Journal
CANCER
Volume 124, Issue 19, Pages 3909-3917Publisher
WILEY
DOI: 10.1002/cncr.31666
Keywords
adolescents and young adults (AYAs); pediatric; psychosocial; quality of life; randomized controlled trial; resilience
Categories
Funding
- National Institutes of Health [KL2TR000421]
- CureSearch for Children's Cancer
- NATIONAL CANCER INSTITUTE [K12CA088084] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [KL2TR000421] Funding Source: NIH RePORTER
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BACKGROUND: Adolescents and young adults (AYAs) with cancer are at risk for poor psychosocial outcomes. This study aimed to determine whether a novel intervention targeting resilience resources would improve patient-reported resilience, quality of life, and psychological distress. METHODS: In this parallel. phase 2 randomized controlled trial, English-speaking AYAs (12-25 years old) with cancer were randomized to the Promoting Resilience in Stress Management (PRISM) intervention or usual care (UC). PRISM is a brief. skills-based intervention targeting stress management, goal setting, cognitive reframing, and meaning making. Participants completed surveys at enrollment and 6 months. Mixed effects regression models evaluated associations between PRISM and the primary outcome (10-item Connor-Davidson Resilience Scale scores) and secondary outcomes (generic and cancer-related quality of life [Pediatric Quality of Life modules], psychological distress [Kessler-6], and anxiety/depression [Hospital Anxiety and Depression]) at 6 months. RESULTS: Ninety-two AYAs were enrolled, were randomized, and completed baseline surveys (48 in the PRISM group and 44 in the UC group); 73% were 12 to 17 years old, and 62% had leukemia or lymphoma. Attrition was primarily due to medical complications and/or death; 36 PRISM participants and 38 UC participants completed 6-month surveys. PRISM was associated with improved resilience (+3.0 points; 95% confidence interval [Cl], 0.5-5.4; P = .02) and cancer-specific quality of life (+9.6; 95% Cl, 2.6-16.7; P = .01) and reduced psychological distress (-2.1: 95% Cl, -4.1 to -0.2; P = .03) but not generic quality of life (+7.2; 95% Cl. -0.8 to 151: P = .08). Although anxiety was similar between the groups, 2 PRISM participants (6%) and 8 UC participants (21%) met the criteria for depression at 6 months (odds ratio. 0.09; 95% CI, 0.01-1.09: P = .06). CONCLUSIONS: PRISM was associated with improved psychosocial outcomes in comparison with UC, suggesting that brief, skills-based interventions for AYAs may provide a benefit. (C) 2018 American Cancer Society.
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