Review
Cell Biology
Jiali Zhang, Defa Huang, Xianbin Lan, Dongming Deng, Jijing Li, Dongzhi Zhang, Yue Li, Tianyu Zhong, Shaoping Peng
Summary: Nasopharyngeal carcinoma (NPC) is a malignant tumor that originates from the epithelium of the nasopharynx. Early diagnosis of NPC is crucial to improve prognosis, and small extracellular vesicles (sEVs) have shown potential as biomarkers for malignancy detection in NPC. This review summarizes the application of sEVs as biomarkers in NPC diagnosis, their role in NPC metastasis and prognosis, and discusses future applications and limitations.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Medical Laboratory Technology
Ting Yang, Xiaoqing Lin, Liangming Zhang, Lili Yu, Qingwei Wu, Songgao Zhang, Funan Qiu, Yi Huang
Summary: Serum IgG autoantibodies against p53, CTAG1A, and TIF1 gamma, as well as IgA autoantibody against TIF1 gamma, present diagnostic value for early HCC, with anti-p53-IgG being a preferable biomarker. The panel comprised of four autoantibodies might contribute to early HCC diagnosis.
CLINICA CHIMICA ACTA
(2021)
Article
Cell Biology
Ye Lei, Hong-Fen Shen, Qi-Wen Li, Sheng Yang, Hong-Ting Xie, Xu-Feng Li, Mei -Ling Chen, Jia-Wei Xia, Sheng-Chun Wang, Guan-Qi Dai, Ying Zhou, Ying-Chun Li, Shi-Hao Huang, Dan-Hua He, Zhi-Hao Zhou, Jin-Ge Cong, Xiao-Lin Lin, Tao-Yan Lin, Ai -Bing Wu, Dong Xiao, Sheng-Jun Xiao, Xin-Ke Zhang, Jun-Shuang Jia
Summary: Bmi-1 is overexpressed in various cancer types, including nasopharyngeal carcinoma (NPC). High Bmi-1 levels were observed in NPC cell lines and specimens, especially in advanced cases. Depletion of Bmi-1 suppressed cell proliferation, induced cell cycle arrest, reduced cell stemness, and inhibited cell migration and invasion in NPC cells. Hairy gene homolog (HRY) upregulated Bmi-1 by binding to its promoter, promoting NPC cell stemness. Silencing Bmi-1 suppressed NPC progression.
Article
Oncology
Yunlai Liang, Yating Ma, Kun Wang, Manglin Xiang, Bin Yi
Summary: The association of NUCB-2/Nesfatin-1 with nasopharyngeal carcinoma was unclear, so this study aimed to clarify its role in the development, progression, and diagnosis of NPC. The results showed that NUCB-2 level was higher in NPC tissue than in rhinitis tissue, and suppression of NUCB-2 inhibited NPC cell proliferation while improvement of NUCB-2 promoted cell propagation. Moreover, serum NUCB-2 level could potentially be a serological marker for the early diagnosis of nasopharyngeal carcinoma.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Qianyu Zhu, Pingping He, Cuiling Zheng, Zhibin Chen, Saiping Qi, Donghu Zhou, Yanmeng Li, Qin Ouyang, Huaduan Zi, Hengcheng Tang, Jie Xing, Yibin Xie, Shengtao Zhu, Jiansong Ren, Jian Huang
Summary: In this study, novel serum autoantibody-based biomarkers for precancerous lesion and early gastric cancer were identified. The identified autoantibodies showed higher levels in patients compared with healthy individuals and had good potential for differentiating between different stages of gastric cancer. Predictive models incorporating these autoantibodies improved the diagnostic efficiency for early detection of gastric cancer and precancerous lesion.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Ao Zhang, Guanqing Zhong, Luocan Wang, Rongzeng Cai, Runkun Han, Caixia Xu, Shulin Chen, Peng Sun, Hao Chen
Summary: This study aimed to explore reliable and minimally invasive prognostic indicators for predicting the efficacy of PD-1 inhibitors combination therapy in recurrent or metastatic nasopharyngeal carcinoma (RM-NPC). A risk score prediction model was constructed based on dynamic changes in LDH and AST/ALT, which showed predictive and prognostic value for NPC patients treated with PD-1 inhibitors. The high-risk group identified by the model had shorter progression-free survival compared to the low-risk group, demonstrating the potential utility of dynamic serum markers in predicting treatment outcomes in RM-NPC patients.
CANCER CELL INTERNATIONAL
(2021)
Review
Immunology
Maheswari Muruganandam, Angie Ariza-Hutchinson, Rosemina A. Patel, Wilmer L. Sibbitt
Summary: Systemic sclerosis is a complex autoimmune disease characterized by vascular damage, inflammation, and fibrosis. Biomarkers play an important role in understanding the disease process and potential therapeutic targets. Anti-nuclear antibodies are classical biomarkers, while other proteins and pathways are also implicated. The use of biomarker panels combined with advanced analysis techniques can help determine disease activity and treatment response.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Oncology
Shan-Qiang Zhang, Su-Ming Pan, Shu-Zhen Lai, Hui-Jing Situ, Jun Liu, Wen-Jie Dai, Si-Xian Liang, Li-Qing Zhou, Qi-Qi Lu, Pei-Feng Ke, Fan Zhang, Hai-Bin Chen, Ji-Cheng Li
Summary: This study aimed to identify biomarkers for early identification of beneficiaries of induction chemotherapy (IC) in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC). By analyzing the plasma protein expression profiles, proteins associated with IC benefits were identified, including PON1, IGFBP3, v-kappa-3, and DDX55. These proteins may play a significant role in IC treatment and can be used for individualized treatment of nasopharyngeal carcinoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Minjie Mao, Xueping Wang, Hui Sheng, Huilan Li, Wen Liu, Runkun Han, Wangrong Wen, Wanli Liu
Summary: The study revealed that plasma HSP90 alpha level is closely associated with the clinical stage, metastasis, and therapeutic effect of NPC, indicating it may serve as a new biomarker for the diagnosis and treatment of NPC.
ADVANCES IN THERAPY
(2021)
Review
Otorhinolaryngology
Yue Yuan, Fei Ye, Jian-Hui Wu, Xiao-Yan Fu, Zhong-Xi Huang, Tao Zhang
Summary: This paper reviews recent advances in early screening for nasopharyngeal carcinoma (NPC) and cell-free DNA (cfDNA) methylation, highlighting the low positive predictive value (PPV) of current screening methods and the potential of combining cfDNA methylation analysis with Epstein-Barr virus (EBV) serological testing to improve PPV.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Mahdokht Kohansal-Nodehi, Magdalena Swiatek-de Lange, Konstantin Kroeniger, Vinzent Rolny, Gloria Tabares, Teerha Piratvisuth, Tawesak Tanwandee, Satawat Thongsawat, Wattana Sukeepaisarnjaroen, Juan Ignacio Esteban, Marta Bes, Bruno Koehler, Henry Lik-Yuen Chan, Holger Busskamp
Summary: The site-specific glycosylation profile of Haptoglobin (Hp) was analyzed in patients with liver diseases, early-stage hepatocellular carcinoma (HCC), and late-stage HCC. The study identified Hp glycopeptides that showed significant differences in early- and late-stage HCC. Some of these glycobiomarkers had higher diagnostic value than the commonly used biomarker AFP. These findings suggest that glycobiomarkers can be effective in the early diagnosis of HCC.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell Biology
Jia-Mei Dong, Rui-Qi Wang, Ning-Ning Yuan, Jia-Hao Guo, Xin-Yang Yu, Ang-Hui Peng, Jia-Yi Cai, Lei Xue, Zhi-Ling Zhou, Yi-Hao Sun, Ying-Yin Chen
Summary: Hepatocellular carcinoma (HCC), accounting for 90% of all primary liver cancers, is a major malignancy globally. Aptasensors, known for their high sensitivity, excellent selectivity, and low production costs, have attracted attention for the diagnosis and surveillance of HCC. Optical aptasensors, offering advantages of a wide range of targets, rapid response, and simple instrumentation, show great potential in early diagnosis and prognosis monitoring of HCC. This review summarizes recent progress in various types of optical aptasensors for biomarkers in HCC, evaluates their strengths and limitations, and discusses the challenges and future perspectives for their use in HCC diagnosis and surveillance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Pei-Chun Hsueh, Kai-Ping Chang, Hao-Ping Liu, Wei-Fan Chiang, Xiu-Ya Chan, Chu-Mi Hung, Lichieh Julie Chu, Chih-Ching Wu
Summary: This study evaluated the performance of nine salivary autoantibodies as biomarkers for oral cavity squamous cell carcinoma (OSCC). A panel of four autoantibodies achieved high sensitivity and specificity for early diagnosis of OSCC. This multiplex autoantibody platform shows clinical applicability for OSCC screening.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Chao-Qun Hong, Xue-Fen Weng, Xu-Chun Huang, Ling-Yu Chu, Lai-Feng Wei, Yi-Wei Lin, Liu-Yi Chen, Can-Tong Liu, Yi-Wei Xu, Yu-Hui Peng
Summary: A panel of autoantibodies targeting BMI-1, HSP70, NY-ESO-1, and p53 showed potential in detecting early stage breast cancer with high sensitivity and specificity.
Article
Oncology
Zhibin Chen, Jie Xing, Cuiling Zheng, Qianyu Zhu, Pingping He, Donghu Zhou, Xiaojin Li, Yanmeng Li, Saiping Qi, Qin Ouyang, Bei Zhang, Yibin Xie, Jiansong Ren, Bangwei Cao, Shengtao Zhu, Jian Huang
Summary: This study identified CETN2 and POFUT1 autoantibodies as potential diagnostic markers for early ESCC and HGIN using serological proteome analysis and ELISA.
FRONTIERS IN ONCOLOGY
(2023)