Article
Biology
Sharn P. Shelley, Rob S. James, Steven J. Eustace, Emma Eyre, Jason Tallis
Summary: This study found that stimulation frequency has an effect on the force, power, and fatigue of muscles, with different effects on different assessments of muscle performance. It suggests that when assessing maximal power, higher stimulation frequencies should be used, while sub-maximal stimulation frequencies should be used for fatigue assessments to avoid excessive negative work.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Physiology
Sharn P. Shelley, Rob S. James, Steven J. Eustace, Emma L. J. Eyre, Jason Tallis
Summary: Evidence suggests that high-dose vitamin D-3 supplementation has limited effects on skeletal muscle contractility and does not offset the adverse effects of a high-fat diet. However, small to moderate effect sizes suggest improvement in muscle performance and animal morphology in high-fat diet with vitamin D supplementation groups.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kristina Sharlo, Irina Lvova, Olga Turtikova, Sergey Tyganov, Vitaliy Kalashnikov, Boris Shenkman
Summary: Recent studies have shown that support afferentation plays a key role in controlling postural muscle function, structure and phenotype. Lack of support afferentation can negatively affect muscle performance and life quality, while simulating support afferentation can maintain muscle fiber characteristics.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Biology
Camila Vesga-Castro, Javier Aldazabal, Ainara Vallejo-Illarramendi, Jacobo Paredes
Summary: In recent years, there has been a growing interest in evaluating the contractile force (CF) of engineered muscle tissues, but there are currently no standards available for selecting the most suitable experimental platform, measuring system, culture protocol, or stimulation patterns. Cantilever deflection, post deflection, and force transducers are commonly used configurations for CF assessment, and future studies are recommended to report detailed information on construct size, contractile area, maturity level, sarcomere length, and the tetanus-to-twitch ratio.
Article
Geriatrics & Gerontology
Navneet N. Lal, Jon Cornwall, Philip W. Sheard
Summary: This study aimed to develop a reliable assay for identifying denervated muscle fibers and explore the impact of denervation on age-related force-generation in mouse skeletal muscle. By injecting fluorescent deoxyglucose analog 2-NBDG and stimulating the tibial nerve, the researchers labeled active muscle fibers and collected data on muscle force generation. The results showed that aged muscles had more denervated fibers, increased passive force, and decreased specific force, but denervation only partly explained the age-related deficits in specific force. Further investigations are necessary to identify other contributors to the decrease in force generation.
Article
Biochemistry & Molecular Biology
Cecilia Leijding, Ida Viken, Joseph D. D. Bruton, Daniel C. C. Andersson, Arthur J. J. Cheng, Hakan Westerblad
Summary: During the initial phase of fatigue, tetanic force decreases despite increasing tetanic cytosolic calcium concentration. However, the increase in calcium concentration has positive effects on force in early fatigue.
Article
Physiology
Leonit Kiriaev, Ben D. Perry, David A. Mahns, Peter J. Shortland, Asma Redwan, John W. Morley, Stewart I. Head
Summary: The study showed that high dose minocycline treatment can reduce maximal isometric force production in fast-twitch EDL and impair protein synthesis in C2C12 cultured cells. These findings are significant for future research on the efficacy of minocycline treatment in neuromuscular disorders or muscle atrophy conditions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yoko Ino, Takashi Ohira, Ken Kumagai, Yusuke Nakai, Tomoko Akiyama, Kayano Moriyama, Yuriko Takeda, Tomoyuki Saito, Akihide Ryo, Yutaka Inaba, Hisashi Hirano, Yayoi Kimura
Summary: Gravity-dependent physical processes are crucial for maintaining musculoskeletal health in elderly people. Identifying gravity-responsive molecules and establishing objective indicators for musculoskeletal maintenance is necessary. This study found that certain muscle proteins, such as Myl6b and Pvalb, respond to gravitational loading, indicating changes in muscle fiber type. Pvalb levels might serve as a useful objective marker for evaluating muscle atrophy and bone loss.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Dumitru Constantin-Teodosiu, Despina Constantin
Summary: Muscle fatigue can decrease the capacity of muscles to complete tasks over time, with short-lasting fatigue often caused by overtraining, undertraining, or physical injury, while persistent and severe fatigue may be associated with pathological states or chronic exposure to certain substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Xiaolong He, Karan Taneja, Jiun-Shyan Chen, Chung-Hao Lee, John Hodgson, Vadim Malis, Usha Sinha, Shantanu Sinha
Summary: This paper introduces a multiscale modeling framework to investigate the influence of microscale passive muscle components on force output and deformations of skeletal muscle. The study explores the effects of muscle architectural changes due to aging on force output and muscle deformation, and discusses the correlations between different components.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2022)
Article
Cell Biology
Simeon P. Cairns, John P. Leader, Amanda Higgins, Jean-Marc Renaud
Summary: This study investigated the factors affecting the peak force-resting membrane potential (EM) relationships in mouse muscles and found that the variability of intracellular K+ activity has a significant impact on the resting membrane potential. The study also revealed differences in the action potential overshoot-resting EM relationships between short and prolonged depolarization periods, as well as changes in force and overshoot magnitude with variations in other ion concentrations. Furthermore, the depolarization of the resting membrane potential during fatigue was found to have a significant influence on muscle force.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Takashi Yamada, Iori Kimura, Yuki Ashida, Katsuyuki Tamai, Hiroyori Fusagawa, Noritsugu Tohse, Hakan Westerblad, Daniel C. Andersson, Tatsuya Sato
Summary: Interval training with high-intensity contractions improves fatigue resistance in skeletal muscle by increasing mitochondrial function, specifically through increased expression of mitochondrial respiratory chain complexes.
Article
Cell Biology
Amanda J. Genders, Jujiao Kuang, Nicholas J. Saner, Javier Botella, David J. Bishop
Summary: Exercise training can increase mitochondrial content and respiration, but high-intensity exercise may be limited by mild acidosis. This study aimed to determine the effects of administering ammonium chloride before each exercise session on mitochondrial content and respiration in rats. The results showed that ammonium chloride administration reduced the exercise-induced increase in mitochondrial respiration in the soleus muscle but did not alter mitochondrial content. These effects were not observed in the white gastrocnemius muscle.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Neurosciences
Simeon P. Cairns, Jean-Marc Renaud
Summary: During repeated intense exercise, a decrease in muscle glycogen content and disturbances in potassium (K+) concentration across muscle membranes occur simultaneously, contributing to skeletal muscle fatigue. This study aimed to investigate the interaction between elevated extracellular K+ concentration and reduced glycogen on force production. The results showed that severe depletion of glycogen led to a significant decline in force production, and the decline was exacerbated at elevated extracellular K+ concentration. Additionally, the replenishment of glucose increased both glycogen content and force production. These findings provide direct evidence of the synergistic interaction between elevated extracellular K+ concentration and reduced muscle glycogen, which may contribute to muscle fatigue by shifting the resting-force relationship towards a more negative resting membrane potential.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Physiology
Matthew J. Fogarty, Joline E. Brandenburg, Wen-Zhi Zhan, Gary C. Sieck
Summary: This study quantified transdiaphragmatic pressure deficits, diaphragm muscle weakness, and fiber type-specific atrophy in spa mutant mice, providing insights into the respiratory dysfunctions in spastic cerebral palsy (sCP).
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Geriatrics & Gerontology
J. Tallis, R. S. James, V. M. Cox, M. J. Duncan
JOURNAL OF NUTRITION HEALTH & AGING
(2017)
Article
Physiology
Jason Tallis, Cameron Hill, Rob S. James, Val M. Cox, Frank Seebacher
JOURNAL OF APPLIED PHYSIOLOGY
(2017)
Article
Geriatrics & Gerontology
Cameron Hill, Rob S. James, Val M. Cox, Jason Tallis
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2018)
Article
Physiology
Josh Hurst, Rob S. James, Val M. Cox, Cameron Hill, Jason Tallis
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2019)
Article
Nutrition & Dietetics
Cameron Hill, Rob S. James, Val M. Cox, Jason Tallis
Article
Biochemistry & Molecular Biology
Pavneet Singh, Rob S. James, Christopher J. Mee, Igor Y. Morozov
Article
Multidisciplinary Sciences
Sophie Fletcher, Helen Maddock, Rob S. James, Rob Wallis, Mayel Gharanei
SCIENTIFIC REPORTS
(2020)
Article
Physiology
Pablo Padilla, Jason Tallis, Josh Hurst, Julien Courant, Rob S. James, Anthony Herrel
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2020)
Article
Biology
Jason Tallis, Rob S. James, Emma L. J. Eyre, Val M. Cox, Josh Hurst
Summary: This study examined the effects of high-fat diet on muscle contractile performance and thermal sensitivity in mice. The results showed that increasing temperature initially improved contractile function, but the optimal temperature for maximal performance differed depending on the muscle and contractile mode. Moreover, high-fat diet had specific effects on contractile function, but did not alter the relationship between temperature and performance.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Sport Sciences
Lesley McBride, Rob S. James, Sian Alsop, Samuel W. Oxford
Summary: This study aimed to establish the reliability of a commercially available dynamometer in measuring isometric neck strength. The results showed that the dynamometer can reliably assess neck strength and provide reference values for healthy individuals.
Review
Biology
Rob S. James, Frank Seebacher, Jason Tallis
Summary: This Review summarizes the potential impact of anthropogenic climate change and pollution on animal tissue mechanics, particularly focusing on the acute and chronic effects of temperature on muscle tissues. The ability of species to acclimate to changes in temperature varies, which can have long-term effects on species range. The impact of anthropogenic pollutants on animal tissue mechanics is relatively understudied.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Review
Biodiversity Conservation
Rob S. James, Jason Tallis
CONSERVATION PHYSIOLOGY
(2019)
Article
Sport Sciences
Mark R. Noon, Rob S. James, Neil D. Clarke, Richard J. Taylor, C. Douglas Thake
Article
Biology
Jason Tallis, Matthew F. Higgins, Val M. Cox, Michael J. Duncan, Rob S. James
JOURNAL OF EXPERIMENTAL BIOLOGY
(2018)