Journal
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
Volume 89, Issue 8, Pages 533-537Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/Y11-051
Keywords
atrial natriuretic factor; heart; embryology; gene expression; transcription factors; congenital heart disease; patterning
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Funding
- National Institutes for Health/National Heart Lung and Blood Institute
- California Institutes of Regenerative Medicine
- Lawrence J. and Florence A. De-George Charitable Trust/American Heart Association
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The developing heart forms during the early stages of embryogenesis, and misregulated heart development results in congenital heart defects (CHDs). To understand the molecular basis of CHDs, a deep understanding of the morphological and genetic basis of heart development is necessary. Atrial Natriuretic Factor (ANF) is an important and extremely sensitive marker for specific regions of the developing heart, as well as for disturbances in the patterning of the heart. This review summarizes the dynamic expression of ANF in the developing heart and its usefulness in understanding the early molecular defects underlying CHDs.
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