Review
Chemistry, Multidisciplinary
Susmit Mhatre, Catherine A. Opere, Somnath Singh
Summary: Glaucoma is a common cause of blindness worldwide, characterized by progressive degeneration of the retinal ganglion cells. Current treatments focus on reducing intraocular pressure, but an ideal treatment should also offer neuroprotection and regeneration of retinal ganglion cells. Hydrogen sulfide, a gasotransmitter, shows potential therapeutic applications in glaucoma by increasing aqueous humor outflow and providing neuroprotection. However, its delivery to different parts of the eye is challenging due to its unique physicochemical properties.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Wioletta Rozpedek-Kaminska, Grzegorz Galita, Natalia Siwecka, Steven L. Carroll, John Alan Diehl, Ewa Kucharska, Dariusz Pytel, Ireneusz Majsterek
Summary: The study evaluated the effectiveness of the PERK inhibitor LDN-0060609 in a cellular model of glaucoma using primary HTM cells, showing significant decrease of ER stress marker proteins and improvements in cell viability, DNA damage reduction, proliferation increase, morphology restoration, apoptosis reduction, and cell cycle distribution normalization under induced ER stress conditions. PERK inhibitors, like LDN-0060609, may offer an innovative treatment strategy against POAG.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Andy Tran, Wenyuan He, Jim T. C. Chen, Denise D. Belsham
Summary: This review discusses the involvement of spexin in the hypothalamic control of energy homeostasis and reproduction, as well as the disorders and treatments related to energy homeostasis and reproduction that alter spexin expression. The review also explores the biochemical basis of spexin, its interaction with its cognate receptors, and the potential for developing therapeutics for energy homeostasis and reproductive disorders.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Faisal Mahmood, Ruixian Xu, Maher Un Nisa Awan, Yuzhu Song, Qinqin Han, Xueshan Xia, Jinyang Zhang
Summary: The role of PDIA3 in catalyzing disulphide bonds, acting as a chaperone, and its association with cancer, cellular stress, and viral infections is highlighted. Inhibitors targeting PDIA3 show potential in interfering with viral infections, suggesting a promising avenue for future research in combating viral diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Younsik Kim, Min-Seok Kim, Dongwook Kim, Minjae Kim, Minsoo Kim, Cheng-Maw Cheng, Joonyoung Choi, Saegyeol Jung, Donghui Lu, Jong Hyuk Kim, Soohyun Cho, Dongjoon Song, Dongjin Oh, Li Yu, Young Jai Choi, Hyeong-Do Kim, Jung Hoon Han, Younjung Jo, Ji Hoon Shim, Jungpil Seo, Soonsang Huh, Changyoung Kim
Summary: The Kondo hybridization in FeTe is observed, and its role in the mechanism of magnetic order is discussed.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Ruixuan You, Xinglan He, Zhuotong Zeng, Yi Zhan, Yangfan Xiao, Rong Xiao
Summary: Autoimmune diseases are a group of heterogeneous diseases caused by the destruction of immune tolerance and the production of autoantibodies. Excessive exacerbation of pyroptosis, a form of programmed cell death, plays a crucial role in the development of autoimmune diseases. Inflammasomes act as switches for pyroptosis, and various pyroptosis pathways disrupt immune system homeostasis and promote autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Xueyang Zou, Yi Zhang, Xiaoya Wang, Rongchao Zhang, Wei Yang
Summary: The causes of infertility are still unclear, but studies have found that AIRE deficiency might be related to infertility, possibly due to the production of autoantibodies against sperm, poor development of germ cells, and abnormal ovarian function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiraporn Ousingsawat, Raquel Centeio, Rainer Schreiber, Karl Kunzelmann
Summary: SLC26A9 is apically localized in superficial airway epithelial cells in human and porcine lungs, mainly expressed in ciliated epithelial cells. Both CFTR and SLC26A9 contribute to basal chloride currents in non-stimulated BCi-NS1 airway epithelia, with CFTR being the dominating Cl- conductance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Jinfeng Xu, Fan Zhou, Xiaodong Wang, Chunheng Mo
Summary: Ferroptosis is a regulated form of cell death characterized by iron overload, lipid peroxidation, and antioxidant system disruption. Recent evidence suggests that it is associated with pregnancy related diseases such as spontaneous abortion, pre-eclampsia, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, and spontaneous preterm birth. Inhibiting ferroptosis may offer a potential treatment option for these disorders. This review summarizes the mechanisms and advancements in ferroptosis, its pathogenic role in pregnancy related diseases, and potential therapeutic interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Wen-Cui Shen, Bing-Qing Huang, Jin Yang
Summary: This review summarizes the main regulatory mechanisms of retinal ganglion cell (RGC) death in normal tension glaucoma (NTG), including autophagy, glutamate neurotoxicity, oxidative stress, neuroinflammation, immunity, and vasoconstriction. The article also discusses the research progress on potential options for the protection of RGCs.
NEURAL REGENERATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yuqing Wang, Wei Wang, Haoming Wu, Yu Zhou, Xiaodan Qin, Yan Wang, Jia Wu, Xiu-Yuan Sun, Yan Yang, Hui Xu, Xiaoping Qian, Xuewen Pang, Yan Li, Zhiqian Zhang, Jiahuai Han, Yu Zhang
Summary: Metastasis is a major cause of cancer-related death. The study demonstrates the significant role of PRAK in regulating tumor metastasis, with Prak deficiency inhibiting lung metastases through a mechanism involving reduced HIF-1 alpha protein synthesis. Targeting PRAK could be a promising strategy in treating metastasis.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Said Kdimati, Christina Susanne Mullins, Michael Linnebacher
Summary: Human immunoglobulin G (IgG) is the primary component of human serum antibody fraction, with different subclasses having unique physiological functions through binding to different IgG-Fc receptors. Recent discoveries suggest that IgG expressed in tumor cells may promote cancer progression and could potentially be targeted for therapeutic purposes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Hai-Tao Xiao, Jing Jin, Zu-Guo Zheng
Summary: As the first histone acetyltransferase to be cloned and identified in yeast, general control non-depressible 5 (GCN5) plays a crucial role in epigenetic and chromatin modifications, and its involvement in human diseases and therapeutic potential are extensively studied. This paper provides an introduction to GCN5 and its role in regulating diseases, followed by a review of GCN5 inhibitors from a medicinal chemistry perspective. The importance of identifying and creating highly selective and effective inhibitors for the treatment of GCN5-related diseases is emphasized.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Neurosciences
Laura Mahoney-Sanchez, Hind Bouchaoui, Scott Ayton, David Devos, James A. Duce, Jean-Christophe Devedjian
Summary: Parkinson's Disease is a common neurodegenerative disorder with motor impairments and non-motor symptoms. Pathological features include dopaminergic neuronal death, alpha-synuclein deposition, iron accumulation, oxidative stress, and lipid peroxidation damage. Targeting pathways like ferroptosis could have therapeutic potential in treating PD.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Immunology
Yiyang Zhou, Wei Lin, Tian Rao, Jinyu Zheng, Tianlei Zhang, Min Zhang, Zhenlang Lin
Summary: This study explores the occurrence and regulatory mechanism of ferroptosis and summarizes its research progress in the pathogenesis and treatment of neurological diseases. Ferroptosis plays a vital role in the pathophysiology of various systems, including the nervous system, and may be closely linked to the occurrence and development of neurodegenerative diseases, strokes, and brain tumors. Investigating ferroptosis can provide novel ideas for the treatment and research of neurological diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
