Article
Oncology
Xueyi Hu, Caiwu Su, Jian Wei
Summary: This study found that high expression of SPON2 in triple-negative breast cancer (TNBC) is associated with worse patient outcomes, and inhibiting SPON2 expression can reduce TNBC cell proliferation, migration, and invasion while promoting apoptosis. It also affects the PI3K-ATK pathway and the expression of CCL2 protein.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xia Zhang, Rikiya Taoka, Dage Liu, Yuki Matsuoka, Yoichiro Tohi, Yoshiyuki Kakehi, Mikio Sugimoto
Summary: RRM1, an important DNA replication/repair enzyme, is a key molecular target for gemcitabine. Inhibition of RRM1 has shown to reduce cancer cell proliferation and increase sensitivity to gemcitabine in bladder cancer. Combination therapy of RRM1 inhibition and gemcitabine may offer new treatment options for gemcitabine-resistant bladder tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Laura Mainz, Mohamed A. F. E. Sarhan, Sabine Roth, Ursula Sauer, Charis Kalogirou, Markus Eckstein, Elena Gerhard-Hartmann, Helen-Desiree Seibert, Hans-Ulrich Voelker, Carol Geppert, Andreas Rosenwald, Martin Eilers, Almut Schulze, Markus Diefenbacher, Mathias T. Rosenfeldt
Summary: The potential therapeutic target of macroautophagy/autophagy for various diseases, including cancer, is mainly based on preclinical mouse studies. This study introduces a shRNA transgenic mouse model that allows simultaneous knockdown of Atg7 in most organs, providing a valuable tool for further understanding of the role of autophagy impairment at different disease stages.
Article
Food Science & Technology
Pan Chao, Feng Yongheng, Zhou Jin, Zhu Yu, Yang Shiyong, Yang Kunxing, Ma Yong
Summary: This study revealed that in gastric cancer development, HOTAIR expression increases while miRNA-206 expression decreases. Knockdown of HOTAIR suppresses cell viability, increases apoptosis, inhibits invasion and migration by regulating miRNA-206, and suppresses CCND1 and CCND2 expression. HOTAIR targeting miRNA-206 and miRNA-206 targeting CCND1 and CCND2 play crucial roles in the antitumor effects in gastric cancer.
FOOD SCIENCE & NUTRITION
(2021)
Article
Oncology
Beibei Chen, Sai-Qi Wang, Jinxi Huang, Weifeng Xu, Huifang Lv, Caiyun Nie, Jianzheng Wang, Huichen Zhao, Yingjun Liu, Jitian Li, Canrong Lu, Jianying Zhang, Xiao-Bing Chen
Summary: The study revealed that Krm2 is significantly up-regulated in gastric cancer and plays a role in promoting tumorigenesis and metastasis. Knockdown of Krm2 inhibited cell survival, induced apoptosis, and suppressed migration in gastric cancer cells both in vitro and in vivo. The mechanism involves the suppression of the PI3K/Akt pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ze Peng, Tenzin Wangmu, Lingli Li, Guangsu Han, Dongmei Huang, Ping Yi
Summary: The combination of berberine and low glucose can inhibit the growth of gastric cancer through the activation of the PP2A/GSK38/MCL-1 signaling pathway, making it a new safe and effective anti-cancer therapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Timofey Lebedev, Anton Buzdin, Elmira Khabusheva, Pavel Spirin, Maria Suntsova, Maxim Sorokin, Vladimir Popenko, Petr Rubtsov, Vladimir Prassolov
Summary: Neuroblastoma is a pediatric cancer with high clinical and molecular heterogeneity, and patients with high-risk tumors have limited treatment options. Receptor tyrosine kinase KIT has been identified as a potential marker of high-risk neuroblastoma and a promising target for neuroblastoma treatment. Increased KIT expression is associated with activation of cell survival pathways, downregulated apoptosis induction, and cell cycle checkpoint control pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Jiaqi Yang, David Sontag, Yuewen Gong, Gerald Y. Minuk
Summary: The study documented changes in expression levels of certain multidrug resistance proteins (MRPs) in cholangiocarcinoma cells following gemcitabine treatment, with knocking down specific MRPs significantly increasing the cytotoxicity of gemcitabine. Therefore, inhibition of MRP6 in intra-hepatic and MRP5 in extra-hepatic cells may be explored as potential treatments for cholangiocarcinoma.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Cell Biology
Xing Kang, En Xu, Xingzhou Wang, Lulu Qian, Zhi Yang, Heng Yu, Chao Wang, Chuanfu Ren, Yizhou Wang, Xiaofeng Lu, Xuefeng Xia, Wenxian Guan, Tong Qiao
Summary: The study found that Tenascin-c (TNC) is upregulated in gastric cancer tissue and is associated with vasculogenic mimicry (VM) formation and poor prognosis. Inhibition of TNC can significantly suppress VM formation and cell proliferation in gastric cancer. Targeting TNC and ERK may be a potential therapeutic approach to inhibit gastric cancer growth and metastasis.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Cai-xia An, Shou-pin Xie, Hai-long Li, Yong-hua Hu, Rong Niu, Lin-jie Zhang, Yan Jiang, Qiang Li, Yong-ning Zhou
Summary: The study found that MASTL overexpression in gastric cancer tissue is associated with tumor stage, Helicobacter pylori infection, and histological subtypes, while MASTL knockdown decreases tumor cell proliferation and induces apoptosis. Further research is needed to evaluate MASTL as a potential therapeutic target for gastric cancer.
CURRENT MEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Sunisa Yoodee, Paleerath Peerapen, Sirikanya Plumworasawat, Visith Thongboonkerd
Summary: ARID1A is a newly discovered tumor suppressor gene commonly observed in human cells and frequently lost or defective in many cancers. Down-regulation of ARID1A in human endothelial cells directly induces angiogenesis by regulating angiopoietin-2 secretion and endothelial cell activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Handong Xu, Can Hu, Yi Wang, Yunfu Shi, Li Yuan, Jingli Xu, Yanqiang Zhang, Jiahui Chen, Qin Wei, Jiangjiang Qin, Zhiyuan Xu, Xiangdong Cheng
Summary: Gastric cancer (GC) is a deadly malignancy that requires new therapeutic targets for effective treatment. Glutathione peroxidase-2 (GPx2) was found to be overexpressed in clinical GC samples and negatively correlated with prognosis. Knockdown of GPx2 inhibited GC progression and metastasis by suppressing the KYNU-kyn-AhR signaling pathway, which was activated by reactive oxygen species (ROS) accumulation.
Article
Medicine, General & Internal
Wenting Shi, Fang Wang
Summary: This study reveals the crucial role of circ_AKT3 in the resistance of gastric cancer to cisplatin, which is mediated through its interaction with miR-206 and PTPN14.
Article
Oncology
Shih-Min Pai, Kuo-Hung Huang, Ming-Huang Chen, Wen-Liang Fang, Yee Chao, Su-Shun Lo, Anna Fen-Yau Li, Chew-Wun Wu, Yi-Ming Shyr
Summary: The study found that cardia gastric cancer is not an independent prognostic factor. Cardia gastric cancer patients with intestinal-type tumors had more common PIK3CA amplification, while those with diffuse-type tumors had more common HER2 expression. Targeted therapy may be beneficial for these specific patient subgroups.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Bo Cao, Huan Deng, Hao Cui, Ruiyang Zhao, Hanghang Li, Bo Wei, Lin Chen
Summary: This study investigated the role of PGM1 in gastric cancer and its correlation with cell viability, proliferation, and metabolism. High PGM1 expression was associated with shorter survival and advanced tumor stage in GC. Downregulation of PGM1 under glucose deprivation enhanced the anti-cancer effects of Orlistat, providing a potential novel strategy for GC treatment.
CANCER CELL INTERNATIONAL
(2021)