquid biopsies is not widely utilized. In this systematic review, the use of CTCs in prostate cancer management was summarized, highlighting their predictive value for disease progression, survival, and response to therapy.
Review
Biochemistry & Molecular Biology
Jerry Xiao, Paula R. Pohlmann, Claudine Isaacs, Benjamin A. Weinberg, Aiwu R. He, Richard Schlegel, Seema Agarwal
Summary: CTCs play a crucial role in predicting patient survival and understanding the metastasis of cancer, with potential implications for disease management and treatment strategies.
Review
Pharmacology & Pharmacy
Daniel J. Smit, Klaus Pantel, Manfred Juecker
Summary: CTCs play a crucial role in cancer metastasis and their analysis in liquid biopsies can be valuable for prognosis prediction and real-time therapy monitoring. Research on CTCs may lead to new treatment strategies for preventing metastasis or maintaining stable diseases. Studies on inhibitors targeting CTCs have shown promising results, suggesting CTCs may be useful for personalized drug susceptibility testing.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Peng Xie, Xiaoyue Yao, Zhenyu Chu, Yang Yang, Haifeng Li, Siyuan Tan, Haodong Tang, Jiahua Zhou, Wanqin Jin
Summary: The detection of circulating tumor cells (CTCs) plays a crucial role in the early diagnosis of cancers. However, it is challenging due to the low content and similarity in size with other blood cells. This study proposes a novel membrane and microfilter device for the ultrafast isolation and identification of CTCs directly from peripheral blood.
Review
Chemistry, Analytical
Fulai Li, Hengyi Xu, Yufen Zhao
Summary: As a new type of liquid biopsy, circulating tumor cell (CTC) detection and analysis offer the possibility of real-time monitoring of metastatic development, cancer recurrence, and therapeutic efficacy. The rarity and heterogeneity of CTCs present great challenges, and magnetic particle-based methods show promise for effective CTC capture. Progress has been made in utilizing magnetic particles to enhance CTC capture, which is crucial for cancer diagnosis and prognosis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Review
Oncology
Qiong Chen, Jueyao Zou, Yong He, Yanhong Pan, Gejun Yang, Han Zhao, Ying Huang, Yang Zhao, Aiyun Wang, Wenxing Chen, Yin Lu
Summary: Circulating tumor cells (CTCs) play a crucial role in tumor metastasis and can be used for tumor diagnosis, prognosis, and recurrence monitoring. Clustered CTCs have been found to have stronger metastasis ability and can bind with non-tumor cells in the blood, promoting tumor growth and development.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jozsef Petrik, Donatella Verbanac, Marija Fabijanec, Andrea Hulina-Tomaskovic, Andrea Ceri, Anita Somborac-Bacura, Roberta Petlevski, Marija Grdic Rajkovic, Lada Rumora, Bozo Kruslin, Mario Stefanovic, Neven Ljubicic, Neven Barsic, Antonija Hanzek, Luka Bockor, Ivana Celap, Alma Demirovic, Karmela Barisic
Summary: This review provides an overview of the research conducted on circulating tumor cells (CTCs) with the aim of finding suitable detection systems and assessing the possibility of clinical applications in patients with colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)