Article
Emergency Medicine
Anthony J. Renzoni, Gary D. Peksa, Joshua M. DeMott
Summary: A study of 116 emergency department patients found that conducting MRSA nasal screening for pneumonia patients did not decrease the duration of anti-MRSA antibiotics. Secondary outcomes showed no significant differences either. Therefore, there is currently no need for ED providers to consider MRSA nasal screening for patients admitted to general medicine.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Immunology
Maria Suarez-Bustamante Huelamo, Jose Antonio Alonso-Cadenas, Borja Gomez Cortes, Iker Gangoiti Goikoetxea, Susanna Hernandez-Bou, Mercedes de la Torre Espi
Summary: Staphylococcus aureus has become the leading cause of bacteremia among healthy children older than 5 years. This study found that children with S. aureus bacteremia are usually previously healthy and present with an associated focal infection. Predictors of poor outcome included the presence of risk factors for SAB, abnormal pediatric assessment triangle, elevated procalcitonin, and C-reactive protein, with the latter being the only independent predictor.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Microbiology
Elodie Ramond, Anne Jamet, Xiongqi Ding, Daniel Euphrasie, Clemence Bouvier, Louison Lallemant, Xiangyan He, Laurence Arbibe, Mathieu Coureuil, Alain Charbit
Summary: The study established a Drosophila melanogaster larvae model for oral S. aureus infection, revealing that S. aureus infection stimulates host immunity and the catalase of S. aureus plays a key role in this complex environment. It is proposed that fly larvae can provide a general model for studying the colonization capabilities of human pathogens.
Review
Immunology
Valentina Granata, Valentina Possetti, Raffaella Parente, Barbara Bottazzi, Antonio Inforzato, Cristina Sobacchi
Summary: Osteomyelitis is an infectious disease caused by Staphylococcus aureus, and it has a complex pathogenesis involving interactions between bone cells and immune cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Erik T. Nesson, Susan A. McDowell
Summary: An emerging therapeutic approach in the treatment of infectious disease is to augment the host response through repurposing of well-tolerated, non-antibiotic, host-directed therapeutics. However, the therapeutic benefit of statin use in complex infection settings is still controversial, and potential biases in observational studies may lead to an overestimation of the benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
S. -C. Wong, J. H. -K. Chen, S. Y. -C. So, P. -L. Ho, K. -Y. Yuen, V. C. -C. Cheng
Summary: Gastrointestinal colonization of MRSA may contribute to adverse clinical outcomes and pose an unrecognized burden upon hospital infection control.
JOURNAL OF HOSPITAL INFECTION
(2022)
Review
Immunology
Ping Zheng, Fang Liu, Jinzhao Long, Yuefei Jin, Shuaiyin Chen, Guangcai Duan, Haiyan Yang
Summary: Staphylococcus aureus is a significant human pathogen that can cause a wide range of diseases. Conventional mouse studies lack predictive ability due to the differences in immune systems between mice and humans. Humanized mice provide a promising model for studying human-specific virulence factors and the interaction mechanisms of S. aureus with humans.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Marta Garcia Clemente, Casilda Olveira, Rosa Giron, Luis Maiz, Oriol Sibila, Rafael Golpe, Rosario Menendez, Juan Rodriguez, Esther Barreiro, Juan Luis Rodriguez Hermosa, Concepcion Prados, David De la Rosa, Claudia Madrid Carbajal, Marta Solis, Miguel Angel Martinez-Garcia
Summary: The objective of this study was to analyze the factors associated with chronic bronchial infection (CBI) due to methicillin-susceptible Staphylococcus aureus (SA) and assess the clinical impact on severity, exacerbations, hospitalizations, and loss of lung function. The results showed that patients with CBI due to SA were younger, had poorer lung function, and experienced more exacerbations compared to patients without isolation of PPMs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Jill Dreyfus, Holly Yu, Elizabeth Begier, Julie Gayle, Margaret A. Olsen
Summary: This study assessed the 180-day postsurgical Staphylococcus aureus incidence in real-world hospital settings, revealing a high burden of S. aureus infections after both inpatient and outpatient elective surgeries, emphasizing the continued need for surveillance and novel infection prevention efforts.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, Research & Experimental
Yotam Kolben, Yuval Ishay, Henny Azmanov, Assaf Rokney, Moti Baum, Sharon Amit, Ran Nir-Paz
Summary: We report a case of bacterial endocarditis with both methicillin-sensitive and methicillin-resistant Staphylococcus aureus, originating from two distinct clones based on typing. While microbiology lab automation may misinterpret this as a monoclonal multi-drug resistant Staphylococcus aureus, simple microbiology techniques will reveal distinct clonality instantly.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Review
Infectious Diseases
John Hulme
Summary: Atopic dermatitis skin is prone to Staphylococcus aureus infection, exposing it to various toxins and virulent determinants. Treatment options depend on the degree of infection and may include topical solutions and oral/IV antibiotics. Severe skin trauma can lead to rapid SA infection, impairing the immune system and causing local and systemic AD presentations. The desensitization of systemic AD is a lengthy process with potential relapses, necessitating careful monitoring of triggers and flare severity to modify targeted treatments for rapid resolution of symptoms.
Review
Immunology
Dominique Missiakas, Volker Winstel
Summary: Host cell death programs are essential for cellular homeostasis, embryonic development, and tissue regeneration. Pathogens like Staphylococcus aureus use cell death pathways to establish infection, manipulating apoptotic, necroptotic, and pyroptotic modes to shape the immune environment conducive to persistence. This exploitation of cell death pathways is a virulence strategy that must be considered alongside immune evasion mechanisms for the development of effective therapeutics and interventions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Martin Pin, Rajan Somasundaram, Christian Wrede, Frank Schwab, Petra Gastmeier, Sonja Hansen
Summary: The management of antimicrobial resistance varies in German emergency departments, with a greater focus on infection prevention and control than antimicrobial stewardship. There is a clear need for increased implementation of regular training and monitoring with feedback in German EDs.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Food Science & Technology
Daniela Bencardino, Giulia Amagliani, Giorgio Brandi
Summary: Staphylococcus aureus, a common bacterium that colonizes human skin, nasal passages, and GI tract, can cause food poisoning through contamination by asymptomatic food handlers. While most recover without medical intervention, severe cases can be life-threatening. This poses a serious challenge for the food industry and healthcare systems.
Article
Public, Environmental & Occupational Health
Sibylle C. Mellinghoff, Caroline Bruns, Markus Albertsmeier, Juliane Ankert, Louis Bernard, Sofia Budin, Camille Bataille, Annika Y. Classen, Florian B. Cornely, Elodie Couve-Deacon, Maria Fernandez Ferrer, Jesus Fortun, Alicia Galar, Eva Grill, Thomas Guimard, Juergen A. Hampl, Sebastian Wingen-Heimann, Juan P. Horcajada, Felix Koehler, Carolin Koll, Joan Mollar, Patricia Munoz, Mathias W. Pletz, Jule Rutz, Jon Salmanton-Garcia, Harald Seifert, Ferdinand Serracino-Inglott, Alex Soriano, Jannik Stemler, Janne J. Vehreschild, Tim O. Vilz, Jan-Hendrik Naendrup, Oliver A. Cornely, Blasius J. Liss
Summary: This study retrospectively investigated the incidence and risk factors of S. aureus SSI in various surgical disciplines in Europe, and found a low infection rate. The study provides a method for utilizing big data in epidemiological research.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Public, Environmental & Occupational Health
Zerlyn Lee, Joanna Lo, Yi Lei Luan, JoAnne Fernando, Debbie Johannesen, Catherine Masuda, Tracey Swallow, Jocelyn A. Srigley
Summary: The survey conducted at a pediatric and maternity hospital in Vancouver, Canada revealed that patients, families, and visitors have misconceptions and low hand hygiene rates. Despite a preference for hand washing with soap and water, there is a need for interventions to correct misunderstandings and emphasize the consequences of inadequate hand hygiene in healthcare settings.
AMERICAN JOURNAL OF INFECTION CONTROL
(2021)
Article
Microbiology
David M. Goldfarb, Peter Tilley, Ghada N. Al-Rawahi, Jocelyn A. Srigley, Geoffrey Ford, Heather Pedersen, Abhilasha Pabbi, Stephanie Hannam-Clark, Marthe Charles, Michelle Dittrick, Vijay J. Gadkar, Jeffrey M. Pernica, Linda M. N. Hoang
Summary: This study evaluated the performance, stability, and user acceptability of different self-collected sample types for detecting SARS-CoV-2. Saline mouth rinse/gargle samples showed excellent sensitivity and stability, as well as the highest acceptability scores, making them a promising option for outpatient self-collection in adults and school-aged children.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Elizabeth Ann Bryce, Billie Velapatino, Tysha Donnelly-Pierce, Hamed Akbari Khorami, Titus Wong, Richard Dixon, Edouard Asselin, Allison McGeer, Jocelyn A. Srigley, Kevin Katz
Summary: This study evaluated the antimicrobial efficacy and durability of three different formulations of copper-based self-sanitizing surfaces after one year of hospital use. The results showed that copper formulations were effective in reducing bacterial bioburden, but their efficacy varied in different laboratory environments.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Biochemical Research Methods
Vijay J. Gadkar, David M. Goldfarb, Virginia Young, Nicole Watson, Ghada N. Al-Rawahi, Jocelyn A. Srigley, Peter Tilley
Summary: A new multiplex PCR assay (SORP) targeting SARS-CoV-2 Spike and ORF8 genes, with modified human RNaseP internal control, showed high sensitivity and specificity when tested on NPFS specimens. The SORP assay was able to detect variants of concern from the UK and South Africa lineages.
MOLECULAR AND CELLULAR PROBES
(2021)
Article
Infectious Diseases
Mai-Lei Woo Kinshella, Peter Tilley, Ghada N. Al-Rawahi, Jocelyn A. Srigley, Iryna Kayda, Mitchell Canes, Meghan McLennan, Jeffrey N. Bone, Michelle Dittrick, Vijay J. Gadkar, Linda M. N. Hoang, David M. Goldfarb
Summary: The study evaluated the diagnostic sensitivity of self-collected saline gargle samples for the molecular detection of SARS-CoV-2, showing a high sensitivity of unobserved self-collected samples in COVID-19 diagnosis and the potential to simplify the diagnostic cycle, facilitating virus testing implementation.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2022)
Article
Emergency Medicine
Brian Grunau, Sheila F. O'Brien, Tracy L. Kirkham, Jennie Helmer, Paul A. Demers, Michael Asamoah-Boaheng, Steven J. Drews, Mohammad Ehsanul Karim, Jocelyn A. Srigley, Sadaf Sediqi, David O'Neill, Ian R. Drennan, David M. Goldfarb
Summary: Comparison between paramedics and blood donors in Canada showed similar seroprevalence of SARS-CoV-2 infection-specific antibodies overall, but a higher rate among unvaccinated paramedics compared to blood donors.
ANNALS OF EMERGENCY MEDICINE
(2022)
Article
Immunology
Alastair McAlpine, Joan L. Robinson, Michelle Barton, Archana Balamohan, H. Dele Davies, Gwenn Skar, Marie-Astrid Lefebvre, Ahmed Almadani, Dolores Freire, Nicole Le Saux, Jennifer Bowes, Jocelyn A. Srigley, Patrick Passarelli, John Bradley, Sarah Khan, Rupeena Purewal, Isabelle Viel-Theriault, Adrianna Ranger, Michael T. Hawkes
Summary: This study described the characteristics and pathogens of CSF shunt infections in children in Canada and the United States. Staphylococci remain the most common pathogen, but antibiotic resistant Gram-negative bacilli also occur. Empiric antibiotic regimens were inconsistent, highlighting the need for more accurate prediction of pathogens.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Microbiology
Jessica J. Bartoszko, Robyn Mitchell, Kevin Katz, Michael Mulvey, Laura Mataseje
Summary: There is limited information on the epidemiology of extensively drug-resistant (XDR) carbapenemase-producing Enterobacterales (CPE) in Canada. This study found that international travel history, acquisition of CPE from healthcare exposure abroad, specific carbapenemase genes and bacterial strains were significantly associated with XDR status among CPE patients in Canada.
MICROBIOLOGY SPECTRUM
(2022)
Article
Public, Environmental & Occupational Health
Kelly B. Choi, Tim Du, Anada Silva, George R. Golding, Linda Pelude, Robyn Mitchell, Wallis Rudnick, Romeo Hizon, Ghada N. Al-Rawahi, Blanda Chow, Ian Davis, Gerald A. Evans, Charles Frenette, Jennie Johnstone, Pamela Kibsey, Kevin C. Katz, Joanne M. Langley, Bonita E. Lee, Yves Longtin, Dominik Mertz, Jessica Minion, Michelle Science, Jocelyn A. Srigley, Paula Stagg, Kathryn N. Suh, Nisha Thampi, Alice Wong, Jeannette L. Comeau, Susy S. Hota
Summary: The COVID-19 pandemic has had a significant impact on healthcare systems, leading to a notable increase in Clostridioides difficile infection rates in Canadian hospitals.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Katrina H. Assen, Vanessa Paquette, Arianne Y. Albert, Ginger Shi, Jocelyn A. Srigley, Horacio Osiovich, Ashley D. Roberts, Joseph Y. Ting
Summary: This study aimed to evaluate the change in consumption of specific antibiotics in a neonatal intensive care unit after the implementation of an antimicrobial stewardship program (ASP). The results showed a significant decrease in overall antibiotic days of therapy (DOT) and the use of certain antibiotics after the implementation of ASP. This study presents important targets for ongoing ASP work.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Marina Vineta Paramo, Lilian P. L. Ngo, Bahaa Abu-Raya, Frederic Reicherz, Rui Yang Xu, Jeffrey N. Bone, Jocelyn A. Srigley, Alfonso Solimano, David M. Goldfarb, Danuta M. Skowronski, Pascal M. Lavine
Summary: This study aimed to investigate the changes in the severity of RSV cases during the COVID-19 pandemic. The study found a decrease in the number of RSV cases between September 2020 and August 2021, followed by a significant increase in cases in 2021-22 and 2022-23. Additionally, there was an increase in hospitalizations during the 2022-23 period. However, there was no increase in hospitalizations or ICU admissions for premature infants or children with chronic cardiorespiratory conditions.
LANCET REGIONAL HEALTH-AMERICAS
(2023)
Article
Public, Environmental & Occupational Health
Brooke T. Cheng, R. Ayesha Ali, Jun Chen Collet, Tara Donovan Towell, Guanghong Han, Dave Keen, Ka Wai Leung, Julie Mori, Jocelyn A. Srigley
Summary: This study investigated the barriers affecting healthcare workers' adherence to infection prevention and control practices during the COVID-19 pandemic in British Columbia, Canada. The results showed that inadequate staffing, limited space in staff rooms, multibed rooms, and confusing messages about IPAC practices were the main barriers identified by the respondents. Suggestions for improvement included more support from IPAC leadership and clearer communication about required IPAC practices.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Immunology
Tim Du, Kelly B. Choi, Anada Silva, George R. Golding, Linda Pelude, Romeo Hizon, Ghada N. Al-Rawahi, James Brooks, Blanda Chow, Jun C. Collet, Jeannette L. Comeau, Ian Davis, Gerald A. Evans, Charles Frenette, Guanghong Han, Jennie Johnstone, Pamela Kibsey, Kevin C. Katz, Joanne M. Langley, Bonita E. Lee, Yves Longtin, Dominik Mertz, Jessica Minion, Michelle Science, Jocelyn A. Srigley, Paula Stagg, Kathryn N. Suh, Nisha Thampi, Alice Wong, Susy S. Hota
Summary: We investigated the epidemiology and molecular characteristics of healthcare-associated and community-associated Clostridioides difficile infection (CDI) in adult patients in Canadian hospitals. Our study found higher mortality rate associated with healthcare-associated CDI, and a decrease in both healthcare-associated and community-associated CDI rates from 2015 to 2019. Certain ribotypes were more commonly associated with CDI-related deaths.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Joan L. Robinson, Alastair McAlpine, Michelle Barton, Archana Balamohan, H. Dele Davies, Gwenn Skar, Marie-Astrid Lefebvre, Ahmed Almadani, Dolores Freire, Nicole Le Saux, Jennifer Bowes, Jocelyn A. Srigley, Patrick Passarelli, John Bradley, Sarah Khan, Rupeena Purewal, Isabelle Viel-Theriault, Michael T. Hawkes
Summary: This retrospective multicenter study examined 154 children with cerebrospinal fluid shunt infections and found that the duration of antibiotic therapy and time to shunt replacement varied, potentially depending on the targeted pathogen and site of infection. Most patients received a longer course of antibiotics and had delayed shunt reimplantation compared to the guidelines set by the Infectious Diseases Society of America.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Letter
Medicine, General & Internal
Alison Lopez, Jocelyn Srigley
