Review
Pharmacology & Pharmacy
Masaki Kobayashi, Katsuya Narumi, Ayako Furugen, Ken Iseki
Summary: The human monocarboxylate transporters hMCT1 and hMCT4 are involved in the transport of monocarboxylates such as L-lactate, playing essential roles in cellular metabolism and pH regulation. Overexpression of hMCT1 and hMCT4 in cancers, along with their association with cancer prognosis, has led to recent focus on inhibiting these transporters as a novel therapeutic strategy.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Cell Biology
Khuong T L Nguyen, Jhih-Yi Chiou, You-Chi Liu, Fang-Ju Cheng, Yi-Cheng Shen, Chao-Jung Chen, Chih-Hsin Tang, Wei-Chien Huang, Chia-Hung Chen, Chih-Yen Tu
Summary: In this study, it was found that lactic acid promotes resistance to PKC inhibitors by competing for uptake through transporters rather than activating its receptor, which explains the limited response of PKC inhibitors in clinical trials.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anna-Lena Kopnick, Katharina Geistlinger, Eric Beitz
Summary: Monocarboxylate transporter isoforms play a crucial role in proton-coupled transport of l-lactate, potentially offering promising targets for anticancer therapy. This study identified Cys159 as a critical binding site for the inhibitory effects of pCMBS on MCT1 and provided insights into the mechanism of action.
Article
Neurosciences
Liangcai Zhao, Haowei Jiang, Jiaojiao Xie, Danjie Shen, Qingqing Yi, Jiapin Yan, Chen Li, Hong Zheng, Hongchang Gao
Summary: In this study, the effects and mechanisms of FGF21 on DACD were investigated in a mouse model. It was found that FGF21 treatment improved lactate utilization and uptake, leading to improvements in learning and memory. These effects were mediated by increased LDH-B activity, ATP levels, and PI3K signaling pathway.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Masaki Ueno, Yoichi Chiba, Ryuta Murakami, Yumi Miyai, Koichi Matsumoto, Keiji Wakamatsu, Genta Takebayashi, Naoya Uemura, Ken Yanase
Summary: The choroid plexus (CP) regulates the microenvironment of the central nervous system by secreting cerebrospinal fluid (CSF) and controlling its composition. CP epithelial cells form a blood-CSF barrier and have transporters for glucose and lactate. The distribution and significance of monocarboxylate transporters (MCTs) in CP epithelial cells are summarized in this review paper.
Article
Pharmacology & Pharmacy
Koji Kasai, Ryosuke Segawa, Ryo Onodera, Sanki Asakawa, Masahiro Hiratsuka, Noriyasu Hirasawa
Summary: This study investigated the molecular mechanisms by which Ni ions increase lactate release and the role of lactate in enhancing the elution of Ni ions using a human fibroblast cell line, KMST-6. Results suggested that elution of Ni ions from metals promotes lactate production via HIF-1α-mediated gene expression and causes further Ni elution, indicating a positive feedback mechanism of Ni elution.These findings may provide insights for potential targets to protect against metal elution from metal devices.
Article
Chemistry, Multidisciplinary
Jiantao Yu, Zixiang Wei, Qing Li, Feiyan Wan, Zhicong Chao, Xindan Zhang, Li Lin, Hong Meng, Leilei Tian
Summary: Recent research has shown that lactate is a major energy source for cells, prompting the development of a new strategy for cancer starvation therapy involving dual deprivation of lactate and glucose. Nanoplatforms are used to co-deliver CHC and GOx in order to achieve this, resulting in enhanced anti-tumor effects both in vitro and in vivo.
Article
Pharmacology & Pharmacy
Tsuyoshi Nishioku, Rumi Anzai, Sami Hiramatsu, Ayaka Terazono, Mamiko Nakao, Miyu Moriyama
Summary: This study investigated the aerobic glycolysis and lactate production by LDHA in osteoclasts, and found that inhibition of LDHA can suppress osteoclast differentiation and bone-resorbing activity. This finding may provide a novel therapeutic strategy for controlling excessive bone resorption in osteoporosis and rheumatoid arthritis.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Takeru Shima, Reika Kawabata-Iwakawa, Hayate Onishi, Subrina Jesmin, Tomonori Yoshikawa
Summary: This study investigated the effects of light-intensity exercise on hippocampal complications in type 2 diabetes mellitus mice, as well as its correlation with monocarboxylate transporter and miRNA. The results showed that light-intensity exercise can improve hippocampal memory function in mice and restore aberrant expression of disease-related miRNA.
METABOLIC BRAIN DISEASE
(2023)
Article
Multidisciplinary Sciences
Emmanuela N. Bonglack, Joshua E. Messinger, Jana M. Cable, James Ch'ng, K. Mark Parnell, Nicolas M. Reinoso-Vizcaino, Ashley P. Barry, Veronica S. Russell, Sandeep S. Dave, Heather R. Christofk, Micah A. Luftig
Summary: The study found that EBV infection directly induced temporal expression of MCT1 and MCT4 in B lymphocytes, with MCT1 being crucial for early B cell proliferation and MCT4 upregulation leading to acquired resistance to MCT1 antagonism in LCLs. Dual inhibition of MCT1/4 resulted in growth arrest and lactate buildup in LCLs, suggesting a potential therapeutic approach for targeting viral lymphomas associated with EBV and KSHV.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Jinren Zhou, Qing Shao, Yunjie Lu, Yu Li, Zibo Xu, Bo Zhou, Qiuyang Chen, Xiangyu Li, Xiaozhang Xu, Yufeng Pan, Zhenhua Deng, Yiming Wang, Yue Yu, Jian Gu
Summary: Resistance to anti-PD-1 therapy in hepatocellular carcinoma (HCC) may be associated with monocarboxylate transporter (MCT) and lactate signaling in regulatory T cells (Tregs).
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Tina Schumann, Joerg Koenig, Christian von Loeffelholz, Daniel F. Vatner, Dongyan Zhang, Rachel J. Perry, Michel Bernier, Jason Chami, Christine Henke, Anica Kurzbach, Nermeen N. El-Agroudy, Diana M. Willmes, Dominik Pesta, Rafael de Cabo, John F. O. Sullivan, Eric Simon, Gerald Shulman, Bradford S. Hamilton, Andreas L. Birkenfeld
Summary: Schumann et al. demonstrate that the loss of a lactate transporter Slc16a13 increases mitochondrial respiration in the liver, which reduces hepatic lipid accumulation while increasing hepatic insulin sensitivity in mice fed a high-fat diet. This study suggests SLC16A13 as a potential target for the treatment of type 2 diabetes and non-alcoholic fatty liver disease.
COMMUNICATIONS BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ana Silva, Beatriz Antunes, Alberta Batista, Filipa Pinto-Ribeiro, Fatima Baltazar, Julieta Afonso
Summary: The transportation of lactate produced by glycolytic cancer cells plays a crucial role in cancer development, with MCT1 being a key transporter. The specific MCT1 inhibitor AZD3965 has shown promising anticancer effects in vivo, especially in combination therapy. This suggests its potential as a valuable treatment option in clinical settings.
Article
Medicine, Research & Experimental
Qi Li, Xiaoling Qin, Xiaotong Kou, Jingyu Li, Zhongsha Li, Chang Chen
Summary: The study showed that anagliptin can reduce tumor growth and induce apoptosis of cancer cells by regulating lactate excretion and intracellular pH gradient. Anagliptin reverses the abnormal pH gradient by suppressing lactate excretion, reducing mitochondrial membrane potential, and inducing apoptosis. These findings suggest that anagliptin may be a potential treatment for cancer.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Endocrinology & Metabolism
Arthur Ingersen, Malte Schmucker, Christina Alexandersen, Benjamin Graungaard, Tobias Thorngreen, Jacob Borch, Jens Juul Holst, Jorn Wulff Helge, Flemming Dela
Summary: The study aimed to investigate the interaction of semaglutide treatment and aerobic training on pancreatic β-cell secretory function in patients with type 2 diabetes. The results showed that aerobic training increased insulin secretion, and semaglutide treatment further improved β-cell secretory function. The combination of aerobic training and semaglutide treatment synergistically enhanced β-cell secretory function.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Editorial Material
Endocrinology & Metabolism
Katrin Esefeld, Stephan Kress, Meinolf Behrens, Peter Zimmer, Michael Stumvoll, Ulrike Thurm, Bernhard Gehr, Christian Brinkmann, Martin Halle
Article
Sport Sciences
Theresa Schoerkmaier, Yvonne Wahl, Christian Brinkmann, Wilhelm Bloch, Patrick Wahl
Summary: Recent studies have shown that applying nonivamide-nicoboxil cream can increase muscle oxygenation, but does not improve endurance performance.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2021)
Editorial Material
Endocrinology & Metabolism
Christian Brinkmann
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Sarah Valder, Christian Brinkmann
Summary: This review examines the effects of exercise training on the gut microbiota composition and intestinal barrier function in T2DM, finding that regular exercise can improve T2DM by increasing SCFA-producing bacteria and enhancing gut barrier integrity. Further studies are needed to explore the efficacy of different training programs, the role of myokines, SCFA-producing bacteria, and SCFAs in relevant metabolic pathways.
Article
Nutrition & Dietetics
Roman Holzer, Benedikt Schulte-Koerne, Jan Seidler, Hans-Georg Predel, Christian Brinkmann
Summary: There were no significant differences in the effects of different types of exercise on glucose levels when comparing values over a longer period of time.
Article
Chemistry, Analytical
Roman Holzer, Wilhelm Bloch, Christian Brinkmann
Summary: Continuous glucose monitoring systems have great potential in healthcare, wellness, and sports, even for individuals without diabetes. They can help detect abnormal glucose regulation early, improve nutritional and physical activity behavior, and optimize nutritional strategies for exercise.
Review
Nutrition & Dietetics
Frederike Maria Meuffels, Eduard Isenmann, Malte Strube, Alessio Lesch, Max Oberste, Christian Brinkmann
Summary: Physical training combined with dietary supplement intake can potentially enhance specific health outcomes in patients with type 2 diabetes mellitus, but negative effects may also be observed. Further research is needed to explore the mechanisms behind these effects for the development of safe recommendations.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Roman Holzer, Fabian Werner, Meinolf Behrens, Carsten Volkery, Christian Brinkmann
Summary: This study identified the key features desired by patients with T1DM for an ideal self-management app with functions for sports and exercise, including data security, integration of health data, individual target setting, abnormal warnings, and diary function.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2022)
Editorial Material
Endocrinology & Metabolism
Sarah Valder, Christian Brinkmann
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Katrin Esefeld, Stephan Kress, Meinolf Behrens, Peter Zimmer, Michael Stumvoll, Ulrike Thurm, Bernhard Gehr, Martin Halle, Christian Brinkmann
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2023)
Article
Environmental Sciences
Frederike Maria Meuffels, Hans-Peter Kempe, Ulrike Becker, Martin Kornmann, Stephan Kress, Thorsten Kreutz, Christian Brinkmann
Summary: This study examined the feasibility and impact of a 5-day hiking tour on quality of life, diabetes distress, and glucose profile in type 2 diabetes mellitus (T2DM) patients. The tour was accompanied by healthcare professionals and included both insulin-treated and non-insulin-treated patients. Results showed a significant improvement in quality of life, while diabetes distress did not change significantly. Only a small number of insulin-treated patients experienced hypoglycemic episodes. The study suggests that hiking tours can be beneficial and safe for T2DM patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Environmental Sciences
Samir Akrimi, Christian Brinkmann
Summary: Combining regular exercise and a healthy diet is recommended to fight type 2 diabetes. Low-carbohydrate diets have gained attention, but they may affect muscle building and maximum performance during high-intensity workouts. Further research is needed to compare the effects of this combination with other diets and exercise.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Christian Brinkmann, Hannah Hof, Detlef-Bernd Gysan, Christian Albus, Stefanie Millentrup, Birna Bjarnason-Wehrens, Joachim Latsch, Gerd Herold, Karl Wegscheider, Christian Heming, Melchior Seyfarth, Hans-Georg Predel
Summary: This study aimed to evaluate the effects of a multimodal intervention on the health and long-term cardiovascular disease mortality risk of individuals with pre-diabetes or diabetes mellitus at high CVD risk. The results showed improvements in various health markers and a significant decrease in cardiovascular disease risk score through the intervention. The study demonstrates the feasibility and potential effectiveness of a multimodal lifestyle program in improving the health of individuals with pre-diabetes or diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Christian Brinkmann, Wilhelm Bloch, Giorgio C. Mutinati
Summary: The ELSAH project, funded by EU's Horizon 2020 program, aims to develop a wearable smart patch system that can measure multiple biomarkers in users' dermal interstitial fluid. This system has various use cases, including early detection of diabetes, improving physical performance, promoting a healthier lifestyle, performance diagnostics, and warning of health threats. The ELSAH patch system has great potential in enhancing health and wellbeing in users.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Christian Brinkmann, Olivier Weh-Gray, Wilhelm Bloch, Klara Brixius, Hans-Georg Predel, Thorsten Kreutz
Summary: This study analyzed the effects of an 8-week training intervention on circulating irisin levels in patients with type 2 diabetes mellitus (T2DM), and found no training-induced changes in irisin levels, as well as no differences between men and women. Further large-scale studies are needed to determine if basal irisin levels can be changed in T2DM patients through other forms of training to counteract T2DM.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2022)
