Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Stefan Schreiber, Shomron Ben-Horin, Jaroslaw Leszczyszyn, Robert Dudkowiak, Adi Lahat, Beata Gawdis-Wojnarska, Aldis Pukitis, Marek Horynski, Katalin Farkas, Jaroslaw Kierkus, Maciej Kowalski, Sang Joon Lee, Sung Hyun Kim, Jee Hye Suh, Mi Rim Kim, Seul Gi Lee, Byong Duk Ye, Walter Reinisch
Summary: This study demonstrated the pharmacokinetic noninferiority of CT-P13 SC to CT-P13 IV, with comparable clinical remission rates between the two formulations.
Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Review
Immunology
Susanna Esposito, Giulia Antoniol, Marialuisa Labate, Lucrezia Passadore, Patrizia Alvisi, Valeria Dacco, Chiara Ghizzi, Carla Colombo, Nicola Principi
Summary: The incidence of inflammatory bowel diseases (IBDs) is rising globally, leading to a higher risk of infections in children with dysfunctional immune systems. Vaccines are essential for preventing these infections, and should be administered according to specific immunization guidelines for IBD patients. Compliance with vaccination recommendations is generally low, highlighting the need for multidisciplinary educational programs to improve vaccination coverage and protect children with IBD from vaccine-preventable diseases.
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Review
Biochemistry & Molecular Biology
Maria Jose Sanchez-Quintero, Cristina Rodriguez-Diaz, Francisco J. Rodriguez-Gonzalez, Alejandra Fernandez-Castaner, Eduardo Garcia-Fuentes, Carlos Lopez-Gomez
Summary: Mitochondria play a crucial role in maintaining cellular functions and are involved in various cellular processes. Dysfunction of mitochondria has been linked to complex disorders, including inflammatory bowel diseases (IBD). The impact of mitochondrial dysfunction on IBD, including its role in intestinal mucosa, immune cell populations, mucosal repair, microbiota-brain-gut axes, and the development of colitis-associated colorectal cancer, is discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Anna Maria Rychter, Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Michal Michalak, Piotr Eder, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: The study found that reduced physical activity, smoking, and coffee and alcohol consumption are risk factors for osteoporosis in patients with inflammatory bowel disease. Patients with Crohn's disease who were diagnosed with osteopenia and osteoporosis had significantly lower physical activity levels compared to those with normal bone mineral density. Women with inflammatory bowel disease who had normal bone mineral density exercised more frequently than those with osteopenia and osteoporosis. However, no significant differences were observed in bone mineral density with regards to coffee use, alcohol consumption, or smoking.
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Flavia Baccini, Federica Micheli, Giovanni Di Nardo, Caterina Lombardo
Summary: This study found that patients with inflammatory bowel disease have poorer subjective sleep quality compared to controls, with even worse sleep quality in those with active IBD. However, there were no differences within IBD subtypes. These results highlight the importance of considering sleep quality as a relevant comorbidity in IBD.
SLEEP MEDICINE REVIEWS
(2021)
Article
Gastroenterology & Hepatology
Anthony Buisson, Maria Nachury, Maud Reymond, Clara Yzet, Pauline Wils, Laure Payen, Marie Laugie, Luc Manlay, Nicolas Mathieu, Bruno Pereira, Mathurin Fumery
Summary: This study assessed the effectiveness of switching from intravenous to subcutaneous infliximab in patients with inflammatory bowel diseases (IBDs). The results showed that switching from intravenous to subcutaneous infliximab was safe and well accepted, with a low risk of relapse in IBD patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Rogerio Serafim Parra, Sandro da Costa Ferreira, Vanessa Foresto Machado, Cintia Maura Caseiro Nigro, Jose Joaquim Ribeiro da Rocha, Luiz Ernesto de Almeida Troncon, Omar Feres
Summary: This study aimed to analyze Brazilian patients with inflammatory bowel diseases (IBD) perception regarding access to high-cost drugs in the public health care system. The results showed that most patients were unable to obtain biological drugs within one year. This study highlights the need for improvement in the healthcare system to ensure the correct supply of medication.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Cong Dai, Yu-Hong Huang, Min Jiang
Summary: This study summarizes the current evidence and perspectives on combination therapies in Inflammatory Bowel Diseases (IBD). The combination of infliximab and thiopurines has been shown to be more effective than monotherapy in inducing and maintaining remission in IBD. However, data on the combination of other biological agents and immunosuppressors is lacking or conflicting. Vedolizumab may be an effective maintenance regimen after calcineurin inhibitors-based rescue therapy in acute severe ulcerative colitis (ASUC). Dual Targeted Therapy, which combines two biological agents and/or small molecules, may be a reasonable choice for certain IBD patients but is associated with an increased risk of adverse events and malignancies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anna Krystyna Zielinska, Maciej Salaga, Pawel Siwinski, Marcin Wlodarczyk, Adam Dziki, Jakub Fichna
Summary: The study found that IBD patients had significantly decreased SOD activity, GSH and GSSG levels, and GPX activity was significantly diminished only in CD patients. CAT and COX-1 activity was increased, while COX-2 was significantly decreased in IBD patients. TBARS were significantly higher in CD patients compared to the control group. There was no correlation between pain scores, inflammatory status, disease activity, disease duration, or dietary habits and OS markers.
Article
Gastroenterology & Hepatology
Shaden Mahmmod, Johannes P. D. Schultheiss, Ad A. van Bodegraven, Gerard Dijkstra, Lennard P. L. Gilissen, Frank Hoentjen, Maurice W. M. D. Lutgens, Nofel Mahmmod, Andrea E. Van der Meulen-de Jong, Lisa J. T. Smits, Adriaan C. I. T. L. Tan, Bas Oldenburg, Herma H. Fidder
Summary: In a retrospective multicenter cohort study, about 9.9% of IBD patients who were switched from originator infliximab to biosimilar CT-P13 experienced reverse switching, predominantly due to biosimilar-attributed adverse effects. Some patients showed symptom improvement after reverse switching, with a good response seen in those who had lost response to CT-P13.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Camilla de Almeida Martins, Matheus Freitas Cardoso de Azevedo, Alexandre Sousa Carlos, Aderson Omar Mourao Cintra Damiao, Carlos Walter Sobrado Jr, Sergio Carlos Nahas, Natalia Sousa Freitas Queiroz
Summary: This study has enhanced our understanding of the predictive factors of treatment response to IFX in a well-characterized Brazilian IBD population. The study found that the duration of IFX therapy and higher albumin levels increased the likelihood of clinical remission, while previous surgery decreased its chance. Prior use of adalimumab and higher C-reactive protein levels reduced the likelihood of endoscopic remission.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Ruize Liu, Dalin Li, Talin Haritunians, Yunfeng Ruan, Mark J. Daly, Hailiang Huang, Dermot P. B. McGovern
Summary: This study presents a novel molecular-based prediction model that combines genetics, serum biomarkers, and smoking information to assist in the diagnosis of Crohn's disease and ulcerative colitis. The joint model explains approximately 46% of phenotypic variation, with genetics making unique contributions to distinguishing disease subtypes and smoking status potentially not being an effective biomarker.
Editorial Material
Medicine, General & Internal
Vivian Huang, Richard Fedorak
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2016)
Article
Gastroenterology & Hepatology
Vivian W. Huang, Connie Prosser, Karen I. Kroeker, Haili Wang, Carol Shalapay, Neil Dhami, Darryl K. Fedorak, Brendan Halloran, Levinus A. Dieleman, Karen J. Goodman, Richard N. Fedorak
INFLAMMATORY BOWEL DISEASES
(2015)
Article
Gastroenterology & Hepatology
Farhad Peerani, May Choi, Justin Weinkauf, Richard N. Fedorak, Brendan Halloran
INFLAMMATORY BOWEL DISEASES
(2015)
Article
Gastroenterology & Hepatology
Troy Perry, Juan Jovel, Jordan Patterson, Gane Wong, Richard N. Fedorak, Aducio Thiesen, Bryan Dicken, Karen L. Madsen
INFLAMMATORY BOWEL DISEASES
(2015)
Article
Gastroenterology & Hepatology
Christopher Ma, Vivian Huang, Darryl K. Fedorak, Karen I. Kroeker, Levinus A. Dieleman, Brendan P. Halloran, Richard N. Fedorak
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2015)
Article
Gastroenterology & Hepatology
Maria E. Negron, Ali Rezaie, Herman W. Barkema, Kevin Rioux, Jeroen De Buck, Sylvia Checkley, Paul L. Beck, Matthew Carroll, Richard N. Fedorak, Levinus Dieleman, Remo Panaccione, Subrata Ghosh, Gilaad G. Kaplan
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2016)
Article
Gastroenterology & Hepatology
Richard N. Fedorak, Kathleen P. Ismond
DIGESTIVE DISEASES
(2016)
Article
Gastroenterology & Hepatology
Julia J. Liu, Theresa M. Kay, Elisabeth M. Davis, Yuefei Lou, Dina Kao, Brian Claggett, Richard N. Fedorak, Randall T. Irvin
DIGESTIVE DISEASES AND SCIENCES
(2016)
Editorial Material
Gastroenterology & Hepatology
Christopher Ma, Richard N. Fedorak, Brendan P. Halloran
Article
Gastroenterology & Hepatology
Miguel Regueiro, Brian G. Feagan, Bin Zou, Jewel Johanns, Marion A. Blank, Marc Chevrier, Scott Plevy, John Popp, Freddy J. Cornillie, Milan Lukas, Silvio Danese, Paolo Gionchetti, Stephen B. Hanauer, Walter Reinisch, William J. Sandborn, Dario Sorrentino, Paul Rutgeerts
Article
Gastroenterology & Hepatology
Thomas Lee, Thomas Clavel, Kirill Smirnov, Annemarie Schmidt, Ilias Lagkouvardos, Alesia Walker, Marianna Lucio, Bernhard Michalke, Philippe Schmitt-Kopplin, Richard Fedorak, Dirk Haller
Article
Gastroenterology & Hepatology
Krista M. Reich, Richard N. Fedorak, Karen Madsen, Karen I. Kroeker
INFLAMMATORY BOWEL DISEASES
(2016)
Article
Gastroenterology & Hepatology
Christopher Ma, Candace L. Beilman, Vivian W. Huang, Darryl K. Fedorak, Karen I. Kroeker, Levinus A. Dieleman, Brendan P. Halloran, Richard N. Fedorak
INFLAMMATORY BOWEL DISEASES
(2016)
Article
Endocrinology & Metabolism
Dina Kao, Kathleen P. Ismond, Victor Tso, Braden Millan, Naomi Hotte, Richard N. Fedorak
Article
Gastroenterology & Hepatology
Christopher Ma, Candace L. Beilman, Vivian W. Huang, Darryl K. Fedorak, Karen Wong, Karen I. Kroeker, Levinus A. Dieleman, Brendan P. Halloran, Richard N. Fedorak
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2016)
