Article
Multidisciplinary Sciences
Jorge Diaz-Alvarez, Patricia Roiz, Luis Gorospe, Ana Ayala, Sergio Perez-Pinto, Javier Martinez-Sanz, Matilde Sanchez-Conde, Jose L. Casado, Maria J. Perez-Elias, Ana Moreno, Raquel Ron, Maria J. Vivancos, Pilar Vizcarra, Santiago Moreno, Sergio Serrano-Villar
Summary: In this pilot program, the prevalence of lung cancer among people with HIV screened using LDCT was 3.6%, and the number needed to screen to detect one case of lung cancer was 28. While data from additional cohorts with longitudinal measurements are needed, people with HIV are a target population for lung cancer screening with LDCT.
Review
Medicine, General & Internal
Scott J. Adams, Emily Stone, David R. Baldwin, Rozemarijn Vliegenthart, Pyng Lee, Florian J. Fintelmann
Summary: Randomised controlled trials have shown that low-dose CT lung cancer screening reduces mortality compared with chest radiography or no screening. However, uncertainties remain about optimizing clinical and cost effectiveness. This Review provides an international perspective on lung cancer screening, covering clinical trials, identification of individuals who benefit, management of screen-detected findings, smoking cessation interventions, cost-effectiveness, artificial intelligence and biomarkers, and challenges and opportunities in implementation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yihui Du, Grigory Sidorenkov, Marjolein A. Heuvelmans, Rozemarijn Vliegenthart, Harry J. M. Groen, Marcel J. W. Greuter, Geertruida H. de Bock
Summary: Lowering the screening starting age from 55 to 50 years increases the risk of radiation-induced lung cancers in women by 50%. However, the benefits of LDCT lung cancer screening still outweigh the assumed radiation harm.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Medicine, General & Internal
Michael G. Milligan, Inga T. Lennes, Saif Hawari, Melin J. Khandekar, Yolonda Colson, Jo-Anne O. Shepard, Angela Frank, Lecia Sequist, Henning Willers, Florence K. Keane
Summary: This study conducted in a lung nodule and lung cancer screening clinic aimed to evaluate the role of stereotactic body radiation therapy among patients enrolled in a lung cancer screening program. The findings revealed that one in four patients with screen-detected pulmonary nodules requiring intervention were treated with stereotactic body radiation therapy, highlighting the importance of radiation oncologists in the multidisciplinary management of pulmonary nodules.
Article
Oncology
Anton Schreuder, Onno M. Mets, Cornelia M. Schaefer-Prokop, Colin Jacobs, Mathias Prokop
Summary: The study suggests that conducting three additional annual CT screening rounds in the National Lung Screening Trial may lead to substantial reduction in lung cancer mortality, with earlier diagnosis of lung cancer patients compared to original screening methods.
Article
Radiology, Nuclear Medicine & Medical Imaging
Anastasia K. A. L. Kwee, Bart Luijk, Pim A. de Jong, Harry J. M. Groen, Joachim G. J. V. Aerts, Jean-Paul Charbonnier, Rozemarijn Vliegenthart, Firdaus A. A. Mohamed Hoesein
Summary: Bronchiectasis has a prevalence of 5.4% in lung cancer screening participants and is associated with more respiratory symptoms and, in those with COPD, lower lung function and more emphysema. However, incidental findings of mild bronchiectasis are not very relevant in a lung cancer screening population unless COPD is also present.
EUROPEAN RADIOLOGY
(2023)
Review
Oncology
Jan P. Van Meerbeeck, Emma O'Dowd, Brian Ward, Paul Van Schil, Annemiek Snoeckx
Summary: This paper reviews the current status and challenges of lung cancer screening in Europe, emphasizing the importance of multidisciplinary cooperation. The implementation of Europe's Beating Cancer Plan is expected to promote the general implementation of lung cancer screening. Low-dose CT screening has shown significant reduction in lung cancer-specific mortality in high-risk populations. The implementation of population-based lung cancer screening in Europe is variable and fragmented, mainly due to the cost and capacity of CT scanners and radiologists.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sohee Park, Hyunho Park, Sang Min Lee, Yura Ahn, Wooil Kim, Kyuhwan Jung, Joon Beom Seo
Summary: The study found that the use of CAD can slightly improve inter-reader agreement in Lung-RADS categorization while reducing measurement variability and substantial management change in cancer-positive cases.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Jan M. Eberth, Michael R. Gieske, Gerard A. Silvestri
Summary: Although the revised recommendations for lung cancer screening in the US offer potential benefits, members of the National Lung Cancer Roundtable warn of upcoming challenges. They stress the importance of a patient-centered approach that includes shared decision-making, improved access to care and navigation, and streamlined systems of care.
Article
Oncology
Andrew M. D. Wolf, Kevin C. Oeffinger, Tina Ya-Chen Shih, Louise C. Walter, Timothy R. Church, Elizabeth T. H. Fontham, Elena B. Elkin, Ruth D. Etzioni, Carmen E. Guerra, Rebecca B. Perkins, Karli K. Kondo, Tyler B. Kratzer, Deana Manassaram-Baptiste, William L. Dahut, Robert A. Smith
Summary: Lung cancer is the leading cause of cancer-related deaths and years of life lost in the US. Early detection through screening has been shown to reduce mortality. The American Cancer Society has updated its guidelines for lung cancer screening, recommending annual low-dose CT screening for individuals aged 50-80 who currently smoke or formerly smoked and have a significant smoking history.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Oncology
Junli Park, Jaeho Lee, Yeol Kim
Summary: This study investigated public opinions towards the National Lung Cancer Screening Program in Korea, showing that the majority of the respondents supported the implementation of the program. Factors such as smoking history and frequency of health checkups influenced opinions, with quality of screening facilities being more important than accessibility.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Caryn E. S. Oshiro, Timothy B. Frankland, Joanne Mor, Carmen P. Wong, Yannica Theda Martinez, Cheryl K. K. Aruga, Stacey Honda
Summary: The study examined racial and ethnic differences in lung cancer screening completion and follow-up rates in a multiethnic population in Hawaii. Disparities were found in completion rates among different racial and ethnic groups, with Asian individuals and their subgroups having higher completion rates.
Article
Oncology
Hilary A. Robbins, Karine Alcala, Anthony J. Swerdlow, Minouk J. Schoemaker, Nick Wareham, Ruth C. Travis, Philip A. J. Crosbie, Matthew Callister, David R. Baldwin, Rebecca Landy, Mattias Johansson
Summary: In UK cohorts, the ability of risk prediction models to classify future lung cancer cases as eligible for screening was best for LCDRAT/LCRAT, very good for PLCOm2012, and lowest for LLPv2. This highlights the importance of validating prediction tools in specific countries.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cardiac & Cardiovascular Systems
Reenika Aggarwal, Andrew Cl Lam, Jingyue Huang, Katrina Hueniken, Daniel Nguyen, Khaleeq Khan, Taariq Shaikh, Frances A. Shepherd, Ming-Sound Tsao, Wei Xu, John Kavanagh, Geoffrey Liu
Summary: This study identified individuals ineligible for lung cancer screening who are most likely to become eligible in the future. Factors such as smoking history, current smoking status, lower education level, and presence of chronic obstructive pulmonary disease (COPD) were significantly associated with becoming eligible for screening. The predictive model based on observed health behaviors reasonably predicted changes in lung cancer risk and can help identify participants who should be closely monitored for potential future eligibility.
RESPIRATORY MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mario Silva, Giulia Picozzi, Nicola Sverzellati, Sandra Anglesio, Maurizio Bartolucci, Edoardo Cavigli, Annalisa Deliperi, Massimo Falchini, Fabio Falaschi, Domenico Ghio, Paola Gollini, Anna Rita Larici, Alfonso Marchiano, Stefano Palmucci, Lorenzo Preda, Chiara Romei, Carlo Tessa, Cristiano Rampinelli, Mario Mascalchi
Summary: Smoking is the main risk factor for lung cancer, and low dose computed tomography (LDCT) screening has been proven to reduce lung cancer mortality, especially in women. Several Italian initiatives are currently offering LDCT screening and smoking cessation to high-risk individuals, with the aim of implementing a population-based screening program. This position paper provides recommendations for LDCT scan protocol, nodule classification, and management based on international guidelines.
Article
Cell Biology
Mahmoud Reza Azarpazhooh, Abolfazl Avan, Lauren E. Cipriano, David G. Munoz, Mandiyeh Erfanian, Amin Amiri, Saverio Stranges, Vladimir Hachinski
AGEING RESEARCH REVIEWS
(2020)
Article
Health Care Sciences & Services
Michael Fairley, Lauren E. Cipriano, Jeremy D. Goldhaber-Fiebert
MEDICAL DECISION MAKING
(2020)
Article
Public, Environmental & Occupational Health
Erica A. Yarmol-Matusiak, Lauren E. Cipriano, Saverio Stranges
Summary: Compared to other Nordic countries, Sweden had higher incidence and death rates from COVID-19, as well as higher mortality rates in seniors' care homes. The country also faced challenges with contact tracing and testing strategies, likely due to looser government restrictions at the beginning of the outbreak. Sweden has since increased testing rates, implemented more preventive measures, and expanded intensive care unit bed capacity to improve epidemic control.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2021)
Review
Clinical Neurology
Abolfazl Avan, Amin Amiri, Naghmeh Mokhber, Mahdiyeh Erfanian, Lauren E. Cipriano, Saverio Stranges, Golnaz Shojaeianbabaei, Shahram Abootalebi, M. Reza Azarpazhooh
Summary: LB, HS, and CAA are common neuropathologies among community-dwelling elderly, and while they are independently associated with dementia, many individuals remain non-demented by death.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Thomas N. Vilches, Shokoofeh Nourbakhsh, Kevin Zhang, Lyndon Juden-Kelly, Lauren E. Cipriano, Joanne M. Langley, Pratha Sah, Alison P. Galvani, Seyed M. Moghadas
Summary: Research has shown that implementing frequent testing of staff, and vaccination of staff and residents in Canadian long-term care facilities (LTCFs) can significantly reduce COVID-19 infection rates, hospitalization rates, and death rates. Weekly routine testing of staff with 2-day turnaround time can reduce infections among residents by at least 25.9% compared to baseline measures of mask-wearing, symptom screening, and staff cohorting alone. Vaccination averted 2-4 times more infections in both staff and residents as compared to routine testing, and markedly reduced hospitalizations and deaths among residents by 95.9% and 95.8%, respectively, over 200 days from the start of vaccination.
PREVENTIVE MEDICINE
(2021)
Article
Clinical Neurology
Abolfazl Avan, Vladimir Hachinski
Summary: Brain health is crucial for physical and mental health, social well-being, productivity, and creativity. Current neurological research focuses on treating diseased brains and preventing further deterioration rather than on developing and maintaining brain health. Interdisciplinary collaboration may shed light on the interconnectedness of physical, mental, environmental, and socioeconomic determinants of brain disease and health.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Joshua O. Cerasuolo, Jennifer Mandzia, Lauren E. Cipriano, Moira K. Kapral, Jiming Fang, Vladimir Hachinski, Luciano A. Sposato
Summary: Thrombolysis administration following first-ever ischemic stroke was independently associated with a reduced rate of dementia.
Review
Clinical Neurology
Austyn D. Roseborough, Lorenzo Saad, Maren Goodman, Lauren E. Cipriano, Vladimir C. Hachinski, Shawn N. Whitehead
Summary: The primary aim of this paper is to improve the clinical interpretation of white matter hyperintensities (WMHs) by investigating their associations with cognitive outcomes. The results suggest that WMHs increase the risk of cognitive impairment and dementia, particularly in individuals with mild cognitive impairment (MCI) and those who have had a stroke. The study also highlights the importance of considering factors such as the apolipoprotein E (APOE) genotype and specific cognitive changes in strategic anatomical locations.
ALZHEIMERS & DEMENTIA
(2023)
Article
Public, Environmental & Occupational Health
Thomas N. Vilches, Elaheh Abdollahi, Lauren E. Cipriano, Margaret Haworth-Brockman, Yoav Keynan, Holden Sheffield, Joanne M. Langley, Seyed M. Moghadas
Summary: The study found that non-pharmaceutical interventions (NPIs) played a crucial role in mitigating COVID-19 outbreaks in Nunavut, preventing a significant increase in case numbers. Vaccination had a significant impact on preventing infections and severe outcomes, but public health implementation of NPIs also played an essential role in the short term before high levels of immunity were achieved in the population.
Letter
Health Care Sciences & Services
Michael Fairley, Lauren E. Cipriano, Jeremy D. Goldhaber-Fiebert
MEDICAL DECISION MAKING
(2022)
Editorial Material
Health Care Sciences & Services
Lauren E. Cipriano
MEDICAL DECISION MAKING
(2023)
Article
Psychiatry
Olajumoke M. Ologundudu, Lena Palaniyappan, Lauren E. Cipriano, Ben F. M. Wijnen, Kelly K. Anderson, Shehzad Ali
Summary: Treating all individuals at ultra-high risk of psychosis may be cost-effective compared to risk stratification, according to an economic model evaluation.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Multidisciplinary Sciences
Lauren E. Cipriano, Wael M. R. Haddara, Gregory S. Zaric, Eva A. Enns
Summary: Research shows that university students are highly connected to the surrounding community. Targeted screening for this population can significantly reduce COVID-19 infections, critical care admissions, and deaths in the community.
Article
Substance Abuse
Nicholas J. Bansback, Carolina Barbosa, Joshua Barocas, Ahmed M. Bayoumi, Czarina Behrends, Jag Chhatwal, Lauren E. Cipriano, Phillip Coffin, Jeremy Goldhaber-Fiebert, Jeffrey S. Hoch, Mike Irvine, Hawre Alal, Emanuel Krebs, Benjamin P. Linas, Brandon D. L. Marshall, Natasha Martin, Kathryn McCollister, Zachary Meisel, Sean Murphy, Bohdan Nosyk, Bruce R. Schackman, Gary Zarkin
INTERNATIONAL JOURNAL OF DRUG POLICY
(2021)
Article
Neuroimaging
Austyn D. Roseborough, Kristopher D. Langdon, Robert Hammond, Lauren E. Cipriano, Stephen H. Pasternak, Shawn N. Whitehead, Ali R. Khan
NEUROIMAGE-CLINICAL
(2020)