Article
Surgery
Binhao Huang, Maria Christine Xu, Arjun Pennathur, Zhigang Li, Zhiguo Liu, Qi Wu, Jing Wang, Kongjia Luo, Jianying Bai, Zhi Wei, Jiaqing Xiang, Wentao Fang, Jie Zhang
Summary: This study found similar outcomes in terms of overall survival and relapse-free survival between endoscopic R0 resection (ER) plus adjuvant treatment (AT) and esophagectomy for esophageal squamous cell cancer patients in T1aM3-T1b stage. ER + AT may be considered for high-risk patients or those who refuse esophagectomy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Biochemistry & Molecular Biology
Shangqi Song, Cheng Shen, Yang Hu, Yazhou He, Yong Yuan, Yuyang Xu
Summary: IVMTE has emerged as a promising treatment option for individualized treatment and improved outcomes in patients with esophageal cancer.
Article
Gastroenterology & Hepatology
E. Jezerskyte, L. M. Saadeh, E. R. C. Hagens, M. A. G. Sprangers, L. Noteboom, H. W. M. van Laarhoven, W. J. Eshuis, M. C. C. M. Hulshof, M. I. van Berge Henegouwen, S. S. Gisbertz
Summary: The study found that long-term health-related quality of life (HR-QoL) in disease-free patients following transthoracic esophagectomy (TTE) or transhiatal esophagectomy (THE) for distal esophageal or GEJ cancer is largely comparable, with any differences favoring TTE.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Hiroshi Miyata, Keijirou Sugimura, Takeshi Kanemura, Tomohira Takeoka, Masaaki Yamamoto, Naoki Shinno, Hisashi Hara, Takeshi Omori, Sachiko Yamamoto, Ryu Ishihara, Hiroshi Wada, Hidenori Takahashi, Junichi Nishimura, Chu Matsuda, Masayoshi Yasui, Masahiko Yano
Summary: Endoscopic treatment combined with esophagectomy or CRT can be a curative treatment option for patients with superficial esophageal cancer. Esophagectomy is recommended over CRT for patients with massive submucosal tumor invasion due to the risk of recurrence after CRT.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Faizan Ullah, Awais Naeem, Nighat Bakhtiar, Osama Shakeel, Shahid Khattak, Aamir Ali Syed
Summary: The objective of this study was to review the experience of dealing with oncological emergency esophagectomies at a dedicated Cancer hospital. A retrospective review of data from eleven patients who underwent emergency esophagectomies at a cancer hospital in Pakistan was conducted. The study found that emergency esophagectomy is a lifesaving procedure, and early diagnosis and management are crucial.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Deven C. Patel, Chi-Fu Jeffrey Yang, Hao He, Douglas Z. Liou, Leah M. Backhus, Natalie S. Lui, Joseph B. Shrager, Mark F. Berry
Summary: This study investigated the influence of facility volume on long-term survival in patients with esophageal cancer treated with esophagectomy. The results showed that patients treated at higher volume facilities had significantly better long-term survival than patients treated at lower volume facilities.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Surgery
Timothy J. Holleran, Michael A. Napolitano, Andrew D. Sparks, Jared L. Antevil, Fredrick J. Brody, Gregory D. Trachiotis
Summary: Increased hospital case volume is associated with improved outcomes after esophagectomy in the Veterans Affairs system, with a threshold of >4 cases/year leading to significantly lower mortality rates and shorter hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Zhenhua Li, Chunyue Gai, Yuefeng Zhang, Shiwang Wen, Huilai Lv, Yanzhao Xu, Chao Huang, Bo Zhao, Ziqiang Tian
Summary: This study compared the differences in lymph node dissection (LND) between minimally invasive esophagectomy (MIE) and open esophagectomy (OE) in thoracic esophageal cancer patients. The results suggest that MIE may have an advantage in lymph node dissection of the upper mediastinum 2L and 4L groups, but is similar to OE in other LND stations.
CHINESE MEDICAL JOURNAL
(2022)
Article
Surgery
Richard Hunger, Rene Mantke
Summary: This study examined the relationship between hospital volume and in-hospital mortality rates in pancreatic surgery in Germany. The findings suggest that hospitals with lower procedure volume can still achieve high-quality care with mortality rates comparable to high-volume hospitals. Therefore, volume alone may not be an adequate measure for assessing individual hospital quality, and more sophisticated certification systems should be preferred.
Article
Surgery
Eivind Gottlieb-Vedi, Joonas H. H. Kauppila, Fredrik Mattsson, Mats Lindblad, Magnus Nilsson, Pernilla Lagergren, Ioannis Rouvelas, Jesper Lagergren, FINEGO Grp
Summary: This study suggests that minimally invasive esophagectomy (MIE) is associated with higher 5-year survival compared to open esophagectomy (OE) in patients with esophageal cancer, especially total MIE.
Article
Multidisciplinary Sciences
Natnael Moges, Kassaye Ahmed, Dires Birhanu, Fekadesellasie Belege, Asrat Dimtse, Gashaw Kerebeh, Belayneh Dessie Kassa, Kumlachew Geta, Keder Essa Oumer, Edgeit Abebe Zewde, Anteneh Mengist Dessie, Denekew Tenaw Anley, Solomon Demis, Fisha Alebel GebreEyesus, Berihun Bantie
Summary: This study aimed to assess the surgical outcome and identify predictors of newborns with esophageal atresia admitted at Tikur Anbesa specialized hospital. The results showed that only 25% of newborns had successful surgical outcomes, and the poor surgical outcomes were associated with severe thrombocytopenia, timing of surgery, aspiration pneumonia, and related abnormalities.
Article
Oncology
Alexander C. Mertens, Marianne C. Kalff, Wietse J. Eshuis, Thomas M. Van Gulik, Mark I. Van Berge Henegouwen, Suzanne S. Gisbertz
Summary: In a propensity score-matched cohort, transthoracic esophagectomy showed a better lymph node dissection with higher yield, but also resulted in increased morbidity and short-term mortality.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Alexander Harris, James Butterworth, Piers R. Boshier, Hugh MacKenzie, Masanori Tokunaga, Hideki Sunagawa, Stella Mavroveli, Melody Ni, Sameh Mikhail, Chi-Chuan Yeh, Natalie S. Blencowe, Kerry N. L. Avery, Richard Hardwick, Arnulf Hoelscher, Manuel Pera, Giovanni Zaninotto, Simon Law, Donald E. Low, Jan J. B. van Lanschot, Richard Berrisford, Christopher Paul Barham, Jane M. Blazeby, George B. Hanna
Summary: A reliable surgical quality assurance system for 2-stage esophagectomy has been developed, which includes an operation manual, video, and photographic assessment tools. It aims to ensure surgical quality in surgical oncology randomized controlled trials.
Article
Gastroenterology & Hepatology
Samuel Han, Jennifer M. Kolb, Patrick Hosokawa, Chloe Friedman, Charlie Fox, Frank Scott, Christopher H. Lieu, Ravy K. Vajravelu, Martin McCarter, Caitlin C. Murphy, Michael B. Cook, Ana Gleisner, Gary W. Falk, David A. Katzka, Sachin Wani
Summary: Using the National Cancer Database, this study found that facilities with higher annual esophageal adenocarcinoma (EAC) case volume had better survival rates compared to lower volume facilities. The results suggest centralization of care for EAC patients at facilities with high annual case volume for improved outcomes.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nadav Rappoport, David M. Shahian, Noya Galai, Gal Aviel, John F. Keaney Jr, Oz M. Shapira
Summary: This study assessed the relationship between the number of cardiac surgeries and outcomes of resternotomy coronary artery bypass grafting (CABG). The results showed that the experience of individual surgeons had a more significant impact on surgical outcomes. Surgeon experience played a key role in improving surgical outcomes.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Martijn G. ten Berge, Naomi Beck, Willem Hans Steup, Ad F. T. M. Verhagen, Thomas J. van Brakel, Wilhelmina H. Schreurs, Michel W. J. M. Wouters
Summary: The study aimed to develop a new composite measure 'textbook outcome' to evaluate and improve quality of surgical care for NSCLC patients. Results showed that 26.4% of patients achieved textbook outcome, with insufficient lymph node dissection being the most substantial factor affecting it.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Oncology
Emma H. A. Stahlie, Viola Franke, Charlotte L. Zuur, Willem M. C. Klop, Bernies van der Hiel, Bart A. van de Wiel, Michel W. J. M. Wouters, Yvonne M. Schrage, Winan J. van Houdt, Alexander C. J. van Akkooi
Summary: The study demonstrates that intralesional T-VEC monotherapy can achieve high complete and durable responses. The prediction model suggests that using T-VEC in patients with less tumor burden is associated with better outcomes, indicating the potential benefit of earlier intervention in the disease course.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Fieke Hoeijmakers, Koen J. Hartemink, Ad F. Verhagen, Willem H. Steup, Elske Marra, W. F. Boudewijn Roell, David J. Heineman, Wilhelmina H. Schreurs, Rob A. E. M. Tollenaar, Michel W. J. M. Wouters
Summary: In the Netherlands, there is wide variation in the incidence and perioperative (preventive) management of PAL. Using water seal instead of suction drainage and increasing awareness are potential measures to reduce this variation.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Oncology
Robert T. van Kooten, Renu R. Bahadoer, Bouwdewijn ter Buurkes de Vries, Michel W. J. M. Wouters, Rob A. E. M. Tollenaar, Henk H. Hartgrink, Hein Putter, Johan L. Dikken
Summary: This study investigates the added value of machine learning to linear regression in predicting complications after upper gastrointestinal cancer surgery. The results show that while machine learning can predict complications, it does not outperform linear regression.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
V. T. Hoek, S. Buettner, C. L. Sparreboom, R. Detering, A. G. Menon, G. J. Kleinrensink, M. W. J. M. Wouters, J. F. Lange, J. K. Wiggers
Summary: This study aimed to develop a robust preoperative prediction model for anastomotic leakage after surgical resection for rectal cancer. Significant risk factors were identified and included in the prediction model, which can be used for patient counselling and risk-stratification before undergoing rectal resection for cancer.
Article
Health Care Sciences & Services
Rawa Kamaran Ismail, Jesper van Breeschoten, Silvia van der Flier, Caspar van Loosen, Anna Maria Gerdina Pasmooij, Maaike van Dartel, Alfons van den Eertwegh, Anthonius de Boer, Michel Wouters, Doranne Hilarius
Summary: The Dutch Institute for Clinical Auditing's Medicines Program evaluates the real-world effectiveness of expensive medicines using existing data sources. This study demonstrates the potential of adding declaration data to quality registries to provide benchmark information for participating centers. By linking national registries to clinical and financial data, as well as survival data, detailed insights into medication use, treatment information, clinical outcomes, and costs are obtained.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Oncology
Jesper van Breeschoten, Rawa K. Ismail, Michel W. J. M. Wouters, Doranne L. Hilarius, Liesbeth C. de Wreede, John B. Haanen, Christian U. Blank, Maureen J. B. Aarts, Franchette W. P. J. van den Berkmortel, Jan Willem B. de Groot, Geke A. P. Hospers, Ellen Kapiteijn, Djura Piersma, Rozemarijn S. van Rijn, Marion A. Stevense-den Boer, Astrid A. M. van der Veldt, Gerard Vreugdenhil, Marye J. Boers-Sonderen, Karijn P. M. Suijkerbuijk, Alfons J. M. van den Eertwegh
Summary: The minority of Dutch patients with metastatic melanoma started a new systemic therapy in the last phase of life. However, the percentages varied between Dutch melanoma centers. Financial impact of these therapies in the last phase of life is relatively small.
JCO ONCOLOGY PRACTICE
(2022)
Article
Oncology
Nansi Maliko, Nina Bijker, Monique E. M. M. Bos, Michel W. J. M. Wouters, Marie-Jeanne T. F. D. Vrancken Peeters
Summary: This study compares the patient and treatment characteristics of young and older breast cancer patients and analyzes the outcome of quality indicators over time. The results show that young patients often have unfavorable tumors, but treatment procedures are performed with higher adherence to quality indicators. Both young and older patients benefit from some treatment de-escalation trends.
Article
Oncology
Lisanne P. Zijlker, Max Bakker, Bernies van Der Hiel, Annemarie Bruining, W. Martin C. Klop, Charlotte L. Zuur, Michel W. J. M. Wouters, Alexander C. J. van Akkooi
Summary: This study aimed to determine the value of baseline ultrasound (US) and (18)fluorodeoxyglucose-positron emission tomography/computed tomography ((18)FDG-PET/CT) imaging in MCC patients. The results showed that baseline imaging frequently upstaged Stage I/II MCC patients to Stage III, both by US and FDG-PET/CT, while Stage IV disease was rarely identified. Patients who presented with palpable nodes were frequently upstaged to Stage IV by FDG-PET/CT imaging.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Robert T. T. van Kooten, Cor J. J. Ravensbergen, Sophie C. D. van Bueseck, Willem Grootjans, Koen C. M. J. Peeters, Fabian A. A. Holman, Jan W. T. Heemskerk, Michel W. J. M. Wouters, Ana Navas Canete, Rob A. E. M. Tollenaar
Summary: This study found that decreased muscle measurements (PMI and SMI) on preoperative CT scans were associated with increased risk of anastomotic leakage. These results suggest that preoperative CT-based muscle measurements can be used as prognostic factors for risk stratification of anastomotic leakage.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Daan Jan Willem Rauwerdink, Remco van Doorn, Jos van der Hage, Alfonsus J. M. Van den Eertwegh, John B. A. G. Haanen, Maureen Aarts, Franchette Berkmortel, Christian U. Blank, Marye J. Boers-Sonderen, Jan Willem B. De Groot, Geke A. P. Hospers, Melissa de Meza, Djura Piersma, Rozemarijn S. Van Rijn, Marion Stevense, Astrid Van der Veldt, Gerard Vreugdenhil, Michel W. J. M. Wouters, Karijn Suijkerbuijk, Monique van der Kooij, Ellen Kapiteijn
Summary: This study aimed to compare the efficacy of immunotherapy and BRAF/MEK inhibitors in metastatic nodular melanoma and metastatic superficial spreading melanoma. The results showed no difference in efficacy between the two treatments for patients with either type of melanoma. However, patients with nodular melanoma had shorter distant metastasis-free survival and worse overall survival, suggesting that the poorer overall survival of nodular melanoma is mainly due to the propensity for metastatic spread after the primary diagnosis.
Article
Oncology
Melissa M. M. De Meza, Willeke A. M. Blokx, Johannes J. J. Bonenkamp, Christian U. U. Blank, Maureen J. B. Aarts, Franchette W. P. J. van den Berkmortel, Marye J. J. Boers-Sonderen, Jan Willem B. De Groot, John B. A. G. Haanen, Geke A. P. Hospers, Ellen Kapiteijn, Olivier J. J. Van Not, Djura Piersma, Rozemarijn S. S. Van Rijn, Marion Stevense-den Boer, Astrid A. M. van der Veldt, Gerard Vreugdenhil, Alfonsus J. M. van den Eertwegh, Karijn P. M. Suijkerbuijk, Michel W. J. M. Wouters
Summary: BRAF/MEK therapy and anti-PD-1 therapy have shown better recurrence-free survival in stage III melanoma patients with BRAF V600 mutations. This study aimed to compare the toxicity and survival outcomes of these therapies in daily practice. The results showed that grade >= 3 toxicity occurred in 11.5% of patients, leading to early treatment discontinuation in 71.1% of cases. At 12 months, patients treated with BRAF/MEK therapy had better progression-free survival than those treated with anti-PD-1 therapy, but this difference was no longer observed at 18 months.
Article
Endocrinology & Metabolism
Silvia A. G. de Vries, Jessica C. G. Bak, Vincent A. Stangenberger, Michel W. J. M. Wouters, Max Nieuwdorp, Theo C. J. Sas, Carianne L. Verheugt
Summary: The study examined healthcare resource utilization and hospital expenditure of patients with diabetes in Dutch hospitals from 2019 to 2020. The results showed that the hospital resource use of Dutch diabetes patients is high, mainly due to the burden of cardiovascular complications. Therefore, early treatment and prevention of complications are crucial for controlling future healthcare expenditure on diabetes patients.
DIABETES OBESITY & METABOLISM
(2023)
Article
Oncology
Olivier J. van Not, Thijs T. Wind, Rawa K. Ismail, Arkajyoti Bhattacharya, Mathilde Jalving, Christian U. Blank, Maureen J. B. Aarts, Franchette W. P. J. van den Berkmortel, Marye J. Boers-Sonderen, Alfonsus J. M. van den Eertwegh, Jan Willem B. de Groot, John B. Haanen, Ellen Kapiteijn, Manja Bloem, Djura Piersma, Rozemarijn S. van Rijn, Marion Stevense-den Boer, Astrid A. M. van der Veldt, Gerard Vreugdenhil, Michel W. J. M. Wouters, Willeke A. M. Blokx, Karijn P. M. Suijkerbuijk, Rudolf S. N. Fehrmann, Geke A. P. Hospers
Summary: This study aimed to identify prognostic factors in advanced melanoma patients with brain metastases treated with immune checkpoint inhibitors. The analysis found that the serum lactate dehydrogenase (LDH) level was the strongest clinical parameter associated with survival.
Review
Health Care Sciences & Services
Elaine A. C. Albers, Itske Fraterman, Iris Walraven, Erica Wilthagen, Sanne B. Schagen, Iris M. van der Ploeg, Michel W. J. M. Wouters, Lonneke V. van de Poll-franse, Kelly M. de Ligt
Summary: Graphic visualization formats for Patient-Reported Outcome Measures (PROMs) data in clinical practice were evaluated in this systematic literature review. The study found no predominant format preference or interpretation accuracy among patients and clinicians. Patients preferred bar charts and line graphs for easy and quick retrieval of PROMs scores over time, while clinicians had similar accuracy and preferences for different graphic visualization formats. The interpretation of PROMs data can be improved by using colors, descriptive labels, and brief definitions.
JOURNAL OF PATIENT-REPORTED OUTCOMES
(2022)