Review
Biochemistry & Molecular Biology
Francesca Bonomini, Gaia Favero, Stefania Castrezzati, Elisa Borsani
Summary: Orofacial pain is a complex biomedical challenge without a satisfactory solution. This review evaluates the involvement of neurotrophins in orofacial nociception and their potential role as targets for pain modulation. Further studies are needed to clarify their application in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Masamichi Shinoda, Yoshiki Imamura, Yoshinori Hayashi, Noboru Noma, Akiko Okada-Ogawa, Suzuro Hitomi, Koichi Iwata
Summary: Studies have shown that trigeminal nerve injury can lead to persistent orofacial pain, which is difficult to diagnose and treat. Animal research has revealed the involvement of various molecules in the communication between neurons and non-neuronal cells, as well as the potential ascending pathways in processing pathological orofacial pain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Yu-Zhi Jia, Hai-Tao Li, Guang-Ming Zhang, Hong-Yun Wu, Si-Shuo Zhang, Hong-Wei Zhi, Ya-Han Wang, Jing-Wen Zhu, Yi-Fan Wang, Xiang-Qing Xu, Cai-Jun Tian, Wen-Qiang Cui
Summary: Electroacupuncture (EA) can alleviate orofacial pain and anxiety-like behavior in patients with trigeminal neuralgia by modulating synaptic plasticity in the hippocampal CA1 region.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Yuhui Luo, Abbie Suttle, Qiaojuan Zhang, Peng Wang, Yong Chen
Summary: Orofacial pain, affecting millions of Americans, is influenced by transient receptor potential (TRP) ion channels. The orofacial sensory system differs from the spinal sensory system in pain processing and sensitivities. TRPs in trigeminally-mediated pain have not been extensively documented compared to spinally-mediated pain.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yukinori Nagakura, Shogo Nagaoka, Takahiro Kurose
Summary: This review discusses potential molecular targets for treating neuropathic orofacial pain based on current findings in animal models, highlighting the importance of preclinical research in elucidating the pathophysiology of the disease. Investigating the biological processes associated with trigeminal nerve damage or compression can provide insights into the generation and exacerbation of orofacial pain, leading to the discovery of better therapies. Translation of therapeutic candidates from animal models to human patients holds promise for developing improved treatments for neuropathic orofacial pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Jinyue Liu, Shilin Jia, Fang Huang, Hongwen He, Wenguo Fan
Summary: This study reviewed the mechanisms of peripheral glutamate-mediated orofacial pain, the regulation of glutamate in the periphery, and the translation of these findings into pain treatments.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Tianjin Tao, Yi Liu, Jingqi Zhang, Wenli Lai, Hu Long
Summary: The nerve growth factor (NGF) and calcitonin gene-related peptide (CGRP) play a crucial role in the regulation of orofacial pain. This study found that ATPase subunit 1 is involved in vesicular transport in neurons and regulates orofacial pain by influencing the expression and release of CGRP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yumi Tsutsumi, Yayoi Morita, Fumihiko Sato, Takahiro Furuta, Katsuro Uchino, Jaerin Sohn, Tahsinul Haque, Yong Chul Bae, Hitoshi Niwa, Yoshihisa Tachibana, Atsushi Yoshida
Summary: This study investigated the projections from the supratrigeminal nucleus (Su5) to the cerebellar nuclei, specifically for orofacial proprioception. The results showed that the Su5 projections terminated mainly in the dorsolateral hump of the cerebellar interposed nucleus (Int) and the dorsolateral protuberance of the cerebellar medial nucleus. In addition, a smaller number of terminals were observed in the vestibular group Y nucleus. In contrast, projections from the external cuneate nucleus (ECu), which receives proprioceptive input from the forelimb/neck muscles, terminated mainly in the dorsomedial crest of the Int and the group Y.
Article
Neurosciences
Yumi Tsutsumi, Fumihiko Sato, Takahiro Furuta, Katsuro Uchino, Masayuki Moritani, Yong Chul Bae, Takafumi Kato, Yoshihisa Tachibana, Atsushi Yoshida
Summary: This study investigates the motor control regions in the cerebellar cortex that receive proprioceptive signals from muscle spindles. The results show that proprioceptive signals from the orofacial muscles are processed differently from those from the forelimb and neck muscles in the rat cerebellar cortex.
Article
Neurosciences
Heather A. Hansen, Patricia Stefancin, Andrew B. Leber, Zeynep M. Saygin
Summary: Misophonia, a prevalent yet understudied condition, is believed to be caused by higher connectivity between the auditory cortex and orofacial motor cortex. However, our study found that the previously defined orofacial cortex using resting-state fMRI did not capture true orofacial cortex, and there was no selectivity to orofacial action in these regions. Instead, we observed increased connectivity between finger cortex and insula, providing neural evidence for non-orofacial triggers. These findings have important implications for understanding and treating misophonia.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Shinichi Furuya, Ryuya Tanibuchi, Hayato Nishioka, Yudai Kimoto, Masato Hirano, Takanori Oku
Summary: This preliminary study using a hand exoskeleton robot shows that passive movement training can enhance motor skills of pianists, with a more pronounced effect in adolescent pianists. It emphasizes the importance of somatosensory-motor training in professional music education during adolescence.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Yoshizo Matsuka
Summary: The Special Issue Orofacial Pain: Molecular Mechanisms, Diagnosis, and Treatment 2021 is a collection of 6 articles published by 41 authors from different countries, focusing on various aspects of orofacial pain. The articles cover topics such as molecular mechanisms, diagnosis, and treatment options, and include studies on specific pain models and related biological factors, such as GABAergic neurons and ATP signaling. Additionally, a review paper on trigeminal neuralgia is included.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Bradley M. Colquitt, Kelly Li, Foad Green, Robert Veline, Michael S. Brainard
Summary: Sensory feedback is crucial for the stable execution of learned motor skills. This study focused on the gene expression changes in the songbird sensorimotor circuit following deafening. The results showed that deafening preferentially alters gene expression in the premotor and striatal regions, with genes associated with synaptic transmission, neuronal spines, and neuromodulation being affected. Additionally, the inter-region coordination of transcriptional states was disrupted in deafened birds, indicating a destabilization of the song.
Review
Biochemistry & Molecular Biology
Barry J. Sessle
Summary: Diagnosing and treating chronic orofacial pain conditions can be challenging due to their complexity. Variability between individuals in risk factors and pain expression suggests a role for genetic and environmental factors. Understanding underlying mechanisms and individual differences is crucial for effective management of chronic orofacial pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
H. Liang, H. Hu, D. Shan, J. Lyu, X. Yan, Y. Wang, F. Jian, X. Li, W. Lai, H. Long
Summary: CGRP is upregulated in trigeminal neurons and SGCs following orofacial pain induction. Knockdown of CGRP reduces pain and its expression in neurons and SGCs. CGRP upregulates inducible nitric oxide synthase in SGCs through p38 signaling pathway, leading to a positive-feedback neuron-glia crosstalk mediated by CGRP.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jian Li, Dong Peng, Ting Jiang, Limor Avivi-Arber
INTERNATIONAL JOURNAL OF PROSTHODONTICS
(2017)
Review
Dentistry, Oral Surgery & Medicine
L. Avivi-Arber, B. J. Sessle
JOURNAL OF ORAL REHABILITATION
(2018)
Article
Anatomy & Morphology
Limor Avivi-Arber, Ze'ev Seltzer, Miriam Friedel, Jason P. Lerch, Massieh Moayedi, Karen D. Davis, Barry J. Sessle
FRONTIERS IN NEUROANATOMY
(2017)
Article
Multidisciplinary Sciences
Limor Avivi-Arber, Doran Avivi, Marilena Perez, Nadir Arber, Shiran Shapira
Article
Biochemical Research Methods
Sandeep Chakraborty, Szu-Yu Lee, Jye-Chang Lee, Chen-Tung Yen, Chi-Kuang Sun
JOURNAL OF BIOPHOTONICS
(2019)
Article
Dentistry, Oral Surgery & Medicine
Farhan Shah, Per Stal, Jian Li, Barry J. Sessle, Limor Avivi-Arber
ARCHIVES OF ORAL BIOLOGY
(2019)
Review
Medicine, General & Internal
Adrien Naveau, Kouhei Shinmyouzu, Colman Moore, Limor Avivi-Arber, Jesse Jokerst, Sreenivas Koka
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Anatomy & Morphology
J-C Lee, C-H Cheng, C-T Yen
FOLIA MORPHOLOGICA
(2019)
Article
Medicine, Research & Experimental
L. T. Melo, V Panchalingam, P. Cherkas, A. R. Campos, L. Avivi-Arber, B. J. Sessle
Article
Cell Biology
Ming-Kai Pan, Yong-Shi Li, Shi-Bing Wong, Chun-Lun Ni, Yi-Mei Wang, Wen-Chuan Liu, Liang-Yin Lu, Jye-Chang Lee, Etty P. Cortes, Jean-Paul G. Vonsattel, Qian Sun, Elan D. Louis, Phyllis L. Faust, Sheng-Han Kuo
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Neurosciences
Han-Yuan Yeh, Jye-Chang Lee, Han-Hsiung Chi, Chih-Cheng Chen, Qin Liu, Chen-Tung Yen
Summary: Neuropathic pain is caused by damage to the somatosensory nervous system, and the study found that nerve degeneration is related to the initiation of pain while nerve sprouting is related to the maintenance of pain.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Bhaskar Jyoti Borah, Jye-Chang Lee, Han-Hsiung Chi, Yang-Ting Hsiao, Chen-Tung Yen, Chi-Kuang Sun
Summary: The Nyquist-Shannon criterion is difficult to achieve in a laser-scanning mesoscopic multiphoton microscope. By introducing a Nyquist figure-of-merit (NFOM) parameter, researchers have successfully improved the optical resolution retrieval capability of laser-scanning MPMs and achieved high field-of-view-resolution ratios.
Article
Cell Biology
Han-Hsiung Chi, Jye-Chang Lee, Chih-Cheng Chen, Shih-Kuo Chen, Chen-Tung Yen
Proceedings Paper
Biophysics
Filiz Bunyak, Naru Shiraishi, Kannappan Palaniappan, Teresa E. Lever, Limor Avivi-Arber, Kazutaka Takahashi
2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2017)
Article
Otorhinolaryngology
Yuki Nakamura, Jose Iriarte-Diaz, Fritzie Arce-McShane, Courtney P. Orsbon, Kevin A. Brown, McKenna Eastment, Limor Avivi-Arber, Barry J. Sessle, Makoto Inoue, Nicholas G. Hatsopoulos, Callum F. Ross, Kazutaka Takahashi