Article
Engineering, Biomedical
Zixiang Dai, Xianju Xie, Ning Zhang, Song Li, Kai Yang, Minjia Zhu, Michael D. Weir, Hockin H. K. Xu, Ke Zhang, Zeqing Zhao, Yuxing Bai
Summary: The study demonstrated that incorporating 10%-30% of NACP did not compromise the biocompatibility and physical properties of the resin infiltrant, and the ICON + 30% NACP group showed significant effects in releasing Ca and P ions. The novel infiltrant has promising potential in inhibiting enamel white spot lesions, protecting enamel, and increasing its hardness.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ivana Nedeljkovic, Behrouz Zandieh Doulabi, Marwa Abdelaziz, Albert J. Feilzer, Rob A. M. Exterkate, Slawomir Szafert, Nurbey Gulia, Ivo Krejci, Cornelis J. Kleverlaan
Summary: The cytotoxicity of a hybrid-glass-based infiltrant and its effect on biofilm attachment, growth, and metabolic activity were assessed and compared to a resin-based infiltrant. The results showed that the hybrid-glass-based infiltrant had minimal impact on cell viability and reduced bacterial attachment compared to the resin-based infiltrant.
Article
Dentistry, Oral Surgery & Medicine
Richard Johannes Wierichs, Hannah Selzner, Sotiria Bourouni, Elena Kalimeri, Kyriaki Seremidi, Hendrik Meyer-Luckel, Dimitrios Kloukos
Summary: This study aimed to compare the masking effects of resin infiltration and fluoride treatment on initial caries lesions during fixed orthodontic treatment. The results showed that resin infiltration effectively masked the lesions immediately after treatment and at the last appointment before debonding, with better results than fluoride treatment.
JOURNAL OF DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Igor Paulino Mendes Soares, Giovana Anovazzi, Caroline Anselmi, Maria Luisa Leite, Debora Lopes Salles Scheffel, Diana Gabriela Soares, Carlos Alberto de Souza Costa, Josimeri Hebling
Summary: The study investigated the biological effects of treating EWSLs with resin infiltration components on odontoblast-like cells and human dental pulp cells. The results showed that RICs reduced cell viability, ALP activity, and MN formation, while upregulating inflammatory cytokines and downregulating mineralization-related genes. Among the RICs, the Etch component had the most detrimental effects.
Article
Dentistry, Oral Surgery & Medicine
Atieh Hashemian, Sima Shahabi, Marjan Behroozibakhsh, Farhood Najafi, Bahaa Abdulrazzaq Jerri Al-Bakhakh, Hamidreza Hajizamani
Summary: The addition of PUA to TEGDMA improved mechanical properties and decreased water sorption and solubility. The FD-BG fillers significantly enhanced resistance to demineralisation of enamel samples, while FHA fillers also improved resistance but not significantly. The composite of PUA+TEGDMA+FD-BG/FHA showed potential as an alternative material for enamel infiltration with better mechanical properties and remineralisation potential.
JOURNAL OF DENTISTRY
(2021)
Article
Multidisciplinary Sciences
Mahtab Memarpour, Arefe Abedinzade, Azade Rafiee, Atieh Hashemian
Summary: This study aimed to determine the penetration depth and enamel microhardness in primary teeth with early enamel lesions, using different treatment agents. The results showed that the combination of Icon and Clinpro with hydrochloric acid pretreatment showed the highest penetration percentage and microhardness recovery.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Linda Wang, Maria Cristina Carvalho de Almendra Freitas, Anuradha Prakki, Victor Mosquim, Alejandra Hortencia Miranda Gonzalez, Daniela Rios, Heitor Marques Honorio
Summary: The study aimed to evaluate the penetration depth of experimental resin infiltrants containing different percentages of triethylene glycol dimethacrylate (TEGDMA) and phosphoric acid 2-hydroxyethyl methacrylate ester (PAM) in artificial carious white spot lesions. The results showed that the combination of TEGDMA and PAM in different proportions can achieve similar penetration depth to commercial infiltrants without acid-etching the enamel surface.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Danilo Augusto de Holanda Ferreira, Nathalie Murielly Rolim de Abreu, Kassia Regina Simoes Meira, Frederico Barbosa de Sousa
Summary: The type of enamel caries affects the organic volume and permeability of the surface layer. Artificial enamel caries induced by gel has the highest organic volume and lowest permeability, which is preferred in in vitro studies.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
R. J. Wierichs, B. Abou-Ayash, C. Kobbe, M. Esteves-Oliveira, M. Wolf, I. Knaup, H. Meyer-Lueckel
Summary: This study qualitatively and quantitatively assessed the masking efficacy and color stability of resin infiltration on post-orthodontic ICL after 1 year. The results showed that resin infiltration effectively masked the enamel both 7 days and 12 months after treatment, which was supported by both quantitative and qualitative analysis.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Omar Abd El Sadek El Meligy, Najlaa Mohammed Alamoudi, Shimaa Tag Eldin Ibrahim, Osama Mahmood Felemban, Amani Ahmed Al-Tuwirqi
Summary: Resin infiltration with ICON significantly increased the surface roughness and hardness of early proximal caries lesions, as shown in this in vitro study.
JOURNAL OF DENTAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Su Yang, Baiyan Sui, Yinan Cui, Xin Liu, Jiao Sun, Jun Wang
Summary: This study developed a TEGDMA-free infiltration resin IBMA which showed similar enamel morphologic and esthetic restorative effects in chalky lesions compared to the commercial TEGDMA-based resin ICON. IBMA also demonstrated favorable cell viability, durable biofilm-repellent performance, and higher enamel microhardness. Its high crosslink density and low water sorption make IBMA more resistant to hydrolysis than ICON. Enamel lesions treated with IBMA showed good color stability after the tea-staining challenge, which was significantly better than that in the ICON group.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Frank Lippert, Jennifer S. Eder, George J. Eckert, Jonathan Mangum, Kerry Hegarty
Summary: This in vitro study investigated the ability of a blue protein-based hydroxyapatite porosity probe to selectively detect artificial enamel caries-like lesions of varying severities.
JOURNAL OF DENTISTRY
(2023)
Article
Materials Science, Multidisciplinary
Anna Nowak-Wachol, Anna Korytkowska-Walach, Bartosz Chmiela, Kacper Wachol, Magdalena Wyszynska, Maciej Lopacinski, Sayedamirreza Mostafavi, Tadeusz Morawiec, Malgorzata Skucha-Nowak
Summary: This study aimed to evaluate the penetration depth of a dental infiltrant into decalcified root cementum tissue and observe the effects of a single and repeated hydrochloric acid etching process on the root cementum tissue. The results showed that the infiltration of the resin could be observed at a depth of approximately 80-120 μm.
Article
Immunology
Xiaoyu Huang, Jingou Liang, Wen Zhou, Tao Ma, Michael D. Weir, Gary D. Hack, Guadalupe Garcia Fay, Thomas W. Oates, Lei Cheng, Hockin H. K. Xu
Summary: By incorporating DMAEM into a resin infiltrant, white spot lesions can be effectively inhibited and enamel hardness can be improved, without increasing cytotoxicity. In addition, DMAEM has antibacterial effects, reducing biofilm metabolic activity and lactic acid production.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Marcella Esteves-Oliveira, Vanara F. Passos, Tereza M. A. Z. C. Russi, Argus R. R. Fernandes, Caroline N. N. Terto, Juliano S. Mendonca, Guglielmo Campus, Richard J. Wierichs, Hendrik Meyer-Lueckel, Juliana P. M. Lima
Summary: This study evaluated the effect of different surface polishing protocols on enamel roughness, bacterial adhesion, and caries-protective effect of a resin infiltrant. The results showed that certain polishing protocols can decrease the roughness of enamel, but did not have a significant impact on bacterial counts or demineralization.
SCIENTIFIC REPORTS
(2022)
Letter
Dentistry, Oral Surgery & Medicine
Katrin Hertrampf, Christian Floerke, Jonas Conrad, Nicole Passia, Burkhard Kunzendorf, Birte Groessner-Schreiber, Christof Doerfer, Matthias Kern, Wolfgang Orthuber, Joerg Wiltfang
Article
Dentistry, Oral Surgery & Medicine
Haitham Askar, Joachim Krois, Csaba Rohrer, Sarah Mertens, Karim Elhennawy, Livia Ottolenghi, Marta Mazur, Sebastian Paris, Falk Schwendicke
Summary: Deep learning proves to have satisfactory accuracy in detecting white spot lesions in dental photographs, especially fluorotic lesions. Models trained to detect different types of lesions showed similar performance, with lower sensitivity. False positive detections were mainly attributed to light reflections.
JOURNAL OF DENTISTRY
(2021)
Article
Biology
Mohamed Mekhemar, Sameh Attia, Christof Doerfer, Jonas Conrad
Summary: This study investigated the impact of the COVID-19 pandemic on the mental health of dental students in German universities from July 2020 to January 2021. Results showed that female students, those with cardiovascular conditions or smoking habits, and participants perceiving COVID-19 as a financial risk were significantly more affected.
Article
Dentistry, Oral Surgery & Medicine
David W. Christofzik, Patrick Glandorf, Jonas Conrad, Karim M. Fawzy El-Sayed, Birte Groessner-Schreiber, Christof E. Doerfer
Summary: This study revealed significant differences in tooth substance loss during endodontic access cavity preparations among operators of different experience levels, but not significantly associated with the employed imaging/planning modality. There were no significant differences in pulp chamber floor, iatrogenic perforations, and incomplete pulpal roof removal between operator groups or imaging/planning modalities.
AUSTRALIAN ENDODONTIC JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ahmed Said Rozeik, Mohamed Sad Chaar, Sandra Sindt, Sebastian Wille, Christine Selhuber-Unkel, Matthias Kern, Samar El-Kholy, Christof Doerfer, Karim M. Fawzy El-Sayed
Summary: This study investigated the viability, proliferation, and adhesion of human gingival fibroblasts (HGFs) on different implant materials in vitro. The results showed that wettability of the materials significantly affected HGF proliferation and adhesion. Within the limitations of this study, zirconia (Zr) was found to be the most biocompatible abutment material.
Article
Nutrition & Dietetics
Louisa Mewes, Carina Knappe, Christian Graetz, Juliane Wagner, Tobias J. Demetrowitsch, Julia Jensen-Kroll, Karim Mohamed Fawzy El-Sayed, Karin Schwarz, Christof E. Dorfer, Stefan Schreiber, Matthias Laudes, Dominik M. Schulte
Summary: Vitamin C and ω-3 fatty acid Docosapentaenoic acid may play a role in the pathophysiology of human periodontitis.
Article
Dentistry, Oral Surgery & Medicine
Florentina Melzow, Sarah Mertens, Hristo Todorov, David A. Groneberg, Sebastian Paris, Alexander Gerber
Summary: This study evaluated aerosol exposure during different dental treatments and demonstrated that the use of high-volume suction (HVS) can significantly reduce aerosol spreading, thereby reducing the risk of patient infection.
Article
Medicine, General & Internal
Antje Geiken, Louise Holtmann, Christian H. Splieth, Jonas Conrad, Christof E. Doerfer, Christian Graetz
Summary: The survey results showed that as children grew older, referral to dental examinations was increasingly implemented among pediatricians. Specific fluoride recommendations were generally accepted by pediatricians.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Mohamed Mekhemar, Johannes Toelle, Yasmine Hassan, Christof Doerfer, Karim Fawzy El-Sayed
Summary: Thymoquinone (TQ) from Nigella sativa shows promising biomedical properties, with this study revealing that TQ can maintain the pluripotency of gingival mesenchymal stem/progenitor cells (G-MSCs) and promote cellular differentiation towards an immunocompetent phenotype through increased TLR3 expression.
Article
Pediatrics
Antje Geiken, Louise Holtmann, Christof E. Doerfer, Christiane Schwarz, Christian Graetz
Summary: There is a lack of awareness and recommendations from midwives regarding early childhood caries screening and fluoride, and more educational work is needed to promote their understanding and implementation.
Article
Dentistry, Oral Surgery & Medicine
Christian Graetz, Naomi Sayk, Paulina Dueffert, Ralf Heidenreich, Christof E. Doerfer, Miriam Cyris
Summary: This study analyzed different methods for controlling air quality during and after aerosol-generating procedures (AGPs) in a small skills lab, focusing on the worst-case scenario for aerogen infection control in preclinical dental training. The combination of high-volume evacuation (HVE) and an extraoral mobile scavenger (EOS) was found to be similarly effective in controlling aerosol emissions of particles between one and ten micrometers during AGPs as compared to non-AGPs. After AGPs, air exchange with the air conditioning system (AC) should be complemented by opening doors for better air quality if natural ventilation through open windows is restricted.
INTERNATIONAL JOURNAL OF DENTISTRY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Antonio H. S. Delgado, Salvatore Sauro, Adriano F. Lima, Alessandro D. Loguercio, Alvaro Della Bona, Annalisa Mazzoni, Fabricio Mezzomo Collares, Frode Staxrud, Jack Ferracane, James Tsoi, Julia Amato, Klaus W. Neuhaus, Laura Ceballos, Lorenzo Breschi, Matthias Hannig, Mary Anne Melo, Mutlu Ozcan, Nicola Scotti, Niek Opdam, Satoshi Yamaguchi, Sebastian Paris, Lezize Sebnem Turkun, Sophie Domejean, Vinicius Rosa, William Palin, Falk Schwendicke
Summary: This study developed a risk of bias tool for pre-clinical dental materials research, aiming to support reporting of future investigations and improve assessment in systematic reviews. The tool features four domains and nine items, and provides signaling questions and a guide for bias judgment.
JOURNAL OF DENTISTRY
(2022)
Review
Medicine, General & Internal
Marcus Cebula, Gerd Goestemeyer, Joachim Krois, Vinay Pitchika, Sebastian Paris, Falk Schwendicke, Susanne Effenberger
Summary: The present study conducted a meta-analysis to evaluate the certainty of evidence for resin infiltration of proximal carious lesions in primary and permanent teeth. The results showed that resin infiltration can effectively arrest caries lesions in both primary and permanent teeth. However, the certainty of evidence remains unclear due to the high or unclear risk of bias in the included trials.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Gerd Goestemeyer, Mareike Preus, Karim Elhennawy, Falk Schwendicke, Sebastian Paris, Haitham Askar
Summary: In this study, the diagnostic accuracy of radiographic evaluation, visual-tactile assessment, laser-fluorescence, and near-infrared-light transillumination were evaluated for proximal root caries lesions. The results showed that near-infrared-light transillumination was not applicable for detecting proximal root caries, while laser-fluorescence and visual-tactile assessment were more accurate than radiographic evaluation for detecting these lesions.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Christian Graetz, Viktor Huelsbeck, Paulina Dueffert, Susanne Schorr, Martin Strassburger, Antje Geiken, Christof E. Doerfer, Miriam Cyris
Summary: When performing aerosol-generating procedures in dentistry, the use of high-volume evacuation suction can significantly reduce splatter contamination. Specifically, using a 16mm diameter suction cannula with a flow rate of 250 l/min or higher resulted in the lowest splatter contamination values.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chang Zeng, Pei Hu, Colin P. Egan, Brian E. Bergeron, Franklin Tay, Jingzhi Ma
Summary: The study compared the bacteria debridement efficacy of the first and second generations of sonic root canal irrigant activation systems. The results showed that activation of 2% NaOCl with either EndoActivator or SmartLite Pro EndoActivator significantly reduced the overall intracanal bacterial load compared to syringe-side-vented needle delivery. However, delivering 2% NaOCl for 5 minutes using the syringe-side-vented needle produced better bacteria debridement than either sonic agitation system.
JOURNAL OF DENTISTRY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Alaa Husni Qari, Raghad Mohammed Alharbi, Shahd Saud Alomiri, Banan Nasser Alandanusi, Lina Ayman Mirza, Mohammad Hasan Al-Harthy
Summary: The study compares the experience of patients seen using teledentistry with traditional Orofacial Pain and TMD visits. Results indicated a borderline difference in effectively using teledentistry for follow-ups among different age groups, but no significant differences were found in patients' experience between virtual and conventional visits. This suggests that high-quality dental care services can be provided remotely without adversely affecting patient experience or quality of care.
JOURNAL OF DENTISTRY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Giovanna Iezzi, Barbara Zavan, Morena Petrini, Letizia Ferroni, Tania Vanessa Pierfelice, Ugo D'Amora, Alfredo Ronca, Emira D'Amico, Carlo Mangano
Summary: This study characterized the surface topography and evaluated the biological responses of various cells to a novel 3D-printed dental implant. The surface of the implant showed a highly interconnected porous architecture and roughness, leading to good adhesion and growth of human oral osteoblasts, gingival fibroblasts, mesenchymal stem cells, and monocytes. These findings suggest that this 3D-printed implant has excellent potential for clinical applications.
JOURNAL OF DENTISTRY
(2024)