Article
Biochemistry & Molecular Biology
Jesus Delgado-Calle, Kevin McAndrews, Gerald Wu, Ashley L. Orr, Adam Ferrari, Xiaolin Tu, Venkatesan Srinivasan, G. David Roodman, Frank H. Ebetino, Robert K. Boeckman, Teresita Bellido
Summary: This study reveals that PTH signaling upregulates Notch pathway components, and Notch activation contributes to the catabolic actions of PTH in bone. Deleting the PTH receptor or overexpressing sclerostin in osteocytes abolishes the increase in Notch components caused by PTH. Moreover, bone-targeted Notch inhibition enhances the bone anabolic effects of intermittent PTH.
Review
Biochemistry & Molecular Biology
Tobias M. Ballhause, Shan Jiang, Anke Baranowsky, Sabine Brandt, Peter R. Mertens, Karl-Heinz Frosch, Timur Yorgan, Johannes Keller
Summary: Notch1-4 receptors and their signaling pathways are crucial in cell fate decision by coordinating cell proliferation, differentiation and apoptosis, with differential expression and activation observed in various organs and tissues. In bone, Notch receptors control remodeling and regeneration, with distinct expression and function depending on differentiation stages. The crosstalk between Notch signaling and other pathways in bone turnover, including Wnt/beta-catenin, BMP and RANKL/OPG, is outlined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Yoshimitsu Nakanishi, Sujin Kang, Atsushi Kumanogoh
Summary: This article reviews the recent advances in understanding the molecular mechanism of skeletal-neural interactions in bone homeostasis, with a focus on the functions of axon guidance molecules in the establishment and maintenance of the skeletal system.
Review
Immunology
Jie Xu, Linxin Yu, Feng Liu, Longbiao Wan, Zhenhua Deng
Summary: The complicated connections and cross talk between the skeletal system and the immune system are developing into the field of Osteoimmunology. Cytokines, such as TNF, IL, IFN, and chemokines, play a critical role in bone remodeling, particularly in the pathogenesis and development of osteoporosis. This review summarizes the effects of cytokines on osteoblasts and osteoclasts, offering a reference for the role of immunology in osteoporosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Wenbo Zhao, Philip Wiedemann, Eva Maria Woelfel, Mona Neven, Stephanie Peters, Thomas Imhof, Manuel Koch, Bjoern Busse, Michael Amling, Thorsten Schinke, Timur Alexander Yorgan
Summary: Col22a1, predominantly expressed in bone, deficiency may result in trabecular osteopenia and increased osteoclast numbers.
Review
Pharmacology & Pharmacy
Kok-Yong Chin, Sophia Ogechi Ekeuku, Anne Trias
Summary: Nitrogen-containing bisphosphonates cause BRONJ by inhibiting bone resorption, but GGOH shows promise in managing BRONJ, pending further research and clinical trials for validation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Physiology
Scott Epsley, Samuel Tadros, Alexander Farid, Daniel Kargilis, Sameer Mehta, Chamith S. Rajapakse
Summary: Bone remodeling is a continual process involving osteoblasts and osteoclasts, where inflammation plays a crucial role in skewing the process towards resorption. Inflammatory mediators interact with bone cells to alter the expression of regulatory factors, leading to various bone-related pathologies. Further research is needed to advance early detection and treatments for bone diseases influenced by inflammation.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Saravanan Sekaran, Anitha Roy, Lakshmi Thangavelu
Summary: Bone disorders are a global concern, and flavonoids, with their multi-faceted biological activities, play a significant role in maintaining bone health.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Biochemistry & Molecular Biology
Yongguang Gao, Suryaji Patil, Jingxian Jia
Summary: Osteoporosis is a major bone disorder affecting both men and women, primarily due to an imbalance in bone remodeling. Understanding the effects of molecules produced by different cells on bone can help identify new therapeutic targets and approaches for preventing and treating bone disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Barbara Kolodziejska, Natalia Stepien, Joanna Kolmas
Summary: This study summarizes the role of strontium in the treatment of osteoporosis, highlighting its multidirectional effects on bone tissue and its similarities to calcium. It discusses the unique mechanism of action of strontium ranelate and the increasing interest in using strontium ions in ceramics as bone replacement materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Anna Ruocco, Anna Sirico, Rubina Novelli, Silvia Iannelli, Shane Vontelin Van Breda, Diego Kyburz, Paul Hasler, Andrea Aramini, Pier Giorgio Amendola
Summary: Bone remodeling is a dynamic process dependent on the functions of osteoblasts and osteoclasts. The complement system plays a crucial role in regulating the functions of these cells, particularly in inflammatory states. This review analyzes the role of the C5a-C5aR1 axis in bone physiology and pathophysiology, including its involvement in inflammatory bone diseases such as rheumatoid arthritis, osteoporosis and bone cancer metastasis. Furthermore, pharmacological approaches targeting C5aR1 for the treatment of these conditions are examined. The article highlights the importance of the C5a-C5aR1 axis as a therapeutic target for mediating interactions between the skeletal and immune systems, considering the growing interest in osteoimmunology and the lack of data on its role in bone pathophysiology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Chen Chen, Ya-Mei Liu, Bin-Lan Fu, Liang-Liang Xu, Bin Wang
Summary: MiRNAs are small regulatory RNA molecules that play important roles in gene expression, with miR-21 in particular having significant effects in orthopedic diseases by influencing osteoblasts, osteoclasts, and the occurrence, development, treatment, and prevention of bone diseases through various mechanisms.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Jolene Helena, Anna Joubert, Peace Mabeta, Magdalena Coetzee, Roy Lakier, Anne Mercier
Summary: In this study, the potential radiosensitizing effects of ESE-16 were investigated in an in vitro bone metastasis model. The results showed increased cytotoxicity in tumor and endothelial cells, with spared bone cells. Tumor cells displayed increased mitotic indices, DNA damage with impaired repair, and reduced metastatic signaling.
Article
Endocrinology & Metabolism
Jun Hou, Hongjie Su, Xiaocong Kuang, Wencong Qin, Kaibing Liu, Kaixiang Pan, Bokai Zhang, Sijie Yang, Shenghui Yang, Xiao Peng, Xinyu Nie, Qikai Hua
Summary: This study identified the research hotspots and development process of osteoblasts-osteoclasts in bone disease using bibliometric and visual methods. It provides a valuable reference for researchers concerned with osteoblasts-osteoclasts in bone diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Takenobu Ishii, Montserrat Ruiz-Torruella, Kenta Yamamoto, Tsuguno Yamaguchi, Alireza Heidari, Roodelyne Pierrelus, Elizabeth Leon, Satoru Shindo, Mohamad Rawas-Qalaji, Maria Rita Pastore, Atsushi Ikeda, Shin Nakamura, Hani Mawardi, Umadevi Kandalam, Patrick Hardigan, Lukasz Witek, Paulo G. Coelho, Toshihisa Kawai
Summary: Further investigation is needed to understand the pathological role of Sema4D in periodontitis. In a mouse model, inhibition of Sema4D promoted bone regeneration without affecting local TNF-alpha and RANKL production or systemic skeletal bone remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Orthopedics
Andre Busch, Alexander Wegner, Marcel Haversath, Marcus Jaeger
Summary: The study discusses the advantages and drawbacks of bone substitutes and their current research status, highlighting limitations of autologous bone grafting and exploring the development of combining ceramic substitutes with osteoinductive substances.
ZEITSCHRIFT FUR ORTHOPADIE UND UNFALLCHIRURGIE
(2021)
Article
Orthopedics
Marcel Haversath, Martin Lichetzki, Sebastian Serong, Andre Busch, Stefan Landgraeber, Marcus Jaeger, Tjark Tassemeier
Summary: In this study, the alignment of a collarless straight tapered HA-coated stem was retrospectively analyzed during the learning phase of the direct anterior approach (DAA) for primary total hip arthroplasty (THA). The results showed that in the learning curve, DAA can be associated with a high incidence of varus stem alignment, especially in men with coxa vara deformity: low CCD, high femoral offset, and long thigh neck.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2021)
Article
Sport Sciences
Martin Husen, Lars Burgsmueller, Manuel Burggraf, Marcus Jaeger, Marcel Dudda, Max Kauther
Summary: Rink Hockey is a high-risk sport where players wear little protective gear, head injuries are the most common and caused mostly by ball contact and player contact, it is recommended to use protective gear.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2021)
Review
Orthopedics
Robert L. Parisien, Cooper Ehlers, Antonio Cusano, Paul Tornetta, Xinning Li, Dean Wang
Summary: Analysis of 19 RCTs evaluating PRP for surgical RCRs showed low fragility index (FI) and fragility quotient (FQ), suggesting lack of statistical stability and potential for trial significance alteration with few outcome events. Reporting FI and FQ alongside P value analysis is recommended for future comparative trials to carefully interpret statistical stability.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Siyuan Zhu, Xinning Li, Jia-Lin Wu, Lei Bao, Peng Wang, Haifeng Gu, Chenglong Wang, Jianhua Wang
Summary: The study described a non-anatomic arthroscopic all-inside repair technique for medial meniscus posterior root tears in middle-aged and older patients, showing good clinical outcomes and structural healing. The method was effective in treating MMPRTs in this patient population as an alternative to the transtibial pullout repair technique.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Review
Orthopedics
Robert L. Parisien, Michael Constant, Bryan M. Saltzman, Charles A. Popkin, Christopher S. Ahmad, Xinning Li, David P. Trofa
Summary: The study analyzed 19 RCTs from 11 orthopedic journals and found that the literature evaluating articular cartilage defects of the knee is fragile, with relatively few outcome events potentially altering the significance of statistical findings. The recommendation is to conduct comprehensive fragility analysis and report the P value, FI, and FQ to aid in the interpretation and contextualization of clinical findings in cartilage restoration literature.
Article
Biology
Nadia Feddahi, Monika Herten, Tjark Tassemeier, Heike Rekasi, Alexander Hackel, Marcel Haversath, Marcus Jaeger
Summary: The study compared the yield and regenerative potency of MSCs in bone marrow aspirate collected using two different needle systems and found that both systems were similar in their ability to produce around 40,000 MSCs per 10 mL, which can be used to enhance bone healing.
Review
Primary Health Care
Lori Jia, William H. Huffman, Antonio Cusano, David P. Trofa, Xinning Li, John D. Kelly, Robert L. Parisien
Summary: Rigorous preventive and surveillance measures can reduce the risk of COVID-19 transmission in athletes during return to sport. However, athletes are more susceptible to COVID-19 compared to the general population, and wearing masks and maintaining social distance pose the greatest challenges to athletes.
PHYSICIAN AND SPORTSMEDICINE
(2023)
Article
Biology
Roman M. Mueller-Heck, Bjoern Boesken, Ivo Michiels, Marcel Dudda, Marcus Jaeger, Stefanie B. Flohe
Summary: This study investigated the impact of invasive spine surgery on the relationship between monocytes and NK cells in response to Staphylococcus aureus. The findings showed that NK cells continuously lost their ability to produce IFN-gamma during the first week after surgery independently from monocyte-derived IL-12 secretion. Additionally, pre-operative levels of GDF-15 in the serum were associated with the extent of NK cell suppression and hospitalization.
Article
Surgery
Sehar Resad Ferati, Robert L. Parisien, Patrick Joslin, Brock Knapp, Xinning Li, Emily J. Curry
Summary: Financial, personal, and structural barriers affect access to orthopaedic specialty care in all aspects. Disparities in access to care exist across all subspecialties of orthopaedic surgery in the United States. Improving timely access to care in orthopaedic surgery is crucial for promoting health equity and optimizing patient outcomes. Options for improving orthopaedic access include increasing physician payments, providing secondary resources for financially limited patients, and reducing language barriers in clinical care and patient education.
Review
Orthopedics
Michael N. Megafu, Hassan S. Mian, Mahad M. Hassan, Bradford O. Parsons, Xinning Li, Robert L. Parisien
Summary: The purpose of this study was to assess the robustness of RCTs evaluating distal biceps tendon repairs through fragility analysis. The results suggest that the dichotomous outcomes were statistically fragile, and statistically significant outcomes had higher fragility compared to other orthopedic specialties.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Engineering, Biomedical
Marcus Jaeger, Agnieszka Latosinska, Monika Herten, Andre Busch, Thomas Grupp, Andrea Sowislok
Summary: This study investigates the composition of the initial protein layer on endoprosthetic surfaces and finds that proteins relevant for osseointegration are already adsorbed within 2 minutes. These findings are important for optimizing implant surfaces in orthopedic and trauma surgery.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Orthopedics
Nathan Howlett, Robert L. Parisien, Sung Jun Son, Xinning Li
Summary: Repairing subscapularis tendon tears has been shown to improve functional outcomes while decreasing retear rates in patients with large rotator cuff tears. However, diagnosing subscapularis tendon tears can be challenging and present technical difficulties.
ARTHROSCOPY TECHNIQUES
(2021)
Meeting Abstract
Sport Sciences
Victor Jr Lopez, Kiera G. Borthwick, Christian Victoria, Samuel Y. Haleem, Som P. Singh, Xinning Li, Richard Ma, Answorth A. Allen
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Medicine, Research & Experimental
Charlotte Bielefeld, Harald Engler, Marcus Jaeger, Alexander Wegner, Dennis Wassenaar, Andre Busch
Summary: The study evaluated the use of the AD-1 test in predicting successful infection eradication in patients undergoing two-stage revision arthroplasty for PJI, but further research is needed to identify more suitable biomarkers for indicating persistent infection before reimplantation.