4.6 Article

SERS detection of expired tetracycline hydrochloride with an optical fiber nano-probe

Journal

ANALYTICAL METHODS
Volume 7, Issue 4, Pages 1307-1312

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ay02725f

Keywords

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Funding

  1. Natural Science Foundation of China (NSFC) [61107076, 61177088]
  2. National Program on Key Basic Research Project (973 Program) [2012CB723405]
  3. Key Laboratory of Specialty Fiber Optics and Optical Access Networks [SKLSFO2012-01, SKLSFO2013-02]

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In this paper, we have developed a Raman spectroscopy analytical method for the analysis of tetracycline hydrochloride. Surface enhanced Raman spectroscopy (SERS) was carried out with optical fiber nano-probe coated nanoparticles. Both normal and expired tetracycline hydrochloride were analyzed in direct detection mode and remote detection mode. The results showed that the surface-enhanced Raman spectra could provide chemical information for distinguishing normal drugs from the expired ones. It has been demonstrated that the drug could be analyzed rapidly by SERS with the optical fiber nano-probe.

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