Review
Critical Care Medicine
Andrew Harrison, Volker Alt
Summary: LIPUS has been shown to accelerate fracture repair, but its effectiveness is controversial in some cases. Studies indicate that LIPUS may have greater benefits for patients at risk of fracture healing.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Review
Biochemistry & Molecular Biology
Laura Caliogna, Marta Medetti, Valentina Bina, Alice Maria Brancato, Alberto Castelli, Eugenio Jannelli, Alessandro Ivone, Giulia Gastaldi, Salvatore Annunziata, Mario Mosconi, Gianluigi Pasta
Summary: This article reviews the signaling pathways modulated by PEMFs and their clinical applications, based on studies from PubMed and Embase. While identifying cell membrane receptors and pathways involved in bone healing, further research and clinical trials are needed to understand the dose-response relationship and practical applications of PEMFs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama
Summary: Higher-intensity ultrasound and radial extracorporeal shock waves can accelerate fracture healing, but shock wave treatment may increase the risk of periosteal callus formation. Electrical stimulation does not affect the healing process.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Review
Psychiatry
Yong Liu, Nannan Gu, Xinyi Cao, Yikang Zhu, Jijun Wang, Robert C. Smith, Chunbo Li
Summary: Transcranial electrical stimulation (tES) shows significant efficacy on working memory in schizophrenia in follow-up assessment, but not immediately after the last tES session. There was no significant difference in tolerability and dropouts between the active stimulation group and the sham stimulation group. Further large-scale RCTs with longer follow-ups are needed to confirm these findings.
PSYCHIATRY RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Peizhen Zhang, Pengdong Li, Shihai Liao, Xuan Li, Wufan Chen, Xiaoyun Wang, Qing Wang
Summary: The study demonstrated the positive effect of LIPUS on bone fracture healing and found no evidence that LIPUS promotes HO formation. Ultrasonography can serve as a potential tool for monitoring the effectiveness of LIPUS therapy.
BIOMED RESEARCH INTERNATIONAL
(2021)
Review
Anesthesiology
Hector Beltran-Alacreu, Diego Serrano-Munoz, David Martin-Caro Alvarez, Juan J. Fernandez-Perez, Julio Gomez-Soriano, Juan Avendano-Coy
Summary: This review compares the effectiveness of percutaneous electrical nerve stimulation (PENS) and transcutaneous electrical nerve stimulation (TENS) in reducing musculoskeletal pain intensity. The overall effect of PENS on pain was statistically significant but not clinically superior to TENS. However, when analyzing only studies with low risk of bias, there was no difference between TENS and PENS in pain intensity.
Article
Medicine, General & Internal
Shai Factor, Ido Druckmann, Franck Atlan, Yishai Rosenblatt, Daniel Tordjman, Raphael Krespi, Efi Kazum, Tamir Pritsch, Gilad Eisenberg
Summary: This study aimed to determine if the application of a novel method of generating pulsed electromagnetic field (PEMF), called the Fracture Healing Patch (FHP), can accelerate the healing of acute distal radius fractures (DRF) compared to a sham treatment. The results showed that fractures treated with active PEMF had a significantly higher union rate at 4 weeks, as assessed by CT scans. The PEMF treated group also had significantly higher physical scores and shorter time to cast removal. The early addition of PEMF treatment can accelerate bone healing and lead to a shorter cast immobilization, allowing for an earlier return to daily activities and work. There were no complications related to the PEMF device (FHP).
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Engineering, Biomedical
Ruizeng Luo, Jieyu Dai, Jiaping Zhang, Zhou Li
Summary: When the integrity of the skin is compromised, an endogenous electric field is generated to facilitate wound healing, while exogenous electric fields can assist in treating wounds that cannot heal on their own. The effects of exogenous electrical stimulation on wound healing involve inflammation, blood flow, cell proliferation and migration, and wound scarring. New electrical stimulation methods and devices are characterized by being safe, low-cost, stable, and small in size.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Clinical Neurology
Ron Gadot, Ricardo Najera, Samad Hirani, Adrish Anand, Eric Storch, Wayne K. Goodman, Ben Shofty, Sameer A. Sheth
Summary: Deep brain stimulation (DBS) has been shown to be effective in alleviating treatment-resistant obsessive-compulsive disorder (TROCD) by not only reducing OCD symptoms but also improving comorbid depressive symptoms. Studies utilizing the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) have demonstrated high responder rates to DBS therapy at last follow-up.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Review
Polymer Science
Yt Jun Cheah, Muhamad Ramdzan Buyong, Mohd Heikal Mohd Yunus
Summary: Electrical stimulation is a promising field in wound healing, offering various mechanisms and approaches to enhance wound repair. Understanding the effects of electrical stimulation on cellular and molecular levels can improve the speed and quality of wound healing. Exploring the application and integration of electroconductive biomaterials has opened up new possibilities for modern wound dressings.
Review
Biotechnology & Applied Microbiology
Ye Liu, Mei-fei Li, Meng-yuan Li, Innie Chen, Ri-hua Xie, Xiao-ying Yan
Summary: This study explored the effects of low frequency electrical stimulation (LFES) in preventing urinary retention after radical hysterectomy in women with cervical cancer. The results showed that women receiving LFES had improved therapeutic effect, reduced residual urine volume, and shorter catheter retention time. Additionally, the muscle strength scores of pelvic floor muscles were higher in the LFES group.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Rehabilitation
Ester Moreira de Castro-Carletti, Frauke Mueggenborg, Liz Dennett, Ana Izabela Sobral de Oliveira-Souza, Norazlin Mohamad, Adriana Pertille, Delaine Rodrigues-Bigaton, Susan Armijo-Olivo
Summary: This systematic review summarizes the evidence from randomized controlled trials and controlled trials on the effectiveness of electrotherapy in treating orofacial pain. The results show that transcutaneous electric nerve stimulation therapy can significantly reduce pain intensity and tenderness, demonstrating its effectiveness for patients with mixed temporomandibular disorders.
CLINICAL REHABILITATION
(2023)
Review
Behavioral Sciences
Gabriel Damon Lavezzi, Sofia Sanz Galan, Hallie Andersen, Daniel Tomer, Laura Cacciamani
Summary: Transcranial direct current stimulation (tDCS) is a novel method of modulating brain activity by applying electrical current to the scalp. This systematic review and meta-analysis investigated the effects of tDCS on object perception. Results showed that anodal tDCS, particularly on frontal brain regions, can enhance object perception and increase accuracy scores.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Nannan Bian, Yi Yuan, Yingwei Li, Mengyang Liu, Xiaoli Li
Summary: The study demonstrates that low-intensity pulsed ultrasound stimulation (PUS) significantly inhibits cortical spreading depression (CSD) in rats by improving motor activity, reducing CSD propagation speed, and increasing levels of brain-derived neurotrophic factor protein in brain tissue. These findings suggest that PUS has the potential to be a treatment for brain disorders associated with CSD.
Article
Acoustics
Xiaowei Huang, Lili Niu, Long Meng, Zhengrong Lin, Wei Zhou, Xiufang Liu, Jiqing Huang, Derek Abbott, Hairong Zheng
Summary: Autophagy, the process of cellular self-digestion, plays a crucial role in eliminating abnormal proteins in mammalian cells. Studies have shown that low-intensity pulsed ultrasound (LIPUS) stimulation can enhance neuronal autophagy, indicating its potential as a safe and effective tool for activating autophagy in neurons.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Review
Clinical Neurology
Mahmood AminiLari, Li Wang, Samuel Neumark, Taranah Adli, Rachel J. Couban, Aidan Giangregorio, Colleen E. Carney, Jason W. Busse
Summary: This systematic review suggests that medical cannabis and cannabinoids may have a slight improvement in sleep disturbance for patients with chronic pain, but the magnitude of benefit is small. At the same time, medical cannabis may increase the risk of adverse effects such as dizziness, somnolence, dry mouth, fatigue, and nausea.
Editorial Material
Ophthalmology
Mark R. Phillips, David H. Steel, Charles C. Wykoff, Jason W. Busse, Raveendhara R. Bannuru, Lehana Thabane, Mohit Bhandari, Varun Chaudhary
Editorial Material
Ophthalmology
Andrea J. Darzi, Jason W. Busse, Mark R. Phillips, Rishi P. Singh, Frank G. Holz, Lehana Thabane, Mohit Bhandari, Varun Chaudhary, Charles C. Wykoff, Sobha Sivaprasad, Peter Kaiser, David Sarraf, Sophie J. Bakri, Sunir J. Garg, Rishi P. Singh, Tien Y. Wong, Robyn H. Guymer
Article
Medicine, General & Internal
Abdul Rehman Qureshi, Oluwatoni Makanjuola, Samuel Neumark, Andrew Garas, Li Wang, Jason W. Busse
Summary: The study identified research priorities among Canadian military veterans with chronic noncancer pain, including optimizing pain management after release, establishing the effectiveness of self-care, and identifying and treating mental illness in veterans with chronic pain. The importance of improving chronic pain care while in the military was rated higher by females.
Article
Medicine, Research & Experimental
Jason W. Busse, Sheila Sprague
Summary: The study aims to determine whether online CBT can reduce the prevalence of moderate to severe persistent post-surgical pain among participants with an open or closed fracture of the appendicular skeleton. A multi-centre randomized controlled trial will be conducted, enrolling 1000 participants from approximately 10 hospitals in North America.
Article
Clinical Neurology
Jeremy Y. Ng, Halton Quach, Mark R. Phillips, Jason W. Busse
Summary: Despite the increasing use of medical cannabis for chronic pain management among Canadians, pain physicians expressed uncertainty regarding the evidence supporting this therapy and acknowledged significant barriers to access.
JOURNAL OF PAIN RESEARCH
(2022)
Review
Surgery
Jian-jun Xue, Yi-yang Cui, Jason W. Busse, Long Ge, Ting Zhou, Wei-hua Huang, Sheng-shuang Ding, Jie Zhang, Ke-hu Yang
Summary: A systematic review showed that transversus thoracic muscle plane blocks (TTMPBs) during cardiac surgery can reduce postoperative pain at rest and with movement, opioid consumption, ICU length of stay, and the incidence of nausea and vomiting.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Alex Thabane, Jason W. Busse, Ranil Sonnadara, Mohit Bhandari
Summary: A strong pipeline of creative ideas and individuals is critical in order to address the complex healthcare challenges of the 21st century. The field of creativity in surgery is currently underexplored and it is important to examine the level and nature of creativity among surgeons from various specialties and backgrounds. Identifying the areas of surgery with strong and weak levels of creativity, as well as the predictors of high creativity among surgeons, may aid in the selection and training of future surgeons.
Article
Health Care Sciences & Services
Linan Zeng, Shelly-Anne Li, Mengting Yang, Lijiao Yan, Lise M. Helsingen, Michael Bretthauer, Thomas Agoritsas, Per O. Vandvik, Reem A. Mustafa, Jason Busse, Reed A. C. Siemieniuk, Lyubov Lytvyn, Lingli Zhang, Romina Brignardello-Petersen, Gordon H. Guyatt
Summary: This study explores guideline panelists' understanding of panel surveys in eliciting patient values and preferences, and their influence on making recommendations. The results show that most panelists found the survey easy to follow and that it helped incorporate patient values and preferences in the tradeoffs, enhancing the rationale behind the decisions.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Review
Medicine, General & Internal
Mansi Patel, Jane Jomy, Rachel J. Couban, Helene Le Scelleur, Jason W. Busse
Summary: This review examines the challenges and transition needs of military personnel living with chronic pain as they return to civilian life. The study identified several challenges in areas such as identity, interpersonal interactions, employment, education, finances, self-care and mental health, and accessing services and care. However, there is a lack of specific research on individuals released with chronic pain, highlighting the need for further studies to address their unique needs and well-being.
Article
Medicine, General & Internal
Minghong Yao, Yuning Wang, Jason W. Busse, Matthias Briel, Fan Mei, Guowei Li, Kang Zou, Ling Li, Xin Sun
Summary: This study aims to explore the integration of non-randomised studies of interventions (NRSIs) into meta-analysis of randomised controlled trials (RCTs) and investigate the impact of including NRSIs on pooled estimates. A systematic survey of 210 systematic reviews published from 2017 to 2022 will be conducted to assess the concordance between NRSIs and RCTs, and the factors associated with agreement will be examined through regression analysis. The findings will be disseminated through peer-reviewed publications, conference presentations, and condensed summaries for clinicians, health policymakers, and guideline developers.
Article
Oncology
Aaron M. Gazendam, Patricia Schneider, Diane Heels-Ansdell, Mohit Bhandari, Jason W. Busse, Michelle Ghert
Summary: This study investigated the functional outcomes of musculoskeletal oncology patients undergoing lower extremity endoprosthetic reconstruction. It found that poor pre-operative function, older age, and reconstruction for soft tissue sarcomas were associated with worse functional outcomes. On the other hand, reconstruction for giant cell tumors was associated with better post-operative function.
Article
Health Care Sciences & Services
Peter C. Emary, Amy L. Brown, Mark Oremus, Lawrence Mbuagbaw, Douglas F. Cameron, Jenna DiDonato, Jason W. Busse
Summary: This study found that noncancer spinal pain patients who received chiropractic care were less likely to be prescribed opioids, with a higher risk reduction for patients who received chiropractic care within 30 days of their index visit. The calendar year of the index visit was also associated with opioid prescription probability.
JOURNAL OF MANIPULATIVE AND PHYSIOLOGICAL THERAPEUTICS
(2022)
Letter
Clinical Neurology
Jason W. Busse, David Juurlink, D. Norman Buckley
CANADIAN JOURNAL OF PAIN-REVUE CANADIENNE DE LA DOULEUR
(2022)
Article
Pharmacology & Pharmacy
Mahmood AminiLari, Jason W. Busse, Jasmine Turna, James MacKillop
Summary: This study examined the shift in cannabis use behaviors among individuals who used cannabis for medical purposes after legalization of nonmedical cannabis. The findings showed that younger men without medical authorization for cannabis use were more likely to switch to exclusively nonmedical use after legalization.
CANNABIS AND CANNABINOID RESEARCH
(2022)
