Article
Oncology
Derek D. Kao, Rocco M. Ferrandino, Joshua M. Bauml, Deborah C. Marshall, Richard Bakst, Scott Roof, Yeun-Hee A. Park, Keith M. Sigel
Summary: This retrospective study compared the effects of timing of prophylactic feeding tube (PFT) and reactive feeding tube (RFT) placement on survival, body weight trends, and hospitalization rates in head and neck cancer patients. The results showed that there was no significant difference in overall survival, body weight changes, and hospitalization rates between PFT and RFT groups after propensity score matching. However, patients who received PFT had lower hospitalization rates compared to those who received RFT.
Review
Biochemistry & Molecular Biology
Sindhu Nair, James A. Bonner, Markus Bredel
Summary: EGFR is overexpressed in head and neck squamous cell carcinoma and anti-EGFR strategies have shown some clinical benefit but often lead to resistance. Mutations in various domains of the EGFR gene can impact drug binding, radiation response, and overall survival in HNSCC patients. Understanding the EGFR mutational landscape and its effects on treatment resistance can help stratify patients for targeted therapies and maximize therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Zeng-Hong Wu, Yi Zhong, Tao Zhou, Hong-Jun Xiao
Summary: The study used RNA sequencing and miRNA sequencing data to reveal the dysfunctional miRNAs microenvironment in head and neck squamous cell carcinoma and provide useful biomarkers for miRNAs therapy. By predicting the target genes of miRNAs, nine genes correlated with patient's overall survival outcomes were identified.
Review
Biochemistry & Molecular Biology
Xin Zhou, Xiaoshen Wang
Summary: This review provides a detailed illustration of the biology, genomic features, and immune landscapes of HPV-associated HNSCC, supporting the synergistic effect of radioimmunotherapy. Current evidence and ongoing clinical trials suggest the potential of radioimmunotherapy in recurrent/metastatic or definitive settings. Future challenges include optimization of radiotherapy and the incorporation of novel therapeutic options.
Review
Medicine, General & Internal
Kamila Romanowska, Agnieszka Sobecka, Agnieszka A. Rawluszko-Wieczorek, Wiktoria M. Suchorska, Wojciech Golusinski
Summary: Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer worldwide, with molecular pathogenesis involving cell cycle disorders, intercellular signaling, proliferation, squamous cell differentiation, and apoptosis. In addition to genetic mutations, epigenetic alterations such as DNA methylation and histone modifications play a key role in promoting cancer formation and progression, making them potential biomarkers and therapeutic targets for HNSCC.
Article
Oncology
Kayla R. Getz, Emily Bellile, Katie R. Zarins, Cailey Rullman, Steven B. Chinn, Jeremy M. G. Taylor, Laura S. Rozek, Gregory T. Wolf, Alison M. Mondul
Summary: The study identified a significant inverse association between statin use and overall death, disease-specific death, and recurrence in untreated HNSCC patients. This protective effect was particularly pronounced in patients with HPV-positive disease.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Yazan Abu-Shama, Julia Salleron, Florent Carsuzaa, Xu-Shan Sun, Carole Pflumio, Idriss Troussier, Claire Petit, Matthieu Caubet, Arnaud Beddok, Valentin Calugaru, Stephanie Servagi-Vernat, Joel Castelli, Jessica Miroir, Marco Krengli, Paul Giraud, Edouard Romano, Jonathan Khalifa, Melanie Dore, Nicolas Blanchard, Alexandre Coutte, Charles Dupin, Shakeel Sumodhee, Yungan Tao, Vincent Roth, Lionel Geoffrois, Bruno Toussaint, Duc Trung Nguyen, Jean-Christophe Faivre, Juliette Thariat
Summary: A retrospective multicentric study on 322 patients with head and neck cancers of unknown primary (HNCUP) found that neck dissection (ND) improved progression-free survival (PFS) regardless of nodal stage, but did not improve survival rates. The extent of ND did not affect the benefits of the procedure, and the benefits decreased with a more advanced nodal stage.
Article
Oncology
Juan L. Callejas-Valera, Daniel W. Vermeer, Christopher T. Lucido, Caitlin Williamson, Marisela Killian, Paola D. Vermeer, William C. Spanos, Steven F. Powell
Summary: Blocking the PD-1/L1 interaction represents a breakthrough in the treatment of head and neck squamous cell carcinoma (HNSCC), with improved efficacy when combined with chemoradiotherapy. While this therapy decreases PD-1-expressing T cells, it may also lead to an increase in populations contributing to immune exhaustion.
Article
Oncology
Yu Dou, Chao Ma, Ketao Wang, Shaohua Liu, Jintang Sun, Wanye Tan, Markus Neckenig, Qingjie Wang, Zuoqing Dong, Wenjuan Gao, Anwei Chen, Dong Zhang, Bing Wang, Liang Shi, Zhaodi Nan, Dan Ai, Wenjie Yu, Jia Liu, Bingfeng Song, Lei Zhao, Qianqian Shao, Yong Zhu, Tao Wang, Jianing Wang, Wei Hu, Fengcai Wei, Xin Xu, Xun Qu
Summary: The study reveals an association between tumor microbiota and outcomes of HNSCC patients, with poor prognosis patients having lower microbial richness and specific genera enrichment, while good prognosis patients having richer and health-promoting microbial communities. The microbial dysbiosis index (MDI) shows significant association with overall survival (OS) and disease free survival (DFS), independently of other clinical factors.
Article
Oncology
Nancy Y. Lee, Robert L. Ferris, Amanda Psyrri, Robert Haddad, Makoto Tahara, Jean Bourhis, Kevin Harrington, Peter Mu-Hsin Chang, Jin-Ching Lin, Mohammad Abdul Razaq, Maria Margarida Teixeira, Jozsef Lovey, Jerome Chamois, Antonio Rueda, Chaosu Hu, Lara A. Dunn, Mikhail Vladimirovich Dvorkin, Steven De Beukelaer, Dmitri Pavlov, Holger Thurm, Ezra Cohen
Summary: This study aimed to evaluate the addition of avelumab (anti-PD-L1) to chemoradiotherapy for locally advanced squamous cell carcinoma of the head and neck, but the primary objective of prolonging progression-free survival was not met. The most common grade 3 or worse treatment-related adverse events were neutropenia, mucosal inflammation, dysphagia, and anemia.
Article
Oncology
Kimberley L. Kiong, Christopher M. K. L. Yao, Fang-Yu Lin, Diana Bell, Renata Ferrarotto, Randal S. Weber, Carol M. Lewis
Summary: A study found that a longer time to surgery (≥34 days) after neoadjuvant chemotherapy in head and neck squamous cell carcinoma patients leads to significantly worse distant metastasis-free rate and disease-free survival rate, but no significant differences in overall survival and locoregional recurrence rate.
Article
Medicine, Research & Experimental
Vaishali Chandel, Saurabh Maru, Arun Kumar, Ashok Kumar, Ashok Sharma, Brijesh Rathi, Dhruv Kumar
Summary: Head and Neck tumors exhibit highly altered metabolism, with cancer cells utilizing different pathways for energy production. Monocarboxylate transporters play a crucial role in regulating lactate and maintaining pH balance, essential for cancer cell survival and growth control.
Article
Oncology
Zongtai Qi, Yating Liu, Michael Mints, Riley Mullins, Reilly Sample, Travis Law, Thomas Barrett, Angela L. Mazul, Ryan S. Jackson, Stephen Y. Kang, Patrik Pipkorn, Anuraag S. Parikh, Itay Tirosh, Joseph Dougherty, Sidharth V. Puram
Summary: Tumors are composed of diverse cells rather than a uniform ball of cells. Recent studies have shown that deconvolution algorithms can be used to computationally estimate cell-type proportions from gene expression data, although their performance in tumor tissues remains unclear.
Article
Medicine, Research & Experimental
Angela Boros, Pierre Blanchard, Arlette Dade, Philippe Gorphe, Ingrid Breuskin, Caroline Even, France Nguyen, Eric Deutsch, Francois Bidault, Francois Janot, Stephane Temam, Haitham Mirghani, Yungan Tao
Summary: The study found that upfront neck dissection (UFND) could improve overall survival (OS) and progression-free survival (PFS) in N3 head and neck squamous cell carcinoma (HNSCC) patients, especially for non-oropharyngeal cancer, regardless of neck node size.
Review
Biochemistry & Molecular Biology
Ching-Yun Hsieh, Ching-Chan Lin, Wei-Chao Chang
Summary: Taxanes, especially docetaxel, are widely used in combination therapy for head and neck squamous cell carcinoma (HNSCC) and have shown advantages in improving patient outcomes. Taxanes not only function as antimitotics, but also impair various oncogenic signaling pathways. However, the development of drug resistance remains a major obstacle to treatment response.