Oncogenic mutations in cervical cancer

Worse prognosis of KRASc.35 G > A mutant metastatic colorectal cancer (MCRC) patients treated with intensive triplet chemotherapy plus bevacizumab (FIr-B/FOx)

(2013) Gemma Bruera et al.   BMC Medicine

KRAS mutations are associated with inferior clinical outcome in patients with metastatic colorectal cancer, but are not predictive for benefit with cediranib

(2013) John C. Smith et al.   EUROPEAN JOURNAL OF CANCER

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

(2013) Gunther Zimmermann et al.   NATURE

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

(2013) Kristian Cibulskis et al.   NATURE BIOTECHNOLOGY

Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models

(2012) Ryan B. Corcoran et al.   CANCER CELL

PIK3CA Mutation H1047R Is Associated with Response to PI3K/AKT/mTOR Signaling Pathway Inhibitors in Early-Phase Clinical Trials

(2012) F. Janku et al.   CANCER RESEARCH

Pathway-Specific Analysis of Gene Expression Data Identifies the PI3K/Akt Pathway as a Novel Therapeutic Target in Cervical Cancer

(2012) Julie K. Schwarz et al.   CLINICAL CANCER RESEARCH

Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review

(2012) X. Liao et al.   CLINICAL CANCER RESEARCH

Prognostic significance of adenocarcinoma histology in women with cervical cancer

(2012) Vijaya Galic et al.   GYNECOLOGIC ONCOLOGY

PIK3CA mutational status and overall survival in patients with cervical cancer treated with radical chemoradiotherapy

(2012) John B. McIntyre et al.   GYNECOLOGIC ONCOLOGY

PI3K/AKT/mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies HarboringPIK3CAMutations

(2012) Filip Janku et al.   JOURNAL OF CLINICAL ONCOLOGY

Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study

(2012) Pasi A Jänne et al.   LANCET ONCOLOGY

An intracellular targeted antibody detects EGFR as an independent prognostic factor in ovarian carcinomas

(2011) Aurelia Noske et al.   BMC CANCER

EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target

(2011) K Iida et al.   BRITISH JOURNAL OF CANCER

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Membranous Expression of Ectodomain Isoforms of the Epidermal Growth Factor Receptor Predicts Outcome after Chemoradiotherapy of Lymph Node–Negative Cervical Cancer

(2011) Cathinka Halle et al.   CLINICAL CANCER RESEARCH

HPV-18 is a poor prognostic factor, unlike the HPV viral load, in patients with stage IB–IIA cervical cancer undergoing radical hysterectomy

(2011) Woo Dae Kang et al.   GYNECOLOGIC ONCOLOGY

PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro

(2011) Florianne E Henken et al.   Molecular Cancer

PIK3CA Mutations Frequently Coexist with RAS and BRAF Mutations in Patients with Advanced Cancers

(2011) Filip Janku et al.   PLoS One

Outcomes after radical hysterectomy in patients with early-stage adenocarcinoma of uterine cervix

(2010) J-Y Park et al.   BRITISH JOURNAL OF CANCER

Activated PI3K/Akt/COX-2 Pathway Induces Resistance to Radiation in Human Cervical Cancer HeLa Cells

(2010) Shu Xia et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

A comparison of pure adenocarcinoma and squamous cell carcinoma of the cervix after radical hysterectomy in stage IB–IIA

(2010) Yoo-Young Lee et al.   GYNECOLOGIC ONCOLOGY

Genetic Alterations in the K-Ras Gene Influence the Prognosis in Patients With Cervical Cancer Treated by Radiotherapy

(2010) Pia Wegman et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

The PI3K Pathway As Drug Target in Human Cancer

(2010) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular Signature of HPV-Induced Carcinogenesis: pRb, p53 and Gene Expression Profiling

(2009) Agueda Buitrago-Perez et al.   CURRENT GENOMICS

Human Papillomavirus Genotype Distributions: Implications for Vaccination and Cancer Screening in the United States

(2009) Cosette M. Wheeler et al.   JNCI-Journal of the National Cancer Institute

Somatic LKB1 Mutations Promote Cervical Cancer Progression

(2009) Shana N. Wingo et al.   PLoS One

Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples

(2009) Laura E. MacConaill et al.   PLoS One

Absence of epidermal growth factor receptor mutations in cervical cancer

(2007) H. ARIAS-PULIDO et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER