Article
Medicine, General & Internal
Manuel Lim, Byung Kwan Park, Kyo Won Lee, Jae Berm Park, Kyeong Deok Kim, Jaehun Yang, Jieun Kwon, Eun Sung Jeong, Seunghwan Lee
Summary: This study evaluated the technical feasibility, procedure safety, and clinical outcomes of two-week protocol biopsy. The results showed that two-week protocol biopsy is technically feasible and safe, and it contributes to early detection of subclinical rejection. Platelet count and blood urea nitrogen should be carefully checked prior to the biopsy to predict major complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Takehito Nota, Ken Kageyama, Akira Yamamoto, Atsushi Jogo, Etsuji Sohgawa, Hiroki Yonezawa, Kazuki Murai, Satoyuki R. Ogawa, Yukio R. Miki, Vanessa R. Carels
Summary: This study evaluated the clinical outcomes of tract embolization using a gel-like radiopaque material and confirmed its viscosity and hemostatic efficacy. The results showed that tract embolization with this material is safe, feasible, and cost-effective.
Article
Medicine, General & Internal
Makoto Iijima, Takahiro Arisaka, Akira Yamamiya, Keiichi Tominaga, Kazunori Nagashima, Akira Kanamori, Satoshi Masuyama, Yuichi Majima, Kenichi Goda, Kazuyuki Ishida, Atsushi Irisawa
Summary: The study found that TJLB is highly useful and safe in patients who are not suitable for PLB, with a high procedural success rate, clinical response rate, and tissue sampling rate, and no serious adverse events were observed in either group.
Article
Respiratory System
Jeffrey Thiboutot, Peter B. Illei, Fabien Maldonado, Christopher M. Kapp, Andrew DeMaio, Hans J. Lee, David Feller-Kopman, Robert J. Lentz, Priya Sathyanarayan, Najib M. Rahman, Gerard A. Silvestri, Lonny Yarmus
Summary: This study aimed to investigate the safety of transbronchial lung biopsy using a novel 1.1-mm cryoprobe. Results showed that out of 50 participants, there were no significant complications related to the procedure, indicating that transbronchial cryobiopsy using a 1.1-mm cryoprobe is feasible with an acceptable safety profile.
Article
Clinical Neurology
X. Li, J. Li, N. Zheng, H. Hu, X. Xie, G. Huang
Summary: This study evaluated the feasibility, histopathologic yield, and safety of ultrasound fusion-guided core needle biopsies for deep head and neck space lesions. The results showed that ultrasound-guided biopsy was feasible in all 16 patients, with a high histopathologic yield and no major complications.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yuji Koretsune, Miyuki Sone, Yasuaki Arai, Shunsuke Sugawara, Chihiro Itou, Shintaro Kimura, Masahiko Kusumoto
Summary: The craniocaudal approach for superior sulcus lesions was found to be a safe and feasible option for patients for whom the conventional intercostal approach was difficult. Technical and clinical success were achieved in all patients, with no major complications reported. The median procedure time was 25 minutes, with needle passage routes including the first and second intercostal spaces, as well as between the clavicle and the first rib.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Oncology
Steffan K. Soosman, Matthew P. Schenker, Emanuele Mazzola, Emma Voligny, Anna Smokovich, Camden Bay, Tom Nguyen, Kesi Michael, Pasi A. Janne, Michael Rabin, Daniel I. Glazer, Bruce E. Johnson, Jia Luo
Summary: Image-guided percutaneous core needle biopsies are a common opportunity for collecting research samples, but the safety of additional biopsies for research purposes is unclear. This study found that biopsies performed solely for research did not have a significantly higher risk of adverse events compared to those performed for clinical trials or clinical indications. However, adverse events were most frequent in lung biopsies.
Article
Critical Care Medicine
Bertrand Mathon, Malory Favreau, Vincent Degos, Aymeric Amelot, Alexandre Le Joncour, Nicolas Weiss, Benjamin Rohaut, Loic Le Guennec, Anne-Laure Boch, Alexandre Carpentier, Franck Bielle, Karima Mokhtari, Ahmed Idbaih, Mehdi Touat, Alain Combes, Alexandre Demoule, Eimad Shotar, Vincent Navarro, Mathieu Raux, Sophie Demeret, Marc Pineton De Chambrun
Summary: Brain biopsy in critically ill patients with neurologic disease of unknown etiology is associated with high diagnostic yield, therapeutic modifications, and postbiopsy survival advantage. The safety profile seems acceptable in most patients. The benefit/risk ratio of brain biopsy in this population should be carefully weighted.
CRITICAL CARE MEDICINE
(2022)
Article
Oncology
Paulina J. Haight, David A. Barrington, Stephen M. Graves, Rachael N. Piver, Jae Baek, Melissa Ardizzone, Jenifer A. Akinduro, Audrey C. Busho, Deborah Fadoju, Radhika Pandit, Raeshawn Stephens, Lauren M. Strowder, Shreekari Tadepalli, Brianna VanNoy, Bhargavi Sriram, Eric M. McLaughlin, Michelle D. S. Lightfoot, Kristin L. Bixel, David E. Cohn, Casey M. Cosgrove, David O'Malley, Ritu Salani, Christa I. Nagel, Floor J. Backes
Summary: A retrospective study was conducted to assess the feasibility of same day discharge following minimally invasive hysterectomy in morbidly obese patients. It was found that morbid obesity alone should not be a contraindication to same day discharge, and patients who were discharged on the day of surgery did not have an increased risk of adverse outcomes.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Olga R. Brook, Kimberly G. Piper, Noe B. Mercado, Makda S. Gebre, Dan H. Barouch, Kathleen Busman-Sahay, Carly E. Starke, Jacob D. Estes, Amanda J. Martinot, Linda Wrijil, Sarah Ducat, Jonathan L. Hecht
Summary: Ultrasound-guided minimally invasive autopsy in COVID-19 patients was found to be feasible and safe, providing high-quality tissue samples for pathology analysis and viral load detection. The method effectively targeted organs for biopsy, with the highest SARS-CoV-2 viral load detected in the lung, liver, and spleen.
ABDOMINAL RADIOLOGY
(2021)
Article
Physiology
Jonathan I. Quinlan, Amritpal Dhaliwal, Felicity Williams, Sophie L. Allen, Leigh Breen, Carolyn A. Greig, Janet M. Lord, Matthew J. Armstrong, Ahmed M. Elsharkawy
Summary: This study demonstrated the feasibility and efficacy of percutaneous muscle biopsies in patients with ESLD. The procedure successfully obtained muscle tissue with a high consent rate and yielded sufficient tissue for analysis. The study provides evidence for the safe use of muscle biopsies in this population, even considering disease-specific complications, medications, and comorbidities.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Immunology
Haoyue Hu, Yue Chen, Songtao Tan, Silin Wu, Yan Huang, Shengya Fu, Feng Luo, Jun He
Summary: Combining anti-angiogenesis therapy with immunotherapy has shown promising results in treating solid tumors, but has been less effective in certain types of cancers. The resistance to anti-angiogenesis agents and lack of biomarkers remain challenging obstacles in achieving optimal therapeutic outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yan Wang, Yingying Wei, Lin Chen, Yongzhen Yang, Fan Jia, Weiran Yu, Shizhao Zhou, Shiping Yu
Summary: Vascular endothelial growth factor (VEGF) plays a crucial role in the development of diseases like tumors, ocular neovascular disease, and endometriosis. Inhibiting abnormal VEGF expression through small interfering RNA for VEGF (siVEGF) shows promise as an effective treatment. However, challenges such as immune response, enzymatic degradation, and limited therapeutic effect need to be addressed. Targeted siVEGF complexes constructed with nanocarriers can overcome these challenges and improve the efficiency of disease treatment by combining siVEGF with other therapeutic tools.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Respiratory System
Jean Pastre, Sandeep Khandhar, Scott Barnett, Inga Ksovreli, Haresh Mani, A. Whitney Brown, Oksana A. Shlobin, Kareem Ahmad, Vikramjit Khangoora, Shambhu Aryal, Diana L. Morris, Christopher S. King, Steven D. Nathan
Summary: This study evaluated the safety and tolerability of VATS among ILD patients referred to a tertiary care center. The results demonstrate that VATS lung biopsy as a same-day procedure in the modern era is safe, tolerable, and feasible, especially when patients are first vetted by a team with expertise in the field of ILD. These findings support a lower threshold to pursue a VATS biopsy when histology is required for an ILD diagnosis.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Multidisciplinary Sciences
Qingde Wu, Bihui Cao, Yujin Zheng, Baoxia Liang, Manting Liu, Lu Wang, Jinling Zhang, Liyan Meng, Shaoyong Luo, Xuxia He, Zhenfeng Zhang
Summary: The study evaluated a separate inserted positioning fine needle-mediated breathing-control technique for CT-guided percutaneous puncture in small lung/liver nodules near the diaphragm. The technique achieved a high puncture success rate with minimal complications, making it a feasible and effective approach for similar clinical scenarios.
SCIENTIFIC REPORTS
(2021)
Review
Pathology
Martina Rudelius, Olga K. Weinberg, Charlotte M. Niemeyer, Akiko Shimamura, Katherine R. Calvo
Summary: The classification of hematologic neoplasia is critical for diagnosis, therapy, research, and clinical trials. This review summarizes recent advances in the classification of myeloid and lymphoblastic neoplasia with germline predisposition, providing important genetic and phenotypic information, relevant laboratory testing, and pathological bone marrow features. It also focuses on the updated classification of pediatric myelodysplastic syndrome and juvenile myelomonocytic leukemia, highlighting the genetic definitions and distinguishing features.
Article
Radiology, Nuclear Medicine & Medical Imaging
Syed M. S. Reza, Winston T. Chu, Fatemeh Homayounieh, Maxim Blain, Fatemeh D. Firouzabadi, Pouria Y. Anari, Ji Hyun Lee, Gabriella Worwa, Courtney L. Finch, Jens H. Kuhn, Ashkan Malayeri, Ian Crozier, Bradford J. Wood, Irwin M. Feuerstein, Jeffrey Solomon
Summary: This study employs deep-learning techniques to quantitatively analyze the CT scans of nonhuman primates exposed to SARS-CoV-2, specifically focusing on whole-lung and lung-lesion segmentation. Through the use of a novel multi-model ensemble technique, the automated segmentation of lung lesions is improved, demonstrating superior performance compared to other methods. The application of automated segmentation methods provides a standardized and automated approach for disease detection and quantification.
ACADEMIC RADIOLOGY
(2023)
Article
Infectious Diseases
Camila D. D. Odio, Kelsey E. E. Lowman, Melissa Law, Rosemary A. A. Aogo, Sally Hunsberger, Brad J. J. Wood, Michael Kassin, Elliot Levy, Viviane Callier, Saba Firdous, Chloe M. M. Hasund, Charlie Voirin, Robbie Kattappuram, Christina Yek, Jessica Manning, Anna Durbin, Stephen S. S. Whitehead, Leah C. C. Katzelnick
Summary: This study is a clinical trial conducted on healthy adults to investigate the impact of pre-vaccine host immunity on the safety and immunogenicity of dengue fever vaccines. By comparing immune responses before and after virus exposure, as well as after exposure to different serotypes, this research can help improve vaccine evaluations and expand potential target populations.
BMC INFECTIOUS DISEASES
(2023)
Article
Veterinary Sciences
Juan A. Esparza-Trujillo, William F. Pritchard, Michal Mauda-Havakuk, Matthew F. Starost, Paul Wakim, Johnathan Zeng, Andrew S. Mikhail, Ivane Bakhutashvili, Bradford J. Wood, John W. Karanian
Summary: In this study, cryoablation was characterized as a clinical intervention mode for adult woodchucks with hepatocellular carcinoma (HCC). The results showed that cryoablation was effective in causing necrosis and removing tumors in woodchucks with HCC.
COMPARATIVE MEDICINE
(2023)
Article
Engineering, Biomedical
Hengtao Guo, Hanqing Chao, Sheng Xu, Bradford J. Wood, Jing Wang, Pingkun Yan
Summary: This paper presents a novel deep learning approach, named deep contextual-contrastive network (DC2-Net), for sensorless ultrasound volume reconstruction from freehand 2D ultrasound scans without tracking information. The proposed method efficiently exploits content correspondence between ultrasound frames to estimate spatial movement and contrastive features and achieves superior performance compared with other methods, with a drift rate of 9.64% and a prostate Dice of 0.89. The promising results demonstrate the capability of deep neural networks for universal ultrasound volume reconstruction.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Enis C. Yilmaz, Joanna H. Shih, Mason J. Belue, Stephanie A. Harmon, Tim E. Phelps, Charisse Garcia, Lindsey A. Hazen, Antoun Toubaji, Maria J. Merino, Sandeep Gurram, Peter L. Choyke, Bradford J. Wood, Peter A. Pinto, Baris Turkbey
Summary: This study aimed to evaluate the performance of PI-RADS version 2.1 in prostate cancer detection and identify MRI features for improving csPCa detection. A total of 454 men who were suspected or known to have prostate cancer participated in this study. The results showed that csPCa rates varied among different PI-RADS categories, and MRI features including lesion volume, shape, and EPE scores could predict csPCa.
Correction
Multidisciplinary Sciences
Ayele H. Negussie, Andrew S. Mikhail, Joshua W. Owen, Natalie Hong, Camella J. Carlson, Yiqing Tang, Kendal Paige Carrow, Michal Mauda-Havakuk, Andrew L. Lewis, John W. Karanian, William F. Pritchard, Bradford J. Wood
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Cecilia Monge, Changqing Xie, Yuta Myojin, Kelley Coffman, Donna Mabry Hrones, Sophie Wang, Jonathan M. Hernandez, Bradford J. Wood, Elliot B. Levy, Israa Juburi, Stephen M. Hewitt, David E. Kleiner, Seth M. Steinberg, William D. Figg, Bernadette Redd, Philip Homan, Maggie Cam, Benjamin Ruf, Austin G. Duffy, Tim F. Greten
Summary: This study evaluated the safety and efficacy of the combination of PexaVec, durvalumab, and tremelimumab in patients with refractory pMMR mCRC. The results showed that the combination therapy has potential clinical activity without unexpected toxicities.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ming Li, Sherif Mehralivand, Sheng Xu, Nicole Varble, Ivane Bakhutashvili, Sandeep Gurram, Peter A. Pinto, Peter L. Choyke, Bradford J. Wood, Baris Turkbey
Summary: An augmented reality (AR) system was developed to facilitate real-time needle guidance for transperineal prostate (TP) procedures. The system uses preprocedural volumetric images to superimpose annotated anatomy onto a patient, providing real-time needle tip localization and visualization. The accuracy of the system was evaluated on a phantom, and the feasibility was further demonstrated by implanting soft tissue markers into a pelvic phantom. The results showed accurate needle guidance and the potential for more flexibility in TP procedures.
JOURNAL OF MEDICAL IMAGING
(2023)
Article
Acoustics
Hengtao Guo, Xuanang Xu, Xinrui Song, Sheng Xu, Hanqing Chao, Joshua Myers, Baris Turkbey, Peter A. Pinto, Bradford J. Wood, Pingkun Yan
Summary: In this study, a novel method for fusing ultrasound and magnetic resonance images using deep neural networks is proposed. The method is validated on a clinical dataset of 618 subjects and shows promising results in real-time navigation tasks.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2023)
Article
Hematology
Robert R. West, Thomas R. Bauer Jr, Laura M. Tuschong, Lisa J. Embree, Katherine R. Calvo, Desiree Tillo, Joie Davis, Steven M. Holland, Dennis D. Hickstein
Summary: GATA2 mutations are common in patients with GATA2 deficiency, but this study discovered a multigeneration family with the clinical features of GATA2 deficiency but lacking an apparent GATA2 mutation. Whole genome sequencing revealed a unique variant in the GATA2 enhancer that leads to overexpression of GATA2. The study highlights the association between GATA2 overexpression and MonoMAC syndrome.
Proceedings Paper
Computer Science, Artificial Intelligence
Xinrui Song, Xuanang Xu, Sheng Xu, Baris Turkbey, Thomas Sanford, Bradford J. Wood, Pingkun Yan
MEDICAL IMAGING 2023
(2023)
Meeting Abstract
Urology & Nephrology
Anjali Pillai, Zoe Blake, Daniel R. Nemirovsky, Jacob J. Enders, Neil Mendhiratta, Alexander P. Kenigsberg, Michael B. Rothberg, Jibriel Noun, Daniel Nethala, Sandeep Gurram, Bradford J. Wood, Baris Turkbey, Peter A. Pinto
JOURNAL OF UROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tim E. E. Phelps, Enis C. C. Yilmaz, Stephanie A. A. Harmon, Mason J. J. Belue, Joanna H. H. Shih, Charisse Garcia, Lindsey A. A. Hazen, Antoun Toubaji, Maria J. J. Merino, Sandeep Gurram, Peter L. L. Choyke, Bradford J. J. Wood, Peter A. A. Pinto, Baris Turkbey
Summary: This study evaluates the cancer detection rates of reduced-core biopsy schemes in patients with unilateral mpMRI-visible intraprostatic lesions and finds that the combined strategy of targeted biopsy and systematic biopsy maximizes the detection of clinically significant prostate cancer.
ABDOMINAL RADIOLOGY
(2023)
Article
Engineering, Biomedical
Neil Glossop, Reto Bale, Sheng Xu, William F. Pritchard, John W. Karanian, Bradford J. Wood
Summary: This study aimed to evaluate the feasibility of using personalized needle guidance grid templates for implementing in vivo ablation treatment plans with multiple needles. The personalized templates were fabricated using intraprocedural CT images, and multiple needle trajectories were planned. A numerical-controlled milling machine was used to drill the corresponding holes, and the needles were inserted to the calculated depth. The needle placement accuracy was high, and the procedure was performed rapidly.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)