Article
Critical Care Medicine
Jane Turner, Gregory R. Pond, Alain Tremblay, Michael Johnston, Glen Goss, Garth Nicholas, Simon Martel, Rick Bhatia, Geoffrey Liu, Heidi Schmidt, Martin C. Tammemagi, Serge Puksa, Sukhinder Atkar-Khattra, Ming-Sound Tsao, Stephen Lam, John R. Goffin
Summary: The study found that perceived lung cancer risk was positively associated with calculated risk, but not consistently related to worry. Factors such as younger age and family history were associated with higher risk perception, as well as with lung cancer worry and reported intent to quit smoking. Promotion of screening programs may benefit from focusing on factors associated with higher risk perception.
Review
Medicine, General & Internal
Scott J. Adams, Emily Stone, David R. Baldwin, Rozemarijn Vliegenthart, Pyng Lee, Florian J. Fintelmann
Summary: Randomised controlled trials have shown that low-dose CT lung cancer screening reduces mortality compared with chest radiography or no screening. However, uncertainties remain about optimizing clinical and cost effectiveness. This Review provides an international perspective on lung cancer screening, covering clinical trials, identification of individuals who benefit, management of screen-detected findings, smoking cessation interventions, cost-effectiveness, artificial intelligence and biomarkers, and challenges and opportunities in implementation.
Article
Oncology
Marco Colamonici, Nader Khouzam, Catherine Dell, Kristin Auge-Bronersky, Esther Pacheco, Israel Rubinstein, Bradley Recht
Summary: This study successfully increased lung cancer screening referrals by primary care providers through patient education, shared decision-making, and tracking of initial LDCT completion. It was found that a proportion of patients did not show up for the screening, which may be influenced by racial and socioeconomic factors. Additionally, the initial lung cancer risk assessment reports had a slightly higher prevalence of higher-grade scores than expected. Therefore, a large-scale, multisite quality improvement project is needed to address transportation barriers in high-risk patient populations.
Article
Oncology
Rebecca Landy, Li C. Cheung, Corey D. Young, Anil K. Chaturvedi, Hormuzd A. Katki
Summary: This study quantifies the effects of quit-years and concomitant aging on lung cancer risk, showing that the risk continues to increase beyond 15 quit-years. It suggests that exempting or curtailing lung cancer screening for individuals with more than 15 quit-years is not supported. Augmenting the quit-year criterion with the LYFS-CT prediction model can prevent more deaths with higher efficiency.
Article
Critical Care Medicine
Nina A. Thomas, Ralph Ward, Nichole T. Tanner, Alana M. Rojewski, Benjamin Toll, Mulugeta Gebregziabher, Gerard A. Silvestri
Summary: In a secondary analysis of the NLST arm of the American College of Radiology Imaging Network, it was found that only a quarter of lung cancer screening patients received pharmacologic therapy for smoking cessation, and those who did receive treatment were more likely to attempt to quit. Patients with high nicotine dependence benefited most from dual pharmacologic therapy.
Article
Public, Environmental & Occupational Health
Fatemeh Zarghami, Hamid Allahverdipour, Mohammad Asghari Jafarabadi
Summary: This study aimed to explore smokers' perception of lung cancer risk and readiness to quit smoking, finding significant relationships between perceived susceptibility, severity, response efficacy, and self-efficacy. The results highlighted the importance of these factors for smokers with different levels of readiness to quit, which could inform the design of tailored smoking cessation programs.
Article
Oncology
Nathan Chu, Haley Tupper, Tamara Galoyan, Armine Lulejian, James Dickhoner, Marine Hovhannisyan, Shant Shekherdimian
Summary: In Armenia, a high incidence of lung cancer is observed, especially among male smokers. The study highlights the importance of early detection through low-dose computed tomography screening in reducing mortality rates. However, there are significant barriers such as lack of symptoms and high costs that hinder screening participation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Jacqueline V. Aredo, Sophia J. Luo, Rebecca M. Gardner, Nilotpal Sanyal, Eunji Choi, Thomas P. Hickey, Thomas L. Riley, Wen-Yi Huang, Allison W. Kurian, Ann N. Leung, Lynne R. Wilkens, Hilary A. Robbins, Elio Riboli, Rudolf Kaaks, Anne Tjonneland, Roel C. H. Vermeulen, Salvatore Panico, Loic Le Marchand, Christopher I. Amos, Rayjean J. Hung, Neal D. Freedman, Mattias Johansson, Iona Cheng, Heather A. Wakelee, Summer S. Han
Summary: The study revealed that smoking is a risk factor for second primary lung cancer (SPLC), and smoking cessation may reduce the risk of SPLC. Additionally, individuals who meet the U.S. Preventive Services Task Force's criteria at the diagnosis of initial primary lung cancer also have an increased risk of developing SPLC.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Review
Oncology
Dana Moldovanu, Harry J. de Koning, Carlijn M. van der Aalst
Summary: Randomized-controlled trials have shown that low-dose computed tomography screening can reduce lung cancer mortality, but evidence on integrating smoking cessation support is lacking. Combining lung cancer screening with smoking cessation can significantly reduce mortality risk. Multi-modality interventions delivered by clinicians may be the most successful in influencing smoking behavior.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Critical Care Medicine
Anna Holman, Erin Kross, Kristina Crothers, Allison Cole, Karen Wernli, Matthew Triplette
Summary: This study aimed to understand patients' perspectives on barriers and facilitators to adherence to annual lung cancer screening. Through semi-structured interviews with 40 participants, the study identified seven themes and highlighted key facilitators (such as patient reminders and provider recommendations) to improve long-term screening behavior, as well as barriers that could be addressed through patient navigation.
Article
Oncology
Randi M. Williams, Marisa Cordon, Ellie Eyestone, Laney Smith, George Luta, Brady J. McKee, Shawn M. Regis, David B. Abrams, Raymond S. Niaura, Cassandra A. Stanton, Vicky Parikh, Kathryn L. Taylor
Summary: This study found that lung cancer screening could serve as a teachable moment for smoking cessation, with individuals who were extremely worried about lung cancer being more motivated to quit smoking and more ready to quit within the next 30 days.
Article
Multidisciplinary Sciences
Ambreen Sayani, Mandana Vahabi, Mary Ann O'Brien, Geoffrey Liu, Stephen Hwang, Peter Selby, Erika Nicholson, Meredith Giuliani, Lawson Eng, Aisha Lofters
Summary: This study explored the background and lived experiences of individuals with low income in relation to their choice of participating in lung cancer screening, highlighting the influence of economic and healthcare resources on their screening decisions. The findings underscore the need for multipronged interventions at the individual, system, and structural levels to reduce inequities in lung cancer risk and access to healthcare services such as cancer screening.
Article
Oncology
Ugo Pastorino, Vito Ladisa, Sara Trussardo, Federica Sabia, Luigi Rolli, Camilla Valsecchi, Roberta E. Ledda, Gianluca Milanese, Paola Suatoni, Mattia Boeri, Gabriella Sozzi, Alfonso Marchiano, Elena Munarini, Roberto Boffi, Silvano Gallus, Giovanni Apolone
Summary: Cytisine, combined with counseling, is an effective and safe medication for smoking cessation, as demonstrated by a study in Italy. It significantly increases the quit rate and can be used to improve lung cancer screening outcomes.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Xin Yin, Cheryl Pui Yi Chan, Adeline Seow, Wai-Ping Yau, Wei Jie Seow
Summary: A case-control study conducted in Singapore found that family history is a significant risk factor for lung cancer in Singaporean Chinese women, especially among never-smokers. This highlights the importance of considering family history in assessing lung cancer risk, particularly in non-smoking populations.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Alex H. Krist, Karina W. Davidson, Carol M. Mangione, Michael J. Barry, Michael Cabana, Aaron B. Caughey, Esa M. Davis, Katrina E. Donahue, Chyke A. Doubeni, Martha Kubik, C. Seth Landefeld, Li Li, Gbenga Ogedegbe, Douglas K. Owens, Lori Pbert, Michael Silverstein, James Stevermer, Chien-Wen Tseng, John B. Wong
Summary: Lung cancer is the second most common cancer and leading cause of cancer death in the US, with smoking and increasing age being the primary risk factors. Annual screening with low-dose computed tomography is recommended for adults aged 50 to 80 years with a 20 pack-year smoking history.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Oncology
Angela R. Bradbury, Ju-Whei Lee, Jill Bennett Gaieski, Shuli Li, Ilana F. Gareen, Keith T. Flaherty, Benjamin A. Herman, Susan M. Domchek, Angela M. DeMichele, Kara N. Maxwell, Adedayo A. Onitilo, Shamsuddin Virani, SuJung Park, Bryan A. Faller, Stefan C. Grant, Ryan C. Ramaekers, Robert J. Behrens, Gopakumar S. Nambudiri, Ruth C. Carlos, Lynne I. Wagner
Summary: This study found that patients who received genetic education before tumor genetic sequencing had increased understanding and reduced distress, particularly in women. However, the effects were not significant in men and patients with lower health literacy.
Article
Oncology
Sofia F. Garcia, Robert J. Gray, Joseph A. Sparano, Amye J. Tevaarwerk, Ruth C. Carlos, Betina Yanez, Ilana F. Gareen, Timothy J. Whelan, George W. Sledge, David Cella, Lynne I. Wagner
Summary: The study found that patients with early-stage breast cancer who received adjuvant chemoendocrine therapy reported greater fatigue and endocrine symptoms at early time points, but these differences lessened over time, demonstrating early chemotherapy effects more than long-term ones. Treatment arm differences in endocrine symptoms were more evident in postmenopausal patients.
Editorial Material
Oncology
Ruth C. Carlos, Samilia Obeng-Gyasi, Steven W. Cole, Bradley J. Zebrack, Etta D. Pisano, Melissa A. Troester, Lava Timsina, Lynne I. Wagner, Jon A. Steingrimsson, Ilana Gareen, Christoph I. Lee, Alyce S. Adams, Consuelo H. Wilkins
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Gelareh Sadigh, Robert J. Gray, Joseph A. Sparano, Betina Yanez, Sofia F. Garcia, Lava R. Timsina, Samilia Obeng-Gyasi, Ilana Gareen, George W. Sledge, Timothy J. Whelan, David Cella, Lynne Wagner, Ruth C. Carlos
Summary: This study evaluated the impact of racial disparities on clinical outcomes in breast cancer patients, showing that Black women had significantly shorter relapse-free interval and overall survival compared to White women. Factors such as insurance coverage and neighborhood deprivation index do not fully explain this disparity.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hamid Chalian, Holman Page McAdams, Youkyung Lee, Fenghai Duan, Yanning Wu, Pegah Khoshpouri, Edward F. Patz
Summary: Enlarged mediastinal lymph nodes found on lung cancer screening CT scans are associated with an increased risk of lung cancer, earlier diagnosis, more advanced-stage disease, and higher mortality.
Article
Oncology
Samilia Obeng-Gyasi, Noah Graham, Shaji Kumar, Ju-Whei Lee, Susanna Jacobus, Matthias Weiss, David Cella, Fengmin Zhao, Edward H. Ip, Nathaniel O'Connell, Fangxin Hong, Devin J. Peipert, IIana. F. Gareen, Lava R. Timsina, Robert Gray, Lynne I. Wagner, Ruth C. Carlos
Summary: The objective of this study is to examine the association between neighborhood socioeconomic status (nSES) and baseline allostatic load (AL) and clinical trial endpoints in patients enrolled in the E1A11 therapeutic trial in multiple myeloma (MM). The study found that an increase in baseline AL was associated with higher odds of high fatigue at baseline and worse overall survival. Additionally, high nSES was associated with worse baseline bother. However, there was no association between AL or nSES and symptom burden, non-completion of induction therapy, or progression-free survival.
BLOOD CANCER JOURNAL
(2022)
Article
Medicine, General & Internal
Soudabeh Fazeli, Bradley S. Snyder, Ilana F. Gareen, Constance D. Lehman, Seema A. Khan, Justin Romanoff, Constantine A. Gatsonis, Ralph L. Corsetti, Habib Rahbar, Derrick W. Spell, Kenneth B. Blankstein, Linda K. Han, Jennifer L. Sabol, John R. Bumberry, Kathy D. Miller, Joseph A. Sparano, Christopher E. Comstock, Lynne Wagner, Ruth C. Carlos
Summary: This study found that patient preferences and receipt of surgery for DCIS were influenced by MRI results and surgeon recommendations. These findings emphasize the importance of ensuring adequate information and ongoing communication about the clinical significance of MRI findings and the benefits and risks of available treatment options.
Article
Public, Environmental & Occupational Health
Brett M. Goshe, Autumn W. Rasmussen, Lynne Wagner, JoRean D. Sicks, Ilana F. Gareen, Ruth C. Carlos, Benjamin A. Herman, Angela Wangari Walter, Susan Regan, Douglas E. Levy, Irene Mahon, Alona Muzikansky, Jordan M. Neil, Michelle Lui, Deepika Dilip, Laura Malloy, Irina Gonzalez, Lucy Finkelstein-Fox, Caitlin McCann, Elissa Perez, Jamie S. Ostroff, Elyse R. Park
Summary: This paper describes a nationwide clinical trial protocol aimed at evaluating the effectiveness of a virtual tobacco treatment intervention for cancer patients and exploring the barriers and facilitators of implementing tobacco treatment in community oncology settings, using NCORP as an example.
Article
Respiratory System
Ke Xu, Alejandro A. Diaz, Fenghai Duan, Minyi Lee, Xiaohui Xiao, Hanqiao Liu, Gang Liu, Michael H. Cho, Adam C. Gower, Yuriy O. Alekseyev, Avrum Spira, Denise R. Aberle, George R. Washko, Ehab Billatos, Marc E. Lenburg
Summary: Studying gene expression alterations in individuals with radiological bronchiectasis without a clinical diagnosis can enhance our understanding of the early-stage bronchiectasis process.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Clinical Neurology
Consuelo H. Wilkins, Charles C. Windon, Peggye Dilworth-Anderson, Justin Romanoff, Constantine Gatsonis, Lucy Hanna, Charles Apgar, Ilana F. Gareen, Carl Hill, Bruce E. Hillner, Andrew March, Barry A. Siegel, Rachel A. Whitmer, Maria C. Carrillo, Gil D. Rabinovici
Summary: This study compares the amyloid PET positivity among a diverse cohort of individuals with mild cognitive impairment or dementia. The results show racial and ethnic differences in amyloid PET positivity, with lower odds observed in Asian, Black, and Hispanic participants compared to White participants.
Article
Medicine, General & Internal
Ilana F. Gareen, Roee Gutman, JoRean Sicks, Tina D. Tailor, Richard M. Hoffman, Amal N. Trivedi, Efren Flores, Ellen Underwood, Jerson Cochancela, Caroline Chiles
Summary: This retrospective study analyzed the significant incidental findings (SIFs) in patients undergoing low-dose computed tomography (LDCT) lung screening. The study found a high prevalence of SIFs, most of which were considered reportable and required follow-up. Standardization of SIF reporting in future screening trials is recommended.
JAMA INTERNAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Meng-Yun Lin, Tao Liu, Constantine Gatsonis, JoRean D. Sicks, Stephannie Shih, Ruth C. Carlos, Ilana F. Gareen
Summary: This study examined the utilization patterns of diagnostic procedures after lung cancer screening among participants enrolled in the National Lung Screening Trial. The study found that the utilization of imaging and invasive procedures varied depending on the screening modality, with a lower utilization rate for low-dose CT compared to chest X-ray. The utilization of invasive and surgical procedures was also lower after subsequent screening examinations compared to baseline screening.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Vivek Narayan, Tao Liu, Yunjie Song, Joshua Mitchell, Jorean Sicks, Ilana F. Gareen, Lova Sun, Srinivas Denduluri, Ciaran P. Fisher, Jesse Manikowski, Mark Wojtowicz, Joseph Vadakara, Naomi Balzer Haas, Kenneth B. Margulies, Bonnie Ky
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Oncology
Fengmin Zhao, John Peipert, Vered Stearns, Victor Tsu-Shih Chang, Opeyemi Jegede, Edward Ip, Ju-Whei Lee, Nathaniel S. O'Connell, Noah Graham, Norah Lynn Henry, Charles L. Loprinzi, Patrick J. Flynn, Michael Jordan Fisch, Ilana F. Gareen, Ruth C. Carlos, Mary Lou Smith, David Cella, Joseph A. Sparano, Robert James Gray, Lynne I. Wagner
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Sheetal Mehta Kircher, Fenghai Duan, Ellen Underwood, Ilana F. Gareen, Jorean Sicks, Gelareh Sadigh, Jennifer Marie Suga, Heather Kehn, Paul Tracy Mehan, Rajesh Bajaj, David Sam Hanson, Samir Dalia, Jared David Acoba, Michael A. Taylor, Lynne I. Wagner, Ruth C. Carlos
JOURNAL OF CLINICAL ONCOLOGY
(2022)