Review
Biochemistry & Molecular Biology
Xin Zhou, Xiaoshen Wang
Summary: This review provides a detailed illustration of the biology, genomic features, and immune landscapes of HPV-associated HNSCC, supporting the synergistic effect of radioimmunotherapy. Current evidence and ongoing clinical trials suggest the potential of radioimmunotherapy in recurrent/metastatic or definitive settings. Future challenges include optimization of radiotherapy and the incorporation of novel therapeutic options.
Article
Microbiology
Abbas Karimi, Elham Mohebbi, Sandrine Mckay-Chopin, Hamideh Rashidian, Maryam Hadji, Vahideh Peyghambari, Maryam Marzban, Ahmad Naghibzadeh-Tahami, Mahin Gholipour, Farin Kamangar, Massimo Tommasino, Tarik Gheit, Kazem Zendehdel
Summary: This study analyzed the detection of alpha-, beta-, and gamma-HPVs in oral rinse samples of HNSCC cases and controls in Iran, finding that the contribution of alpha-HPVs to HNSCC in Iran is lower than global prevalence, and high-risk alpha-HPVs or cutaneous beta- and gamma-HPVs were not associated with HNSCC development.
MICROBIOLOGY SPECTRUM
(2022)
Article
Oncology
Ping Wu, Chubo Xie, Ling Yang, Yalan Liu, Junfeng Zeng, Xin Li, Xing Fang, Yuhua Fan, Suping Zhao, Ni Kuang, Tao Xuan, Xuefeng Xia, Xin Yi, Yi Huang, Zicheng Yu, Yaoyun Tang
Summary: This study used next-generation sequencing to analyze genetic alterations in different samples of HNSCC patients, finding that TATs may inherit tumorigenic mutations from ancestral clones where the tumor originated or gain private mutations independent of the primary tumors, suggesting that TATs may play an important role in HNSCC relapse.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Laurence Bauwens, Aline Baltres, Danny-Joe Fiani, Philippe Zrounba, Guillaume Buiret, Bertrand Fleury, Nazim Benzerdjeb, Vincent Gregoire
Summary: The study aimed to compare the prevalence and distribution of neck node metastases in HPV+ and HPV- oropharyngeal squamous cell carcinoma patients, showing a higher rate of metastases in the HPV+ group.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shu Wang, Xibing Zhuang, Caixia Gao, Tiankui Qiao
Summary: The study found that the expression of p16, p53, and TLR9 in HNSCC is strongly associated with HPV status. High expression of p53 and TLR9 may be linked to poor prognosis. The two-marker signature of high p16/low p53 in tumor cells is a reliable tool for predicting patient survival in HNSCC.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Erin T. Wong, Shao Hui Huang, Brian O'Sullivan, Vincent Persaud, Jie Su, John Waldron, David P. Goldstein, John de Almeida, Jolie Ringash, John Kim, Andrew Hope, Scott Bratman, John Cho, Meredith Giuliani, Ali Hosni, Anna Spreafico, Aaron Hansen, Li Tong, Wei Xu, Eugene Yu
Summary: The study on surveillance imaging utilization pattern of head and neck revealed that imaging surveillance reduces the need for neck dissection, but routine surveillance without clinical symptoms/signs may not effectively identify locoregional failure or toxicity. For radiologic residual LNs, if two consecutive follow-up scans demonstrate stable/regressing features, clinical surveillance without further imaging appears to be safe.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Hans Prakash Sathasivam, Sangeetha Passu Davan, Szu May Chua, Rahmuna Fazlina Rohaizat, Rohaizam Japar, Zahirrudin Zakaria, Abd Razak Ahmad, Hasmah Hashim, Shashi Gopalan Marimuthu, Yew Toong Liew, Doh Jeing Yong, Pappathy Vairavan, Avatar Singh Mohan Singh, Benjamin Hong Beng Goh, Zulkifli Yusof, Khairul Azlan Shahril Abu Dahari, Ali Haron, Masaany Mansor, Mohd Zambri Ibrahim, Shiraz Qamil Muhammad Abdul Kadar, Mohamad Hazri Hamal, Wan Emelda Wan Mohamad
Summary: The prevalence of HPV-associated OPSCC is increasing in Malaysia, especially in Chinese patients. While patients with HPV-associated OPSCC have better overall survival, traditional risk factors should still be considered for prognosis evaluation.
INFECTIOUS AGENTS AND CANCER
(2023)
Article
Oncology
Jad Chahoud, Frederico O. Gleber-Netto, Barrett Z. McCormick, Priya Rao, Xin Lu, Ming Guo, Maggaret B. Morgan, Randy A. Chu, Magaly Martinez-Ferrer, Agda Karina Eterovic, Curtis R. Pickering, Curtis A. Pettaway
Summary: This study conducted whole-exome sequencing analysis on penile squamous cell carcinoma (PSCC) and found that most PSCC samples showed enrichment for Notch pathway alterations, and the mutation signatures were most comparable with head and neck squamous cell carcinoma (HNSC). A subset of PSCC patients with enrichment of APOBEC-related mutation signature had significantly higher tumor mutation burden and worse overall survival.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Masato Mima, Atsushi Okabe, Takayuki Hoshii, Takuya Nakagawa, Tomoya Kurokawa, Satoru Kondo, Harue Mizokami, Masaki Fukuyo, Ryoji Fujiki, Bahityar Rahmutulla, Tomokazu Yoshizaki, Toyoyuki Hanazawa, Kiyoshi Misawa, Atsushi Kaneda
Summary: Human papillomavirus (HPV) plays a causal role in the development of head and neck squamous cell carcinoma (HNSCC) by integrating into the host genome and causing genomic alterations. This study analyzed the epigenome, transcriptome, and interactome of HPV-positive HNSCCs to understand the role of epigenetic dysregulation in tumorigenesis. The results showed that genes neighboring HPV integration sites were upregulated and correlated with oncogenic phenotypes in HPV-positive HNSCCs. The epigenetic activation of HPV-interacting regions (HPVIRs) contributed to the genesis of HPV-positive HNSCC.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Oncology
Dauren Adilbay, Saudamini Lele, John Pang, Ameya Asarkar, Jason Calligas, Cherie-Ann Nathan
Summary: Circulating human papillomavirus (HPV) DNA is a promising tool in managing HPV-positive oropharyngeal cancer, enabling changes in treatment, diagnosis, and patient monitoring. With the increasing incidence of HPV-related head and neck cancers, the use of circulating HPV DNA can help identify patients suitable for de-escalation protocols and those at risk of treatment failure.
Editorial Material
Genetics & Heredity
David J. Peace, Evgeny Izumchenko, David Sidransky
Summary: A study uses single-cell RNA sequencing to analyze human papillomavirus (HPV)-positive and -negative oropharyngeal squamous cell carcinoma, discovering significant diversity within and between tumors. In HPV-positive tumors, subsets of malignant cells are identified with undetectable HPV expression and decreased HPV-related phenotypes, potentially impacting prognosis and therapeutic response.
Review
Biology
Delphine Avril, Jean-Philippe Foy, Jebrane Bouaoud, Vincent Gregoire, Pierre Saintigny
Summary: This article aims to review recently proposed biomarkers of radioresistance in HPV-negative HNSCC, which can be useful for stratifying tumor patients based on their predicted level of radioresistance.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Pathology
Justin R. Shinn, Seth J. Davis, Krystle A. Lang-Kuhs, Sarah Rohde, Xiaowei Wang, Ping Liu, William D. Dupont, Dale Plummer, Wade L. Thorstad, Rebecca D. Chernock, Mitra Mehrad, James S. Lewis
Summary: The study found a high positivity rate of p16 and HPV mRNA in oropharyngeal squamous cell carcinoma patients, with those who had concordant testing results showing higher survival rates. While patients with discordant testing results had survival rates falling between the two concordant groups, there was no significant difference found in outcomes in multivariate analysis.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Oncology
Rita Abi-Raad, Manju L. Prasad, Syed Gilani, James Garritano, Deborah Barlow, Guoping Cai, Adebowale J. Adeniran
Summary: At least 40% of p16 expression in tumor clusters may be appropriate threshold for p16 positivity in cytology CB specimens. HPV by PCR on needle rinse can serve as a substitute for p16 expression in surgical specimens, with 88% sensitivity and 100% specificity.
CANCER CYTOPATHOLOGY
(2021)
Article
Oncology
Hira Shaikh, Julie E. McGrath, Brittany Hughes, Joanne Xiu, Pavel Brodskiy, Ammar Sukari, Sourat Darabi, Chukwuemeka Ikpeazu, Chadi Nabhan, Wolfgang Michael Korn, Trisha M. Wise-Draper
Summary: Recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) patients overall have a poor prognosis. Human papillomavirus (HPV)-associated R/M oropharyngeal squamous cell carcinoma (OPSCC) is associated with a better prognosis compared to HPV-negative disease. Immune checkpoint blockade (ICB) is the standard of care for R/M HNSCC, but whether HPV and p16 predict an improved response to ICB remains controversial.
Article
Oncology
Chao Liu, Theresa Guo, Guorong Xu, Akihiro Sakai, Shuling Ren, Takahito Fukusumi, Mizuo Ando, Sayed Sadat, Yuki Saito, Zubair Khan, Kathleen M. Fisch, Joseph Califano
CLINICAL CANCER RESEARCH
(2018)
Article
Multidisciplinary Sciences
Mizuo Ando, Yuki Saito, Guorong Xu, Nam Q. Bui, Kate Medetgul-Ernar, Minya Pu, Kathleen Fisch, Shuling Ren, Akihiro Sakai, Takahito Fukusumi, Chao Liu, Sunny Haft, John Pang, Adam Mark, Daria A. Gaykalova, Theresa Guo, Alexander Favorov, Srinivasan Yegnasubramanian, Elana J. Fertig, Patrick Ha, Pablo Tamayo, Tatsuya Yamasoba, Trey Ideker, Karen Messer, Joseph A. Califano
NATURE COMMUNICATIONS
(2019)
Article
Oncology
Chao Liu, Theresa Guo, Akihiro Sakai, Shuling Ren, Takahito Fukusumi, Mizuo Ando, Sayed Sadat, Yuki Saito, Joseph A. Califano
Article
Otorhinolaryngology
Mizuo Ando, Hiroshi Kobayashi, Aya Shinozaki-Ushiku, Hirotaka Chikuda, Yoshitaka Matsubayashi, Masafumi Yoshida, Yuki Saito, Shinji Kohsaka, Katsutoshi Oda, Kiyoshi Miyagawa, Hiroyuki Aburatani, Hiroyuki Mano, Tatsuya Yamasoba
AURIS NASUS LARYNX
(2020)
Article
Oncology
Chao Liu, Sayed H. Sadat, Koji Ebisumoto, Akihiro Sakai, Bharat A. Panuganti, Shuling Ren, Yusuke Goto, Sunny Haft, Takahito Fukusumi, Mizuo Ando, Yuki Saito, Theresa Guo, Pablo Tamayo, Huwate Yeerna, William Kim, Jacqueline Hubbard, Andrew B. Sharabi, J. Silvio Gutkind, Joseph A. Califano
CLINICAL CANCER RESEARCH
(2020)
Article
Otorhinolaryngology
Yuki Saito, Alexander Favorov, Michael Forman, Shuling Ren, Akihiro Sakai, Takahito Fukusumi, Chao Liu, Sayed Sadat, Mizuo Ando, Guorong Xu, Zubair Khan, John Pang, Alex Valsamakis, Kathleen M. Fisch, Joseph A. Califano
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2020)
Article
Otorhinolaryngology
Sarek Shen, Yuki Saito, Shuling Ren, Chao Liu, Theresa Guo, Jesse Qualliotine, Zubair Khan, Sayed Sadat, Joseph A. Califano
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2020)
Article
Multidisciplinary Sciences
Akihiro Sakai, Mizuo Ando, Takahito Fukusumi, Shuling Ren, Chao Liu, Jesse Qualliotine, Sunny Haft, Sayed Sadat, Yuki Saito, Theresa W. Guo, Guorong Xu, Roman Sasik, Kathleen M. Fisch, J. Silvio Gutkind, Elana J. Fertig, Alfredo A. Molinolo, Joseph A. Califano
Article
Oncology
Yuki Saito, Ryuichi Hayashi, Yoshiyuki Iida, Takatsugu Mizumachi, Takashi Fujii, Fumihiko Matsumoto, Takeshi Beppu, Masafumi Yoshida, Hirotaka Shinomiya, Ryosuke Kamiyama, Mutsukazu Kitano, Kazuhiko Yokoshima, Yasushi Fujimoto, Takanori Hama, Taku Yamashita, Kenji Okami, Kouki Miura, Takuo Fujisawa, Daisuke Sano, Hisayuki Kato, Shujiro Minami, Masashi Sugasawa, Muneyuki Masuda, Ichiro Ota, Shigemichi Iwae, Ryo Kawata, Nobuya Monden, Takayuki Imai, Takahiro Asakage, Masafumi Okada, Takanori Yoshikawa, Kensuke Tanioka, Megumi Kitayama, Mariko Doi, Satoshi Fujii, Masato Fujii, Nobuhiko Oridate, Munenaga Nakamizo, Seiichi Yoshimoto, Akihiro Homma, Ken-ichi Nibu, Katsunari Yane
Article
Oncology
Takahito Fukusumi, Theresa W. Guo, Shuling Ren, Sunny Haft, Chao Liu, Akihiro Sakai, Mizuo Ando, Yuki Saito, Sayed Sadat, Joseph A. Califano
Summary: The study found that in head and neck squamous cell carcinoma, HEY1 promotes EMT by upregulating SOX2 expression and forming a positive reciprocal feedback loop. HEY1 also regulates NOTCH4 expression, enhancing the specific upregulation of this pathway.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Ken Akashi, Toshihiko Sakai, Osamu Fukuoka, Yuki Saito, Masafumi Yoshida, Mizuo Ando, Takeshi Ito, Yoshinori Murakami, Tatsuya Yamasoba
Summary: Early detection of recurrence in head and neck cancer is crucial. We validated the usefulness of HPV-derived ctDNA as a biomarker for predicting the recurrence of p16-positive oropharyngeal cancer, providing a potential tool for monitoring disease progression.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Susumu Okano, Akihiro Homma, Naomi Kiyota, Makoto Tahara, Nobuhiro Hanai, Takahiro Asakage, Kazuto Matsuura, Takenori Ogawa, Yuki Saito, Daisuke Sano, Takeshi Kodaira, Atsushi Motegi, Koichi Yasuda, Shunji Takahashi, Kaoru Tanaka, Takuma Onoe, Tomoya Yokota, Yoshinori Imamura, Yosuke Ariizumi, Tetsuo Akimoto, Ryuichi Hayashi
Summary: Induction chemotherapy is a treatment option for head and neck squamous cell carcinoma, with the current standard regimen being docetaxel, cisplatin and 5-FU. Careful consideration should be given to factors such as toxicity, cost, and treatment duration when choosing this therapy, and there is still no consensus on the best treatment option after induction chemotherapy.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Atsuto Katano, Ryousuke Takenaka, Hideomi Yamashita, Mizuo Ando, Masafumi Yoshida, Yuki Saito, Takahiro Asakage, Osamu Abe, Keiichi Nakagawa
Summary: This study retrospectively evaluated the clinical outcomes of 34 patients with external auditory canal carcinoma treated with EBRT, showing slightly different 5-year overall survival rates and progression-free survival rates, with some patients experiencing disease relapse after treatment.
MOLECULAR AND CLINICAL ONCOLOGY
(2021)
Review
Oncology
Tomoya Yokota, Akihiro Homma, Naomi Kiyota, Makoto Tahara, Nobuhiro Hanai, Takahiro Asakage, Kazuto Matsuura, Takenori Ogawa, Yuki Saito, Daisuke Sano, Takeshi Kodaira, Atsushi Motegi, Koichi Yasuda, Shunji Takahashi, Kaoru Tanaka, Takuma Onoe, Susumu Okano, Yoshinori Imamura, Yosuke Ariizumi, Ryuichi Hayashi
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Go Omura, Mizuo Ando, Yasuhiro Ebihara, Yuki Saito, Kenya Kobayashi, Osamu Fukuoka, Ken Akashi, Masafumi Yoshida, Takahiro Asakage, Tatsuya Yamasoba