Article
Polymer Science
Imran Kazmi, Fahad A. Al-Abbasi, Syed Sarim Imam, Muhammad Afzal, Muhammad Shahid Nadeem, Hisham N. Altayb, Sultan Alshehri
Summary: LPHNPs encapsulated with PPN were developed to overcome the physicochemical limitations of PPN. The optimized PPN-LPHNPs showed small particle size, low polydispersity index, and high positive surface charge. PPN-LPHNPs exhibited excellent cytotoxicity against breast cancer cells and improved intestinal permeation and oral bioavailability compared to the conventional PPN suspension.
Article
Pharmacology & Pharmacy
Indrajeet Karnik, Ahmed Adel Ali Youssef, Poorva Joshi, Siva Ram Munnangi, Sagar Narala, Corinne Varner, Sateesh Kumar Vemula, Soumyajit Majumdar, Michael Repka
Summary: The study aimed to develop and evaluate a hot-melt extruded bioadhesive ophthalmic insert containing a fixed-dose combination of Prednisolone Sodium Phosphate (PSP) and Sulfacetamide Sodium (SA) for the treatment of ocular bacterial infections. The inserts were prepared using FDA-approved biocompatible polymers, and their physicochemical characteristics, drug release, permeation, and stability were assessed. The developed inserts showed prolonged release of the drugs and exhibited good bioadhesive strength and stability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Zihan Shao, Jing Han, Jiejie Wang, Yue Sun, Xueling Li, Jin Liang
Summary: The study successfully optimized the process parameters of Agaricus bisporus extruded rice through extrusion technology and addition of mushroom powder, improving its texture, antioxidant activity, and other properties.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Green & Sustainable Science & Technology
Tumpa R. Sarker, Sonil Nanda, Ajay K. Dalai
Summary: This study investigates the optimal conditions for producing H2-rich fuel gas from canola hull pellets using supercritical water gasification. Temperature was found to be the most important parameter, followed by biomass-to-water ratio and residence time. The highest H2 yield of 3.43 mol/kg was achieved at 575 degrees C, 45 min, and a biomass-to-water ratio of 1:20. Comparative evaluation showed that torrefaction treatment significantly enhanced gas yield and composition. Hydrochar produced at higher temperatures had better quality.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Beibei Tan, Bolun Sun, Nan Sun, Chao Li, Jinjie Zhang, Wenge Yang
Summary: The study investigated the structure, physicochemical properties, and iron bioavailability of myoglobin (Mb) extracted from P. japonicus, as well as the effects of glycosylation on these parameters. Glycosylation of Mb resulted in a more ordered structure, decreased surface hydrophobicity, increased water solubility, enhanced antioxidant capacity, and improved stability in enzymatic digestion. The bioavailability of Mb-iron was significantly higher than FeSO4, and further elevated by glycosylation, providing a basis for developing Mb-based iron supplements and promoting the utilization of fish-processing industries wastes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Nanoscience & Nanotechnology
Yoon Tae Goo, Cheol-Ki Sa, Ji Yeh Choi, Min Song Kim, Chang Hyun Kim, Hyeon Kyun Kim, Young Wook Choi
Summary: By optimizing the SSuM, the oral bioavailability of revaprazan was significantly enhanced, demonstrating great potential for the development of solidified formulations for poorly water-soluble drugs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Hany S. M. Ali, Sameh A. A. Ahmed, Abdulmalik A. A. Alqurshi, Ali M. M. Alalawi, Ahmed M. M. Shehata, Yaser M. M. Alahmadi
Summary: This study aimed to address the bioavailability concerns of Tadalafil (TAD) by preparing nano-emulsions using ultrasonic technology. Through optimization, a stable nano-emulsion-based jelly (NEJ) formulation was obtained, which showed improved drug dissolution and bioavailability in in vitro and in vivo evaluations. This has significant clinical implications for the administration of TAD.
Article
Multidisciplinary Sciences
Vishal C. Gurumukhi, Vivek P. Sonawane, Ganesh G. Tapadiya, Sanjaykumar B. Bari, Sanjay J. Surana, Shailesh S. Chalikwar
Summary: The present work focuses on the QbD-based development of FEB-loaded nanoemulsion (FEB-NE) to improve bioavailability and permeability. Risk assessment using the Ishikawa diagram and FMEA study were conducted to identify critical process parameters and material attributes. Quality target product profiles and critical quality attributes were determined to ensure quality in the nanoemulsion. The optimized FEB-NE formulation showed enhanced drug release, permeability, and bioavailability.
Article
Pharmacology & Pharmacy
Vancha Harish, Devesh Tewari, Sharfuddin Mohd, Pilli Govindaiah, Malakapogu Ravindra Babu, Rajesh Kumar, Monica Gulati, Kuppusamy Gowthamarajan, SubbaRao Madhunapantula, Dinesh Kumar Chellappan, Gaurav Gupta, Kamal Dua, Siva Dallavalasa, Sachin Kumar Singh
Summary: This study focuses on improving the poor oral bioavailability and weak pharmacokinetic profile of Xanthohumol (XH) by developing Xanthohumol-loaded solid lipid nanoparticles (XH-SLNs). The optimized XH-SLNs showed improved bioavailability and sustained release, demonstrating good anticancer properties against PC-3 cells.
Article
Pharmacology & Pharmacy
S. Ramkanth, P. Anitha, R. Gayathri, S. Mohan, Dinesh Babu
Summary: This study aimed to design and optimize nano-transferosomes loaded with pioglitazone and eprosartan mesylate for transdermal delivery as a novel combination therapy for hypertensive diabetic patients. The results suggest that such a combinational delivery system can effectively treat diabetes and hypertension.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Green & Sustainable Science & Technology
Sonja Simic, Jovana Petrovic, Dusan Rakic, Biljana Pajin, Ivana Loncarevic, Antun Jozinovic, Aleksandar Fistes, Sanja Nikolic, Marijana Blazic, Borislav Milicevic
Summary: Adding extruded sugar beet pulp (SBPEs) to cookies can significantly increase the dietary fiber and mineral content, although it may increase cookie hardness. Adjusting the particle size of the extrudates also impacts the sensory characteristics of the cookies.
Article
Chemistry, Medicinal
Thi Mai Anh Pham, Dong Ho Lee, Young-Guk Na, Minki Jin, Minwoo Jung, Ha-Eun Kim, Hyelim Yoo, Jong-Hee Won, Jae-Young Lee, Jong-Suep Baek, Su-Cheol Han, Hong-Ki Lee, Cheong-Weon Cho
Summary: In this study, S(+)-zaltoprofen-loaded nanostructured lipid carriers (NLCs) were prepared to improve the oral bioavailability. The optimal NLC-SZPF exhibited high encapsulation efficiency, sustained-release profile, biocompatibility, and permeability across the intestinal tract. The relative bioavailability of NLC-SZPF was significantly enhanced compared to SZPF.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Saliha Ilyas, Safirah Maheen, Mehwish Andleeb, Hafeez Ullah Khan, Shahid Shah, Ghulam Abbas, Saleha Shabbir, Muhammad Sher, Syeda Amna Masood, Syed Salman Shafqat
Summary: The current research focuses on designing and optimizing controlled release solid lipid microparticles of Bisoprolol using biocompatible waxes. The study characterizes the microparticles using different analysis techniques and evaluates their drug release characteristics. The results show that the innovative technique can improve drug pharmacokinetics, enhance compliance in hypertensive patients, and eliminate inefficiencies of traditional drug delivery methods.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Anroop B. Nair, Bandar E. Al-Dhubiab, Jigar Shah, Bapi Gorain, Shery Jacob, Mahesh Attimarad, Nagaraja Sreeharsha, Katharigatta N. Venugopala, Mohamed A. Morsy
Summary: The study aimed to develop a gel formulation for the transungual delivery of terbinafine using iontophoresis. Optimization of crucial variables such as chemical enhancer, applied voltage, and application time showed improved drug delivery into the nail tissue. The results suggest that the optimized formulation with low voltage iontophoresis could be an effective tool in improving the success rate of topical nail therapy for onychomycosis.
Article
Materials Science, Paper & Wood
Dan Liu, Yongcai Ma, Jun Li, Da Teng, Shiting Qiu, Yanlong Li, Xin Mao, Hanyang Wang
Summary: By investigating the effects of pellets-associated variables on the mechanical properties of fuel pellets made from biomass residue, the optimal condition was determined and regression models were established to explain the differences between the actual and predicted values.
Article
Pharmacology & Pharmacy
Xueliang Xiu, Shichao Ma, Zhiyong Li, Zhipeng Li, Xuemei Li, Yangtao Ruan, Dezhao Li, Jianwei Wang, Fengsen Ma
Summary: Liposomes are promising delivery vehicles for drugs and vaccines. The use of microfluidic chips for liposome preparation is an effective method. However, traditional liposome preparation technologies hinder their industrial production and clinical application. This study presents a novel three-dimensional integrated microfluidic device for continuous liposome preparation and purification, which shows potential for industrial production of nano-pharmaceutical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2024)