Article
Biochemistry & Molecular Biology
Tatiana J. Carneiro, Joana Pinto, Eva M. Serrao, Antonio S. Barros, Kevin M. Brindle, Ana M. Gil
Summary: Using NMR metabolomics, specific metabolic markers were identified to distinguish pancreatic inflammation from normal and precancerous tissue. The study also revealed metabolic changes associated with the progression from inflammation to pancreatic cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Stephano S. Mello, Brittany M. Flowers, Pawel K. Mazur, James J. Lee, Fabian Muelle, Sarah K. Denny, Sofia Ferreira, Kathryn Hanson, Seung K. Kim, William J. Greenleaf, Laura D. Wood, Laura D. Attardi
Summary: The majority of pancreatic ductal adenocarcinomas (PDACs) have TP53 mutations, highlighting the critical role of p53 in suppressing PDAC. This study shows that p53 suppresses PDAC by limiting acinar-to-ductal metaplasia (ADM) and suppressing PanIN cell proliferation. Furthermore, p53 dampens KRAS signaling in PanINs and regulates ECM remodeling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Oncology
Guillaume Le Cosquer, Charlotte Maulat, Barbara Bournet, Pierre Cordelier, Etienne Buscail, Louis Buscail
Summary: Chronic alcoholic pancreatitis is a major risk factor for pancreatic cancer. The risk is higher for hereditary pancreatitis, with PRSS1 and SPINK1 mutations having a risk of 19% and 12% respectively. The diagnosis is difficult due to the similarity in clinical and radiological features of chronic pancreatitis and pancreatic cancer. Endoscopic ultrasound-guided fine-needle biopsy with molecular biology can assist in diagnosis. Short-term follow-up is necessary for chronic pancreatitis patients with clinical and radiological suspicion of cancer, and pancreatic surgery may be required if doubt persists.
Review
Health Care Sciences & Services
Darren Cowzer, Mohammed Zameer, Michael Conroy, Walter Kolch, Austin G. Duffy
Summary: This article reviews therapeutic innovations targeting RAS signaling in pancreatic cancer from a clinical perspective. Despite the strong resistance of pancreatic cancer to treatment, new approaches such as inhibiting mutated KRAS, KRAS activators, and effectors show promise in breaking this therapeutic deadlock.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jihao Tu, Zhehao Huang, Yin Wang, Meijing Wang, Zukun Yin, Xianglin Mei, Meiying Li, Lisha Li
Summary: This study analyzed transcriptome data and constructed co-expression networks to reveal gradually activated gene networks during the progression of pancreatic diseases. The number of differentially expressed genes increases as the pancreatic disease worsens, with upregulation of gene networks involving T cells and interferon.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Oncology
Katherine J. Aney, Sahar Nissim
Summary: Studies have highlighted the potential role of NR5A2 in modulating PDAC risk, with findings suggesting that NR5A2 may contribute to PDAC precursors in ways beyond its previously characterized acinar cell-autonomous role. Understanding these roles will be crucial for guiding new preventive and treatment strategies for PDAC.
JOURNAL OF PATHOLOGY
(2021)
Article
Gastroenterology & Hepatology
John M. DeWitt, Mohammad A. Al-Haddad, Jeffrey J. Easler, Stuart Sherman, James Slaven, Timothy B. Gardner
Summary: Real-time EUS findings and ePFTs significantly impact the clinical assessment of MCCP. The diagnosis of EPI shows poor correlation with the EUS diagnosis of MCCP.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Public, Environmental & Occupational Health
Signe E. J. Hansen, Anne Langsted, Anette Varbo, Christian M. Madsen, Anne Tybjaerg-Hansen, Borge G. Nordestgaard
Summary: The study found that extreme low and high plasma pancreatic amylase levels were associated with a 2-3 fold higher risk of pancreatic cancer and chronic pancreatitis in apparently healthy individuals from the general population.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
J. H. Strickler, H. Satake, T. J. George, R. Yaeger, A. Hollebecque, I Garrido-Laguna, M. Schuler, T. F. Burns, A. L. Coveler, G. S. Falchook, M. Vincent, Y. Sunakawa, L. Dahan, D. Bajor, S-Y Rha, C. Lemech, D. Juric, M. Rehn, G. Ngarmchamnanrith, P. Jafarinasabian, Q. Tran, D. S. Hong
Summary: This study evaluated the safety and efficacy of sotorasib in patients with KRAS p.G12C-mutated pancreatic cancer who had previously received treatment. The results showed that sotorasib demonstrated anticancer activity and had an acceptable safety profile in these patients.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Editorial Material
Medicine, General & Internal
Cornelis J. M. Melief
Summary: Pancreatic ductal adenocarcinoma is the deadliest of all common cancers. The study reported remarkable deep and durable tumor shrinkage in a heavily pretreated patient who received an infusion of autologous T cells transduced.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Anna C. Lilly, Igor Astsaturov, Erica A. Golemis
Summary: Pancreatic cancer is difficult to detect and treat, resulting in poor survival outcomes. The increasing incidence of this cancer is related to aging populations, obesity, and pancreatitis. Risk factors for pancreatic cancer include signaling from fat cells, elevated levels of intrapancreatic adipocytes, inflammation from immune cells, and fibrosis caused by pancreatic obstruction and cell lysis. Further studies are needed to understand the role of adipocytes in the pre-cancerous niche and their implications in mouse models.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Yenan Wu, Isabelle Seufert, Fawaz N. Al-Shaheri, Roman Kurilov, Andrea S. Bauer, Mehdi Manoochehri, Evgeny A. Moskalev, Benedikt Brors, Christin Tjaden, Nathalia A. Giese, Thilo Hackert, Markus W. Buechler, Joerg D. Hoheisel
Summary: A signature of six DNA methylation sites has been identified to effectively distinguish pancreatic ductal adenocarcinoma (PDAC) from chronic pancreatitis (CP), with 100% diagnostic accuracy. The success of this machine-learning approach could greatly impact treatment success in patients with suspected pancreatic cancer.
Review
Gastroenterology & Hepatology
I. J. Visser, I. J. M. Levink, M. P. Peppelenbosch, G. M. Fuhler, M. J. Bruno, D. L. Cahen
Summary: DNA alterations in pancreatic juice have high specificity for detecting high-grade dysplasia or pancreatic cancer, but their sensitivity is poor, which can be improved by combining multiple DNA alterations.
Article
Endocrinology & Metabolism
Liang Qi, Qiong Wei, Muhan Ni, Dechen Liu, Jiantong Bao, Yingqi Lv, Hong Xia, Qian Wang, Lei Wang, Jianhua Su, S. J. Pandol, Ling Li
Summary: This study investigated the pancreatic and gut hormone responses in patients with post-chronic pancreatitis diabetes mellitus (PPDM-C) compared to non-diabetic chronic pancreatitis (CP), type 2 diabetes patients, and healthy controls. The results showed that PPDM-C patients exhibited decreased responses of C-peptide, insulin, ghrelin, and PYY, and similar levels of glucagon, PP, GIP, and GLP-1 compared to type 2 diabetes patients. These findings provide valuable insights for the diagnosis and understanding of PPDM-C.
DIABETES & METABOLISM
(2022)
Article
Oncology
Ananya Chakraborty, Bithika Halder, Souravi Mondal, Amanda Barrett, Wenbo Zhi, Gabor Csanyi, Maria E. Sabbatini
Summary: Patients with chronic pancreatitis (CP) are at higher risk of pancreatic ductal adenocarcinoma (PDAC) compared to the general population. Activated pancreatic stellate cells (PaSCs) in CP play a role in the progression of non-invasive pancreatic intraepithelial neoplasia (PanIN) to invasive PDAC. In this study, we investigated the role of NADPH oxidase 1 (Nox1) in CP-activated PaSCs and found that Nox1 enhances the growth and invasion of pancreatic cancer cells through Twist1/MMP-9 expression and changes in the extracellular matrix composition. Blocking Nox1 signaling in CP-activated PaSCs can potentially reduce extracellular matrix reorganization and protect neoplastic cells from cellular stresses, thereby ameliorating the progression of PDAC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
