Review
Oncology
Drishti Tolani, Julia Wilcox, Sharvari Shyam, Neha Bansal
Summary: As chemotherapy improves, understanding the effects on the cardiovascular system is increasingly important. Cardiotoxicity is a major determinant of morbidity and mortality in cancer survivors. New imaging modalities and biomarkers may detect subclinical cardiotoxicity earlier. Dexrazoxane remains the most effective therapy for preventing anthracycline-induced cardiomyopathy. Neurohormonal modulating drugs have not been effective in preventing cardiotoxicity. Advanced cardiac therapies, like heart transplant, should be considered for cancer survivors with end-stage HF. Research on genetic associations may produce treatments to reduce cardiovascular morbidity and mortality.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Abby R. Rosenberg, Chuan Zhou, Miranda C. Bradford, John M. Salsman, Katie Sexton, Alison O'Daffer, Joyce P. Yi-Frazier
Summary: This study explored the 2-year trajectories of patient-reported well-being among AYA cancer survivors, finding that the PRISM intervention was associated with sustained improvements in psychosocial outcomes reported by adolescents and young adults. Those who initially responded positively to PRISM continued to experience well-being 2 years later.
Article
Oncology
Elizabeth J. Siembida, Bryce B. Reeve, Brad J. Zebrack, Mallory A. Snyder, John M. Salsman
Summary: The study examined the variability in HRQOL among adolescent and young adult cancer survivors, finding that treatment status and developmental stage significantly impacted symptoms and functioning, with developmental stage being a more critical predictor than cancer type.
Article
Oncology
Julian Surujballi, Grace Chan, Caron Strahlendorf, Amirrtha Srikanthan
Summary: Adolescent and young adult (AYA) oncology patients have specialized needs and are underserved in Canada. This study identified the priority list and sequence for new AYA programs through literature review, consensus documents, and expert opinion. Stakeholders were engaged to co-develop program goals and activities, and the Delphi technique was used to prioritize implementation. The study found that patient care was the top priority, followed by HCP education, patient and family education, and program sustainability.
Article
Oncology
Tatsuo Akechi, Izumi Mishiro, Shinji Fujimoto
Summary: Adolescent and young adult (AYA) patients with cancer in Japan have a high risk of major depressive disorder (MDD), especially those with multiple cancer categories, leukemia, and those who receive aggressive anticancer treatments.
Article
Public, Environmental & Occupational Health
Eric Adjei Boakye, Katherine M. Polednik, Teresa L. Deshields, Arun Sharma, Yamile Molina, Lidia Schapira, Justin M. Barnes, Nosayaba Osazuwa-Peters
Summary: This study examined emotional distress in cancer survivors diagnosed as adolescents or young adults compared to survivors diagnosed as middle/older adults and the general population without a history of cancer. The findings showed that emotional distress was more prevalent among young adult cancer survivors than middle/older adult survivors. However, there was no difference in emotional distress between young adult cancer survivors and the general population without cancer.
ANNALS OF EPIDEMIOLOGY
(2022)
Review
Oncology
Leslie Coker Appiah, Yueyang Frances Fei, Mallery Olsen, Steven R. Lindheim, Diane M. Puccetti
Summary: This article addresses the impact of cancer and its treatments on fertility and reproductive health, highlighting disparities in access to fertility preservation care for the pediatric, adolescent, and young adult population. Further research is needed to improve care and address gaps in knowledge.
Review
Oncology
Mary Jane Lim-Fat, Maria Macdonald, Sarah Lapointe, Seth Andrew Climans, Chantel Cacciotti, Manik Chahal, Sebastien Perreault, Derek S. Tsang, Andrew Gao, Stephen Yip, Julia Keith, Julie Bennett, Vijay Ramaswamy, Jay Detsky, Uri Tabori, Sunit Das, Cynthia Hawkins
Summary: The 2021 World Health Organization classification of CNS tumors includes molecular signatures with histology and emphasizes the differences between pediatric and adult-type CNS tumors. This study aims to propose a comprehensive approach to molecular testing for adolescent and young adult (AYA) patients across this spectrum, in order to improve their diagnosis and care.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Amirrtha Srikanthan, Jolanta Karpinski, Abha Gupta
Summary: The Canadian National AYA Cancer Task Force and Canadian Partnership Against Cancer have developed standardized criteria for structured academic programs in AYA Oncology in Canada, in order to meet the distinctive needs of this age group and advance AYA oncology care.
Article
Psychology, Multidisciplinary
Pandora Patterson, Fiona E. J. McDonald, Kimberley R. Allison, Helen Bibby, Michael Osborn, Karen Matthews, Ursula M. Sansom-Daly, Kate Thompson, Meg Plaster, Antoinette Anazodo
Summary: The study demonstrates that the AYA-POST is a suitable tool for psychosocial screening of AYAs with cancer, facilitating the identification of distress and unique concerns in this population and valuable in triaging and tailoring care for young cancer patients. Participants' responses show high levels of satisfaction with the tool, indicating its appropriateness, practicability, and acceptability, as well as its role in facilitating communication about psychosocial needs and prompt referrals. Ratings of clinical utility did not differ significantly between AYA and HCP groups, suggesting consistency in perceptions of the tool's effectiveness across different stakeholders.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
Morgan Young-Speirs, Caitlin Forbes, Michaela Patton, K. Brooke Russell, Mehak Stokoe, Kathleen Reynolds, Fiona Schulte
Summary: Survivors of childhood cancer have comparable perceived health to controls without cancer diagnosis, with pain, physical activity, and concerns related to health resources being significant predictors of perceived health. Understanding factors influencing perceived health in SCCs may help in developing interventions and further research.
Article
Oncology
Gabriela M. Maron, Diego R. Hijano, Rebecca Epperly, Yin Su, Li Tang, Randall T. Hayden, Swati Naik, Seth E. Karol, Stephen Gottschalk, Brandon M. Triplett, Aimee C. Talleur
Summary: CD19-specific CAR T cell therapy has revolutionized the treatment of relapsed/refractory B-ALL in pediatric and AYA patients. However, the infectious disease challenges associated with this therapy are not well understood. This study examines the infections that occurred in pediatric and AYA patients after receiving CD19-CAR T cells and identifies risk factors for infection. The results show that infections are common in the first 90 days after CAR T cell therapy, with bacterial infections being more frequent early on and viral infections occurring throughout the post-infusion period. The study highlights the need for further research to improve surveillance, prophylaxis, and treatment strategies for infectious complications.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Hazel B. Nichols, Chris D. Baggett, Stephanie M. Engel, Darios Getahun, Chelsea Anderson, Nancy T. Cannizzaro, Laura Green, Parul Gupta, Cecile A. Laurent, Paul C. Lin, Clare Meernik, Lisa M. Moy, Ethan Wantman, Lanfang Xu, Marilyn L. Kwan, Jennifer E. Mersereau, Chun R. Chao, Lawrence H. Kushi
Summary: The AYA Horizon study aims to provide high-quality, contemporary evidence on reproductive outcomes for female cancer survivors in the United States. The study found that active response to the survey component was low overall, especially among minority groups.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Lauren C. Heathcote, Sarah J. Cunningham, Sarah N. Webster, Vivek Tanna, Elia Mattke, Nele Loecher, Sheri L. Spunt, Pamela Simon, Gary Dahl, Marta Walentynowicz, Elizabeth Murnane, Perri R. Tutelman, Lidia Schapira, Laura E. Simons, Claudia Mueller
Summary: This study assessed the feasibility of using Ecological Momentary Assessment (EMA) to capture scanxiety in real-time using patients' personal smartphones. The findings indicate that EMA is a feasible, acceptable, and valid research tool for studying scanxiety. Participants reported higher levels of fear of cancer recurrence (FCR) in the days before surveillance scans, aligning with the expected trajectory of scanxiety. Additionally, the monitoring of bodily threats was associated with daily FCR, suggesting that it may be a risk factor for scanxiety, deserving further investigation.
Article
Oncology
Elizabeth J. Siembida, Holli A. Loomans-Kropp, Irene Tami-Maury, David R. Freyer, Lillian Sung, Howland E. Crosswell, Brad H. Pollock, Michael E. Roth
Summary: This study examines the patterns of barriers and facilitators between high- and low-enrolling community-based clinics for AYA patients with cancer. High-enrolling clinics face more barriers downstream in the enrollment process, such as physician gatekeeping, while low-enrolling clinics struggle with earlier steps in the CCT enrollment process, such as identifying eligible trials. These findings highlight the need for multi-level, tailored interventions to improve AYA enrollment in the community setting.