Article
Fisheries
Mustafa Ture, Ayse Cebeci, Ilhan Altinok, Elif Aygur, Nihal Caliskan
Summary: In this study, several lytic phages against A. hydrophila were isolated and characterized. These phages demonstrated cytotoxicity against A. hydrophila strains in vitro and in vivo, but showed no impact on fish or cell lines. Therefore, these phages can be used safely as a cocktail for treating A. hydrophila infection.
Article
Environmental Sciences
Ning Ding, Lin Jiang, Xiao Wang, Chun Wang, Yue Geng, Jianxin Zhang, Yingxue Sun, Yanping Zhang, Quan Yuan, Hong Liu
Summary: This study assessed the toxicity of microplastic exposure using zebrafish. Results showed that microplastics can negatively affect the growth rate and intestinal enzyme activities of zebrafish. However, under the tested conditions, concurrent exposure to microplastics and bacteria did not significantly increase zebrafish mortality.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Fisheries
Hui Yang, Qingsheng Cao, Zhu Zhu, Yangyang Cao, Tongwei Ji, Wenzhi Wei, Haiyong Zhao, Yingying Zhang
Summary: The study found that Bdellovibrio has a certain lysing effect on common aquatic pathogens and can significantly reduce the mortality rate of fish caused by infections. Additionally, Bdellovibrio may colonize in fish. These results provide a theoretical basis for the application of Bdellovibrio in aquaculture.
Article
Microbiology
Gang Xiao, Xiaofeng Zheng, Jiyun Li, Yang Yang, Jie Yang, Ning Xiao, Junqi Liu, Zhiliang Sun
Summary: This study revealed the significant role of the EnvZ/OmpR TCS in the growth, motility, virulence, and stress response of A. hydrophila, providing important insights for the development of novel antibacterial and vaccine therapies targeting EnvZ/OmpR against A. hydrophila.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Kai Chen, Ting Qin, Liangkun Pan, Xuwen Bing, Bingwen Xi, Jun Xie
Summary: The study found that glycyrrhetinic acid beta (GA) could inhibit the hemolytic activity of A. hydrophila in vitro without affecting its growth. However, oral administration of GA was found to be ineffective in controlling acute infections caused by A. hydrophila in vivo.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Weiming Zhong, Puyu Tang, Ting Liu, Tianyu Zhao, Jiajing Guo, Zhipeng Gao
Summary: This study prepared Linalool nano-emulsion (LN) with different medium chain triglycerides (MCT) concentrations using the ultrasonic method. LN showed good stability and strong antibacterial activity against Aeromonas hydrophila, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 0.3125% and 0.625% v/v, respectively. The nano-emulsion exhibited a disruptive effect on cell membranes, highlighting its potential in controlling and preventing A. hydrophila in aquaculture.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Yunchao Cao, Tianshun Kou, Liaotian Peng, Hetron Mweemba Munang'andu, Bo Peng
Summary: Aquatic food is an important source of micronutrients for human beings, and aquaculture plays an increasingly important role in providing this food source. However, bacterial infection poses a severe threat to aquaculture and strategies for managing these infections without antibiotics are lacking. This study investigates the metabolic changes of crucian carp infected with Aeromonas hydrophila and identifies fructose as a crucial biomarker. Supplementation of fructose increases fish survival rate by enhancing the expression of lysozyme and complement 3, leading to reduced bacterial load. These findings demonstrate a metabolism-based approach to manage bacterial infection by modulating the immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Xiaoyi Ma, Cang Wang, Mingcan Qin, Xiaopeng Tian, Shihui Fan, Hangtian Zu, Mingsheng Lyu, Shujun Wang
Summary: A DNAzyme targeting Aeromonas hydrophila was developed through in vitro selection, and a fluorescent biosensor was designed for detecting the bacteria efficiently. The biosensor showed stable performance for more than 6 months and was validated for detecting the pathogen in food samples, demonstrating its potential for use in preventing and detecting foodborne pathogens in the food industry.
Article
Virology
Lingting Pan, Dengfeng Li, Wei Lin, Wencai Liu, Chenxin Qu, Minhua Qian, Ruqian Cai, Qin Zhou, Fei Wang, Yigang Tong
Summary: Ahy-yong1 is a newly discovered phage that can effectively treat multi-antibiotic-resistant pathogen A. hydrophila. It has showed strong biofilm removal capacity and protective effect in fish.
Review
Immunology
Mave Harshitha, Ashwath Nayak, Somanath Disha, Uchangi Satyaprasad Akshath, Saurabh Dubey, Hetron Mweemba Munang'andu, Anirban Chakraborty, Indrani Karunasagar, Biswajit Maiti
Summary: The application of nanotechnology in aquaculture for developing efficient vaccines has shown great potential. Nanovaccination, through encapsulating fish pathogen antigens and achieving sustained release, enhances immune responses and protective efficacy of vaccines. However, thorough evaluation of the potential toxicity of nanoparticles is necessary before widespread application.
Article
Food Science & Technology
Jing Dong, Tianhui Yan, Qiuhong Yang, Yi Song, Bo Cheng, Shun Zhou, Yongtao Liu, Xiaohui Ai
Summary: Aeromonas hydrophila is a common pathogen in freshwater aquaculture that can also cause health problems in humans. Antibiotic-resistant strains of A. hydrophila are a concern as they limit antibiotic usage and can lead to treatment failure. Additionally, antibiotic residues in aquatic products pose a risk to quality and safety. This study explores alternative strategies to combat infections caused by antibiotic-resistant bacteria, focusing on palmatine, a compound that inhibits the expression of a key virulence factor in A. hydrophila. The findings suggest that palmatine could be a promising treatment for A. hydrophila-associated infections in aquaculture.
Article
Microbiology
Pengji Zhou, Haiyan Huang, Jiaoyang Lu, Zirong Zhu, Junyan Xie, Liqiu Xia, Sisi Luo, Kexuan Zhou, Wenhui Chen, Xuezhi Ding
Summary: The study demonstrated the enhanced antibacterial effect of BaX030 through compound mutagenesis, leading to potential applications in aquaculture. The mutated strain N-11 showed significant increase in the production of macrolactin A and oxydifficidin, as well as elevated expression of immune factors in grass carp. The study identified a probiotic strain with promising antibacterial activity for aquaculture production, offering a new strategy for discovering strains with higher biological activity.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Virology
Jian-Bin Wang, Mei-Shiuan Yu, Tsai-Tien Tseng, Ling-Chun Lin
Summary: Ahp2 is a lytic phage that infects and lyses A. hydrophila, showing potential as a candidate for therapeutic phage cocktails. The genome of Ahp2 is closely related to other Aeromonas phages, and its tail module likely determines its host range.
Article
Biochemical Research Methods
Wanxin Li, Yiyang Zhao, Jing Yu, Ling Lin, Srinivasan Ramanathan, Guibin Wang, Xiangmin Lin, Huanying Pang
Summary: This study reveals the downregulation of energy metabolism-related proteins and upregulation of iron-related proteins in high OXY-resistant strains. Deletion of four TonB-dependent receptor-coded genes does not affect susceptibility to OXY, but shows different evolution rates in spontaneous OXY evolution compared with the wildtype strain, especially for AHA_0971 and AHA_4251. This suggests the important role of TonB-dependent receptor proteins in bacterial antibiotics resistance evolution and offers a potential new prophylactic strategy against antibiotic resistance development.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Food Science & Technology
Ji Yoon Kim, Eun Bi Jeon, Min Gyu Song, Sung Hee Park, Shin Young Park
Summary: This study developed predictive growth models for Aeromonas hydrophila on raw tuna and found that the growth of A. hydrophila increased with temperature. These models can be used to predict the growth of A. hydrophila at different low temperatures.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
