Article
Agriculture, Multidisciplinary
Shi Dong-ya, Ren Wei-chao, Wang Jin, Zhang Jie, Jane Ifunanya Mbadianya, Mao Xue-wei, Chen Chang-jun
Summary: The study investigated the function of the Nsf1 orthologue FgNsf1 in Fusarium graminearum. Results showed that FgNsf1 plays a crucial role in vegetative growth, reproduction, stress responses, fungicide sensitivity, and virulence in F. graminearum.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Article
Microbiology
Kouhan Liu, Xintong Wang, Ying Li, Yifeng Shi, Yanyan Ren, Aolin Wang, Bingjie Zhao, Peng Cheng, Baotong Wang
Summary: This study investigated the biological functions of FgEps1, a disulfide bond isomerase in the fungal pathogen Fusarium graminearum. The results showed that FgEps1 plays important roles in nutritional growth, reproduction, stress tolerance, pathogenicity, toxin biosynthesis, and host infection. Further investigation revealed that FgEps1 suppresses the immune response of plants and promotes infection.
Article
Microbiology
Taiying Li, Dohyun Kim, Jungkwan Lee
Summary: This study characterized a new NADPH oxidase, FgNoxD, in Fusarium graminearum. The findings demonstrate that FgNoxD plays important roles in stress adaptation, conidiation, sexual development, and virulence.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Chenyu Wang, Yao Wang, Liyuan Zhang, Ziyi Yin, Yuancun Liang, Lei Chen, Shenshen Zou, Hansong Dong
Summary: RUD3 protein, a Golgin protein in Fusarium graminearum, is essential for growth, ascospore discharge, DON biosynthesis, and pathogenicity. It mediates retrograde trafficking in the ER-to-Golgi pathway and plays a crucial role in various aspects of the fungal life cycle and pathogenicity, making it a potential target for disease control.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Microbiology
Haixia Wang, Yun Chen, Tingjun Hou, Yunqing Jian, Zhonghua Ma
Summary: This study identified the VLCFA elongase gene FgElo2 in Fusarium graminearum and found that it plays important roles in fungal development, tebuconazole sensitivity, stress responses, and virulence.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Microbiology
Ahai Chen, Yifan Zhou, Yiyi Ren, Chao Liu, Xingmin Han, Jing Wang, Zhonghua Ma, Yun Chen
Summary: In this study, it was found that E3 ligase Tom1 and deubiquitinating enzyme Ubp14 regulated the ubiquitination and deubiquitination of Gcn5, respectively, in the important plant pathogenic fungus Fusarium graminearum. This finding highlights the important role of the Tom1-Gcn5-Ubp14 circuit in fungal virulence.
Article
Microbiology
Xueqin Han, Qingyi Li, Xuenan Li, Xiang Lv, Li Zhang, Shenshen Zou, Jinfeng Yu, Hansong Dong, Lei Chen, Yuancun Liang
Summary: This study reveals that the deletion of Fgporin in Fusarium graminearum leads to defects in hyphal growth, conidiation, and perithecia development, as well as reduced virulence and impaired autophagy.
Article
Cell Biology
Francesco Tini, Giovanni Beccari, Gianpiero Marconi, Andrea Porceddu, Micheal Sulyok, Donald M. Gardiner, Emidio Albertini, Lorenzo Covarelli
Summary: The study investigated how Fusarium graminearum regulates virulence towards its natural hosts through DNA methylation. It was found that sub-culturing led to a decline in virulence, which could be restored through repeated inoculation. DNA methylation analysis revealed changes in methylation levels of genes related to virulence after subculturing, suggesting the potential of ddRAD-MCSeEd approach in detecting genes associated with fungal virulence.
Article
Microbiology
Donovan Garcia-Ceron, Rohan G. T. Lowe, James A. McKenna, Linda M. Brain, Charlotte S. Dawson, Bethany Clark, Oliver Berkowitz, Pierre Faou, James Whelan, Mark R. Bleackley, Marilyn A. Anderson
Summary: This study revealed that EVs from Fgr contain protein effectors crucial for fungal virulence, some of which lack predicted secretion signals. Transcriptomic analysis of corn plants infected by Fgr showed high expression of effector genes, indicating that Fgr EVs may serve as a mechanism for unconventional effector and virulence factor secretion. These findings expand our knowledge on fungal EVs in plant pathogenesis and may contribute to the discovery of new antifungals.
Article
Microbiology
Guangfei Tang, Haoxue Xia, Jingting Liang, Zhonghua Ma, Wende Liu
Summary: The study revealed that deletion of spermidine biosynthesis gene FgSPE3 in Fusarium species caused growth defects, reduced reproduction, increased stress sensitivity, decreased mycotoxin production, and weakened virulence in host plants. Exogenous application of spermidine could rescue the growth and virulence defects, indicating that spermidine is essential for growth, development, mycotoxin production, and virulence in Fusarium species, presenting a potential target for controlling Fusarium head blight (FHB).
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Haixia Wang, Yueqi Zhang, Jingrui Wang, Yun Chen, Tingjun Hou, Youfu Zhao, Zhonghua Ma
Summary: This study reveals the important role of FgSUR2 gene in regulating the susceptibility to azoles and virulence of F. graminearum.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Guixia Hao, Susan McCormick, Helene Tiley, Santiago Gutierrez, Gabdiel Yulfo-Soto, Martha M. Vaughan, Todd J. Ward
Summary: Fusarium graminearum causes Fusarium head blight (FHB) on wheat and barley, contaminating grains with toxic mycotoxins. The study found that the newly discovered NX trichothecenes, along with DON, play an important role in FHB infection and spread.
MOLECULAR PLANT-MICROBE INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Chunping Yang, Linjun Xie, Yuqing Ma, Xuewei Cai, Guizhou Yue, Guangwei Qin, Min Zhang, Guoshu Gong, Xiaoli Chang, Xiaoyan Qiu, Liya Luo, Huabao Chen
Summary: The study found that glabridin can inhibit the mycelial growth and conidial germination of Fusarium graminearum by destroying the integrity of the cell membrane, reducing ergosterol content, and inhibiting respiratory rate, ultimately inducing death. Proteomics analysis revealed changes in proteins related to transmembrane transport and ergosterol biosynthesis, providing insights into the fungicidal mechanism of glabridin.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Microbiology
Maydelene Xiao Xuan Liew, Yuichi Nakajima, Kazuyuki Maeda, Naotsugu Kitamura, Makoto Kimura
Summary: Tri6 and Tri10 genes encode a transcription factor and a regulatory protein involved in trichothecene biosynthesis. The regulation of these genes is not well understood, especially in relation to culture medium pH and genetic factors. Changes in the trichothecene gene cluster core region also affect gene expression. This paper discusses the need for a revised understanding of the regulatory mechanism and proposes a model for Tri6 and Tri10 transcription.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Genetics & Heredity
Lin Tang, Haowen Chi, Weidong Li, Li Zhang, Liyuan Zhang, Lei Chen, Shenshen Zou, Huixiang Liu, Yuancun Liang, Jinfeng Yu, Hansong Dong
Summary: Our study characterized two yeast Psd orthologues, FgPsd1 and FgPsd2, in Fusarium graminearum, with FgPsd1 localized in mitochondria and FgPsd2 in Golgi. Deletion of FgPsd2 resulted in impaired mycelial growth, reproduction, virulence, lipid droplet formation, and autophagy in F. graminearum. The findings suggest that FgPsd2 plays a crucial role in multiple cellular processes in this fungus.
FUNGAL GENETICS AND BIOLOGY
(2021)
