Retraction
Chemistry, Multidisciplinary
Laura Fisher
Summary: The paper 'TRIM22 functions as an oncogene in gliomas through regulating the Wnt/beta-catenin signaling pathway' by Shi-lei Tang et al. was retracted from RSC Adv., 2018, 8, 30894-30901, DOI: 10.1039/C8RA05684F.
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Kai Quan, Tesfaye Getachew, Joram M. M. Mwacharo, Aynalem Haile, Yutao Li, Shanhe Wang, Wei Sun
Summary: In our study, we found that CRABP2 was highly expressed in Hu sheep hair follicles, indicating its potential influence on dermal papilla cells (DPCs). Our experiments demonstrated that overexpression of CRABP2 promoted DPC proliferation and activated the Wnt/beta-catenin pathway. These findings highlight the crucial role of CRABP2 in Hu sheep DPC proliferation and shed light on its function in hair follicles.
Article
Environmental Sciences
Yangyang Tian, Jiarui Xia, Guo Yang, Chao Li, Yuanmeng Qi, Kai Dai, Chenchen Wu, Yonghua Guo, Wu Yao, Changfu Hao
Summary: We found that A2aR inhibits fibrosis and the EMT process in silicosis by regulating the Wnt/β-catenin pathway. Our study provides an experimental basis for elucidating the role of A2aR in the development of silicosis and offers new ideas for further exploration of interventions for silicosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Xiaobin Shang, Kai Oliver Boeker, Shahed Taheri, Thelonius Hawellek, Wolfgang Lehmann, Arndt F. Schilling
Summary: Osteoarthritis is a chronic disease that lacks disease-modifying treatment, with the Wnt/beta-catenin pathway playing a key role in its pathophysiology. Both excessive stimulation and suppression of this pathway can contribute to the development of OA. MicroRNAs have been found to regulate various cellular processes in different diseases, offering potential insights for the development of miRNA-based therapeutics for OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Education, Scientific Disciplines
Shupeng Liu, Yang He, Shifeng Li, Xuemin Gao, Fang Yang
Summary: Kinesin family member 3A is a crucial motor protein involved in various physiological and pathological processes. The wingless-related integration site/beta-catenin signaling pathway plays a vital role in embryonic development, organogenesis, tissue regeneration, and carcinogenesis. Recent studies have focused on the molecular mechanisms of kinesin family member 3A, particularly its interaction with the wingless-related integration site/beta-catenin signaling pathway. The upregulation and downregulation of kinesin family member 3A influence disease pathogenesis and patient outcomes through the wingless-related integration site/beta-catenin signaling pathway.
Article
Biotechnology & Applied Microbiology
Zhi Fang, Min Zhong, Ling Zhou, Yi Le, Heng Wang, Ziling Fang
Summary: LRP8 is markedly overexpressed in NSCLC tissues and cell lines, correlating with poor clinicopathological characteristics and prognosis. Depletion of LRP8 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of NSCLC cells, partly by inhibiting the Wnt/beta-catenin pathway.
Article
Medicine, Research & Experimental
Rasha M. S. M. Mohamed, Enssaf Ahmad Ahmad, Bothina H. F. Omran, Amr T. Sakr, Islam A. A. E-H Ibrahim, Mona F. Mahmoud, Mostafa E. El-Naggar
Summary: This study investigated the role of a and 13-adrenergic receptors (13ARs) in the dexamethasone-induced nephrotoxicity and found that blocking either a1ARs or 13ARs can effectively protect against the nephrotoxicity. However, the combined blocking of a1ARs and 13ARs does not enhance the renal protective effects.
Review
Biochemistry & Molecular Biology
Xinbing Yang, Yajing Du, Lulu Luo, Xinru Xu, Shizheng Xiong, Xueni Yang, Li Guo, Tingming Liang
Summary: Dysregulated expression of specific non-coding RNAs (ncRNAs) has been strongly linked to tumorigenesis, cancer progression, and therapeutic resistance. Recent evidence suggests that ncRNAs can interact with the Wnt/beta-catenin signaling pathway, influencing the expression of Wnt target genes in cancer cells. This review aims to unravel the complex associations between ncRNAs and the Wnt/beta-catenin signaling pathway and explore their potential implications for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Pratibha Pandey, Fahad Khan, Sara A. Seifeldin, Khalid Alshaghdali, Samra Siddiqui, Mohamed Elfatih Abdelwadoud, Manish Vyas, Mohd Saeed, Avijit Mazumder, Amir Saeed
Summary: The Wnt pathway is crucial for human development and homeostasis. Dysregulation of this pathway has been linked to cancer. Wnt signaling plays a significant role in the development and metastasis of cancer, and targeting this pathway has become an important focus of cancer research. Flavonoids derived from plants have shown anticancer effects by influencing the Wnt pathway and other signaling pathways. This review comprehensively evaluates the impact of flavonoids on cancer development and metastasis through the Wnt pathway, providing evidence of their impact on molecular targets.
Review
Genetics & Heredity
Ankita Sharma, Rafeeq Mir, Sanjeev Galande
Summary: This review discusses the role of the Wnt/beta-catenin pathway in cell proliferation, differentiation, and migration, as well as its impact on embryonic development, tissue regeneration, and cancer. It highlights the influence of epigenetic factors on the pathway and the crosstalk with other signaling pathways, particularly the Hippo/YAP pathway. The review also emphasizes recent advances in developing potential therapeutic interventions targeting the epigenetic machinery for treating various cancers and regenerative therapies.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Hongzao Ni, Daofei Ji, Jing Li, Zongren Zhao, Jiandong Zuo
Summary: The study revealed that IPO11 knockdown suppressed the malignant phenotypes of glioma cells by inactivating the Wnt/beta-catenin pathway, leading to inhibition of cell proliferation, promotion of apoptosis, and suppression of invasion.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Oncology
Siwei Yu, Ruyue Han, Runliang Gan
Summary: This review aims to analyze the mechanisms of action of related molecules in the Wnt/beta-catenin pathway in hematologic malignancies and explore their feasibility as therapeutic targets.
BIOMARKER RESEARCH
(2022)
Review
Oncology
Esther Martinez-Font, Marina Perez-Capo, Oliver Vogler, Javier Martin-Broto, Regina Alemany, Antonia Obrador-Hevia
Summary: Soft tissue sarcomas are a heterogeneous group of rare tumors originating from mesenchymal tissue, with chemotherapy based on doxorubicin remaining the standard first-line treatment. Understanding the molecular alterations of the WNT signaling pathway in STS is crucial for developing new therapeutic approaches and identifying drug targets.
Article
Oncology
Yuting Wang, Jicheng Yue, Mingzhe Xiao, Xiaomei Lu, Yuen Eugene Chin
Summary: Axin1 is constitutively acetylated in resting cells and is deacetylated by SIRT4 upon Wnt stimulation, leading to reduced assembly of beta-TrCP to the destruction complex and activation of the canonical Wnt signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Chenglong Sun, Tiegang Li, Xiaowei Song, Luojiao Huang, Qingce Zang, Jing Xu, Nan Bi, Guanggen Jiao, Yanzeng Hao, Yanhua Chen, Ruiping Zhang, Zhigang Luo, Xin Li, Luhua Wang, Zhonghua Wang, Yongmei Song, Jiuming He, Zeper Abliz
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Cell Biology
Xin Chen, Lijie Huang, Yang Yang, Suhua Chen, Jianjun Sun, Changcheng Ma, Jingcheng Xie, Yongmei Song, Jun Yang
Article
Oncology
Heyu Zhang, Yongmei Song, Zhenglin Du, Xuefen Li, Jianyun Zhang, Shuai Chen, Feng Chen, Tiejun Li, Qimin Zhan
JOURNAL OF PATHOLOGY
(2020)
Article
Cell Biology
Peng Huang, Yuduo Guo, Zitong Zhao, Weihai Ning, Haoran Wang, Chunyu Gu, Mingshan Zhang, Yanming Qu, Hongwei Zhang, Yongmei Song
Correction
Genetics & Heredity
Ling Zhang, Yong Zhou, Caixia Cheng, Heyang Cui, Le Cheng, Pengzhou Kong, Jiaqian Wang, Yin Li, Wenliang Chen, Bin Song, Fang Wang, Zhiwu Jia, Lin Li, Yaoping Li, Bin Yang, Jing Liu, Ruyi Shi, Yanghui Bi, Yanyan Zhang, Juan Wang, Zhenxiang Zhao, Xiaoling Hu, Jie Yang, Hongyi Li, Zhibo Gao, Gang Chen, Xuanlin Huang, Xukui Yang, Shengqing Wan, Chao Chen, Bin Li, Yongkai Tan, Longyun Chen, Minghui He, Sha Xie, Xiangchun Li, Xuehan Zhuang, Mengyao Wang, Zhi Xia, Longhai Luo, Jie Ma, Bing Dong, Jiuzhou Zhao, Yongmei Song, Yunwei Ou, Enming Li, Liyan Xu, Jinfen Wang, Yanfeng Xi, Guodong Li, Enwei Xu, Jianfang Liang, Xiaofeng Yang, Jiansheng Guo, Xing Chen, Yanbo Zhang, Qingshan Li, Lixin Liu, Yingrui Li, Xiuqing Zhang, Huanming Yang, Dongxin Lin, Xiaolong Cheng, Yongjun Guo, Jun Wang, Qimin Zhan, Yongping Cui
AMERICAN JOURNAL OF HUMAN GENETICS
(2020)
Article
Cell Biology
Xiaohan Gao, Yan Wang, Fang Lu, Xu Chen, Di Yang, Yiren Cao, Weimin Zhang, Jie Chen, Leilei Zheng, Guangchao Wang, Ming Fu, Liying Ma, Yongmei Song, Qimin Zhan
Summary: This study found that EVs derived from ESCC contain P4HB, which induces apoptosis of skeletal muscle cells. P4HB promotes apoptotic response through activating ubiquitin-dependent proteolytic pathway, leading to muscle wasting and weight loss. The P4HB inhibitor CCF642 rescues apoptosis of muscle cells in vitro and prevents body weight loss in the ESCC-induced cachexia mouse model.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Chemistry, Analytical
Qingce Zang, Chenglong Sun, Xiaoping Chu, Limei Li, Wenqiang Gan, Zitong Zhao, Yongmei Song, Jiuming He, Ruiping Zhang, Zeper Abliz
Summary: Spatially resolved metabolomics combined with multicellular tumor spheroid model offers a powerful approach to discover cancer tissue relevant metabolic signatures and reveals metabolic heterogeneity of cancer cells under different proliferative states.
ANALYTICA CHIMICA ACTA
(2021)
Article
Oncology
Yuyao Yuan, Zitong Zhao, Liyan Xue, Guangxi Wang, Huajie Song, Ruifang Pang, Juntuo Zhou, Jianyuan Luo, Yongmei Song, Yuxin Yin
Summary: By integrating lipidomics and machine-learning algorithms, we developed an optimized diagnostic model with a panel of 12 lipid biomarkers for detecting ESCC. Integrative analysis revealed potential mechanisms of lipid dysregulation in the serum.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Yali Wang, Weimin Zhang, Wenzhong Liu, Lijie Huang, Yan Wang, Dan Li, Guangchao Wang, Zitong Zhao, Xinming Chi, Yu Xue, Yongmei Song, Xuefeng Liu, Qimin Zhan
Summary: This study revealed a novel lncRNA-guided mechanism of lymph node metastasis in ESCC, in which VESTAR played a key role in lymphatic metastasis. This may provide a potential target for the treatment of ESCC lymphatic metastasis.
Article
Biochemistry & Molecular Biology
Chengyuan Yang, Zichan Guo, Zitong Zhao, Yuan Wei, Xiaoxia Wang, Yongmei Song
Summary: miR-4306 is downregulated in human ESCC tissue samples and cell lines, and its overexpression can suppress the proliferation, migration, invasion, and induce apoptosis of ESCC cells. It exerts its tumor-suppressing function in ESCC by inhibiting the expression of SIX3.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Wenchang Xiao, Danna Yeerken, Jia Li, Zhangfu Li, Lanfang Jiang, Dan Li, Ming Fu, Liying Ma, Yongmei Song, Weimin Zhang, Qimin Zhan
Summary: Autophagy is a crucial pathway for maintaining intracellular homeostasis and preventing malignant transformation. The study reveals that Nlp, a centrosomal protein, is a novel regulator of autophagy that enhances the interaction between Rab7 and FYCO1, facilitating autophagolysosome formation and accelerating autophagic flux. Deficiency of Nlp leads to hepatic autophagic defects and increased incidence of liver cancer in mice.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Cell Biology
Jing Han, Zitong Zhao, Nan Zhang, Yang Yang, Liying Ma, Li Feng, Xue Zhang, Jing Zuo, Zhisong Fan, Yudong Wang, Yongmei Song, Guiying Wang
Summary: TRIM29 is overexpressed in colorectal cancer and associated with poor clinical outcomes and lymph node metastasis, particularly in right-sided colorectal cancer. GATA2 transcriptionally represses TRIM29 expression, and its loss along with high TRIM29 expression is more common in right-sided colorectal cancer. TRIM29 promotes the malignant phenotype of CRC by targeting PKM1 for degradation, leading to increased reliance on PKM2-mediated aerobic glycolysis as the main energy source in CRC.
Correction
Biochemistry & Molecular Biology
Yulin Chen, Dan Li, Dapeng Wang, Xuefeng Liu, Ning Yin, Yongmei Song, Shih H. Lu, Zhenyu Ju, Qimin Zhan
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Liyan Xue, Weihua Li, Xinyi Fan, Zitong Zhao, Wei Zhou, Zhimin Feng, Linxiu Liu, Hua Lin, Lin Li, Xuemin Xue, Xuanlin Huang, Peide Huang, Jia Guo, Peina Du, Ning Lu, Qimin Zhan, Yongmei Song
Article
Medicine, General & Internal
Zi-Tong Zhao, Yang Li, Hong-Yu Yuan, Fu-Hai Ma, Yong-Mei Song, Yan-Tao Tian
WORLD JOURNAL OF CLINICAL CASES
(2020)