Article
Neurosciences
Zulfar Ghulam-Jelani, Jessica Barrios-Martinez, Aldo Eguiluz-Melendez, Ricardo Gomez, Yury Anania, Fang-Cheng Yeh
Summary: This study identified three redundancy circuits in the primate brains, showing differences in redundancy pathways between human and rhesus macaque brains. The results support the hypothesis of less redundancy in human brain commissural pathways and call for further research to explore neuropathological implications.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Conor Owens-Walton, Chris Adamson, Mark Walterfang, Sara Hall, Danielle Westen, Oskar Hansson, Marnie Shaw, Jeffrey C. L. Looi
Summary: People diagnosed with Parkinson's disease can experience cognitive impairment and dementia, which may be related to structural changes in the corpus callosum. This study used magnetic resonance imaging to investigate the thickness of the corpus callosum and cortex in Parkinson's disease patients with varying levels of cognitive impairment. The results showed thinning of the callosum in patients with dementia, and a positive correlation between the thickness of the anterior callosum and the thickness of the cortex in patients with mild cognitive impairment.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Clinical Neurology
Giovanni Videtta, Letizia Squarcina, Maria Gloria Rossetti, Paolo Brambilla, Giuseppe Delvecchio, Marcella Bellani
Summary: Recent studies using diffusion tensor imaging (DTI) tractography have revealed significant changes in the white matter fascicles of the corpus callosum (CC) in patients with bipolar disorder (BD). These changes include decreased fractional anisotropy, reduced fiber density, altered fiber tract length, and increased radial and mean diffusivity. These structural modifications in the CC may contribute to the cognitive impairments observed in BD, particularly in executive processing, motor control, and visual memory. However, the limitations of small sample sizes and heterogeneity in research methods and clinical characteristics should be considered.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Engineering, Biomedical
Xuesong Zhang, Johannes Weickenmeier
Summary: Brain maturation and neurological diseases are closely related to microstructural changes, which affect the brain's mechanical behavior. This study investigates stiffness changes in the brain due to demyelination using the cuprizone mouse model. The results show that there are region-specific stiffness changes in the corpus callosum, cingulum, and cortex. Fixation of the tissue also has a significant impact on stiffness and interregional stiffness ratios.
ACTA BIOMATERIALIA
(2023)
Article
Neurosciences
Dae Lim Koo, Ryan P. Cabeen, Soon Hyun Yook, Steven Yong Cen, Eun Yeon Joo, Hosung Kim
Summary: Obstructive sleep apnea (OSA) can cause disruptions in white matter (WM) and cognitive deficits. This study used diffusion tensor imaging (DTI) to analyze the extent of WM abnormalities and their connection to cognitive deficits in untreated OSA patients. The results showed lower fractional anisotropy (FA) values in various WM fibers and a correlation between lower FA values in the rostrum of the corpus callosum and impaired visual memory in OSA patients. The study revealed the negative impact of untreated OSA on WM integrity and identified specific fiber tract abnormalities associated with cognitive deficits.
HUMAN BRAIN MAPPING
(2023)
Article
Anatomy & Morphology
Hui Zhang, Yuan Feng, Weiguang Li, Xili Liang, Guanglong Huang, Songtao Qi
Summary: This study investigated the topography and cortical distribution of human callosal fibers using magnetic resonance imaging data. The findings showed a segmented coronal arrangement of the callosal fibers, with overlapping heterotopic bundles between adjacent segments. Additionally, the study found that the strength of the heterotopic callosal bundles was much greater than that of the homotopic bundles. These findings have important implications for understanding interhemispheric connectivity and preventing disconnection syndromes in clinical settings.
FRONTIERS IN NEUROANATOMY
(2023)
Article
Neurosciences
Diego Szczupak, Roberto Lent, Fernanda Tovar-Moll, Afonso C. Silva
Summary: The corpus callosum (CC) is traditionally viewed as a predominantly homotopic structure, but new studies show that most callosal commissural fibers are heterotopic. In this study, we investigated the relationship between heterotopic and homotopic callosal fibers in human subjects and a mouse model of Corpus Callosum Dysgenesis (CCD). Our results demonstrate that CCD alters heterotopic connections and brain connectivity.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Takashi Tarumi, Marina Fukuie, Takayuki Yamabe, Ryota Kimura, David C. C. Zhu, Keigo Ohyama-Byun, Seiji Maeda, Jun Sugawara
Summary: The microstructural organization of the corpus callosum is higher in young endurance athletes compared to sedentary adults, particularly in the fiber tracts connected to the sensorimotor and visual cortices. Aerobic exercise training can improve brain connectivity.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Pediatrics
Lottie W. Stipdonk, Rianne M. Boon, Marie-Christine J. P. Franken, Joost van Rosmalen, Andre Goedegebure, Irwin K. Reiss, Jeroen Dudink
Summary: Language difficulties in very preterm children may be related to weaker development of left lateralization for language processing. Dichotic listening task can reflect the dominance of the left hemisphere in language processing, showing associations with language performance and interhemispheric connectivity in VPT children.
PEDIATRIC RESEARCH
(2022)
Article
Neurosciences
Yurui Guo, Alpen Ortug, Rodney Sadberry, Arthur Rezayev, Jacob Levman, Tadashi Shiohama, Emi Takahashi
Summary: This study aimed to identify symptom-related neuroimaging biomarkers for patients with dysgenesis of the corpus callosum (dCC), revealing differential links between brain volumes and structures and various symptoms. Specifically, left hemisphere GI abnormality could serve as a predictor for the disease.
Article
Neurosciences
Diego Szczupak, Pamela Meneses Iack, Danielle Rayee, Cirong Liu, Roberto Lent, Fernanda Tovar-Moll, Afonso C. Silva
Summary: The corpus callosum is the primary pathway for interhemispheric communication in the brain, and investigating its connectivity is crucial for understanding the brain's organization. Previous studies have underestimated the presence of heterotopic connections, but using advanced imaging techniques, it was found that around 75% of callosal connections are heterotopic. These heterotopic connections play an important role in determining the global properties of brain networks.
Article
Biophysics
Si-Hong Huang, Meng-Jun Li, Fang-Cheng Yeh, Chu-Xin Huang, Hui-Ting Zhang, Jun Liu
Summary: In this study, we evaluated fiber bundles in mild traumatic brain injury (mTBI) patients using differential and correlational tractography in a longitudinal analysis. We found that the changes in anisotropy in the corpus callosum were significantly correlated with the changes in cognitive performance. Our study confirms the feasibility of using correlational and differential tractography as biomarkers to evaluate the disease progress of mTBI.
NMR IN BIOMEDICINE
(2023)
Article
Clinical Neurology
Tomokatsu Yoshida, Ikuko Mizuta, Rei Yasuda, Toshiki Mizuno
Summary: Older-adult-onset Alexander disease cases with an onset age of 65 years or older showed typical neurological and MRI features of bulbospinal ALXDRD, with more severe disease progression compared to younger-adult-onset cases and development of dependence within 2 years from onset. Cerebral white matter damage tended to progress in proportion to the duration of illness.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Danielle Rayee, Pamela Meneses Iack, Raissa R. Christoff, Michele R. Lourenco, Christiane Bonifacio, Jurgen Boltz, Roberto Lent, Patricia P. Garcez
Summary: The corpus callosum (CC) is a major interhemispheric commissure of placental mammals. During typical cortical development, axonal bifurcation rates in the cerebral cortex rise from embryonic day (E)17 and are reduced by postnatal day (P)9. In a CC dysgenesis mouse model, increased rates of axonal bifurcations were observed, suggesting a possible facilitation of aberrant connections in the absence of midline guidepost signaling.
Article
Anatomy & Morphology
Lisa Bartha-Doering, Ernst Schwartz, Kathrin Kollndorfer, Florian Ph. S. Fischmeister, Astrid Novak, Georg Langs, Harald Werneck, Daniela Prayer, Rainer Seidl, Gregor Kasprian
Summary: Complete agenesis of the corpus callosum (ACC) is associated with impaired functions in specific language domains, while partial ACC does not show significant effects; ACC children performed significantly worse than controls in verbal fluency and naming; Stronger functional connectivity between left and right temporal areas is associated with better language abilities in the ACC group.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Clinical Neurology
Romella Durrani, Meng Wang, Emily Cox, Elisabeth Irving, Feryal Saad, Cheryl R. McCreary, Andrew E. Beaudin, Myrlene Gee, Krista Nelles, Tolulope T. Sajobi, Zahinoor Ismail, Richard Camicioli, Eric E. Smith
Summary: Neuroimaging biomarkers, including altered white matter diffusivity, cerebrovascular reactivity, and atrophy, are closely associated with cognitive dysfunction in cerebral amyloid angiopathy (CAA).
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Geriatrics & Gerontology
Alexandra Sammartino-Arbour, Ariane Dufour, Valerie Frenette, Marie-France Forget, Marie-Andree Bruneau, Simon Ducharme, Richard Camicioli, Quoc Dinh Nguyen, Philippe Desmarais
Summary: The onset of neuropsychiatric symptoms in older adults may indicate the early signs of neurodegenerative disorders. The relationship between somatic symptoms and related disorders (SSRD) and the subsequent development of neurodegenerative disorders is still uncertain. This study critically reviewed studies exploring the association between SSRD and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Fronto-temporal dementia, and Lewy body dementia.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Meeting Abstract
Clinical Neurology
Danielle Munsterman, Sarina Falcione, Rebecca Long, Twinkle Joy, Mike Clarke, Andrew E. Beaudin, Richard Camicioli, Eric E. Smith, Glen Jickling
Meeting Abstract
Clinical Neurology
Danielle Munsterman, Sarina Falcione, Rebecca Long, Twinkle Joy, Mike Clarke, Andrew E. Beaudin, Richard Camicioli, Eric E. Smith, Glen Jickling
Article
Neuroimaging
Hannes Almgren, Alexandru Hanganu, Milton Camacho, Mekale Kibreab, Richard Camicioli, Zahinoor Ismail, Nils D. Forkert, Oury Monchi
Summary: Brain atrophy in Parkinson's disease varies in different brain regions, even in the early stage. This study examines the relationship between cortical curvature and thickness in PD diagnosis, motor symptoms, and cognitive performance. The findings indicate an interaction effect between motor symptoms and age, as well as the impact of diagnosis and rigidity on the curvature-thickness association in patients with longer disease durations.
NEUROIMAGE-CLINICAL
(2023)
Review
Geriatrics & Gerontology
Breni Sharma, Meng Wang, Cheryl R. McCreary, Richard Camicioli, Eric E. Smith
Summary: This study reviewed and analyzed the literature on the associations of cerebral small vessel disease (CSVD) with gait impairment and falls. The findings suggest that the severity of CSVD is associated with gait impairment, history of falls, and future falls risk. Therefore, preventing CSVD should be included in a comprehensive public health strategy to improve mobility and reduce the risk of falls in older adults.
Article
Multidisciplinary Sciences
Ricardo Rios-Carrillo, Alonso Ramirez-Manzanares, Hiram Luna-Munguia, Mirelta Regalado, Luis Concha
Summary: Diffusion-weighted magnetic resonance imaging (DW-MRI) is a non-invasive technique sensitive to microstructural geometry in neural tissue and useful for detecting neuropathology. Tensor-valued diffusion encoding schemes (b-tensor) enrich the microstructural data obtained from DW-MRI. This study explores the application of machine learning in analyzing b-tensor encoding data to detect histopathology and neurodegeneration.
Article
Neurosciences
Chih-Hao Chen, Mary Klir Khnaijer, Andrew E. Beaudin, Cheryl R. McCreary, Myrlene Gee, Feryal Saad, Richard Frayne, Zahinoor Ismail, G. Bruce Pike, Richard Camicioli, Eric E. Smith
Summary: In this study, researchers investigated whether cerebral amyloid angiopathy (CAA) is associated with subcortical atrophy. They found that CAA patients did not show substantial atrophy of subcortical volumes compared to Alzheimer's disease (AD) or healthy controls, except for the putamen. Differences in findings may be due to heterogeneity in CAA presenting syndromes or severity.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Linzy Bohn, Peggy McFall, Myrlene Gee, Ronald B. Postuma, Roger A. Dixon, Richard Camicioli
Summary: This study examined the predictive validity and characteristics of the eight-item Montreal Parkinson Risk of Dementia Scale (MoPaRDS) in a geriatric PD cohort. The results showed that the MoPaRDS can reliably discriminate PD patients with incipient dementia from those without dementia.
CANADIAN GERIATRICS JOURNAL
(2023)
Article
Neurosciences
Alejandro Espinosa-Ceron, Alejandro Mendez, Juan Hernandez-Aceves, Juan C. Juarez-Gonzalez, Nelly Villalobos, Marisela Hernandez, Georgina Diaz, Paola Soto, Luis Concha, Ivan N. Perez-Osorio, Juan J. Ortiz-Retana, Raul J. Bobes, Robert M. Parkhouse, P. T. Hamamoto, Gladis Fragoso, Edda Sciutto
Summary: This study describes an experimental murine model that provides improvement for the treatment of EXP-NCC. The model allows evaluation of new therapeutic approaches by monitoring cyst implantation and infection progression through the detection of HP10 antigen and anti-cysticercal antibodies in serum and cerebral spinal fluid. This model will aid in controlling neuroinflammation and immunomodulatory treatments to restore and improve specific anti-cysticercal immunity in EXP-NCC.
Article
Medicine, General & Internal
Manuel Montero-Odasso, Guangyong Zou, Mark Speechley, Quincy J. Almeida, Teresa Liu-Ambrose, Laura E. Middleton, Richard Camicioli, Nick W. Bray, Karen Z. H. Li, Sarah Fraser, Frederico Pieruccini-Faria, Nicolas Berryman, Maxime Lussier, J. Kevin Shoemaker, Surim Son, Louis Bherer
Summary: This randomized clinical trial investigates the effects of aerobic-resistance exercise, cognitive training, and vitamin D supplementation on cognition in older adults with mild cognitive impairment (MCI). The results show that a 20-week multidomain intervention of aerobic-resistance exercise and computerized cognitive training has a greater effect in improving cognition compared to exercise alone, and these improvements are maintained at 12-month follow-up. The addition of vitamin D does not enhance the effect. These findings suggest that pairing aerobic and resistance exercises with sequential computerized cognitive training may improve cognition in older adults with MCI.
Review
Clinical Neurology
Richard Camicioli, Meg E. Morris, Frederico Pieruccini-Faria, Manuel Montero-Odasso, Surim Son, David Buzaglo, Jeffrey M. Hausdorff, Alice Nieuwboer
Summary: This article investigates the gaps in falls prevention for people with Parkinson's disease (PD) and highlights the need for further research on recommended exercises, as well as considering risk factors such as freezing of gait, reduced gait speed, and prior history of falls. It suggests that multimodal and multi-domain interventions may be beneficial and emphasizes the importance of engaging patients, families, and healthcare professionals in falls education. Rating: 8/10.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Neuroimaging
Milton Camacho, Matthias Wilms, Pauline Mouches, Hannes Almgren, Raissa Souza, Richard Camicioli, Zahinoor Ismail, Oury Monchi, Nils D. Forkert
Summary: This work aimed to develop and evaluate a robust explainable deep learning model for PD classification. A total of 2,041 T1-weighted MRI datasets from 13 different studies were collected, and a CNN model was trained using Jacobian maps to achieve high accuracy in distinguishing PD patients from healthy controls.
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Ashley L. Ware, Adrian Onicas, Nishard Abdeen, Miriam H. Beauchamp, Christian Beaulieu, Bruce H. Bjornson, William Craig, Mathieu Dehaes, Sylvain Deschenes, Quynh Doan, Stephen B. Freedman, Bradley G. Goodyear, Jocelyn Gravel, Andree-Anne Ledoux, Roger Zemek, Keith Owen Yeates, Catherine Lebel
Summary: Advanced diffusion-weighted imaging techniques have enhanced understanding of the neuropathology of paediatric mild traumatic brain injury. This study compared the structural connectome of children with concussion to those with mild orthopaedic injury and found that regional network metrics in the post-acute phase can distinguish concussion from mild orthopaedic injury and predict symptom recovery at 1-month post-injury.
BRAIN COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Jonathan Gallego-Rudolf, Maria Corsi-Cabrera, Luis Concha, Josefina Ricardo-Garcell, Erick Pasaye-Alcaraz
Summary: This article introduces an open access, multimodal neuroimaging dataset consisting of EEG and MRI data. The dataset adheres to the BIDS standard and is divided into EEG data and MRI data. It is one of the largest open access EEG-fMRI datasets available, which can be used to assess the impact of artifacts on EEG data, validate artifact removal techniques, conduct hardware comparison studies, and implement and validate multimodal integrative analysis approaches.
