Article
Biochemistry & Molecular Biology
Tapiwa Chiura, Amanda J. Mitchell, Dakota L. Grote, Niloufar Khojandi, Ryan M. Teague, Piotr J. Mak
Summary: Human heme oxygenase-1 (hHO-1) plays a crucial role in metabolizing free heme and has protective properties in cells. In the context of cancer, inhibitors targeting hHO-1 have potential for anti-cancer therapy. This study characterizes the interactions between azole-based inhibitors and hHO-1, providing insights into their binding and inhibitory properties.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Khosrow Kashfi, Kush K. Patel
Summary: This article reviews the history of carbon monoxide, highlighting its toxic effects as well as its roles as an endogenously produced molecule and therapeutic agent. The research into its physiological functions and therapeutic applications are often overshadowed by its reputation as a lethal substance.
BIOCHEMICAL PHARMACOLOGY
(2022)
Editorial Material
Hematology
Nipon Chattipakorn
Summary: Excess free heme and reduced hemopexin in sickle cell disease can lead to the overload of ferrous ion in cardiac cells, promoting cardiomyocyte ferroptosis and potentially impairing cardiac contractility.
Article
Biochemistry & Molecular Biology
Christian Streng, Jana Hartmann, Kai Leister, Norbert Krauss, Tilman Lamparter, Nicole Frankenberg-Dinkel, Franco Weth, Martin Bastmeyer, Zhenzhong Yu, Reinhard Fischer
Summary: This study reveals the involvement of mitochondria in light sensing in fungi, related to phytochrome dependence. Phytochrome photoreceptors in fungi contain a linear, heme-derived tetrapyrrole as chromophore, suggesting different approaches for chromophore biosynthesis and insertion into phytochrome in plants and fungi.
Article
Biochemistry & Molecular Biology
Elena Karnaukhova, Catherine Owczarek, Peter Schmidt, Dominik J. Schaer, Paul W. Buehler
Summary: Plasma hemopexin (HPX) plays a crucial role in limiting the harmful effects of heme released from hemoglobin and myoglobin. Recombinant production of HPX from human cell lines could serve as a relevant intervention for hemolytic disorders. The biophysical assessment of recombinant human HPX (rhHPX) produced in the Expi293F(TM) cell system showed similarities to plasma HPX in terms of heme binding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ayleen Fernandez-Fierro, Samanta C. Funes, Mariana Rios, Camila Covian, Jorge Gonzalez, Alexis M. Kalergis
Summary: The heme oxygenase (HO) system involves three isoforms, with HO-1 being the most studied and overexpression of this enzyme promoting anti-inflammatory products. However, overexpression of HO leading to neonatal jaundice has prompted the development of inhibitors. Various types of inhibitors have been identified, including competitive and non-competitive ones, with potential medical implications in metabolic diseases and immune-mediated diseases such as cancer and Alzheimer's disease. Selective inhibition of HO isoforms may contribute to the treatment of these ailments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Mirrin J. Dorresteijn, Douwe Dekker, Jelle Zwaag, Suzanne Heemskerk, Hennie M. J. Roelofs, Paul Smits, Johannes G. van der Hoeven, Frank A. D. T. G. Wagener, Peter Pickkers
Summary: Inflammation-induced free radical release is important in the pathogenesis of several diseases. This study investigated the impact of atazanavir-induced hyperbilirubinemia on antioxidant capacity, inflammation, and vascular dysfunction in human experimental endotoxemia. The results showed that hyperbilirubinemia increased antioxidant capacity, attenuated interleukin-10 release, and prevented vascular hyporesponsiveness during systemic inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anja Hofmann, Margarete Mueglich, Steffen Wolk, Yazan Khorzom, Pamela Sabarstinski, Irakli Kopaliani, Dmitry Egorov, Franziska Horn, Coy Brunssen, Sindy Giebe, Bianca Hamann, Andreas Deussen, Henning Morawietz, David M. Poitz, Christian Reeps
Summary: Aortic expression of HO-1 was found to be increased in both elective open repair (eAAA) and rupture (rAAA) cases. The severity of disease was positively correlated with HO-1 induction, but also connected to lower oxidative stress and protection of blood vessels.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Biochemistry & Molecular Biology
Akihiro Yachie
Summary: HO-1 is crucial in protecting tissues and organs from oxidative stress and excessive inflammatory reactions. Deficiency in HO-1 leads to dysfunction in monocytes, macrophages, and endothelial cells, resulting in systemic inflammatory response syndrome. Therapeutic induction of HO-1 production through pharmacological intervention shows promise in controlling inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Zhen Liang, Zhaoshi Zheng, Qi Guo, Meng Tian, Jing Yang, Xiu Liu, Xiaojuan Zhu, Songyan Liu
Summary: This study investigates the role of hypoxia-inducible factor (HIF)-1 alpha/heme oxygenase (HO)-1 in hippocampal neuron ferroptosis during epilepsy. The results suggest that there are metabolic differences between epilepsy patients and healthy individuals, with increased oxidative stress, heightened bilirubin, and augmented iron metabolism in epileptic blood. The active HIF-1 pathway in epileptic pathogenesis and perturbations in HIF-1 alpha signaling are reinforced by the analysis. The study implicates that HIF-1 alpha/HO-1 potentially regulates hippocampal neuronal ferroptosis, iron metabolism, and oxidative stress, thereby promoting the propagation of epilepsy.
Review
Biochemistry & Molecular Biology
Valeria Consoli, Valeria Sorrenti, Salvo Grosso, Luca Vanella
Summary: Heme-oxygenase (HO-1) plays a crucial role in maintaining cellular oxidative damage and has implications in cancer research and antioxidant activity.
Review
Biochemistry & Molecular Biology
Virginia Athanassiadou, Stella Plavoukou, Eirini Grapsa, Maria G. Detsika
Summary: The protein heme oxygenase-1 plays a key role in kidney disease and affects immune pathways and responses, as demonstrated by animal models and patient studies.
Article
Biochemistry & Molecular Biology
Kelly J. Peyton, Ghazaleh Behnammanesh, Giovanna L. Durante, William Durante
Summary: Research shows that canagliflozin can act as a novel inducer of HO-1 in human ECs. While HO-1 contributes to the anti-inflammatory action, it does not affect the anti-proliferative and antimigratory effects of the drug.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Qing Yang, Wenqian Wang
Summary: Heme oxygenase-1 (HO-1) is an enzyme involved in the degradation of heme, producing carbon monoxide (CO), free iron, and biliverdin, which can be converted to bilirubin. In addition to its canonical function, HO-1 has been found to have noncanonical functions that are independent of its enzyme activity. This review summarizes the noncanonical functions of HO-1 and its nuclear translocation in various diseases, emphasizing its critical role in tumor formation and progression. The nuclear translocation of HO-1 may serve as a potential target for the prevention and treatment of human diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pan Zhu, Bing Zhou
Summary: Elevating intraparasitic free heme levels negatively impacts the antimalarial action of artemisinin, while having no effect on other antimalarial drugs. The presence of an unknown heme uptake pathway in the parasites prevents effective reduction of free heme levels.
Article
Chemistry, Multidisciplinary
Bogdan-Ionel Bratanovici, Alina Nicolescu, Sergiu Shova, Ioan-Andrei Dascalu, Rodinel Ardeleanu, Vasile Lozan, Gheorghe Roman
RESEARCH ON CHEMICAL INTERMEDIATES
(2020)
Article
Chemistry, Physical
Andreea L. Chibac-Scutaru, Corneliu Cojocaru, Adina Coroaba, Gheorghe Roman, Gabriela Sacarescu, Mihaela Simionescu, Liviu Sacarescu
JOURNAL OF MOLECULAR LIQUIDS
(2020)
Article
Chemistry, Inorganic & Nuclear
Ioan-Andrei Dascalu, Elena A. Mikhalyova, Sergiu Shova, Bogdan-Ionel Bratanovici, Rodinel Ardeleanu, Narcisa Marangoci, Vasile Lozan, Gheorghe Roman
Summary: A series of 3D metal-organic frameworks were synthesized using 2',3',5',6'-tetramethyl-[1,1':4',1 ''-terphenyl]-4,4 ''-dicarboxylic acid (H2L) as the organic linker and various lanthanides. The resulting coordination polymers were characterized through various methods, and the crystal structure for six isostructural networks was determined using single crystal X-ray crystallography. Luminescence investigation showed different emission properties for compounds containing different lanthanide ions.
Article
Chemistry, Physical
Andreea L. Chibac-Scutaru, Corneliu Cojocaru, Gheorghe Roman, Petrisor Samoila, Gabriela Sacarescu, Mihaela Simionescu, Liviu Sacarescu
Summary: A highly stable fluorescent probe for the selective detection of cytosine has been developed based on a polyhydrosilane copolymer with grafted moieties. The novel polymer shows enhanced emission-absorption processes and can be used to design a turn-on fluorescent sensor for recognizing subtle changes in DNA structures.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Inorganic & Nuclear
Bogdan-Ionel Bratanovici, Sergiu Shova, Vasile Lozan, Ioan-Andrei Dascalu, Rodinel Ardeleanu, Gheorghe Roman
Summary: The research presents the synthesis of four coordination polymers and two mononuclear complexes using a polydentate ligand with Cd(II), Co(II), and Cu(II) ions. The compounds were characterized using various techniques and their crystal structures were established. The specific surface area of the coordination polymers derived from Cd(II) and Co(II) ions was found to be negligible.
Article
Chemistry, Physical
Bogdan-Ionel Bratanovici, Corneliu Cojocaru, Alina Nicolescu, Mihaela Dascalu, Gheorghe Roman
Summary: Two novel di-topic hybrid ligands with isoxazole ring and carboxylate group at one end, either tetrazole or imidazole at the other end, were synthesized for coordination polymer generation. The structure of imidazole-acid hydrochloride monohydrate was determined by X-ray diffraction, and also investigated theoretically. Experimental electronic absorption band at 294 nm in DMSO was close to the theoretical wavenumber of 296 nm computed by TD-DFT method.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Polymer Science
Liviu Sacarescu, Corneliu Cojocaru, Gheorghe Roman, Gabriela Sacarescu, Mihaela Simionescu, Petrisor Samoila, Andreea Laura Chibac-Scutaru
Summary: This study demonstrated the ability of oligomeric polydiphenylsilanes to form stable aggregates with fluorescent low molecular weight organic compounds, which could potentially be utilized for the development of highly sensitive and selective fluorescent sensors. The nano-aggregates formed in solution were investigated experimentally and theoretically, revealing a potential amplification efficiency of up to 90% through a FRET mechanism as a result of aggregation.
Review
Chemistry, Medicinal
Gheorghe Roman
Summary: This review provides a comprehensive account of the developments in the field of antimicrobial compounds featuring at least one thiophene ring in their structure over the last decade.
ARCHIV DER PHARMAZIE
(2022)
Review
Chemistry, Medicinal
Gheorghe Roman
Summary: This report summarizes the latest published data on the antiproliferative action and cytotoxic activity of Mannich bases, a structurally heterogeneous category of chemical entities. The overview serves as an update to previously published information up to 2014.
Review
Chemistry, Multidisciplinary
Liviu Sacarescu, Andreea-Laura Chibac-Scutaru, Gheorghe Roman, Gabriela Sacarescu, Mihaela Simionescu
Summary: This article reviews the synthesis and properties of pyrazolines as fluorescent sensors, as well as their capabilities in cellular detection and monitoring of metal ions, sulfites, multi-ionic mixtures, pH, and glutathione. The metals analyzed include zinc, copper, iron, nickel, mercury, aluminum, and calcium.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Petrisor Samoila, Corneliu Cojocaru, Mihaela Simionescu, Gabriela Sacarescu, Gheorghe Roman, Andra-Cristina Enache, Liviu Sacarescu
Summary: This paper discusses the preparation and optical properties of a composite material that encapsulates cobalt spinel ferrite in a polysilane matrix. The material exhibits interesting optical properties and ferrimagnetic behavior. The study shows that the internal magnetic field strongly enhances the emission of polysilane. This research provides an interesting material basis for the development of new detection devices in the future.
Article
Chemistry, Physical
Liviu Sacarescu, Mihaela Dascalu, Andreea-Laura Chibac-Scutaru, Gheorghe Roman
Summary: The effect of conjugation between 1,2,3-triazole ring system and azaindene scaffolds on fluorescence was investigated. Three new 1,2,3-triazole-indolizine hybrids were synthesized using different reactions, and a structurally related 1,2,3-triazole-substituted imidazo[1,2-a]pyridine was obtained. The structures of two of the hybrids were determined by X-ray diffraction. The fluorescence of the 1,2,3-triazole-azaindenes was found to be twofold amplified compared to analogous azaindenes without the 1,2,3-triazole moiety. The 1,2,3-triazole-substituted imidazo[1,2-a]pyridine showed stronger fluorescence emission and selective detection of Hg2+ and UO22+ with similar detection limits.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Physical
Liviu Sacarescu, Andreea-Laura Chibac-Scutaru, Corneliu Cojocaru, Gabriela Sacarescu, Mihaela Simionescu, Gheorghe Roman
Summary: This report describes the preparation and properties of a self-assembled hybrid material composed of tryptophan and polysilane. The study found that the aggregates have regularly shaped structures and the self-assembly mechanism is controlled by the template action of tryptophan.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Mihaela Dasca, Andreea-Laura Chibac-Scutaru, Gheorghe Roman
Summary: A novel tricarboxylate ligand containing a 1,2,3-triazole ring was synthesized through the Dimroth azide-enolate cycloaddition reaction. The coordination polymer [Zn4L2(OH)2(H2O)DMF2](n) was obtained by reacting this ligand with Zn(NO3)2·6H2O in a mixture of DMF and water. The fluorescence quenching of this coordination polymer was investigated and it showed high sensitivity towards nitroaromatics.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Gheorghe Roman, Radu Oghina, Liviu Sacarescu
SCIENTIFIC STUDY AND RESEARCH-CHEMISTRY AND CHEMICAL ENGINEERING BIOTECHNOLOGY FOOD INDUSTRY
(2020)
