Article
Multidisciplinary Sciences
Michal Largman-Chalamish, Asaf Wasserman, Adi Silberman, Tal Levinson, Omri Ritter, Shlomo Berliner, David Zeltser, Itzhak Shapira, Ori Rogowski, Shani Shenhar-Tsarfaty
Summary: This study utilized estimated C-reactive protein velocity (eCRPv) to differentiate between acute viral and bacterial infections. By dividing the admission CRP level by time from symptom onset, eCRPv can provide a rapid and accurate differentiation, especially for patients with high CRP values.
Article
Environmental Sciences
Mehjar Azzouz, Yiyi Xu, Lars Barregard, Bjorn Fagerberg, Bengt Zoller, Peter Molnar, Anna Oudin, Marten Spanne, Gunnar Engstrom, Leo Stockfelt
Summary: This study investigated the associations between air pollution and biomarkers of inflammation and cardiovascular disease. The results showed that long-term residential exposure to moderate levels of particulate air pollution was associated with several biomarkers of inflammation and cardiovascular disease.
ENVIRONMENTAL HEALTH
(2022)
Article
Oncology
Laila A. Gharzai, Ralph Jiang, David Wallington, Gavin Jones, Samuel Birer, Neil Jairath, Elizabeth M. Jaworski, Matthew R. McFarlane, Brandon A. Mahal, Paul L. Nguyen, Howard Sandler, Todd M. Morgan, Zachery R. Reichert, Joshi J. Alumkal, Rohit Mehra, Amar U. Kishan, Karim Fizazi, Susan Halabi, Edward M. Schaeffer, Felix Y. Feng, David Elliott, Robert T. Dess, William C. Jackson, Matthew J. Schipper, Daniel E. Spratt
Summary: This study comprehensively assessed the performance of commonly reported intermediate clinical endpoints in all randomized trials in localized prostate cancer, and found that metastasis-free survival is the only identified surrogate endpoint for overall survival to date.
Article
Chemistry, Multidisciplinary
Jae-Hwan Oh, Jung-Hyuk Kwon, Hye-Hyun Kim, Jeewon Lee
Summary: This study aims to develop an advanced one-step immunoassay for quick and accurate diagnosis of sepsis by measuring PCT concentration in patient sera. By attaching multiple anti-PCT antibodies (IgGs) to a modified hepatitis B virus (HBV) capsid surface to construct a 3D probe, hook effect-free and PCT concentration-dependent optical signals were successfully generated.
Review
Endocrinology & Metabolism
Kechong Zhou, Chao Li, Tao Chen, Xuejun Zhang, Baoluo Ma
Summary: In this meta-analysis of 16 studies, elevated levels of C-reactive protein (CRP) were found to be associated with worse overall survival, cancer-specific survival, and progression-free survival in patients with prostate cancer. Subgroup analysis based on disease staging yielded consistent results. However, further studies are needed to confirm these findings.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Tsion Zewdu Minas, Julian Candia, Tiffany H. Dorsey, Francine Baker, Wei Tang, Maeve Kiely, Cheryl J. Smith, Amy L. Zhang, Symone Jordan, Obadi M. Obadi, Anuoluwapo Ajao, Yao Tettey, Richard B. Biritwum, Andrew A. Adjei, James E. Mensah, Robert N. Hoover, Frank J. Jenkins, Rick Kittles, Ann W. Hsing, Xin W. Wang, Christopher A. Loffredo, Clayton Yates, Michael B. Cook, Stefan Ambs
Summary: There are differences in immune-oncology marker profiles between African and European descent men, particularly in suppression of tumor immunity and chemotaxis. These differences may contribute to the higher burden of prostate cancer in men of African ancestry. This has important implications for cancer therapy guidance.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Kensuke Kudou, Yuichiro Nakashima, Yasuhiro Haruta, Sho Nambara, Yasuo Tsuda, Eiji Kusumoto, Koji Ando, Yasue Kimura, Kenkichi Hashimoto, Keiji Yoshinaga, Hiroshi Saeki, Eiji Oki, Yoshihisa Sakaguchi, Tetsuya Kusumoto, Koji Ikejiri, Mototsugu Shimokawa, Masaki Mori
Summary: This study found that inflammation-based prognostic scores, specifically PI and PNI, were more strongly associated with poor prognosis in patients who underwent surgery for adenocarcinoma of the esophagogastric junction and upper gastric cancer.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Chris Parker, Nicholas L. James, Christopher Brawley, Noel Clarke, Adnan Ali, Claire Amos, Gerhardt P. Attard, Simon Chowdhury, Adrian C. Cook, William Cross, David Dearnaley, Hassan Douis, Duncan J. Gilbert, Clare E. Gilson, Silke I. Gillessen, Alex D. Hoyle, Rob Jones, Ruth Langley, Zafar Malik, Malcolm Mason, David Matheson, Robin Millman, Mary Rauchenberger, Hannah Rush, J. Martin Russell, Hannah Sweeney, Amit Bahl, Alison Birtle, Lisa Capaldi, Omar Din, Daniel Ford, Joanna Gale, Ann M. Henry, Peter A. Hoskin, Mohammed Kagzi, Anna Lydon, Joe O'Sullivan, Sangeeta Paisey, Omi Parikh, Delia Pudney, Vijay Ramani, Peter R. Robson, Narayanan Nair Srihari, Jacob Tanguay, Mahesh K. B. Parmar, Matthew Sydes, STAMPEDETrialCollaborativeGroup
Summary: This study suggests that radiotherapy to the prostate can improve overall survival for patients with newly diagnosed prostate cancer and low metastatic burden, without affecting their quality of life. However, it does not provide the same benefit for patients with high metastatic burden.
Article
Oncology
Britton Trabert, Cassandra A. Hathaway, Megan S. Rice, Eric B. Rimm, Patrick M. Sluss, Kathryn L. Terry, Oana A. Zeleznik, Shelley S. Tworoger
Summary: Data from two large prospective studies in the United States and United Kingdom suggest that total cholesterol levels may be inversely associated with ovarian cancer risk, while triglycerides may be positively associated with risk, especially when assessed at least 2 years before diagnosis.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Review
Pharmacology & Pharmacy
Anusha Muralidhar, Hemanth K. Potluri, Tanya Jaiswal, Douglas G. McNeel
Summary: Prostate cancer is the most diagnosed malignancy in men in the United States, but targeted radionuclide therapies have shown promise in improving patient outcomes. While immune-based treatments have generally had limited success, radiation therapy may be able to combine with immunotherapy to more effectively eliminate metastases. This review provides an overview of targeted radiation agents approved for prostate cancer and explores their potential combination with immunotherapy.
Article
Oncology
Chun-Chieh Huang, I-Chieh Chuang, Yu-Li Su, Hao-Lun Luo, Ya-Chun Chang, Jo-Ying Chen, Chang-Chun Hsiao, Eng-Yen Huang
Summary: This study investigated the role of tumor galectin-1 and galectin-3 in patients with lung adenocarcinoma after radiation therapy. The results showed that overexpression of tumor galectin-1 was associated with worse locoregional progression-free survival, while galectin-3 overexpression had no significant effect on survival outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Enbo Ma, Taichi Shimazu, Minkyo Song, Hadrien Charvat, Norie Sawada, Taiki Yamaji, Manami Inoue, M. Constanza Camargo, Troy J. Kemp, Ruth M. Pfeiffer, Ligia A. Pinto, Charles S. Rabkin, Shoichiro Tsugane
Summary: This study found no significant associations between 62 inflammatory markers and pancreatic cancer risk, but further investigation is warranted for the suggestive association with circulating levels of leukocyte recruiting cytokine CCL8/MCP2.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Medicine, General & Internal
Wojciech Borowicz, Kuba Ptaszkowski, Lucyna Ptaszkowska, Eugenia Murawska-Cialowicz, Joanna Rosinczuk
Summary: Inflammation is important in the development and outcome of ischemic stroke. C-reactive protein (CRP) is an inflammatory biomarker that may indicate the progression of vascular disease. Using CRP as a biomarker may have clinical value in predicting recovery during rehabilitation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Andrea Aguglia, Antimo Natale, Laura Fusar-Poli, Giovanni Battista Gnecco, Alessio Lechiara, Margherita Marino, Matteo Meinero, Fabrizio Pastorino, Alessandra Costanza, Giorgio Alfredo Spedicato, Andrea Amerio, Gianluca Serafini, Eugenio Aguglia, Mario Amore
Summary: The aim of this study was to identify a cut-off of c-reactive protein (c-RP) that could predict high-lethality suicide attempts in an inpatient psychiatric sample. The optimal cut-off threshold for c-RP was found to be 4.65 mg/L, with a sensitivity of 68% and specificity of 71%. Understanding the social and biological factors underlying the lethality of suicide attempts is crucial for implementing personalized preventive strategies.
Article
Medicine, General & Internal
Mutlay Sayan, Jiaming Huang, Wanling Xie, Ming-Hui Chen, Marian Loffredo, Elizabeth Mcmahon, Peter Orio, Paul Nguyen, Anthony V. D'Amico
Summary: This study aimed to evaluate the factors associated with a short time interval to prostate-specific antigen (PSA) failure in order to identify patients who would benefit from treatment escalation. The results showed that young age, high PSA levels, and high Gleason score were associated with a shorter time to PSA failure. These patients may benefit from treatment intensification and should be included in prospective randomized clinical trials.