Article
Oncology
Zhaoming Deng, Wei Liao, Wei Wei, Guihua Zhong, Chao He, Hongbo Zhang, Qiaodan Liu, Xiwei Xu, Jun Liang, Zhigang Liu
Summary: The tyrosine kinase inhibitor Anlotinib shows antitumor effects on oral squamous cell carcinoma cells through apoptotic pathway and mitotic catastrophe pattern, providing promising potential therapy for patients with OSCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Charlotte Dubois, Kateryna Kondratska, Artem Kondratskyi, Angela Morabito, Lina Mesilmany, Valerio Farfariello, Robert-Alain Toillon, Nathalie Ziental Gelus, Emilie Laurenge, Fabien Vanden Abeele, Loic Lemonnier, Natalia Prevarskaya
Summary: Changes in cytosolic free Ca2+ concentration play a central role in cellular processes. ORAI3 channels are expressed in both normal and pancreatic ductal adenocarcinoma cell lines, affecting store-operated calcium entry (SOCE). Silencing ORAI3 increases SOCE in PDAC cell lines and decreases SOCE in normal pancreatic cell line, impacting proliferation, cell cycle, viability, mitotic catastrophe, and cell death.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Shuang Zhao, Yufei Tang, Ruohan Wang, Masoud Najafi
Summary: This article focuses on the cell death mechanisms induced by paclitaxel, a chemotherapy drug, in cancer treatment and the resistance of cancer cells to paclitaxel. The study found that paclitaxel can induce apoptosis and mitotic catastrophe, as well as other cell death mechanisms, and it can also lead to drug resistance. The article also discusses the use of combination therapies to overcome drug resistance.
Review
Biochemistry & Molecular Biology
Xiao Fu, Mu Li, Cuilian Tang, Zezhi Huang, Masoud Najafi
Summary: Increasing apoptosis, mitotic catastrophe, senescence, and necrosis can help overcome tumor resistance to therapy. Stimulation of autophagy cell death may also be useful for cancer therapy. Resveratrol has potential to affect various signaling pathways related to cell death and modulate cancer cell death mechanisms.
Review
Chemistry, Medicinal
Peyman Amini, Reza Moazamiyanfar, Mohammad Sedigh Dakkali, Emad Jafarzadeh, Maryam Ganjizadeh, Nima Rastegar-Pouyani, Kave Moloudi, Ehsan Khodamoradi, Shahram Taeb, Masoud Najafi
Summary: Inducing cell death and inhibiting cell proliferation in cancer is important in anti-tumor therapy. Apigenin, a nature-derived and herbal agent, has shown anticancer properties by directly inducing cell death and enhancing the induction of cell death through other anti-tumor modalities. It can induce various types of cell death, such as apoptosis, autophagic cell death, senescence, anoikis, necroptosis, and ferroptosis. The modulatory actions of apigenin enhance anticancer effects and may be dependent on the type of cancer. Overall rating: 8/10.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mariana Romeiro Motta, Xin'Ai Zhao, Martine Pastuglia, Katia Belcram, Farshad Roodbarkelari, Maki Komaki, Hirofumi Harashima, Shinichiro Komaki, Manoj Kumar, Petra Bulankova, Maren Heese, Karel Riha, David Bouchez, Arp Schnittger
Summary: Flowering plants contain multiple cyclin families, with B1-type cyclins playing a crucial role in cell cycle control during Arabidopsis development. Mutant analysis revealed complex overlapping requirements of B1-type cyclins, with CYCB1;2 being central. The double mutant cycb1;1 cycb1;2, although compromised in growth, provides a unique opportunity to study the function of B1-type cyclins at the organismic level.
Article
Biochemistry & Molecular Biology
Ewa Trybus, Teodora Krol, Wojciech Trybus
Summary: The study investigates the mechanisms of action of azelastine hydrochloride in cancer treatment. The results demonstrate that azelastine can induce degradation processes, increase autophagy activity, and activate apoptosis, leading to anti-proliferative, cytotoxic, autophagic, and apoptotic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Orawan Waenphimai, Panupong Mahalapbutr, Kulthida Vaeteewoottacharn, Sopit Wongkham, Kanlayanee Sawanyawisuth
Summary: The potent inhibitor NMS-P715 showed multiple anti-cancer effects in human CCA cell lines, including inhibiting cell proliferation and colony formation, inducing G2/M arrest, mitotic catastrophe, caspase-dependent apoptosis, autophagosome formation, and suppressing cell migration and invasion. The study suggests that NMS-P715 may have potential for further development in clinical studies as a promising candidate for combating CCA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pathology
Handy Riantana, Orawan Waenphimai, Panupong Mahalapbutr, Kun Karnchanapandh, Kulthida Vaeteewoottacharn, Sopit Wongkham, Kanlayanee Sawanyawisuth
Summary: PLK1 is an essential mitotic checkpoint protein that plays a key role in cell cycle division and its overexpression is associated with poor prognosis in various cancers. In this study, the PLK1 inhibitors BI6727 and GSK461364A effectively suppressed cholangiocarcinoma cell proliferation, induced G2/M arrest, and triggered mitotic catastrophe and cell apoptosis, suggesting that they could be potential drugs for cholangiocarcinoma therapy at the clinical level.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Oncology
Zicheng Wang, Yanqing Liu, Ahmed Eleojo Musa
Summary: Cancer therapy is aimed at killing cancer cells using various therapeutic agents. Melatonin, a circadian regulator hormone, has the potential to activate tumor suppressor genes and attenuate the expression of survival genes in cancer cells. Modulating disrupted or overexpressed cell death or survival genes in cancer cells can improve cancer therapy.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Yan-Bo Zheng, Yan-Qun Dong, Shu-Yi Si, Yong-Su Zhen, Jian-Hua Gong
Summary: IMB5476, a novel nitrobenzoate microtubule inhibitor, exhibits increased aqueous solubility. It disrupts microtubule networks in cells, causing cell cycle arrest and inducing cell death through mitotic catastrophe and apoptosis. IMB5476 also inhibits angiogenesis and overcomes multidrug resistance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Giorgia Iegiani, Marta Gai, Ferdinando Di Cunto, Gianmarco Pallavicini
Summary: Medulloblastoma (MB) is the most frequent brain tumor in children, and current treatments are only partially effective, necessitating the need for more effective therapies. The gene CENPE is critical for normal proliferation and survival of neural progenitors, and inhibiting it has shown potential as a therapeutic strategy for MB treatment, as demonstrated by its effects on MB cell lines and the promising results of testing the inhibitor GSK923295.
Article
Cell Biology
Maria Di Bari, Vanessa Tombolillo, Francesco Alessandrini, Claudia Guerriero, Mario Fiore, Italia Anna Asteriti, Emilia Castigli, Miriam Sciaccaluga, Giulia Guarguaglini, Francesca Degrassi, Ada Maria Tata
Summary: The study reveals that the M2 agonist increases aberrant mitosis in glioblastoma cell lines, suggesting it may be a promising novel therapeutic target for glioblastoma treatment.
Article
Biochemistry & Molecular Biology
Marilena Taggi, Andjela Kovacevic, Chiara Capponi, Marta Falcinelli, Veronica Cacciamani, Elena Vicini, Rita Canipari, Ada Maria Tata
Summary: This study investigates the expression characteristics of muscarinic receptors (mAChRs) in ovarian cancer cell lines and ovarian surface epithelium cell lines. It is found that the M2 receptor is downregulated in cancer cells and its inhibition leads to decreased cell proliferation and increased cell death. Arecaidine propargyl ester hydrobromide (APE), an M2 agonist, is shown to inhibit cell growth and induce abnormal mitosis.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Cell Biology
Weiwei Zhao, Qing Wang, Le Li, Chengshen Xie, Yequn Wu, Mayank Gautam, Lijia Li
Summary: This study discovers that SIRT1 may be involved in regulating mitotic catastrophe (MC) through autophagy and BubR1 signaling. Overexpression of SIRT1 alleviates MC, while its knockdown exacerbates this phenomenon. In addition, the regulation of autophagy and BubR1 signaling also affects MC. These results provide evidence for SIRT1, autophagy, and BubR1 as potential therapeutic targets for cancer.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)