High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes

Experimental Therapies and Clinical Trials in Bone Sarcoma

(2017) Rashmi Chugh   Journal of the National Comprehensive Cancer Network

Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway

(2010) Keinosuke Ryu et al.   BMC CANCER

Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma

(2010) Zhenfeng Duan et al.   CANCER LETTERS

Comprehensive Mapping of p53 Pathway Alterations Reveals an Apparent Role for Both SNP309 and MDM2 Amplification in Sarcomagenesis

(2010) M. Ito et al.   CLINICAL CANCER RESEARCH

Clinical Implications of the Cancer Genome

(2010) Laura E. MacConaill et al.   JOURNAL OF CLINICAL ONCOLOGY

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

(2010) Jordi Barretina et al.   NATURE GENETICS

Crizotinib inALK-Rearranged Inflammatory Myofibroblastic Tumor

(2010) James E. Butrynski et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer

(2010) Eunice L. Kwak et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapamycin Pharmacokinetic and Pharmacodynamic Relationships in Osteosarcoma: A Comparative Oncology Study in Dogs

(2010) Melissa C. Paoloni et al.   PLoS One

Development of Phosphoinositide-3 Kinase Pathway Inhibitors for Advanced Cancer

(2010) James M. Cleary et al.   Current Oncology Reports

Functional genome screen for therapeutic targets of osteosarcoma

(2009) Umio Yamaguchi et al.   CANCER SCIENCE

Novel therapeutic agents for osteosarcoma

(2009) Kathleen O’Day et al.   Expert Review of Anticancer Therapy

mTOR/p70S6K Signal transduction pathway contributes to osteosarcoma progression and patients’ prognosis

(2009) Quan Zhou et al.   MEDICAL ONCOLOGY

Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines

(2009) Z. Duan et al.   MOLECULAR CANCER THERAPEUTICS

Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples

(2009) Laura E. MacConaill et al.   PLoS One

Copy number gains inEGFRand copy number losses inPTENare common events in osteosarcoma tumors

(2008) Serena S. Freeman et al.   CANCER

Major Response to Imatinib Mesylate in KIT-Mutated Melanoma

(2008) F. Stephen Hodi et al.   JOURNAL OF CLINICAL ONCOLOGY

Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer

(2008) Z. Duan et al.   MOLECULAR CANCER THERAPEUTICS

Therapy for Osteosarcoma

(2008) Alexander J Chou et al.   PEDIATRIC DRUGS