Article
Oncology
Jeana E. Havidich, Julie E. Weiss, Tracy L. Onega, Ying H. Low, Martha E. Goodrich, Mathew A. Davis, Brian D. Sites
Summary: This study examined the association between prescription opioids and incident cancers, and found a complex relationship where opioids were negatively associated with breast and colon cancer, but positively associated with kidney, leukemia, liver, lung, and lymphoma cancers. This suggests that cancer site may play an important role in the relationship between opioids and cancer development.
Article
Medical Informatics
Changhee Lee, Alexander Light, Ahmed Alaa, David Thurtle, Mihaela van der Schaar, Vincent J. Gnanapragasam
Summary: The study compared different prognostic models and found that the machine learning-based Survival Quilts model had good discrimination for predicting 10-year prostate cancer-specific mortality, similar to the top multivariable models. Additionally, it was found that multivariable models outperformed tier-based models when models were stratified.
LANCET DIGITAL HEALTH
(2021)
Article
Oncology
Wu Lin, Xuming Pan, Chun Zhang, Bochun Ye, Jia Song
Summary: This study aimed to determine the effect of age on survival in bladder cancer. Analysis of 117,275 bladder cancer patients from the Surveillance, Epidemiology, and End Results database revealed that patients aged 75 years and above had shorter overall survival compared to those aged 54 years and below, and increasing age was associated with decreased bladder cancer-specific survival.
Article
Oncology
Yi Lu, Wei Zhang, Shujun Fan, Zhen Liang, Zhongjia Li, Jia Tian, Jiaqi Kang, Yuxuan Song, Kang Liu, Kechong Zhou, Xiao Wang, Yongjiao Yang, Xiaoqiang Liu
Summary: In individuals aged over 65, metabolic syndrome (MetS) and its components were significant risk factors for upper tract urothelial carcinoma (UTUC) with consistent associations in different tumor stages, grades, and tumor size. Even if a subject did not meet the criteria for MetS, having just one of the components still elevated the risk for UTUC. Strategies to control the epidemic of MetS and its components may help reduce the burden of UTUC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Koji Sasaki, Farhad Ravandi, Tapan M. Kadia, Courtney D. DiNardo, Nicholas J. Short, Gautam Borthakur, Elias Jabbour, Hagop M. Kantarjian
Summary: In a population-based study using Surveillance, Epidemiology, and End Results data, the outcomes of patients with acute myeloid leukemia (AML) have shown incremental improvement over time. With the introduction of targeted therapies and optimizations in supportive care, survival rates are expected to continue improving, especially among older patients.
Review
Medicine, General & Internal
Wen-Qiang Che, Yuan-Jie Li, Chi-Kwan Tsang, Yu-Jiao Wang, Zheng Chen, Xiang-Yu Wang, An-Ding Xu, Jun Lyu
Summary: The Surveillance, Epidemiology, and End Results (SEER) program in the US is the sole comprehensive source of population-based information on cancer stage and patient survival. Although it covers about half of all cancer patients in the country, the large volume and complexity of data in the SEER database have hindered its application. In this review, the commonly used methodologies and study designs for retrospective epidemiological research are systematically overviewed to illustrate the application of the SEER database, with the aim of assisting researchers in selecting appropriate methods and study designs to enhance the robustness and reliability of clinical studies.
MILITARY MEDICAL RESEARCH
(2023)
Article
Oncology
Xiaowei Tang, Nan Hu, Shu Huang, Jiao Jiang, HuiTing Rao, Xin Yang, Yi Yuan, Yanlang Zhang, Guodong Xia
Summary: This study identified prognostic factors and established nomograms for predicting overall survival and cause-specific survival in patients with multi-organ metastatic colorectal cancer. These nomograms can assist clinicians in formulating appropriate treatment plans.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Lee A. Hugar, Jonathan G. Yabes, Pauline Filippou, Elizabeth M. Wulff-Burchfield, Samia H. Lopa, John Gore, Benjamin J. Davies, Bruce L. Jacobs
Summary: This study aimed to quantify the proportion of patients with bladder cancer receiving high-intensity end-of-life care, identify associated risk factors, and assess the impact of palliative care. Results showed that 45% of patients received high-intensity care, with a decrease over time; these patients often had comorbidities, advanced bladder cancer, and nonbladder cancer cause of death. Additionally, they more often received palliative care, but further from bladder cancer diagnosis.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Public, Environmental & Occupational Health
Shi-Ping Yang, Hui-Luan Su, Xiu-Bei Chen, Li Hua, Jian-Xian Chen, Min Hu, Jian Lei, San-Gang Wu, Juan Zhou
Summary: This study analyzed data of advanced epithelial ovarian cancer patients to assess the role of histological subtypes in predicting prognosis among long-term survivors. Different histological subtypes showed varying probabilities of death, with serous subtype associated with higher mortality from primary ovarian cancer. Individualized surveillance programs are important for long-term ovarian cancer survivors.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2021)
Article
Oncology
Zheng-Gang Wang, Zhi-Yi He, Yan-Yan Chen, Huan Gao, Xing-Li Du
Summary: This study characterized the epidemiology and prognostic factors of secondary liver cancer, identifying the primary site and synchronous distant metastasis as significant factors associated with patient prognosis. These findings have implications for clinical diagnosis and treatment, improving understanding of secondary liver cancer in the general population.
TRANSLATIONAL CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Gabriela Vanessa Flores Monar, Thomas Reynolds, Maxie Gordon, David Moon, Chulso Moon
Summary: Bladder cancer is a financially burdensome cancer with significant impact on patients and the medical community. Current detection methods have limitations and there is a need to explore new screening assays. This article provides a comprehensive overview of bladder cancer and analyzes FDA-approved assays for diagnosis and monitoring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Michael S. Chang, Jennifer La, Nicole Trepanowski, David Cheng, John R. Bihn, Nhan Do, Mary Brophy, Nathanael R. Fillmore, Rebecca Hartman
Summary: Veterans with melanoma are diagnosed at later stages, but there has been recent improvement in stage IV MSS.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Sumedha Chhatre, Septimiu Murgu, Anil Vachani, Ravishankar Jayadevappa
Summary: This study analyzed the outcomes of stage I and II non-small cell lung cancer patients treated with photodynamic therapy (PDT), ablation therapy, and radiation therapy. The results showed that PDT was associated with lower mortality rates compared with radiation therapy alone and longer time to follow-up treatment compared with ablation therapy.
Article
Oncology
Fernando Lozano, Carles X. X. Raventos, Albert Carrion, Carme Dinares, Javier Hernandez, Enrique Trilla, Juan Morote
Summary: The urine biomarker XBM can predict early high-risk recurrences in non-muscle invasive bladder cancer (NMIBC), but it has low sensitivity and cannot replace cystoscopy and washing cytology.
Article
Oncology
Taylor D. Ellington, S. Jane Henley, Reda J. Wilson, Jacqueline W. Miller, Manxia Wu, Lisa C. Richardson
Summary: This article analyzes mortality data from the Centers for Disease Control and Prevention from 1999 to 2020 to examine trends in breast cancer mortality. The findings suggest that overall breast cancer mortality is decreasing, but there are variations based on race/ethnicity, age group, and US Census region.