Article
Oncology
Wonkyo Shin, Sang-Yoon Park, Sokbom Kang, Myong Cheol Lim, Sang-Soo Seo
Summary: The study aimed to evaluate the prognosis in patients with synchronous endometrial and ovarian cancer by comparing differences between double primary cancer and metastatic cancer. Results showed that although patients with double primary cancer had longer overall survival, multivariate analysis did not identify any influential factors.
Article
Biochemistry & Molecular Biology
M. M. Alawadhi, F. Al Shammari, F. Mulla Ali, R. Almatar, A. Al-Duwaikhi, M. D. Al-Bader
Summary: Dexamethasone (DEX) induces intrauterine growth restriction (IUGR) by altering the expression of placental MTA1 and MTA3 antigens, while progesterone (P4) improves pregnancy outcome by preventing these changes in MTA expression.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Lucia Manganaro, Gabriele Maria Nicolino, Miriam Dolciami, Federica Martorana, Anastasios Stathis, Ilaria Colombo, Stefania Rizzo
Summary: Radiomics is a developing field focusing on finding connections between quantitative information extracted from imaging exams and clinical data to aid in clinical decision-making. Recent studies have largely examined the role of radiomics in gynecological malignancies, particularly in relation to cervical and endometrial cancers.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Chenlin Liu, Jun Han, Xiaoju Li, Tonglie Huang, Yuan Gao, Baolong Wang, Kuo Zhang, Shuning Wang, Wangqian Zhang, Weina Li, Qiang Hao, Meng Li, Yingqi Zhang, Cun Zhang
Summary: This study systematically explored a new mechanism by which FOXP3 inhibits breast cancer metastasis through the FOXP3-MTA1 pathway. It was found that FOXP3 downregulated MTA1 expression in breast cancer cells by directly inhibiting MTA1 promoter activity, affecting the invasion and metastasis abilities of breast cancer cells. Clinical data showed a significant negative correlation between the expression levels of FOXP3 and MTA1 in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yuko Horiba, Tetsuhiro Yoshino, Megumi Yokota, Takashi Iwata, Kenji Watanabe, Masaru Mimura, Daisuke Aoki
Summary: This study compared climacteric symptoms among patients who underwent surgery for endometrial, ovarian, and cervical cancer, finding that symptoms were more severe in patients with cervical cancer and decreased with longer time elapsed since surgery.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Obstetrics & Gynecology
Nicole Minalt, Amy Caldwell, Grace M. Yedlicka, Sophia Joseph, Sharon E. Robertson, Lisa M. Landrum, Jeffrey F. Peipert
Summary: The intrauterine device (IUD) is a highly effective form of contraception and its use has been increasing in the United States. The two types of IUDs available are the levonorgestrel-releasing IUD and the copper IUD. The levonorgestrel IUD suppresses the endometrium and thickens cervical mucus, while the copper IUD creates an inflammatory response to prevent fertilization. The evidence suggests that both types of IUDs reduce the risk of gynecologic cancers, although the effects on cervical and ovarian cancers are less consistent.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jialu Ma, Chunxiao Li, Haili Qian, Yong Zhang
Summary: Prostate cancer is one of the most common cancers in the male genitourinary system, with a significant increase in morbidity and mortality in recent years. MTA1, a transcriptional coregulator, plays a crucial role in the formation, progression, and metastasis of PCa, making it a potential target for treatment.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Jan Korbecki, Mateusz Bosiacki, Katarzyna Barczak, Ryta Lagocka, Agnieszka Brodowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: CXCL1, a member of the CXC chemokine subfamily, is mainly responsible for attracting neutrophils in the immune system. This review summarizes the clinical significance and involvement of CXCL1 in major reproductive cancers, including breast cancer, cervical cancer, endometrial cancer, ovarian cancer, and prostate cancer. It focuses on the clinical aspects, molecular contributions, and impact of CXCL1 on the tumor microenvironment. The significance of introducing CXCL1-targeting drugs and the role of ACKR1/DARC in reproductive cancers are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Feng Pang, Dong Shi, Lin Yuan
Summary: Cervical cancer, ovarian cancer, and endometrial cancer are the top three cancers in women. This study utilized gene chip and high-throughput sequencing technology to analyze genomic functional omics data and identify potential markers for diagnosis and treatment. The study also explored common differentially expressed genes (DEGs) among these cancers using public databases. The results revealed that DEGs were involved in biological processes such as cell division, mitotic nuclear division, sister chromatid cohesion, and DNA replication. The DEGs also exhibited specific functions in cell components and molecular functions. Additionally, pathway analysis indicated enrichment of upregulated DEGs in cell cycle-related pathways, while downregulated DEGs were enriched in pathways related to thiamine metabolism and protein processing in the endoplasmic reticulum. The most significant module was associated with cell division and microtubule motor activity.
CURRENT BIOINFORMATICS
(2023)
Article
Oncology
Na Guo, Jiawen Zhang
Summary: IL-17 promotes the development and invasion of ovarian cancer cells by upregulating MTA1 expression. These findings provide a new target for ovarian cancer treatment and an important supplement to the study of IL-17 target sites and pathways.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Obstetrics & Gynecology
Philippe Van Trappen
Summary: The concept of pelvic sentinel lymph node mapping has been well investigated in endometrial and cervical cancer, showing safety, efficacy, and diagnostic accuracy. The concept of pelvic sentinel lymph node biopsy has been incorporated in international guidelines for early-stage endometrial and cervical cancer. The application of para-aortic sentinel lymph node mapping is still in development but shows promising results in initial studies.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Anna Golara, Mateusz Kozlowski, Pawel Guzik, Sebastian Kwiatkowski, Aneta Cymbaluk-Ploska
Summary: Selenium and manganese are essential micronutrients that play important roles in cell metabolism. They are involved in enzyme systems and regulate enzyme activity. Disturbances in their homeostasis can lead to diseases and carcinogenesis due to increased oxidative stress and impaired antioxidant properties. Selenium maintains immune-endocrine, metabolic, and cellular homeostasis, while manganese is important in development, digestion, reproduction, antioxidant defense, energy production, immune response, and regulation of neuronal activity. This review highlights their roles in tumor growth, metastasis, and microenvironment remodeling, and their potential as biomarkers for diagnosis and treatment of reproductive organ cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Fengguang Zhai, Jie Wang, Weili Yang, Meng Ye, Xiaofeng Jin
Summary: This paper summarizes the E3 ligases relevant to endometrial carcinoma (EC) and cervical cancer (CC), highlighting their significant roles in the occurrence and progression of these cancers. Additionally, research progress in targeting the ubiquitination process in EC and CC is discussed in this review.
Article
Biochemical Research Methods
Parul Mittal, Matthew Briggs, Manuela Klingler-Hoffmann, Gurjeet Kaur, Nicolle H. Packer, Martin K. Oehler, Peter Hoffmann
Summary: N-linked glycan MALDI MSI can differentiate between normal and cancerous endometrium, as well as endometrial cancer with lymph node metastasis from endometrial cancer without metastasis. This technique has the potential to aid in the identification and characterization of glycan alterations associated with cancer progression.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ting Wang, Fangzhou Sun, Chunxiao Li, Peng Nan, Yan Song, Xuhao Wan, Hongnan Mo, Jinsong Wang, Yantong Zhou, Yuzheng Guo, Aya Ei Helali, Dongkui Xu, Qimin Zhan, Fei Ma, Haili Qian
Summary: Liver metastasis is the most fatal event of colon cancer patients. The study identifies MTA1 as a new ATP synthase modulator that facilitates colon cancer liver metastasis by driving mitochondrial bioenergetic metabolism reprogramming and enhancing oxidative phosphorylation. MTA1 knockout increases the sensitivity of colon cancer to mitochondrial bioenergetic metabolism-targeted drugs and mTOR inhibitors, and inhibiting ATP5A enhances the sensitivity of liver-metastasized colon cancer to sirolimus in an MTA1-dependent manner.
