Article
Clinical Neurology
Marie Kim Wium-Andersen, Ida Kim Wium-Andersen, Terese Sara Hoj Jorgensen, Martin Balslev Jorgensen, Merete Osler
Summary: Patients with affective disorder have higher absolute and relative risks of most somatic diseases, except for cancers. The strongest associations were found for dementia, hip fracture, COPD, and stroke on both the relative and absolute scale. Further research on shared mechanisms could lead to targeted interventions to reduce the risk.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Alessandro Miola, Leonardo Tondo, Marco Pinna, Martina Contu, Ross J. Baldessarini
Summary: Suicidal behavior is more prevalent in patients with bipolar disorder compared to major depressive disorder. The risk and protective factors for suicidal behavior differ between the two disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, General & Internal
Cathrine Fonnesbech Hjorth, Per Damkier, Bent Ejlertsen, Timothy Lash, Henrik Toft Sorensen, Deirdre Cronin-Fenton
Summary: This study aimed to investigate how socioeconomic position influences the effectiveness of cancer-directed treatment in premenopausal breast cancer patients, and found that patients with lower socioeconomic status had an increased risk of mortality, but not always recurrence.
Article
Oncology
Kristine Elberg Dengso, Thordis Thomsen, Elisabeth Wreford Andersen, Carsten Palnaes Hansen, Bo Marcel Christensen, Jens Hillingso, Susanne Oksbjerg Dalton
Summary: Partners of pancreatic cancer patients face a significant psychological symptom burden, with a higher risk of first depression and increased use of anxiolytics and hypnotics. Attention should be paid to the mental health needs of partners of PC patients, especially in the first year post-diagnosis.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Pharmacology & Pharmacy
Vincent Chin-Hung Chen, Tsai-Ching Hsu, Chiao-Fan Lin, Jing-Yu Huang, Yi-Lung Chen, Bor-Show Tzang, Roger S. McIntyre
Summary: The study demonstrated that risperidone has significant tumor inhibition effects on human gastric cancer cells, as well as a potential reduction in gastric cancer risk for users compared to non-users. However, further research and evaluation are needed to confirm these findings.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Sophie Rozanski, Alexandra Schmidt, Amber John, Darya Gaysina
Summary: The study found that childhood neglect has long-lasting negative effects on trajectories of adult mental health, especially impacting the 'high and decreasing', 'high and increasing', and 'persistent mild/moderate' affective symptoms trajectories.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Raphael O. Cerqueira, Carolina Ziebold, Daniel Cavalcante, Giovany Oliveira, Javiera Vasquez, Juan Undurraga, Alfonso Gonzalez-Valderrama, Ruben Nachar, Carlos Lopez-Jaramillo, Cristiano Noto, Nicolas Crossley, Ary Gadelha
Summary: This study compares patients with affective and non-affective psychosis (A-FEP and NA-FEP) in a Latin American sample. The findings suggest that characteristics of FEP patients could be utilized to enhance diagnosis and inform treatment decisions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Acoustics
J. Farren, M. Jalmbrant, N. Falconieri, N. Mitchell-Jones, S. Bobdiwala, M. Al-Memar, S. Tapp, B. Van Calster, L. Wynants, D. Timmerman, T. Bourne
Summary: This study investigated and compared post-traumatic stress (PTS), depression, and anxiety in women and their partners over a 9-month period following miscarriage or ectopic pregnancy. The results showed that women experienced significantly higher levels of PTS, anxiety, and depression compared to their partners during this period.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Clinical Neurology
Wenzhen Li, Dajie Chen, Wenyu Ruan, Ying Peng, Zuxun Lu, Dongming Wang
Summary: This study found that depression and sleep disorder are associated with increased risks of total and specific-cause mortality. Factors such as sex, age, and BMI may influence this association.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Wenzhen Li, Dajie Chen, Wenyu Ruan, Ying Peng, Zuxun Lu, Dongming Wang
Summary: The study found that depression and sleep disorder are associated with mortality, particularly with cardiovascular disease mortality. Men and older individuals are more susceptible to the effects of depression and sleep disorders. There is a dose-response relationship between depression scores, sleep duration and total mortality.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Marta Migo, Kendra Simpson, Amy Peters, Kristen K. Ellard, Tina Chou, Andrew A. Nierenberg, Darin D. Dougherty, Thilo Deckersbach
Summary: By dimensionally analyzing symptom severity in patients with bipolar disorder, more accurate differences in neural responses to emotional stimuli can be captured. There is a correlation between symptom severity and brain activation, with depression severity associated with increased activation in various brain regions and mania severity associated with both increased and decreased activation.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Frank Iorfino, Ciro Marangoni, Lihong Cui, Daniel F. Hermens, Ian B. Hickie, Kathleen Ries Merikangas
Summary: The study found that anxiety-related temperamental traits show familial specificity, but these traits cannot fully explain the shared heritability between anxiety subtypes and mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Geriatrics & Gerontology
Marcus K. Borges, Hans W. Jeuring, Radboud M. Marijnissen, Barbara C. van Munster, Ivan Aprahamian, Rob H. S. van den Brink, Emiel O. Hoogendijk, Richard C. Oude Voshaar
Summary: Frailty and affective disorders, such as depression and anxiety, have a bidirectional relationship. Affective disorders contribute to the progression of frailty, with the most impact seen at lower levels of frailty. The findings suggest that interventions to slow down biological aging should be targeted towards younger and middle-aged individuals, as well as non-frail older patients.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Clinical Neurology
Yi-Hsien Chen, Wei-Ming Wang, I-Hsun Li, Hui-Han Kao, Chin-Bin Yeh, Li-Ting Kao
Summary: The study provides evidence that MDD is an independent risk factor for developing psoriasis, with a higher risk in males. Further investigation is needed to explore the underlying pathological mechanisms in the psychiatric field.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Nicole R. Nugent, Michael Armey, Steven Boker, Leslie Brick, Valerie Knopik, John E. McGeary, Anthony Spirito, Matthias R. Mehl
Summary: This research examines the genomics and in vivo dynamics of family context and experienced affect following discharge from psychiatric hospitalization for suicidal thoughts and behaviors. The study involves a longitudinal, multimethod observational investigation and participants are recruited from an inpatient child and adolescent psychiatric hospital. The research protocol aims to characterize the in vivo, real-world experienced affect and observed family context associated with STB in adolescents during the high-risk weeks post discharge, merging multiple fields of study.
Article
Oncology
Sidsel Pedersen, Rikke B. B. Holmstroem, Annika von Heymann, Laerke K. K. Tolstrup, Kasper Madsen, Morten Aagaard Petersen, Charlotte A. A. Haslund, Christina H. H. Ruhlmann, Henrik Schmidt, Christoffer Johansen, Inge Marie Svane, Eva Ellebaek
Summary: This study investigates the impact of adjuvant immunotherapy on health-related quality of life (HRQoL) in patients with resected melanoma. The findings suggest that HRQoL is lowest in patients who ended therapy 0-6 months ago and that fatigue is more severe in this group. Patients in active treatment for >6 months also have lower HRQoL and more fatigue compared to those who started treatment 0-6 months ago. However, patients who ended therapy >6 months ago have higher HRQoL and less fatigue. HRQoL is associated with treatment status, comorbidity, civil status, and employment status.
Article
Oncology
A. Gouliaev, T. R. Rasmussen, N. Malila, L. Fjellbirkeland, L. Lofling, E. Jakobsen, S. O. Dalton, N. L. Christensen
Summary: This paper describes and compares the characteristics of lung cancer registry data in Denmark, Finland, Norway, and Sweden, and discusses how a more harmonized registration practice could increase their usefulness for mutual learning and quality improvement.
Article
Oncology
Anne Marie Kirkegaard, Susanne Oksbjerg Dalton, Ellen Helle Boesen, Randi V. Karlsen, Henrik Flyger, Christoffer Johansen, Annika von Heymann
Summary: This study investigated the impact of a psychosocial group intervention on long-term survival in women with early-stage breast cancer and compared the characteristics and survival between study participants and non-participants. The results showed that the psychosocial intervention did not significantly improve survival in the intervention group. Participants had higher survival rates than non-participants, but this difference was more attributed to clinical and demographic characteristics rather than study participation.
Article
Oncology
Randi V. Karlsen, Beverley Lim Hoeg, Susanne Oksbjerg Dalton, Lena Saltbaek, Christian Dehlendorff, Christoffer Johansen, Mads Nordahl Svendsen, Pernille E. Bidstrup
Summary: This study examined whether recent socioeconomic factors were associated with health-related quality of life (HRQoL) and self-management in breast cancer patients. The results showed that socioeconomic factors did influence HRQoL, especially within the first five years after diagnosis, specifically in terms of experiencing and reporting relevant symptoms of concern.
Review
Oncology
Sandra Jensen, Zina Bloch, Morten Quist, Tobias Tuse Dunk Hansen, Christoffer Johansen, Helle Pappot, Charlotte Suetta, Bolette Skjodt Rafn
Summary: In patients with lung cancer, chemotherapy treatment leads to significant loss of skeletal muscle mass and a high prevalence of sarcopenia. This is associated with poor clinical outcomes and emphasizes the need for assessment and interventions targeting skeletal muscle mass during treatment.
Article
Oncology
Kristine Elberg Dengso, Thordis Thomsen, Bo Marcel Christensen, Carina Lund Sorensen, Michael Galanakis, Susanne Oksbjerg Dalton, Jens Hillingso
Summary: This study aimed to assess Health Related Quality of Life (HRQoL), anxiety and depression in patients and caregivers during follow-up care after curative treatment for cancer in the pancreas, duodenum, or bile ducts. The study also highlighted the need to systematically screen physical and psychological symptoms in patients and caregivers during follow-up care and prioritize symptom management by clinicians.
Article
Oncology
Neel Maria Helvind, Marie Brinch-Moller Weitemeyer, Annette Hougaard Chakera, Helle Westergren Hendel, Eva Ellebaek, Inge Marie Svane, Mette Wanscher Kjaerskov, Sophie Bojesen, Helle Skyum, Soren Kjaer Petersen, Lars Bastholt, Christoffer Johansen, Pernille Envold Bidstrup, Lisbet Rosenkrantz Holmich
Summary: This study aimed to determine the impact of surveillance with routine FDG PET-CT on hazard, cumulative incidence, and absolute risk of overall, locoregional, and distant recurrence detection in patients with stage IIB to IIID cutaneous melanoma. The study found that patients with stage IIB to IIID melanoma followed with routine FDG PET-CT had a 51% increased hazard of distant recurrence detection within the first two years of surveillance.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Anne Katrine Graudal Levinsen, Trille Kristina Kjaer, Thomas Maltesen, Erik Jakobsen, Ismail Gogenur, Michael Borre, Peer Christiansen, Robert Zachariae, Soren Laurberg, Peter Christensen, Niels Kroman, Signe Benzon Larsen, Thea Helene Degett, Lisbet Rosenkrantz Holmich, Peter de Nully Brown, Christoffer Johansen, Susanne K. Kjaer, Lau Caspar Thygesen, Susanne Oksbjerg Dalton
Summary: Cancer survivors use more healthcare services compared to cancer-free individuals. There is a correlation between educational level and healthcare use, with survivors with lower education being more likely to use general practitioner and acute healthcare services.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Oncology
Mikkel Bandak, Kristine Skovly Nielsen, Michael Kreiberg, Thomas Wagner, Josephine Rosenvilde, Charlotta Pissinger, Christoffer Johansen, Gedske Daugaard, Jakob Lauritsen
Summary: We examined the effects of smoking on the overall survival (OS) of testicular germ cell cancer (TC) patients who received first-line combination chemotherapy (BEP). Using the Danish Testicular Cancer database, we identified patients who underwent BEP for metastatic TC. Information on smoking status at diagnosis was obtained through medical record review. OS and cause of death were compared between current smokers and never-smokers. Of the 1883 eligible patients, smoking status was available for 1156 patients, with 602 being current smokers. The 10-year OS rate was 92% for never-smokers and 83% for current smokers (P < .001), with a hazard ratio for death of 1.85 (95% confidence interval = 1.29 to 2.66, P = .001). A higher proportion of current smokers died from TC compared to nonsmokers (P < .01). Smoking negatively impacts survival after BEP in patients with disseminated TC, highlighting the need for vigorous smoking cessation programs in TC patients.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Gunn Ammitzboll, Ole Hyldegaard, Martin Forchhammer, Henrik Rottensten, Charlotte Lanng, Niels Kroman, Bo Zerahn, Lars Thorbjorn Jensen, Christoffer Johansen, Susanne Oksbjerg Dalton
Summary: This study aimed to explore the effects of Hyperbaric Oxygen Treatment (HBOT) on early breast cancer-related lymphedema (LE) and its implications for quality of life (QOL). In a prospective observational study, participants receiving 40 sessions of HBOT over 8 weeks were followed for 6 months. While there were no consistent changes in objective measures of LE severity, participants reported significant improvements in QOL.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Anne Sofie Friberg, Sigrid V. V. Carlsson, Andrew J. J. Vickers, Susanne Oksbjerg Dalton, Signe Benzon Larsen, Lena Saltbaek, Beverley Lim Hoeg, Pernille Envold Bidstrup, Thomas Helgstrand, Andreas Roder, Klaus Brasso, Christoffer Johansen
Summary: The study examined the risk of suicide among prostate cancer patients compared to cancer-free men, taking into consideration clinical stage, socioeconomic position, somatic comorbidity, and previous depression. The risk of suicide was found to be similar between prostate cancer patients and cancer-free men, but it was highest within the first year after diagnosis. Prostate cancer patients with a history of depression had a higher risk of suicide. Healthcare professionals should pay attention to the risk of suicide among men with previous depression following a prostate cancer diagnosis.
Article
Oncology
Cecilie Hollaender-Mieritz, Emma Balch Steen-Olsen, Claus Andrup Kristensen, Christoffer Johansen, Ivan Richter Vogelius, Helle Pappot
Summary: Consumer wearables, such as smartwatches, can monitor health data and may be useful in the clinical care of cancer patients. The OncoWatch 1.0 study investigated the feasibility of using a smartwatch to monitor heart rate and physical activity in patients with head and neck cancer receiving radiotherapy. Although adherence to wearing the smartwatch was lower than expected, important findings were made regarding data setup and considerations for future studies.
Article
Oncology
Helle Pappot, Benony P. Bjoernsson, Oswin Krause, Christina Baeksted, Pernille E. Bidstrup, Susanne O. Dalton, Christoffer Johansen, Ann Knoop, Ivan Vogelius, Cecilie Hollander-Mieritz
Summary: By analyzing ePRO data using Machine Learning algorithms and permutation importance, this study found that symptoms such as aching joints and numbness/tingling may be important factors leading to nonadherence to planned adjuvant chemotherapy in breast cancer patients.