Targeting Head and Neck Cancer Stem Cells

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

CD271 is a functional and targetable marker of tumor-initiating cells in head and neck squamous cell carcinoma

(2015) Oihana Murillo-Sauca et al.   Oncotarget

Cisplatin Induces Bmi-1 and Enhances the Stem Cell Fraction in Head and Neck Cancer

(2015) Carolina Nör et al.   NEOPLASIA

CD10 as a novel marker of therapeutic resistance and cancer stem cells in head and neck squamous cell carcinoma

(2014) T Fukusumi et al.   BRITISH JOURNAL OF CANCER

SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma

(2014) S H Lee et al.   BRITISH JOURNAL OF CANCER

Cancer stem-like cells from head and neck cancers are chemosensitized by the Wnt antagonist, sFRP4, by inducing apoptosis, decreasing stemness, drug resistance and epithelial to mesenchymal transition

(2014) S Warrier et al.   CANCER GENE THERAPY

Targeting the c-Met/FZD8 Signaling Axis Eliminates Patient-Derived Cancer Stem-like Cells in Head and Neck Squamous Carcinomas

(2014) S. Sun et al.   CANCER RESEARCH

Hedgehog Signaling Drives Radioresistance and Stroma-Driven Tumor Repopulation in Head and Neck Squamous Cancers

(2014) G. N. Gan et al.   CANCER RESEARCH

Distinct Subpopulations of Head and Neck Cancer Cells with Different Levels of Intracellular Reactive Oxygen Species Exhibit Diverse Stemness, Proliferation, and Chemosensitivity

(2014) C.-W. Chang et al.   CANCER RESEARCH

Cancer stem cells: Mediators of tumorigenesis and metastasis in head and neck squamous cell carcinoma

(2014) Steven B. Chinn et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Enhanced Chemosensitivity by Targeting Nanog in Head and Neck Squamous Cell Carcinomas

(2014) Chuan-En Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wnt/β-catenin signalling maintains self-renewal and tumourigenicity of head and neck squamous cell carcinoma stem-like cells by activating Oct4

(2014) Sang Hyuk Lee et al.   JOURNAL OF PATHOLOGY

Oct4 is a critical regulator of stemness in head and neck squamous carcinoma cells

(2014) B S Koo et al.   ONCOGENE

Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence

(2014) I Ramachandran et al.   Cell Death & Disease

Trial Watch:

(2014) Jonathan Pol et al.   OncoImmunology

Targeting gemcitabine containing liposomes to CD44 expressing pancreatic adenocarcinoma cells causes an increase in the antitumoral activity

(2013) Elisa Dalla Pozza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

MicroRNA-125b regulates proliferation and radioresistance of oral squamous cell carcinoma

(2013) M Shiiba et al.   BRITISH JOURNAL OF CANCER

Elevated intrinsic cancer stem cell population in human papillomavirus-associated head and neck squamous cell carcinoma

(2013) Manchao Zhang et al.   CANCER

Grp78 as a therapeutic target for refractory head–neck cancer with CD24−CD44+ stemness phenotype

(2013) C-C Chiu et al.   CANCER GENE THERAPY

miR145 Targets the SOX9/ADAM17 Axis to Inhibit Tumor-Initiating Cells and IL-6-Mediated Paracrine Effects in Head and Neck Cancer

(2013) C.-C. Yu et al.   CANCER RESEARCH

Connective Tissue Growth Factor Activates Pluripotency Genes and Mesenchymal–Epithelial Transition in Head and Neck Cancer Cells

(2013) Cheng-Chi Chang et al.   CANCER RESEARCH

Alteration of cancer stem cell-like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck

(2013) Kazuaki Chikamatsu et al.   CANCER SCIENCE

Cancer stem-like cell properties are regulated by EGFR/AKT/β-catenin signaling and preferentially inhibited by gefitinib in nasopharyngeal carcinoma

(2013) Lei Ma et al.   FEBS Journal

Epstein-Barr virus induction of the Hedgehog signalling pathway imposes a stem cell phenotype on human epithelial cells

(2013) Rebecca J Port et al.   JOURNAL OF PATHOLOGY

Plasma Membrane Proteomics of Tumor Spheres Identify CD166 as a Novel Marker for Cancer Stem-like Cells in Head and Neck Squamous Cell Carcinoma

(2013) Ming Yan et al.   MOLECULAR & CELLULAR PROTEOMICS

MicroRNAs and cancer stem cells: the sword and the shield

(2013) X Sun et al.   ONCOGENE

In vitro Evaluation of Sialyl Lewis X Relationship with Head and Neck Cancer Stem Cells

(2013) Michael J. Czerwinski et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Head and Neck Cancer Stem Cells

(2013) Alice L. Tang et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

CD98 marks a subpopulation of head and neck squamous cell carcinoma cells with stem cell properties

(2013) Sanne R. Martens-de Kemp et al.   Stem Cell Research

Targeting Head and Neck Cancer Stem Cells to Overcome Resistance to Photon and Carbon Ion Radiation

(2013) Gérald Bertrand et al.   Stem Cell Reviews and Reports

Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt

(2012) Selena Z Kuo et al.   BMC CANCER

Perivascular stem cell niche in head and neck cancer

(2012) Kathryn E. Ritchie et al.   CANCER LETTERS

Cancer Stem Cell Vaccination Confers Significant Antitumor Immunity

(2012) N. Ning et al.   CANCER RESEARCH

MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells

(2012) W.-J. Wang et al.   CANCER RESEARCH

Understanding cancer stem cell heterogeneity and plasticity

(2012) Dean G Tang   CELL RESEARCH

Hyaluronan-CD44v3 Interaction with Oct4-Sox2-Nanog Promotes miR-302 Expression Leading to Self-renewal, Clonal Formation, and Cisplatin Resistance in Cancer Stem Cells from Head and Neck Squamous Cell Carcinoma

(2012) Lilly Y. W. Bourguignon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncolytic virotherapy

(2012) Stephen J Russell et al.   NATURE BIOTECHNOLOGY

RAC1 activation mediates Twist1-induced cancer cell migration

(2012) Wen-Hao Yang et al.   NATURE CELL BIOLOGY

Functional effects of SDF-1α on a CD44+ CXCR4+ squamous cell carcinoma cell line as a model for interactions in the cancer stem cell niche

(2012) ANNE FABER et al.   ONCOLOGY REPORTS

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

(2012) S. J. Conley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Resistance to apoptosis-inducing stimuli in CD44+ head and neck squamous cell carcinoma cells

(2011) Kazuaki Chikamatsu et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Targeted Inhibition of CD133+ Cells in Oral Cancer Cell Lines

(2011) M. Damek-Poprawa et al.   JOURNAL OF DENTAL RESEARCH

Targeting Tumor-Initiating Cancer Cells with dCD133KDEL Shows Impressive Tumor Reductions in a Xenotransplant Model of Human Head and Neck Cancer

(2011) N. N. Waldron et al.   MOLECULAR CANCER THERAPEUTICS

MicroRNA Alterations and Associated Aberrant DNA Methylation Patterns across Multiple Sample Types in Oral Squamous Cell Carcinoma

(2011) Erik D. Wiklund et al.   PLoS One

Natural Killer Cells Preferentially Target Cancer Stem Cells; Role of Monocytes in Protection Against NK Cell Mediated Lysis of Cancer Stem Cells

(2011) Anahid Jewett et al.   Current Drug Delivery

Metastatic Potential of Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma

(2010) Samantha J. Davis et al.   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

Characterization of side population cells from laryngeal cancer cell lines

(2010) Guanglun Wan et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase

(2010) Matthew R. Clay et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Head and neck cancer stem cells: The side population

(2010) Mark H. Tabor et al.   LARYNGOSCOPE

Changes in Survival in Head and Neck Cancers in the Late 20th and Early 21st Century: A Period Analysis

(2010) D. Pulte et al.   ONCOLOGIST

Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells

(2010) Cheng-Chia Yu et al.   Journal of Oncology

Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export

(2009) Ryohei Katayama et al.   CANCER SCIENCE